liu.seSearch for publications in DiVA
Endre søk
Link to record
Permanent link

Direct link
BETA
Alternativa namn
Publikasjoner (10 av 175) Visa alla publikasjoner
Jasim, H., Carlsson, A. K., Gerdle, B., Ernberg, M. & Ghafouri, B. (2019). Diurnal variation of inflammatory plasma proteins involved in pain. Pain reports, 4(5), Article ID e776.
Åpne denne publikasjonen i ny fane eller vindu >>Diurnal variation of inflammatory plasma proteins involved in pain
Vise andre…
2019 (engelsk)Inngår i: Pain reports, ISSN 2471-2531, Vol. 4, nr 5, artikkel-id e776Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: Proteomics is a powerful approach for biochemical research because it directly studies the main functional components of biochemical systems. The understanding of the normal fluctuations of the proteome in health is essential to identify pain-specific biomarkers.

Objective: To investigate fluctuations of the plasma proteome in healthy pain-free individuals.

Methods: Blood samples were structurally collected in the early morning and evening from 10 clinically healthy individuals (26.3 ± 3.3 years). High abundant proteins were removed from plasma, and proteins were then analysed by nanoliquid chromatography combined with mass spectrometry. In addition, an assay of 71 cytokines/chemokines/growth factors was analysed.

Results: Multivariate statistical analysis displayed that there were up to 64 proteins whose expression levels were significantly altered between the plasma samples collected during the morning and evening; no changes existed for the assay. The levels of 34 proteins were increased and 30 proteins were decreased during the evening compared with the morning sample. The increased proteins were involved in the biological processes such as protein activation cascade, complement activation, and stress response. The decreased proteins were involved in regulation of endopeptidase activity, inflammatory response, and protein metabolic processes.

Conclusion: The circadian variations in the plasma proteome stress the need to collect blood samples of both patients and controls at a fixed time of the day. The results in this study might be useful for better understanding of the complexity of individual variation in the human plasma proteome over time and provide a baseline for improved pain biomarker discovery.

sted, utgiver, år, opplag, sider
Wolters Kluwer, 2019
Emneord
Diurnal, Mass spectrometry, Nanoliquid chromatography, Plasma, Proteomics
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-164356 (URN)10.1097/PR9.0000000000000776 (DOI)31875183 (PubMedID)2-s2.0-85081410635 (Scopus ID)
Tilgjengelig fra: 2020-03-19 Laget: 2020-03-19 Sist oppdatert: 2020-04-14bibliografisk kontrollert
Boersma, K., Södermark, M., Hesser, H., Flink, I. K., Gerdle, B. & Linton, S. J. (2019). Efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial. Pain, 160(8), 1708-1718
Åpne denne publikasjonen i ny fane eller vindu >>Efficacy of a transdiagnostic emotion-focused exposure treatment for chronic pain patients with comorbid anxiety and depression: a randomized controlled trial
Vise andre…
2019 (engelsk)Inngår i: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 160, nr 8, s. 1708-1718Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The comorbidity between chronic pain and emotional problems has proven difficult to address with current treatment options. This study addresses the efficacy of a transdiagnostic emotion-focused exposure treatment ("hybrid") for chronic pain patients with comorbid emotional problems. Adults (n = 115) with chronic musculoskeletal pain and functional and emotional problems were included in a 2-centre, parallel randomized controlled, open-label trial comparing this treatment to an active control condition receiving a guided Internet-delivered pain management treatment based on CBT principles (iCBT). The hybrid treatment (n = 58, 10-16 sessions) integrates exposure in vivo for chronic pain based on the fear-avoidance model with an emotion-regulation approach informed by procedures in Dialectical Behavior Therapy. The iCBT (n = 57; 8 treatment modules) addresses topics such as pain education, coping strategies, relaxation, problem solving, stress, and sleep management using standard CBT techniques. Patient-reported outcomes were assessed before and after treatment as well as at a 9-month primary end point. Across conditions, 78% participants completed post-treatment and 81% follow-up assessment. Intent-to-treat analyses showed that the hybrid had a significantly better post-treatment outcome on pain catastrophizing (d = 0.39) and pain interference (d = 0.63) and significantly better follow-up outcomes on depression (d = 0.43) and pain interference (d = 0.51). There were no differences on anxiety and pain intensity. Observed proportions of clinically significant improvement favoured the hybrid on all but one comparison, but no statistically significant differences were observed. We conclude that the hybrid emotion-focused treatment may be considered an acceptable, credible, and efficacious treatment option for chronic pain patients with comorbid emotional problems.

sted, utgiver, år, opplag, sider
Lippincott Williams & Wilkins, 2019
Emneord
Chronic pain; Emotional problems; Transdiagnostic; Cognitive-behavioral therapy; Internet; Randomized clinical trial; Exposure
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-160052 (URN)10.1097/j.pain.0000000000001575 (DOI)000480764500006 ()31335641 (PubMedID)2-s2.0-85066118471 (Scopus ID)
Merknad

Funding Agencies|AFA insurance [140356]; Region Ostergotland [LIO-724821]; Swedish Foundation for Humanities and Social Sciences [P14-0799: 1]

Tilgjengelig fra: 2019-09-06 Laget: 2019-09-06 Sist oppdatert: 2019-09-10bibliografisk kontrollert
Grooten, W. J., Tseli, E., Äng, B., Boersma, K., Stålnacke, B.-M., Gerdle, B. & Enthoven, P. (2019). Elaborating on the assessment of the risk of bias in prognostic studies in pain rehabilitation using QUIPS-aspects of interrater agreement. Diagnostic and prognostic research, 3, Article ID 5.
Åpne denne publikasjonen i ny fane eller vindu >>Elaborating on the assessment of the risk of bias in prognostic studies in pain rehabilitation using QUIPS-aspects of interrater agreement
Vise andre…
2019 (engelsk)Inngår i: Diagnostic and prognostic research, ISSN 2397-7523, Vol. 3, artikkel-id 5Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Many studies have been performed to identify important prognostic factors for outcomes after rehabilitation of patients with chronic pain, and there is a need to synthesize them through systematic review. In this process, it is important to assess the study quality and risk of bias. The "Quality In Prognosis Studies" (QUIPS) tool has been developed for this purpose and consists of several prompting items categorized into six domains, and each domain is judged on a three-grade scale (low, moderate or high risk of bias). The aim of the present study was to determine the interrater agreement of the risk of bias assessment in prognostic studies of patients with chronic pain using QUIPS and to elaborate on the use of this instrument.

Methods: We performed a systematic review and a meta-analysis of prognostic factors for long-term outcomes after multidisciplinary rehabilitation in patients with chronic pain. Two researchers rated the risk of bias in 43 published papers in two rounds (15 and 28 papers, respectively). The interrater agreement and Cohen's quadratic weighted kappa coefficient (κ) and 95% confidence interval (95%CI) were calculated in all domains and separately for the first and second rounds.

Results: The raters agreed in 61% of the domains (157 out of 258), with similar interrater agreement in the first (59%, 53/90) and second rounds (62%, 104/168). The overall weighted kappa coefficient (kappa for all domains and all papers) was weak: κ = 0.475 (95%CI = 0.358-0.601). A "minimal agreement" between the raters was found in the first round, κ = 0.323 (95%CI = 0.129-0.517), but increased to "weak agreement" in the second round, κ = 0.536 (95%CI = 0.390-0.682).

Conclusion: Despite a relatively low interrater agreement, QUIPS proved to be a useful tool in assessing the risk of bias when performing a meta-analysis of prognostic studies in pain rehabilitation, since it demands of raters to discuss and investigate important aspects of study quality. Some items were particularly hard to differentiate in-between, and a learning phase was required to increase the interrater agreement. This paper highlights several aspects of the tool that should be kept in mind when rating the risk of bias in prognostic studies, and provides some suggestions on common pitfalls to avoid during this process.

Trial registration: PROSPERO CRD42016025339; registered 05 February 2016.

sted, utgiver, år, opplag, sider
BioMed Central, 2019
Emneord
Chronic pain, Inter-rater agreement, Meta-analysis, Prognosis, Rehabilitation, Review, Risk of bias
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-164355 (URN)10.1186/s41512-019-0050-0 (DOI)31093575 (PubMedID)
Tilgjengelig fra: 2020-03-19 Laget: 2020-03-19 Sist oppdatert: 2020-04-14bibliografisk kontrollert
Ståhl, C., Seing, I., Gerdle, B. & Sandqvist, J. (2019). Fair or square? Experiences of introducing a new method for assessing general work ability in a sickness insurance context. Disability and Rehabilitation, 6, 656-665
Åpne denne publikasjonen i ny fane eller vindu >>Fair or square? Experiences of introducing a new method for assessing general work ability in a sickness insurance context
2019 (engelsk)Inngår i: Disability and Rehabilitation, ISSN 0963-8288, E-ISSN 1464-5165, Vol. 6, s. 656-665Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: To study social validity and perceived fairness of a new method for assessing general work ability in a sickness insurance context. Assessments are based on self-reports, combined with examinations by physicians, and, if needed, occupational therapists, physiotherapists and/or psychologists.

MATERIALS AND METHODS: Interviews with 36 insurance officials, 10 physicians, and 36 sick-listed persons, which were analysed through a qualitative content analysis.

RESULTS: Insurance officials and physicians considered the method useful and that it facilitated benefit decisions. The experiences of persons who had undergone the assessment differed, where the dialog with insurance officials seemed to have had an influence on experiences of the assessment and the decisions it led to.

CONCLUSIONS: The perceived fairness and social validity of the assessment depended on how it was carried out; organisational conditions and priorities; communication skills; and decision outcomes. Professionals have an important pedagogical task in explaining the purpose and procedure of the assessment in order for the sick-listed to perceive it as fair rather than square, i.e., too standardised and not considering individual conditions. If the assessment could be used also for rehabilitative purposes, it could possibly be perceived as more acceptable also in cases where it leads to denied benefits. Implications for rehabilitation The perceived fairness of work ability assessments is dependent on procedures for the assessment, communication with the person, and the outcome. What is considered fair differs between assessing professionals and persons being assessed. Professionals may influence the perceptions of fairness through their way of communication. Assessments need to be coupled with rehabilitation measures in order to perceived as relevant and acceptable.

sted, utgiver, år, opplag, sider
Taylor & Francis, 2019
Emneord
Sweden, Work ability, return to work; assessment, sickness insurance, work disability
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-146118 (URN)10.1080/09638288.2017.1401675 (DOI)000461521100005 ()29145740 (PubMedID)2-s2.0-85034264041 (Scopus ID)
Merknad

Funding agencies: SSIA

Tilgjengelig fra: 2018-03-28 Laget: 2018-03-28 Sist oppdatert: 2020-05-01bibliografisk kontrollert
Dragioti, E., Gerdle, B. & Larsson, B. (2019). Longitudinal Associations between Anatomical Regions of Pain and Work Conditions: A Study from The SwePain Cohort. International Journal of Environmental Research and Public Health, 16(12), Article ID 2167.
Åpne denne publikasjonen i ny fane eller vindu >>Longitudinal Associations between Anatomical Regions of Pain and Work Conditions: A Study from The SwePain Cohort
2019 (engelsk)Inngår i: International Journal of Environmental Research and Public Health, ISSN 1661-7827, E-ISSN 1660-4601, Vol. 16, nr 12, artikkel-id 2167Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We investigated the time-based associations between workload (physical and mechanical), psychosocial work stressors (demands, control, and support), and the number of anatomical regions with pain (ARP). This population-based study with a two-year follow-up included 11,386 responders (5125 men, 6261 women; mean age: 48.8 years; SD: 18.5) living in south-eastern Sweden. Predictive associations were assessed through generalised linear models, and changes over time were examined using a generalised estimating equation. The results of both models were reported as parameter estimates (B) with 95% confidence interval (CIs). Mean changes in the number of ARP, workload, and psychosocial work stressors were stable over time. High mechanical workload and job demands were likely associated with the number of ARP at the two-year follow-up. In the reverse prospective model, we found that the number of ARP was also associated with high physical and mechanical workload and low job control and support. In the two time-based models of changes, we found a reciprocal association between number of ARP and mechanical workload. Our results add epidemiological evidence to the associations between work conditions and the extent of pain on the body. Components of work conditions, including job demands and mechanical strain, must be considered when organisations and health policy makers plan and employ ergonomic evaluations to minimise workplace hazards in the general population.

sted, utgiver, år, opplag, sider
MDPI, 2019
Emneord
musculoskeletal pain; number of pain sites; cohort; physical workload; psychosocial work stressors; job strain
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-159072 (URN)10.3390/ijerph16122167 (DOI)000473750500101 ()31248097 (PubMedID)
Merknad

Funding Agencies|Swedish Pain Foundation; Medical Research Council of Southeast Sweden; Linkoping University

Tilgjengelig fra: 2019-07-22 Laget: 2019-07-22 Sist oppdatert: 2019-08-20
Ringqvist, A., Dragioti, E., Björk, M., Larsson, B. & Gerdle, B. (2019). Moderate and Stable Pain Reductions as a Result of Interdisciplinary Pain Rehabilitation: A Cohort Study from the Swedish Quality Registry for Pain Rehabilitation (SQRP). JOURNAL OF CLINICAL MEDICINE, 8(6), Article ID 905.
Åpne denne publikasjonen i ny fane eller vindu >>Moderate and Stable Pain Reductions as a Result of Interdisciplinary Pain Rehabilitation: A Cohort Study from the Swedish Quality Registry for Pain Rehabilitation (SQRP)
Vise andre…
2019 (engelsk)Inngår i: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 8, nr 6, artikkel-id 905Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Few studies have investigated the real-life outcomes of interdisciplinary multimodal pain rehabilitation programs (IMMRP) for chronic pain. This study has four aims: investigate effect sizes (ES); analyse correlation patterns of outcome changes; define a multivariate outcome measure; and investigate whether the clinical self-reported presentation pre-IMMRP predicts the multivariate outcome. To this end, this study analysed chronic pain patients in specialist care included in the Swedish Quality Registry for Pain Rehabilitation for 22 outcomes (pain, psychological distress, participation, and health) on three occasions: pre-IMMRP, post-IMMRP, and 12-month follow-up. Moderate stable ES were demonstrated for pain intensity, interference in daily life, vitality, and health; most other outcomes showed small ES. Using a Multivariate Improvement Score (MIS), we identified three clusters. Cluster 1 had marked positive MIS and was associated with the overall worst situation pre-IMMRP. However, the pre-IMMRP situation could only predict 8% of the variation in MIS. Specialist care IMPRPs showed moderate ES for pain, interference, vitality, and health. Outcomes were best for patients with the worst clinical presentation pre-IMMRP. It was not possible to predict who would clinically benefit most from IMMRP.

sted, utgiver, år, opplag, sider
MDPI, 2019
Emneord
chronic pain; musculoskeletal pain; patient care team; rehabilitation; treatment outcome
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-159280 (URN)10.3390/jcm8060905 (DOI)000475349300149 ()31238588 (PubMedID)
Merknad

Funding Agencies|Swedish Research Council [2018-02470]; County Council of Ostergotland (forsknings-ALF) [LIO-608021]; AFA insurance [140340]

Tilgjengelig fra: 2019-08-07 Laget: 2019-08-07 Sist oppdatert: 2019-11-15bibliografisk kontrollert
Larsson, B., Dragioti, E., Grimby-Ekman, A., Gerdle, B. & Ejork, J. (2019). Predictors of chronic pain intensity, spread, and sensitivity in the general population: A two-year follow-up study from the SWEPAIN cohort. Journal of Rehabilitation Medicine, 51(3), 183-192
Åpne denne publikasjonen i ny fane eller vindu >>Predictors of chronic pain intensity, spread, and sensitivity in the general population: A two-year follow-up study from the SWEPAIN cohort
Vise andre…
2019 (engelsk)Inngår i: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 51, nr 3, s. 183-192Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: To determine whether the intensity, spread and sensitivity of chronic pain can be predicted using demographic features, socioeconomic conditions and comorbidities.

Design: A longitudinal study design was employed. Data was collected at baseline and at 2-year follow-up. Setting: General population in south-eastern Sweden.

Subjects: A representative stratified random sample of 34,000 individuals, between 18 and 85 years of age, selected from a sampling frame of 404,661 individuals based on the Swedish Total Population Register.

Methods: Eligible individuals were sent postal surveys in 2013 and 2015. The 2 surveys included the same questions about basic demographic data, comorbidities, and chronic pain intensity, spread and sensitivity.

Results: Several socio-demographic features and comorbidities at baseline were significant predictors of characteristics of pain (intensity, spread and sensitivity) at the 2-year follow-up. When characteristics of pain at baseline were included in the regression analyses they were relatively strong significant predictors of characteristics of pain after 2 years. After this adjustment there were fewer socio-demographic and comorbidity predictors; the effect estimates for those significant predictors had decreased.

Conclusion: Clinical assessment should focus on several characteristics of pain and include a broad medical screening to capture the overall burden of pain in adults from a longitudinal perspective.

sted, utgiver, år, opplag, sider
Uppsala, Sweden: Foundation for Rehabilitation Information, 2019
Emneord
general population; follow-up; chronic pain characteristics; sociodemographic; comorbidities
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-155547 (URN)10.2340/16501977-2519 (DOI)000460419000005 ()30815707 (PubMedID)2-s2.0-85062877324 (Scopus ID)
Merknad

Funding Agencies|Swedish Pain Foundation; Linkoping University; Medical Research Council of Southeast Sweden

Tilgjengelig fra: 2019-03-26 Laget: 2019-03-26 Sist oppdatert: 2019-10-04bibliografisk kontrollert
Grundström, H., Gerdle, B., Alehagen, S., Berterö, C., Arendt-Nielsen, L. & Kjölhede, P. (2019). Reduced pain thresholds and signs of sensitization in women with persistent pelvic pain and suspected endometriosis. Acta Obstetricia et Gynecologica Scandinavica, 98(3), 327-336
Åpne denne publikasjonen i ny fane eller vindu >>Reduced pain thresholds and signs of sensitization in women with persistent pelvic pain and suspected endometriosis
Vise andre…
2019 (engelsk)Inngår i: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 98, nr 3, s. 327-336Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

INTRODUCTION: Endometriosis is a gynecological disorder that may cause considerable pelvic pain in women of fertile age. Determining pain mechanisms is necessary in order to optimize the treatment of the disease. The objective of the study was to evaluate pain thresholds in women with persistent pelvic pain with and without confirmed endometriosis, and healthy, unaffected controls, and analyze how pain thresholds in these cohorts related to duration of pelvic pain, quality of life, and symptoms of anxiety and depression.

MATERIAL AND METHODS: Pain thresholds for heat, cold and pressure were assessed with quantitative sensory testing on six locations on a reference group of 55 healthy women and on 37 women with persistent pelvic pain who had been admitted for diagnostic laparoscopy on the suspicion of endometriosis. Validated instruments were applied to assess quality of life and symptoms of anxiety and depression. Data were analyzed by means of uni- and multivariate analysis of variance and Spearman's rank-order correlation.

RESULTS: The women with persistent pelvic pain had significantly lower pain thresholds compared with the reference women. In the women with pain, no differences were observed in pain thresholds between women with (n = 13) and women without (n = 24) biopsy-proven endometriosis. The duration of pelvic pain correlated significantly positively with reduced pain thresholds, ie, the longer the duration, the more sensitization. In the persistent pelvic pain group, pain thresholds for heat correlated significantly with the Short Form Health Survey 36 dimension of bodily pain, and thresholds for cold correlated with Short Form Health Survey 36 bodily pain and with symptoms of depression.

CONCLUSIONS: Our results showed widespread alterations in pain thresholds in women with persistent pelvic pain that are indicative of central sensitization and a time-dependent correlation. Women with pelvic pain and suspicion of endometriosis should probably be treated more thoroughly to prevent or at least minimize the concomitant development of central sensitization.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2019
Emneord
chronic pain, endometriosis, health-related quality of life, pain thresholds, persistent pelvic pain, quantitative sensory testing, sensitization
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-154816 (URN)10.1111/aogs.13508 (DOI)000459481000007 ()30472739 (PubMedID)2-s2.0-85059291957 (Scopus ID)
Merknad

Funding agencies:  Medical Research Council of Southeast Sweden; Region Ostergotland; Linkoping University

Tilgjengelig fra: 2019-02-28 Laget: 2019-02-28 Sist oppdatert: 2019-06-28bibliografisk kontrollert
Gerdle, B. & Larsson, B. (2018). Muscle. In: Winifried Häuser & Serge Perrot (Ed.), Fibromyalgia syndrome and widespread pain: from Construction to relevant Recognition (pp. 215-231). Wolters Kluwer
Åpne denne publikasjonen i ny fane eller vindu >>Muscle
2018 (engelsk)Inngår i: Fibromyalgia syndrome and widespread pain: from Construction to relevant Recognition / [ed] Winifried Häuser & Serge Perrot, Wolters Kluwer, 2018, s. 215-231Kapittel i bok, del av antologi (Annet vitenskapelig)
sted, utgiver, år, opplag, sider
Wolters Kluwer, 2018
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-155653 (URN)9781975102852 (ISBN)
Tilgjengelig fra: 2019-03-22 Laget: 2019-03-22 Sist oppdatert: 2019-03-25bibliografisk kontrollert
Molander, P., Dong, H.-J., Äng, B., Enthoven, P. & Gerdle, B. (2018). The role of pain in chronic pain patients' perception of health-related quality of life: a cross-sectional SQRP study of 40,000 patients.. Scandinavian Journal of Pain, 18(3), 417-429, Article ID /j/sjpain.2018.18.issue-3/sjpain-2018-0003/sjpain-2018-0003.xml.
Åpne denne publikasjonen i ny fane eller vindu >>The role of pain in chronic pain patients' perception of health-related quality of life: a cross-sectional SQRP study of 40,000 patients.
Vise andre…
2018 (engelsk)Inngår i: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 18, nr 3, s. 417-429, artikkel-id /j/sjpain.2018.18.issue-3/sjpain-2018-0003/sjpain-2018-0003.xmlArtikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background and aims Health-related quality of life (Hr-QoL) reflects the burden of a condition on an overarching level. Pain intensity, disability and other factors influence how patients with chronic pain perceive their condition, e.g. Hr-QoL. However, the relative importance of these factors is unclear and there is an ongoing debate as to what importance pain measures have in this group. We investigated the importance of current pain level and mood on aspects of Hr-QoL in patients with chronic pain and investigated whether such relationships are influenced by demographics. Methods Data was obtained from the Swedish Quality Registry for Pain Rehabilitation (SQRP), between 2008 and 2016 on patients ≥18 years old who suffered from chronic pain and were referred to participating specialist clinics. Dependent variables were general Hr-QoL [using two scales from European Quality of Life instrument: EQ5D Index and the European Quality of Life instrument health scale (EQ thermometer)] and specific Hr-QoL [from the Short Form Health Survey (SF36) the physical component summary (SF36-PCS) and the mental (psychological) component summary (SF36-MCS)]. Independent variables were sociodemographic variables, pain variables, psychological distress and pain attitudes. Principal component analysis (PCA) was used for multivariate correlation analyses of all investigated variables and Orthogonal Partial Least Square Regression (OPLS) for multivariate regressions on health aspects. Results There was 40,518 patients (72% women). Pain intensity and interference showed the strongest multivariate correlations with EQ5D Index, EQ thermometer and SF36-PCS. Psychological distress variables displayed the strongest multivariate correlations with SF36-MCS. Demographic properties did not significantly influence variations in the investigated Hr-QoL variables. Conclusions Pain, mood and pain attitudes were significantly correlated with Hr-QoL variables, but these variables cannot explain most of variations in Hr-QoL variables. The results pinpoint that broad assessments (including pain intensity aspects) are needed to capture the clinical presentation of patients with complex chronic pain conditions.

Emneord
acceptance, health, mood, pain, quality of life
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-155122 (URN)10.1515/sjpain-2018-0003 (DOI)29794267 (PubMedID)
Tilgjengelig fra: 2019-03-19 Laget: 2019-03-19 Sist oppdatert: 2019-04-10
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-4316-1264