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Karlsson, Helen
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Publikasjoner (10 av 38) Visa alla publikasjoner
Alijagic, A., Engwall, M., Särndahl, E., Karlsson, H., Hedbrant, A., Andersson, L., . . . Persson, A. (2022). Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing.. Frontiers in Toxicology, 4, Article ID 836447.
Åpne denne publikasjonen i ny fane eller vindu >>Particle Safety Assessment in Additive Manufacturing: From Exposure Risks to Advanced Toxicology Testing.
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2022 (engelsk)Inngår i: Frontiers in Toxicology, E-ISSN 2673-3080, Vol. 4, artikkel-id 836447Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Additive manufacturing (AM) or industrial three-dimensional (3D) printing drives a new spectrum of design and production possibilities; pushing the boundaries both in the application by production of sophisticated products as well as the development of next-generation materials. AM technologies apply a diversity of feedstocks, including plastic, metallic, and ceramic particle powders with distinct size, shape, and surface chemistry. In addition, powders are often reused, which may change the particles' physicochemical properties and by that alter their toxic potential. The AM production technology commonly relies on a laser or electron beam to selectively melt or sinter particle powders. Large energy input on feedstock powders generates several byproducts, including varying amounts of virgin microparticles, nanoparticles, spatter, and volatile chemicals that are emitted in the working environment; throughout the production and processing phases. The micro and nanoscale size may enable particles to interact with and to cross biological barriers, which could, in turn, give rise to unexpected adverse outcomes, including inflammation, oxidative stress, activation of signaling pathways, genotoxicity, and carcinogenicity. Another important aspect of AM-associated risks is emission/leakage of mono- and oligomers due to polymer breakdown and high temperature transformation of chemicals from polymeric particles, both during production, use, and in vivo, including in target cells. These chemicals are potential inducers of direct toxicity, genotoxicity, and endocrine disruption. Nevertheless, understanding whether AM particle powders and their byproducts may exert adverse effects in humans is largely lacking and urges comprehensive safety assessment across the entire AM lifecycle-spanning from virgin and reused to airborne particles. Therefore, this review will detail: 1) brief overview of the AM feedstock powders, impact of reuse on particle physicochemical properties, main exposure pathways and protective measures in AM industry, 2) role of particle biological identity and key toxicological endpoints in the particle safety assessment, and 3) next-generation toxicology approaches in nanosafety for safety assessment in AM. Altogether, the proposed testing approach will enable a deeper understanding of existing and emerging particle and chemical safety challenges and provide a strategy for the development of cutting-edge methodologies for hazard identification and risk assessment in the AM industry.

sted, utgiver, år, opplag, sider
Frontiers Media S.A., 2022
Emneord
adverse outcome, endocrine disruption, genotoxicity, industrial 3D printing, inflammation, mechanism of action, particle emissions
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-193510 (URN)10.3389/ftox.2022.836447 (DOI)35548681 (PubMedID)
Merknad

Fundinge agencies: he Swedish Knowledge Foundation (Grants No. 20190107 and 20160019)

Tilgjengelig fra: 2023-05-02 Laget: 2023-05-02 Sist oppdatert: 2023-10-05
Beazer, J. D., Patanapirunhakit, P., Gill, J. M. R., Graham, D., Karlsson, H., Ljunggren, S., . . . Freeman, D. J. (2020). High-density lipoproteins vascular protective functions in metabolic and cardiovascular disease - could extracellular vesicles be at play?. Clinical Science, 134(22), 2977-2986
Åpne denne publikasjonen i ny fane eller vindu >>High-density lipoproteins vascular protective functions in metabolic and cardiovascular disease - could extracellular vesicles be at play?
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2020 (engelsk)Inngår i: Clinical Science, ISSN 0143-5221, E-ISSN 1470-8736, Vol. 134, nr 22, s. 2977-2986Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

High-density lipoprotein (HDL) is a circulating complex of lipids and proteins known primarily for its role in reverse cholesterol transport and consequent protection from atheroma. In spite of this, therapies aimed at increasing HDL concentration do not reduce the risk of cardiovascular disease (CVD), and as such focus has shifted towards other HDL functions protective of vascular health - including vasodilatory, anti-inflammatory, antioxidant and anti-thrombotic actions. It has been demonstrated that in disease states such as CVD and conditions of insulin resistance such as Type 2 diabetes mellitus (T2DM), HDL function is impaired owing to changes in the abundance and function of HDL-associated lipids and proteins, resulting in reduced vascular protection. However, the gold standard density ultracentrifugation technique used in the isolation of HDL also co-isolates extracellular vesicles (EVs). EVs are ubiquitous cell-derived particles with lipid bilayers that carry a number of lipids, proteins and DNA/RNA/miRNAs involved in cell-to-cell communication. EVs transfer their bioactive load through interaction with cell surface receptors, membrane fusion and endocytic pathways, and have been implicated in both cardiovascular and metabolic diseases - both as protective and pathogenic mediators. Given that studies using density ultracentrifugation to isolate HDL also co-isolate EVs, biological effects attributed to HDL may be confounded by EVs. We hypothesise that some of HDLs vascular protective functions in cardiovascular and metabolic disease may be mediated by EVs. Elucidating the contribution of EVs to HDL functions will provide better understanding of vascular protection and function in conditions of insulin resistance and potentially provide novel therapeutic targets for such diseases.

sted, utgiver, år, opplag, sider
Portland Press on behalf of the Medical Research Society and the Biochemical Society, 2020
Emneord
cardiovascular disease; density ultracentrifugation; extracellular vesicles; high-density lipoprotein; metabolic disease
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-174449 (URN)10.1042/CS20200892 (DOI)33210708 (PubMedID)
Tilgjengelig fra: 2021-03-22 Laget: 2021-03-22 Sist oppdatert: 2021-03-22bibliografisk kontrollert
Helmfrid, I., Ljunggren, S., Nosratabadi, A. R., Augustsson, A., Filipsson, M., Fredrikson, M., . . . Berglund, M. (2019). Exposure of metals and PAH through local foods and risk of cancer in a historically contaminated glasswork area. Environment International, 131, Article ID UNSP 104985.
Åpne denne publikasjonen i ny fane eller vindu >>Exposure of metals and PAH through local foods and risk of cancer in a historically contaminated glasswork area
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2019 (engelsk)Inngår i: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 131, artikkel-id UNSP 104985Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background

Production of crystal glass and colored art glassware have been going on in the south-eastern part of Sweden since the 1700s, at over 100 glassworks and smaller glass blowing facilities, resulting in environmental contamination with mainly arsenic (As), cadmium (Cd), lead (Pb) and polycyclic hydrocarbons (PAH). High levels of metals have been found in soil, and moderately elevated levels in vegetables, mushrooms and berries collected around the glassworks sites compared with reference areas. Food in general, is the major exposure source to metals, such as Cd and Pb, and PAHs. Exposure to these toxic metals and PAH has been associated with a variety of adverse health effects in humans including cancer.

Objective

The aim of the present study was to evaluate the occurrence of cancer in a cohort from the contaminated glasswork area in relation to long-term dietary intake of locally produced foods, while taking into account residential, occupational and life styles factors.

Methods

The study population was extracted from a population cohort of 34,266 individuals who, at some time between the years 1979–2004, lived within a 2 km radius of a glassworks or glass landfill. Register information on cancer incidence and questionnaire information on consumption of local foods (reflecting 30 years general eating habits), life-time residence in the area, life style factors and occupational exposure was collected. Furthermore, blood (n = 660) and urine (n = 400) samples were collected in a subsample of the population to explore associations between local food consumption frequencies, biomarker concentrations in blood (Cd, Pb, As) and urine (PAH metabolite 1-OHPy) as well as environmental and lifestyle factors. The concurrent exposure to persistent organic pollutants (POPs) from food was also considered. A case-control study was performed for evaluation of associations between intakes of local food and risk of cancer.

Results

Despite high environmental levels of Cd, Pb and As at glasswork sites and landfills, current metal exposure in the population living in the surrounding areas was similar or only moderately higher in our study population compared to the general population. Reported high consumption of certain local foods was associated with higher Cd and Pb, but not As, concentrations in blood, and 1-OHPy in urine. An increased risk of cancer was associated with smoking, family history of cancer, obesity, and residence in glasswork area before age 5 years. Also, a long-term high consumption of local foods (reflecting 30 years general eating habits), i.e. fish and meat (game, chicken, lamb), was associated with increased risk of various cancer forms.

Conclusions

The associations between consumption of local food and different types of cancer may reflect a higher contaminant exposure in the past, and thus, if consumption of local food contributes to the risk of acquiring cancer, that contribution is probably lower today than before. Furthermore, it cannot be ruled out that other contaminants in the food contribute to the increased cancer risks observed.

sted, utgiver, år, opplag, sider
Elsevier, 2019
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-160953 (URN)10.1016/j.envint.2019.104985 (DOI)000493550200042 ()31319292 (PubMedID)2-s2.0-85068874468 (Scopus ID)
Merknad

Funding agencies: Swedish Environmental Protection Agency; Medical Research Council of Southeast Sweden; Kamprad Family Foundation, Sweden; Occupational and Environmental Medicine, Linkoping University Hospital, Sweden

Tilgjengelig fra: 2019-10-16 Laget: 2019-10-16 Sist oppdatert: 2020-04-29bibliografisk kontrollert
Ljunggren, S., Bengtsson, T., Karlsson, H., Starkhammar Johansson, C., Palm, E., Nayeri, F., . . . Lönn, J. (2019). Modified lipoproteins in periodontitis: a link to cardiovascular disease?. Bioscience Reports, 39(3), Article ID BSR20181665.
Åpne denne publikasjonen i ny fane eller vindu >>Modified lipoproteins in periodontitis: a link to cardiovascular disease?
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2019 (engelsk)Inngår i: Bioscience Reports, ISSN 0144-8463, E-ISSN 1573-4935, Vol. 39, nr 3, artikkel-id BSR20181665Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

There is a strong association between periodontal disease and atherosclerotic cardiovascular disorders. A key event in the development of atherosclerosis is accumulation of modified lipoproteins within the arterial wall. We hypothesise that patients with periodontitis have an altered lipoprotein profile towards an atherogenic form. Therefore, the present study aims at identifying modifications of plasma lipoproteins in periodontitis. Lipoproteins from ten female patients with periodontitis and gender- and age-matched healthy controls were isolated by density-gradient ultracentrifugation. Proteins were separated by 2D gel-electrophoresis and identified by map-matching or by nano-LC followed by MS. Apolipoprotein (Apo) A-I (ApoA-I) methionine oxidation, Oxyblot, total antioxidant capacity and a multiplex of 71 inflammation-related plasma proteins were assessed. Reduced levels of apoJ, phospholipid transfer protein, apoF, complement C3, paraoxonase 3 and increased levels of alpha-1-antichymotrypsin, apoA-II, apoC-III were found in high-density lipoprotein (HDL) from the patients. In low-density lipoprotein (LDL)/very LDL (VLDL), the levels of apoL-1 and platelet-activating factor acetylhydrolase (PAF-AH) as well as apo-B fragments were increased. Methionine oxidation of apoA-I was increased in HDL and showed a relationship with periodontal parameters. alpha-1 antitrypsin and alpha-2-HS glycoprotein were oxidised in LDL/VLDL and antioxidant capacity was increased in the patient group. A total of 17 inflammation-related proteins were important for group separation with the highest discriminating proteins identified as IL-21, Fractalkine, IL-17F, IL-7, IL-1RA and IL-2. Patients with periodontitis have an altered plasma lipoprotein profile, defined by altered protein levels as well as post-translational and other structural modifications towards an atherogenic form, which supports a role of modified plasma lipoproteins as central in the link between periodontal and cardiovascular disease (CVD).

sted, utgiver, år, opplag, sider
Portland Press, 2019
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-157252 (URN)10.1042/BSR20181665 (DOI)000465453700016 ()30842338 (PubMedID)2-s2.0-85063936955 (Scopus ID)
Merknad

Funding Agencies|Swedish Knowledge Foundation [Dnr20150037]; Foundation Langmanska Kulturfonden; Magnus Bergwalls Foundation

Tilgjengelig fra: 2019-06-04 Laget: 2019-06-04 Sist oppdatert: 2020-05-01bibliografisk kontrollert
Ljunggren, S., Nosratabadi, A. R., Graff, P. & Karlsson, H. (2019). Monthly variation in masses, metals and endotoxin content as well as pro-inflammatory response of airborne particles collected by TEOM monitors. Air quality, atmosphere and health, 12(12), 1441-1448
Åpne denne publikasjonen i ny fane eller vindu >>Monthly variation in masses, metals and endotoxin content as well as pro-inflammatory response of airborne particles collected by TEOM monitors
2019 (engelsk)Inngår i: Air quality, atmosphere and health, ISSN 1873-9318, E-ISSN 1873-9326, Vol. 12, nr 12, s. 1441-1448Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Particle exposure has been linked to an increased incidence of cardiovascular disease. Furthermore, particle exposure has been shown to have a chronic inhibitory effect on lung development in young people and may result in increased respiratory problems in adults or children with respiratory-related diseases. In today’s urban environments, particle levels are mainly monitored gravimetrically; however, other factors such as particle size, shape and surface reactivity have recently been noted as highly important in relation to possible health outcomes. Here, particles from TEOM monitor filters placed in three different cities were studied. The purpose of the study was to investigate whether there are variations in particle masses, cadmium and lead contents, as well as endotoxin levels between locations and time points over the year and if this can be correlated to the particles ability to induce a pro-inflammatory response in vitro. Results showed that it is possible to detect variations at different locations and at different time points over the year and that cadmium, lead and endotoxin levels did not coincide with the increased total particle masses while endotoxin levels coincided with pro-inflammatory responses in vitro. The present study shows that filter analysis is a useful complement to gravimetric or particle-counting measurements in studies of particle-related health effects and will give useful information regarding future air quality measurements.

sted, utgiver, år, opplag, sider
Springer, 2019
Emneord
Particles;PM10;Exposure;TEOM;Metals;Endotoxins;Pro-inflammatory response
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-163801 (URN)10.1007/s11869-019-00767-9 (DOI)000515661400005 ()
Merknad

Funding agencies: Linkoping University

Tilgjengelig fra: 2020-02-20 Laget: 2020-02-20 Sist oppdatert: 2022-04-28
Nosratabadi, A. R., Graff, P., Karlsson, H., Ljungman, A. & Leanderson, P. (2019). Use of TEOM monitors for continuous long-term sampling of ambient particles for analysis of constituents and biological effects. Air quality, atmosphere and health, 12(2), 161-171
Åpne denne publikasjonen i ny fane eller vindu >>Use of TEOM monitors for continuous long-term sampling of ambient particles for analysis of constituents and biological effects
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2019 (engelsk)Inngår i: Air quality, atmosphere and health, ISSN 1873-9318, E-ISSN 1873-9326, Vol. 12, nr 2, s. 161-171Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Many countries have implemented exposure limits for the concentration of ambient particular matter and do therefore have to monitor their concentration. This could be performed with TEOM monitors (Tapered Element Oscillating Microbalance-monitors) that contain a filter on which particles are collected. These filters are regularly exchanged for new ones. The aim of this study was to test the feasibility of collecting used filters from monitors at different locations and establishing a method to extract particles and then study them with respect to their ability to generate oxidants, their endotoxin content, and ability to activate inflammatory cells. Filters from nine geographically spread locations in Sweden were collected during a 21-month period by local technicians who then sent them to the laboratory where they were extracted and analyzed. The procedure to let local technicians perform the filter exchange and send used TEOM filters to the laboratory worked well. A method was established in which pyrogen-free water was used to extract particles that then were aliquoted and stored for later analysis. Particulate matter (PM10) from different locations showed both a considerable seasonal and spatial-dependent difference with respect to oxidative potential (oxidize glutathione), endotoxin content, and ability to activate blood monocytes to release interleukin-1β. This study shows that, instead of discarding TEOM filters, they can be collected and extracted so that particles that have been sampled in a standardized way could be analyzed with respect to variables that reflect their toxicity. This could be done at a low cost. In combination with information about the ambient particle concentration, such information could be helpful in the evaluation of differences in the risk of breathing air at various locations.

sted, utgiver, år, opplag, sider
Springer Netherlands, 2019
Emneord
Air pollution, TEOM monitor, Ambient particles, Surface reactivity, Endotoxin, Seasonal variation
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-154602 (URN)10.1007/s11869-018-0638-5 (DOI)000458121600004 ()2-s2.0-85056389584 (Scopus ID)
Tilgjengelig fra: 2019-02-21 Laget: 2019-02-21 Sist oppdatert: 2022-04-28bibliografisk kontrollert
Ljunggren, S. ., Iggland, M., Rönn, M., Lind, L., Lind, P. M. & Karlsson, H. (2016). Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A.. Toxicology, 347-349, 6-16
Åpne denne publikasjonen i ny fane eller vindu >>Altered heart proteome in fructose-fed Fisher 344 rats exposed to bisphenol A.
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2016 (engelsk)Inngår i: Toxicology, ISSN 0300-483X, E-ISSN 1879-3185, Vol. 347-349, s. 6-16Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Bisphenol A (BPA), is an artificial estrogen initially produced for medical purposes but is today widely used in polycarbonate plastics and epoxy resins. Exposure-related reproductive disorders have been found, but recently it has also been suggested that BPA may be involved in obesity, diabetes, myocardial hypertrophy and myocardial infarction in humans. To mimic a modern lifestyle, female rats were fed with fructose or fructose plus BPA (0.25mg/L drinking water). The myocardial left ventricle proteome of water controls, fructose-fed and fructose-fed plus BPA supplemented rats was explored. The proteome was investigated using nano-liquid chromatography tandem mass spectrometry and two-dimensional gel electrophoresis followed by matrix assisted laser desorption/ionization mass spectrometry identification. In total, 41 proteins were significantly altered by BPA exposure compared to water or fructose controls. Principal component analysis and cellular process enrichment analysis of altered proteins suggested increased fatty acid transport and oxidation, increased ROS generation and altered structural integrity of the myocardial left ventricle in the fructose-fed BPA-exposed rats, indicating unfavorable effects on the myocardium. In conclusion, BPA exposure in the rats induces major alterations in the myocardial proteome.

sted, utgiver, år, opplag, sider
Elsevier, 2016
Emneord
Bisphenol A; Endocrine disrupting chemicals; Fructose; Heart tissue; Proteomics
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-126117 (URN)10.1016/j.tox.2016.02.007 (DOI)000375631700002 ()26930160 (PubMedID)
Merknad

Funding agencies: Swedish research council Formas; County Council of Ostergotland (C-ALF); Faculty of Health Sciences in Linkoping

Tilgjengelig fra: 2016-03-15 Laget: 2016-03-15 Sist oppdatert: 2020-02-20
Ali, N., Mattsson, K., Rissler, J., Karlsson, H. M., Svensson, C. R., Gudmundsson, A., . . . Kåredal, M. (2016). Analysis of nanoparticle-protein coronas formed in vitro between nanosized welding particles and nasal lavage proteins.. Nanotoxicology, 10(2), 226-234
Åpne denne publikasjonen i ny fane eller vindu >>Analysis of nanoparticle-protein coronas formed in vitro between nanosized welding particles and nasal lavage proteins.
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2016 (engelsk)Inngår i: Nanotoxicology, ISSN 1743-5390, E-ISSN 1743-5404, Vol. 10, nr 2, s. 226-234Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Welding fumes include agglomerated particles built up of primary nanoparticles. Particles inhaled through the nose will to some extent be deposited in the protein-rich nasal mucosa, and a protein corona will be formed around the particles. The aim was to identify the protein corona formed between nasal lavage proteins and four types of particles with different parameters. Two of the particles were formed and collected during welding and two were manufactured iron oxides. When nasal lavage proteins were added to the particles, differences were observed in the sizes of the aggregates that were formed. Measurements showed that the amount of protein bound to particles correlated with the relative size increase of the aggregates, suggesting that the surface area was associated with the binding capacity. However, differences in aggregate sizes were detected when nasal proteins were added to UFWF and Fe2O3 particles (having similar agglomerated size) suggesting that yet parameters other than size determine the binding. Relative quantitative mass spectrometric and gel-based analyses showed differences in the protein content of the coronas. High-affinity proteins were further assessed for network interactions. Additional experiments showed that the inhibitory function of secretory leukocyte peptidase inhibitor, a highly abundant nasal protein, was influenced by particle binding suggesting that an understanding of protein function following particle binding is necessary to properly evaluate pathophysiological events. Our results underscore the importance of including particles collected from real working environments when studying the toxic effects of particles because these effects might be mediated by the protein corona.

sted, utgiver, år, opplag, sider
Taylor & Francis, 2016
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-122249 (URN)10.3109/17435390.2015.1048324 (DOI)000371822800010 ()26186033 (PubMedID)
Merknad

Funding agencies: AFA Insurance and Forte; medical faculty of Lund University; Nanometer Structure Consortium (nmC) at Lund University

Tilgjengelig fra: 2015-10-26 Laget: 2015-10-26 Sist oppdatert: 2017-12-01
Liang, W., Ward, L., Karlsson, H., Ljunggren, S., Li, W., Lindahl, M. & Yuan, X. (2016). Distinctive proteomic profiles among different regions of human carotid plaques in men and women. Scientific Reports, 6(26231)
Åpne denne publikasjonen i ny fane eller vindu >>Distinctive proteomic profiles among different regions of human carotid plaques in men and women
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2016 (engelsk)Inngår i: Scientific Reports, E-ISSN 2045-2322, Vol. 6, nr 26231Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The heterogeneity of atherosclerotic tissue has limited comprehension in proteomic and metabolomic analyses. To elucidate the functional implications, and differences between genders, of atherosclerotic lesion formation we investigated protein profiles from different regions of human carotid atherosclerotic arteries; internal control, fatty streak, plaque shoulder, plaque centre, and fibrous cap. Proteomic analysis was performed using 2-DE with MALDI-TOF, with validation using nLC-MS/MS. Protein mapping of 2-DE identified 52 unique proteins, including 15 previously unmapped proteins, of which 41 proteins were confirmed by nLC-MS/MS analysis. Expression levels of 18 proteins were significantly altered in plaque regions compared to the internal control region. Nine proteins showed site-specific alterations, irrespective of gender, with clear associations to extracellular matrix remodelling. Five proteins display gender-specific alterations with 2-DE, with two alterations validated by nLC-MS/MS. Gender differences in ferritin light chain and transthyretin were validated using both techniques. Validation of immunohistochemistry confirmed significantly higher levels of ferritin in plaques from male patients. Proteomic analysis of different plaque regions has reduced the effects of plaque heterogeneity, and significant differences in protein expression are determined in specific regions and between genders. These proteomes have functional implications in plaque progression and are of importance in understanding gender differences in atherosclerosis.

sted, utgiver, år, opplag, sider
NATURE PUBLISHING GROUP, 2016
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-129495 (URN)10.1038/srep26231 (DOI)000376554600001 ()27198765 (PubMedID)
Merknad

Funding Agencies|Swedish Heart Lung Foundation; Linkoping University Hospital Research foundation; Swedish Institute; China Scholarship Council

Tilgjengelig fra: 2016-06-20 Laget: 2016-06-20 Sist oppdatert: 2022-09-15
Sulaiman, W. N., Caslake, M. J., Delles, C., Karlsson, H., Mulder, M. T., Graham, D. & Freeman, D. J. (2016). Does high-density lipoprotein protect vascular function in healthy pregnancy?. Clinical Science, 130(7), 491-497
Åpne denne publikasjonen i ny fane eller vindu >>Does high-density lipoprotein protect vascular function in healthy pregnancy?
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2016 (engelsk)Inngår i: Clinical Science, ISSN 0143-5221, E-ISSN 1470-8736, Vol. 130, nr 7, s. 491-497Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The maternal adaptation to pregnancy includes hyperlipidaemia, oxidative stress and chronic inflammation. In non-pregnant individuals, these processes are usually associated with poor vascular function. However, maternal vascular function is enhanced in pregnancy. It is not understood how this is achieved in the face of the adverse metabolic and inflammatory environment. Research into cardiovascular disease demonstrates that plasma HDL (high-density lipoprotein), by merit of its functionality rather than its plasma concentration, exerts protective effects on the vascular endothelium. HDL has vasodilatory, antioxidant, anti-thrombotic and anti-inflammatory effects, and can protect against endothelial cell damage. In pregnancy, the plasma HDL concentration starts to rise at 10 weeks of gestation, peaking at 20 weeks. The initial rise in plasma HDL occurs around the time of the establishment of the feto-placental circulation, a time when the trophoblast plugs in the maternal spiral arteries are released, generating oxidative stress. Thus there is the intriguing possibility that new HDL of improved function is synthesized around the time of the establishment of the feto-placental circulation. In obese pregnancy and, to a greater extent, in pre-eclampsia, plasma HDL levels are significantly decreased and maternal vascular function is reduced. Wire myography studies have shown an association between the plasma content of apolipoprotein AI, the major protein constituent of HDL, and blood vessel relaxation. These observations lead us to hypothesize that HDL concentration, and function, increases in pregnancy in order to protect the maternal vascular endothelium and that in pre-eclampsia this fails to occur.

Emneord
apolipoprotein AI; cardiovascular disease; high-density lipoprotein (HDL); pre-eclampsia; pregnancy; vascular function
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-126120 (URN)10.1042/CS20150475 (DOI)000371915700003 ()26888561 (PubMedID)
Merknad

Funding agencies:  Malaysian Ministry of Higher Education; grant EU-MASCARA from the European Commission [278249]; grant sysVASC from the European Commission [603288]

Tilgjengelig fra: 2016-03-15 Laget: 2016-03-15 Sist oppdatert: 2018-01-10
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