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Lundström, Ingemar
Publikasjoner (10 av 320) Visa alla publikasjoner
Stehr, J. E., Lundström, I. & Karlsson, J. O. (2019). Evidence that fodipir (DPDP) binds neurotoxic Pt2+ with a high affinity: An electron paramagnetic resonance study. Scientific Reports, 9, Article ID 15813.
Åpne denne publikasjonen i ny fane eller vindu >>Evidence that fodipir (DPDP) binds neurotoxic Pt2+ with a high affinity: An electron paramagnetic resonance study
2019 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 9, artikkel-id 15813Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Oxaliplatin typically causes acute neuropathic problems, which may, in a dose-dependent manner, develop into a chronic form of chemotherapy-induced peripheral neuropathy (CIPN), which is associated with retention of Pt2+ in the dorsal root ganglion. A clinical study by Coriat and co-workers suggests that co-treatment with mangafodipir [Manganese(II) DiPyridoxyl DiPhosphate; MnDPDP] cures ongoing CIPN. These authors anticipated that it is the manganese superoxide dismutase mimetic activity of MnDPDP that explains its curative activity. However, this is questionable from a pharmacokinetic perspective. Another, but until recently undisclosed possibility is that Pt2+ outcompetes Mn2+/Ca2+/Zn2+ for binding to DPDP or its dephosphorylated metabolite PLED (diPyridoxyL EthylDiamine) and transforms toxic Pt2+ into a non-toxic complex, which can be readily excreted from the body. We have used electron paramagnetic resonance guided competition experiments between MnDPDP (10logKML ≈ 15) and K2PtCl4, and between MnDPDP and ZnCl2 (10logKML ≈ 19), respectively, in order to obtain an estimate the 10logKML of PtDPDP. Optical absorption spectroscopy revealed a unique absorption line at 255 nm for PtDPDP. The experimental data suggest that PtDPDP has a higher formation constant than that of ZnDPDP, i.e., higher than 19. The present results suggest that DPDP/PLED has a high enough affinity for Pt2+ acting as an efficacious drug in chronic Pt2+-associated CIPN.

sted, utgiver, år, opplag, sider
Nature Publishing Group, 2019
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-161652 (URN)10.1038/s41598-019-52248-9 (DOI)000493716000014 ()31676855 (PubMedID)2-s2.0-85074277794 (Scopus ID)
Forskningsfinansiär
Medical Research Council of Southeast Sweden (FORSS), 85191
Merknad

Funding agencies: Medical Research Council of Southeast Sweden [FORSS-85191]; Karlsson-Tuner Invest AS, Norway

Tilgjengelig fra: 2019-11-05 Laget: 2019-11-05 Sist oppdatert: 2019-12-13bibliografisk kontrollert
Silverå Ejneby, M., Wu, X., Ottosson, N., Münger, E. P., Lundström, I., Konradsson, P. & Elinder, F. (2018). Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid. The Journal of General Physiology, 150(5), 731-750
Åpne denne publikasjonen i ny fane eller vindu >>Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid
Vise andre…
2018 (engelsk)Inngår i: The Journal of General Physiology, ISSN 0022-1295, E-ISSN 1540-7748, Vol. 150, nr 5, s. 731-750Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Dehydroabietic acid (DHAA) is a naturally occurring component of pine resin that was recently shown to open voltage-gated potassium (KV) channels. The hydrophobic part of DHAA anchors the compound near the channel’s positively charged voltage sensor in a pocket between the channel and the lipid membrane. The negatively charged carboxyl group exerts an electrostatic effect on the channel’s voltage sensor, leading to the channel opening. In this study, we show that the channel-opening effect increases as the length of the carboxyl-group stalk is extended until a critical length of three atoms is reached. Longer stalks render the compounds noneffective. This critical distance is consistent with a simple electrostatic model in which the charge location depends on the stalk length. By combining an effective anchor with the optimal stalk length, we create a compound that opens the human KV7.2/7.3 (M type) potassium channel at a concentration of 1 µM. These results suggest that a stalk between the anchor and the effector group is a powerful way of increasing the potency of a channel-opening drug.

sted, utgiver, år, opplag, sider
New York, United States: Rockefeller Institute for Medical Research, 2018
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-147837 (URN)10.1085/jgp.201711965 (DOI)000434417800008 ()2-s2.0-85046705149 (Scopus ID)
Merknad

Funding agencies: Swedish Research Council [2016-02615]; Swedish Heart-Lung Foundation [20150672]; Swedish Brain Foundation [2016-0326]

Tilgjengelig fra: 2018-05-15 Laget: 2018-05-15 Sist oppdatert: 2018-06-28bibliografisk kontrollert
Karlsson, J. O., Ignarro, L. J., Lundström, I., Jynge, P. & Almén, T. (2015). Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties. Drug Discovery Today, 20(4), 411-421
Åpne denne publikasjonen i ny fane eller vindu >>Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties
Vise andre…
2015 (engelsk)Inngår i: Drug Discovery Today, ISSN 1359-6446, E-ISSN 1878-5832, Vol. 20, nr 4, s. 411-421Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) participate in pathological tissue damage. Mitochondrial manganese superoxide dismutase (MnSOD) normally keeps ROS and RNS in check. During development of mangafodipir (MnDPDP) as a magnetic resonance imaging (MRI) contrast agent, it was discovered that MnDPDP and its metabolite manganese pyridoxyl ethyldiamine (MnPLED) possessed SOD mimetic activity. MnDPDP has been tested as a chemotherapy adjunct in cancer patients and as an adjunct to percutaneous coronary intervention in patients with myocardial infarctions, with promising results. Whereas MRI contrast depends on release of Mn2+, the SOD mimetic activity depends on Mn2+ that remains bound to DPDP or PLED. Calmangafodipir [Ca4Mn(DPDP)5] is stabilized with respect to Mn2+ and has superior therapeutic activity. Ca4Mn(DPDP)5 is presently being explored as a chemotherapy adjunct in a clinical multicenter Phase II study in patients with metastatic colorectal cancer.

sted, utgiver, år, opplag, sider
Elsevier, 2015
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-118607 (URN)10.1016/j.drudis.2014.11.008 (DOI)000354581300005 ()25463039 (PubMedID)
Tilgjengelig fra: 2015-06-04 Laget: 2015-06-02 Sist oppdatert: 2017-12-04bibliografisk kontrollert
Dini, F., Magna, G., Martinelli, E., Pomarico, G., Di Natale, C., Paolesse, R. & Lundström, I. (2015). Combining porphyrins and pH indicators for analyte detection. Analytical and Bioanalytical Chemistry, 407(14), 3975-3984
Åpne denne publikasjonen i ny fane eller vindu >>Combining porphyrins and pH indicators for analyte detection
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2015 (engelsk)Inngår i: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 407, nr 14, s. 3975-3984Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

High sensitivity and cross-selectivity are mandatory properties for sensor arrays. Although metalloporphyrins and pH indicators are among the most common and appropriate choices for the preparation of optical sensor arrays, the sensitivity spectrum of these dyes is limited to those analytes able to induce an optical response. To extend the receptive field of optical sensors, we explore the design of composite materials, where the molecular interaction among the subunits enriches their sensing working mechanisms. We demonstrate that blends of single metalloporphyrins and pH indicators, tested with a transduction apparatus based on ubiquitous and easily available hardware, can be endowed with sensing properties wider than those of single constituents, enabling the recognition of a broad range of volatiles.

sted, utgiver, år, opplag, sider
Springer, 2015
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-118620 (URN)10.1007/s00216-014-8445-9 (DOI)000354190300008 ()25614242 (PubMedID)
Tilgjengelig fra: 2015-06-04 Laget: 2015-06-02 Sist oppdatert: 2017-12-04bibliografisk kontrollert
Vagin, M. Y., Sekretareva, A., Lindgren, P., Håkansson, A., Eriksson, M., Lundström, I., . . . Yakimova, R. (2015). Direct bioelectrocatalysis on anodized epitaxial graphene. In: Program of the XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society14-18 June, 2015Malmö, Sweden: . Paper presented at Program of the XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society 14-18 June, 2015 Malmö, Sweden (pp. 170-170). Lausanne: Bioelectrochemical Society
Åpne denne publikasjonen i ny fane eller vindu >>Direct bioelectrocatalysis on anodized epitaxial graphene
Vise andre…
2015 (engelsk)Inngår i: Program of the XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society14-18 June, 2015Malmö, Sweden, Lausanne: Bioelectrochemical Society , 2015, s. 170-170Konferansepaper, Publicerat paper (Annet vitenskapelig)
Abstract [en]

Graphene as a nanomaterial consisting of a single layer sheets of atoms of carbon in hexagonal arrangement is making a significant impact in variety of technologies such as energy storage and chemical analysis. The significant attention paid to this thinnest nanomaterial resulted in thousands of patent applications is due to its staggering properties. Due to the planar conjugation of the sp2bonds in graphene, two-dimensional electrical conduction is highly efficient. On the contrary, the efficiency of electron exchange at the out-of-plane of the graphene sheet is small. The significant difference of the densities of electronic states at in-plane and out-of-plane of graphene sheet determines two distinct structural contributions (basal and edge plane respectively) to the behavior of all graphitic materials yielding the chemical and electrochemical anisotropy. Being the simplest building block of graphitic materials, graphene offers the possibility to study the behavior on the simplest level of structural organization. However, the major effort of the recent electrochemical studies of graphene were done using a bulk materials based on graphene flakes possessing the domination of edges of high reactivity. The planar orientation of graphene sheets with controllable exposure of basal plane is achievable via the growth by chemical vapor deposition or by epitaxial flash annealing on crystalline structures of silicon carbide. The slow growth of graphene onto crystalline support during annealing in the inert atmosphere results in a development of a high quality graphene monolayer attached to the solid insulating support. The creation of sp3-type reactive defects on the basal plane of graphite can be achieved by anodization at high anodic potentials.

We developed the procedure for the real-time monitoring of epitaxial graphene anodization. The changes of electrochemical properties of graphene monolayer with anodization have been comparatively investigated by electrochemical methods. The estimation of specific capacitance in pure electrolyte and in conditions of Faradaic process has been carried out. Finally, the direct electrocatalysis of laccase (Trametes versicolor) has been used as an electrode reaction to probe the reactivities of anodized epitaxial graphene and conventional carbon materials.

sted, utgiver, år, opplag, sider
Lausanne: Bioelectrochemical Society, 2015
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-122686 (URN)
Konferanse
Program of the XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society 14-18 June, 2015 Malmö, Sweden
Tilgjengelig fra: 2015-11-16 Laget: 2015-11-16 Sist oppdatert: 2017-11-03bibliografisk kontrollert
Lvova, L., Pudi, R., Galloni, P., Lippolis, V., Di Natale, C., Lundström, I. & Paolesse, R. (2015). Multi-transduction sensing films for Electronic Tongue applications. Sensors and actuators. B, Chemical, 207, 1076-1086
Åpne denne publikasjonen i ny fane eller vindu >>Multi-transduction sensing films for Electronic Tongue applications
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2015 (engelsk)Inngår i: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 207, s. 1076-1086Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In this paper the use of multi-transduction principle for sensing materials development is reviewed. In particular, the application of porphyrin-based films to a multi-transduction Electronic Tongue system for different analytical tasks is presented. The optical response of sensing films was registered by means of Computer Screen Photoassisted Technology (CSPT) that applies familiar devices, such as computer monitor screen and web-camera, as illumination light source and signal detectors. Simultaneously the electrochemical amperometric or potentiometric response of the same sensing material was measured. Data analysis combining both signals significantly improves the performance of the Electronic Tongue, thus opening new frontiers in application of such a system.

sted, utgiver, år, opplag, sider
Elsevier, 2015
Emneord
Multi-transduction principle; Electronic Tongue; Optical and electrochemical sensing; Porphyrin films
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-113150 (URN)10.1016/j.snb.2014.10.086 (DOI)000345895400026 ()
Tilgjengelig fra: 2015-01-14 Laget: 2015-01-12 Sist oppdatert: 2017-12-05
Vagin, M., Sekretareva, A., Sanchez, R., Lundström, I., Winquist, F. & Eriksson, M. (2014). Arrays of Screen-Printed Graphite Microband Electrodes as a Versatile Electroanalysis Platform. ChemElectroChem, 1(4), 755-762
Åpne denne publikasjonen i ny fane eller vindu >>Arrays of Screen-Printed Graphite Microband Electrodes as a Versatile Electroanalysis Platform
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2014 (engelsk)Inngår i: ChemElectroChem, ISSN 2196-0216, Vol. 1, nr 4, s. 755-762Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Arrays of microband electrodes were developed by screen printing followed by cutting, which enabled the realization of microband arrays at the cut edge. The microband arrays of different designs were characterized by physical and electro-chemical methods. In both cases, the methods showed that the microband width was around 5 mm. Semi-steady-state cyclic voltammetry responses were observed for redox probes, and chronocoulometric measurements showed the establishment of convergent diffusion regimes characterized by current densities similar to those of a single microelectrode. The analytical performance of the electrode system and its versatility were illustrated with two electrochemical assays: detection of ascorbic acid through direct oxidation and a mediated glucose biosensor fabricated by dip coating. Due to convergent mass transport, both systems showed an enhancement in their analytical characteristics. The developed approach can be adapted to automated electrode recovery.

sted, utgiver, år, opplag, sider
Wiley, 2014
Emneord
graphite screen printing; microarrays; microband; sensors; voltammetry
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-109289 (URN)10.1002/celc.201300204 (DOI)000338296100010 ()
Tilgjengelig fra: 2014-08-11 Laget: 2014-08-11 Sist oppdatert: 2017-11-03bibliografisk kontrollert
Vagin, M. Y., Lundström, I., Turner, A., Beni, V. & Eriksson, M. (2014). Boron-doped diamond microelectrode arrays for electrochemical monitoring of antibiotics contamination in water. In: 15th International Conference on Electroanalysis (ESEAC): . Paper presented at 15th International Conference on Electroanalysis (ESEAC), 11-15 June 2014, Malmö, Sweden.
Åpne denne publikasjonen i ny fane eller vindu >>Boron-doped diamond microelectrode arrays for electrochemical monitoring of antibiotics contamination in water
Vise andre…
2014 (engelsk)Inngår i: 15th International Conference on Electroanalysis (ESEAC), 2014Konferansepaper, Oral presentation with published abstract (Annet vitenskapelig)
Abstract [en]

The improvement of water management and increasing the access to safe drinking water can develop the quality of life for millions of people world-wide and reduce child mortality due to water-borne diseases [1]. Sweden was recently affected by the lack of appropriate water management which resulted in microbial contamination and tens of thousands of people falling ill [2]. Pollution with chemical compounds is also a waterworks concern. The appearance of pharmaceuticals such as antibiotics in raw water affects the cleaning processes at waterworks [3]. Substances which are not, or are only partly, eliminated in the sewage treatment plant will reach the surface water where they may affect organisms of different trophic levels and cause, for example, the of antibiotics resistance [4]. The inhibition of bacteria of waste water plants by antibiotics may seriously affect organic matter degradation. The efficiency of nitrification as an important step in waste water purification, can be decreased by antibiotics inhibition [5]. Boron-doped diamond (BDD) is an advanced electrode material that possesses the combination of good electrical conductivity achieved via film doping and the extreme chemical inertness of diamond, which gives rise to a number of highly desirable properties of BDD as electrode material: a wide potential window in aqueous media allows electrochemical measurements at both extreme anodic and cathodic potentials, very low capacitive currents leads to a sensitivity increase and extreme chemical and structural inertness prevents electrode fouling [6]. Usage of a microelectrode array as the working electrode offers a variety of benefits for electroanalysis: an improvement of the analytical performance in comparison with macroelectrodes under planar diffusion, higher signal-to-noise ratios due to low capacitive currents at the small surface area, shorter response times and less sensitivity to variations in the water flow rate. The BDD arrays of this work contain 2900 microelectrodes (10 mm diameter each) and have been used for the detection of antibiotics (ofloxacine and canamycin A) in water with high amplitude pulse voltammetry processed by multivariate data analysis. The detection limits observed in monitoring mode were comparable with the characteristics of standard protocols of antibiotics detection, which opens the possibility for continuous monitoring of water.

[1] The United Nations, World Water Development Report 4, 2012; [2] Lindberg, A. et al.,

FOI-R--3376--SE, 2011; Dryselius, R.; National Food Agency, Sweden, 2012; [3] Kummerer

K. Chemosphere, 2009, 75, 417; [4] Kummerer K. Chemosphere, 2009, 75, 435; [5]

Dokianakis, S.N. et al., Water Sci. Technol. 50, 341; [6] Goeting, C. et al.,

NewDiam.Front.C.Tech. 1999, 9, 207; Compton, R. et al., Electroanal. 2003, 15, 1349.

 

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-108450 (URN)
Konferanse
15th International Conference on Electroanalysis (ESEAC), 11-15 June 2014, Malmö, Sweden
Forskningsfinansiär
Formas
Tilgjengelig fra: 2014-06-27 Laget: 2014-06-27 Sist oppdatert: 2017-11-03
Lundström, I. (2014). From a Laboratory Exercise for Students to a Pioneering Biosensing Technology. PLASMONICS, 9(4), 741-751
Åpne denne publikasjonen i ny fane eller vindu >>From a Laboratory Exercise for Students to a Pioneering Biosensing Technology
2014 (engelsk)Inngår i: PLASMONICS, ISSN 1557-1955, Vol. 9, nr 4, s. 741-751Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Surface plasmon resonance (SPR) for biosensing was demonstrated 30 years ago. In the present contribution, its general background is described together with the necessary developments both in instrumentation and surface chemistry, leading to the final so-called BIAcore technology. The description is naturally colored by my personal opinion of the developments. SPR for the elucidation of organic mono- and multilayers introduced at the end of the 1970s formed the basis for the first biosensing demonstration of SPR in the beginning of the 1980s. It is pointed out how the need of an up-to-date laboratory exercise for the undergraduate students and the multidisciplinary environment at the Laboratory of Applied Physics at Linkoping University led to this demonstration. The initial experiments are touched upon and the further developments at Pharmacia, which led to the BIAcore technology, are described in some details. Some of the present activities in Linkoping related to optical biosensing with ubiquitous instrumentation are also described, including SPR detection with a computer screen and a web camera and most recently with a cellular phone.

sted, utgiver, år, opplag, sider
Springer Verlag (Germany), 2014
Emneord
Surface plasmon resonance; Historical overview; BIAcore; Computer screen photo-assisted techniques
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-111290 (URN)10.1007/s11468-013-9654-3 (DOI)000341423800004 ()25177230 (PubMedID)
Tilgjengelig fra: 2014-10-14 Laget: 2014-10-14 Sist oppdatert: 2014-10-16
Holub, D., Gifford, R., Lundström, I. & Turner, A. (2014). PoC Amylase Biosensor. In: 24th Anniversary World Congress on Biosensors – Biosensors 2014: . Paper presented at 24th Anniversary World Congress on Biosensors – Biosensors 2014, 27-30 May 2014, Melbourne, Australia. Elsevier
Åpne denne publikasjonen i ny fane eller vindu >>PoC Amylase Biosensor
2014 (engelsk)Inngår i: 24th Anniversary World Congress on Biosensors – Biosensors 2014, Elsevier, 2014Konferansepaper, Poster (with or without abstract) (Annet vitenskapelig)
Abstract [en]

A rapid, inexpensive and quantitative biosensor to measure alpha-amylase activity within the relevant clinical range has been developed.  This device is suited for point-of-care (PoC) applications because it is easy to use and disposable.  Salivary α-amylase activity is correlated to stress levels and, therefore, it is a potential monitoring candidate for neurological conditions (e.g. Multiple Sclerosis) for which there are no objective diagnostics available.  The enzyme is also utilized in many industrial processes like fermentation and textile production, where real-time, on-site monitoring can be advantageous for accurate process control.  In contrast to other α-amylase quantitative methods, this biosensor is rapid (results within 10 minutes), it does not require bench-top or specialized equipment (i.e. it is portable and does not need to be sent to a laboratory for results), and the general public can perform the analysis (no specialized training needed).  An electro-active moiety, which is sensitive to α-amylase activity, is incorporated into the biosensor design and generates a signal that is proportional to the alpha-amylase activity in the sample (Figure 1, below).  This new device will allow researchers to better diagnose and monitor neurological conditions and follow treatment effectiveness without relying solely on subjective assessments.  In addition, using this novel biosensor to monitor industrial processes that utilize α-amylase could reduce production costs and waste generation for these industries.

sted, utgiver, år, opplag, sider
Elsevier, 2014
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-108423 (URN)
Konferanse
24th Anniversary World Congress on Biosensors – Biosensors 2014, 27-30 May 2014, Melbourne, Australia
Tilgjengelig fra: 2014-06-27 Laget: 2014-06-27 Sist oppdatert: 2014-08-26
Organisasjoner