liu.seSearch for publications in DiVA
Endre søk
Link to record
Permanent link

Direct link
BETA
Hansson, Thomas
Publikasjoner (10 av 17) Visa alla publikasjoner
Abdelrahman, I., Elmasry, M., Steinvall, I., Turesson, C., Sjöberg, F. & Hansson, T. (2020). Needle Fasciotomy or Collagenase Injection in the Treatment of Dupuytren’s Contracture: A Retrospective Study. Plastic and Reconstructive Surgery – Global Open, 8(1)
Åpne denne publikasjonen i ny fane eller vindu >>Needle Fasciotomy or Collagenase Injection in the Treatment of Dupuytren’s Contracture: A Retrospective Study
Vise andre…
2020 (engelsk)Inngår i: Plastic and Reconstructive Surgery – Global Open, E-ISSN 2169-7574, Vol. 8, nr 1Artikkel, forskningsoversikt (Fagfellevurdert) Epub ahead of print
Abstract [en]

Background: Dupuytren’s contracture is common among older people in Sweden. Previous studies comparing the treatment with an injection of collagenase with percutaneous needle fasciotomy found no differences. Methods: We retrospectively compared the degree of improvement in the deficit in extension of the joints in 2 groups of patients who had been treated with collagenase (71 fingers) or needle fasciotomy (109 fingers) before and 1 year after treatment. We compared the improvement of the extension deficit among the metacarpophalangeal (MCP) and proximal interphalangeal joints before and after the intervention; additionally, the level of improvement was classified into 3 levels (mild = 0° to 29°; moderate = 30° to 60°; considerable = 61° and more). Results: The degree of improvement of extension in the MCP joints was 11° greater in the collagenase group (P = 0.001). The number of patients who had an improvement of >60° (considerable) in extension was greater in the collagenase group (P = 0.02). Conclusion: Collagenase was more effective than needle fasciotomy in treating extension deficits of the MCP joints in Dupuytren’s contracture in this retrospective analysis. Further prospective studies are required to confirm the finding.

sted, utgiver, år, opplag, sider
Lippincott Williams & Wilkins, 2020
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-163787 (URN)10.1097/GOX.0000000000002606 (DOI)
Tilgjengelig fra: 2020-02-20 Laget: 2020-02-20 Sist oppdatert: 2020-02-20
Povlsen, B., Hansson, T. & Povlsen, S. D. (2014). Treatment for thoracic outlet syndrome. Cochrane Database of Systematic Reviews, 26(11), CD007218
Åpne denne publikasjonen i ny fane eller vindu >>Treatment for thoracic outlet syndrome
2014 (engelsk)Inngår i: Cochrane Database of Systematic Reviews, ISSN 1469-493X, E-ISSN 1469-493X, Vol. 26, nr 11, s. CD007218-Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

BACKGROUND:

Thoracic outlet syndrome (TOS) is one of the most controversial diagnoses in clinical medicine. Despite many reports of operative and non-operative interventions, rigorous scientific investigation of this syndrome leading to evidence-based management is lacking. This is the first update of a review first published in 2010.

OBJECTIVES:

To evaluate the beneficial and adverse effects of the available operative and non-operative interventions for the treatment of TOS a minimum of six months after the intervention.

SEARCH METHODS:

On 23 June 2014 we searched the Cochrane Neuromuscular Disease Group Trials Specialized Register, CENTRAL, The Database of Abstracts of Reviews of Effects (DARE), MEDLINE, EMBASE, CINAHL Plus and AMED. We also searched reference lists of the identified trials.

SELECTION CRITERIA:

We selected randomized or quasi-randomized studies involving participants with the diagnosis of TOS of any type (neurogenic, vascular, and 'disputed'), without limitations as to language of publication.We accepted studies that examined any intervention aimed at treating TOS.The primary outcome measure was change in pain rating, measured on a validated visual analog or similar scale at least six months after the intervention.The secondary outcomes were change in muscle strength, disability, experiences of paresthesias (numbness and tingling sensations), and adverse effects of the interventions.

DATA COLLECTION AND ANALYSIS:

Three authors independently selected the trials to be included and extracted data. Authors rated included studies for risk of bias, according to the methods recommended in the Cochrane Handbook for Systematic Reviews of Interventions.

MAIN RESULTS:

This review was complicated by a lack of generally accepted criteria for the diagnosis of TOS and had to rely exclusively on the diagnosis of TOS by the investigators in the reviewed studies. We identified one study comparing natural progression with an active intervention. We found three randomized controlled trials (RCTs), but only two of them had a follow-up of six months or more, which was the minimum required follow-up for inclusion in the review. The first trial that met our requirements involved 55 participants with the 'disputed type' of TOS and compared transaxillary first rib resection (TFRR) with supraclavicular neuroplasty of the brachial plexus (SNBP). The trial had a high risk of bias. TFRR decreased pain more than SNBP. There were no adverse effects in either group. The second trial that met these requirements analyzed 37 people with TOS of any type, comparing treatment with a botulinum toxin (BTX) injection into the scalene muscles with a saline placebo injection. This trial had a low risk of bias. There was no significant effect of treatment with the BTX injection over placebo in terms of pain relief or improvements in disability, but it did significantly improve paresthesias at six months' follow-up. There were no adverse events of the BTX treatment above saline injection.

AUTHORS' CONCLUSIONS:

This review was complicated by a lack of generally accepted diagnostic criteria for the diagnosis of TOS. There was very low quality evidence that transaxillary first rib resection decreased pain more than supraclavicular neuroplasty, but no randomized evidence that either is better than no treatment. There is moderate evidence to suggest that treatment with BTX injections yielded no great improvements over placebo injections of saline. There is no evidence from RCTs for the use of other currently used treatments. There is a need for an agreed definition for the diagnosis of TOS, especially the disputed form, agreed outcome measures, and high quality randomized trials that compare the outcome of interventions with no treatment and with each other

sted, utgiver, år, opplag, sider
Cochrane Collaboration, 2014
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-114267 (URN)10.1002/14651858.CD007218.pub3 (DOI)000347646200021 ()25427003 (PubMedID)
Merknad

Funding Agencies|Department of Orthopaedics, Guys and St Thomas Hospitals NHS Foundation Trust, UK

Tilgjengelig fra: 2015-02-16 Laget: 2015-02-16 Sist oppdatert: 2019-11-11
Sommar, P., Junker, J., Strandenes, E., Ness, C., Hansson, T., Johnson, H. & Kratz, G. (2013). Osteogenically-induced human dermal fibroblasts as a tool to regenerate bone. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 47(1), 8-13
Åpne denne publikasjonen i ny fane eller vindu >>Osteogenically-induced human dermal fibroblasts as a tool to regenerate bone
Vise andre…
2013 (engelsk)Inngår i: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, ISSN 2000-656X, E-ISSN 2000-6764, Vol. 47, nr 1, s. 8-13Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Engineering of bone tissue could help to overcome the need for extensive reconstruction and associated donor site morbidity, and it has been proposed that osteogenic biomaterials, which are scaffolds that contain osteocompetent cells, could be used to fill large bone defects. This study investigated the potential of osteogenically-induced human dermal fibroblasts cultured on gelatin microcarriers combined with platelet-rich plasma in a model of a femoral defect in athymic rats. Defects were transplanted with one of the following six combinations: 1 = sodium chloride, 2 = platelet-rich plasma, 3 = microcarriers + platelet-rich plasma, 4 = human dermal fibroblasts on microcarriers + platelet-rich plasma, 5 = human osteoblasts on microcarriers + platelet-rich plasma, and 6 = osteogenically induced human dermal fibroblasts on microcarriers + platelet-rich plasma. The femoral defects were assessed 4 weeks postoperatively with computed tomography (CT), routine histological staining, fluorescence in situ hybridisation, and polyclonal antibodies directed towards osteocalcin and osteonectin. Radiographs of all groups taken 4 weeks postoperatively showed unhealed defects. Femoral defects transplanted with osteogenically-induced human dermal fibroblasts on microcarriers (group 6) contained dense clusters of cells with large quantities of extracellular matrix. These clusters were exclusive to this group and stained strongly for osteocalcin and osteonectin. Fluorescence in situ hybridisation showed viable human cells in femoral defects that had been transplanted with microcarriers seeded with cells, which confirmed the survival of implanted cells. In conclusion, osteogenically-induced human dermal fibroblasts survived in this new niche, and bone-like structures were apparent in the defects.

sted, utgiver, år, opplag, sider
Informa Healthcare, 2013
Emneord
Tissue engineering, stem cells, human dermal fibroblasts, differentiation, osteogenic induction, formation of bone
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-89513 (URN)10.3109/2000656X.2012.731411 (DOI)000313681700002 ()
Tilgjengelig fra: 2013-02-27 Laget: 2013-02-26 Sist oppdatert: 2017-12-06
Fornander, L., Nyman, T., Hansson, T., Ragnehed, M. & Brismar, T. (2010). Age- and time-dependent effects on functional outcome and cortical activation pattern in patients with median nerve injury: a functional magnetic resonance imaging study Clinical article. Journal of Neurosurgery, 113(1), 122-128
Åpne denne publikasjonen i ny fane eller vindu >>Age- and time-dependent effects on functional outcome and cortical activation pattern in patients with median nerve injury: a functional magnetic resonance imaging study Clinical article
Vise andre…
2010 (engelsk)Inngår i: Journal of Neurosurgery, ISSN 0022-3085, E-ISSN 1933-0693, Vol. 113, nr 1, s. 122-128Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Object. The authors conducted a study to determine age- and time-dependent effects on the functional outcome after median nerve injury and repair and how such effects are related to changes in the pattern of cortical activation in response to tactile stimulation of the injured hand. Methods. The authors studied 11 patients with complete unilateral median nerve injury at the wrist repaired with epineural suture. In addition, 8 patients who were reported on in a previous study were included in the statistical analysis. In the entire study cohort, the mean age at injury was 23.3 +/- 13.4 years (range 7-57 years) and the time after injury ranged from 1 to 11 years. Sensory perception was measured with the static 2-point discrimination test and monofilaments. Functional MR imaging was conducted during tactile stimulation (brush strokes) of Digits II-III and IV-V of both hands, respectively. Results. Tactile sensation was diminished in the median territory in all patients. The strongest predictor of 2-point discrimination was age at injury (p less than 0.0048), and when this was accounted for in the regression analysis, the other age- and time-dependent predictors had no effect. The activation ratios (injured/healthy hand) for Digit II-III and Digit IV-V stimulation were positively correlated (rho 0.59, p less than 0.011). The activation ratio for Digit II-III stimulation correlated weakly with time after injury (p less than 0.041). The activation ratio of Digits IV-V correlated weakly with both age at injury (p less than 0.048) and time after injury (p less than 0.033), but no predictor reached significance in the regression model. The mean ratio of ipsi- and contralateral hemisphere activation after stimulation of the injured hand was 0.55, which was not significantly different from the corresponding ratio of the healthy hand (0.66). Conclusions. Following a median nerve injury (1-11 years after injury) there may be an initial increase in the volume of the cortical representation, which subsequently declines during the restoration phase. These dynamic changes may involve both median and ulnar nerve cortical representation, because both showed negative correlation with time after injury. These findings are in agreement with animal studies showing that cortical plasticity is an important mechanism for functional recovery after peripheral nerve injury and repair.

sted, utgiver, år, opplag, sider
American Association of Neurological Surgeons, 2010
Emneord
median nerve; hand injury; neuronal plasticity; functional magnetic resonance imaging
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-58291 (URN)10.3171/2009.10.JNS09698 (DOI)000279107300030 ()
Tilgjengelig fra: 2010-08-10 Laget: 2010-08-09 Sist oppdatert: 2017-12-12
Povlsen, B., Belzberg, A., Hansson, T. & Dorsi, M. (2010). Treatment for thoracic outlet syndrome. The Cochrane library (1), CD007218
Åpne denne publikasjonen i ny fane eller vindu >>Treatment for thoracic outlet syndrome
2010 (engelsk)Inngår i: The Cochrane library, ISSN 1465-1858, E-ISSN 1465-1858, nr 1, s. CD007218-Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Background Thoracic outlet syndrome (TOS) is one of the most controversial clinical entities in medicine. Despite many reports of operative and non-operative interventions, rigorous scientific investigation of this syndrome leading to evidence based management is lacking. Objectives To evaluate the beneficial and adverse effects of the available operative and non-operative interventions for the treatment of thoracic outlet syndrome. Search strategy We searched the Cochrane Neuromuscular Disease Group Trials Specialized Register (July 2009), The Cochrane Central Register of Controlled Trials (The Cochrane Library Issue 2, 2009), MEDLINE (January 1966 to June 2009), EMBASE (January 1980 to June 2009), CINAHL (January 1981 to June 2009), AMED (January 1985 to June 2009) and reference lists of articles. Selection criteria We selected randomized or quasi-randomized studies in any language of participants with the diagnosis of any type of thoracic outlet syndrome (neurogenic, vascular, and disputed). The primary outcome measure was change in pain rating on a validated visual analog or similar scale at least six months after the intervention. The secondary outcomes were change in muscle strength and adverse effects of the interventions. Data collection and analysis Four authors independently selected the trials to be included and extracted data. The one included study was rated for risk of bias according to the methods recommended in the Cochrane Handbook for Systematic Reviews of Interventions. Main results This review was complicated by a lack of generally accepted criteria for the diagnosis of TOS and had to rely exclusively on the diagnosis of TOS by the investigators in the reviewed studies. There were no studies comparing natural progression with any active intervention. In one trial with a high risk of bias involving 55 participants transaxillary first rib resection decreased pain more than supraclavicular neuroplasty of the brachial plexus. There were no adverse effects in either group. Authors conclusions This review was complicated by a lack of generally accepted diagnostic criteria for the diagnosis of TOS. There was very low quality evidence that transaxillary first rib resection decreased pain more than supraclavicular neuroplasty but no randomized evidence that either is better than no treatment. There is no randomized evidence to support the use of other currently used treatments. There is a need for an agreed definition for the diagnosis of TOS, especially the disputed form, agreed outcome measures and high quality randomized trials that compare the outcome of interventions with no treatment and with each other.

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-54263 (URN)10.1002/14651858.CD007218.pub2 (DOI)000274653900017 ()
Tilgjengelig fra: 2010-03-05 Laget: 2010-03-05 Sist oppdatert: 2017-12-12
Carlstedt, T., Hultgren, T., Nyman, T. & Hansson, T. (2009). Cortical activity and hand function restoration in a patient after spinal cord surgery. NATURE REVIEWS NEUROLOGY, 5(10), 571-574
Åpne denne publikasjonen i ny fane eller vindu >>Cortical activity and hand function restoration in a patient after spinal cord surgery
2009 (engelsk)Inngår i: NATURE REVIEWS NEUROLOGY, ISSN 1759-4758, Vol. 5, nr 10, s. 571-574Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background. Following a motorcycle accident, a 9-year-old boy experienced a complete right-sided ( dominant) arm and hand paralysis with total sensory loss, Horner syndrome and severe constant pain. This study assessed the long-term outcome of spinal cord surgery undertaken on the patient, focusing on the restored hand function and related cortical activity. The study follows on from previous reports on the same patient. Investigations. Clinical functional and electrophysiological examinations. Functional MRI of cortical activity. Diagnosis. Complete brachial plexus (C5-T1) avulsion from the spinal cord. Management. Spinal cord surgery to restore motor trajectories.

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-54500 (URN)10.1038/nrneurol.2009.137 (DOI)000275392700010 ()
Tilgjengelig fra: 2010-03-19 Laget: 2010-03-19 Sist oppdatert: 2010-03-19
Hansson, T., Nyman, T., Björkman, A., Lundberg, P., Nylander, L., Rosén, B. & Lundborg, G. (2009). Sights of touching activates the somatosensory cortex in humans.. Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi, 43(5), 267-269
Åpne denne publikasjonen i ny fane eller vindu >>Sights of touching activates the somatosensory cortex in humans.
Vise andre…
2009 (engelsk)Inngår i: Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi, ISSN 1651-2073, Vol. 43, nr 5, s. 267-269Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We report our observations of cross-modal interactions between sight and touch using functional magnetic resonance imaging (fMRI). Experiments were devised to show that sight and touch are linked in a cross-modal arrangement, and two separate experiments were done in an MRI scanner. In the first, the subject's right hand was stimulated with a brush; in the second, a video sequence was presented to the subject inside the scanner through video goggles in visual three-dimensional stereo, showing one brushstroke every second on a hand in the same manner as the subject had just previously experienced. The result was that both the primary and the secondary somatosensory cortexes were activated in the participants when the hands were touched, and when the subjects saw only a hand being touched in the same manner. The results indicated cross-modal links between sight and touch of the hand in humans.

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-53090 (URN)10.3109/02844310903123056 (DOI)000272145200006 ()19863430 (PubMedID)
Tilgjengelig fra: 2010-01-15 Laget: 2010-01-15 Sist oppdatert: 2015-10-09
Lundborg, G., Björkman, A., Hansson, T., Nylander, L., Nyman, T. & Rosén, B. (2005). Artificial sensibility of the hand based on cortical audiotactile interaction: A study using functional magnetic resonance imaging. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 39(6), 370-372
Åpne denne publikasjonen i ny fane eller vindu >>Artificial sensibility of the hand based on cortical audiotactile interaction: A study using functional magnetic resonance imaging
Vise andre…
2005 (engelsk)Inngår i: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, ISSN 2000-656X, E-ISSN 2000-6764, Vol. 39, nr 6, s. 370-372Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The capacity of the central nervous system for plastic alterations is the base for our ability to adapt to environmental needs. The crossmodal capacity of the brain makes interaction between senses possible, and deprivation of one sense leads to compensatory changes in other senses. We have recently shown how hearing can substitute for sensation in a transplanted insensitive hand by using a sensor glove equipped with small microphones that pick up the sound of friction, which is elicited by active touch. Here we have used functional magnetic resonance imaging (fMRI) in healthy people to illustrate their capacity for cortical audiotactile interaction with activation of the somatosensory cortex induced by auditory stimuli. The phenomenon occurred only in subjects trained to substitute sensibility by hearing, and no audiotactile interaction was found in untrained subjects. © 2005 Taylor & Francis.

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-31888 (URN)10.1080/02844310500369920 (DOI)17721 (Lokal ID)17721 (Arkivnummer)17721 (OAI)
Tilgjengelig fra: 2009-10-09 Laget: 2009-10-09 Sist oppdatert: 2017-12-13
Hansson, T. & Povlsen, B. (2005). Functional evaluation of regenerated and misrouted low threshold mechanoreceptors and polymodal nociceptors in the skin of rat hindfeet after crush lesions to the sciatic nerve. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 39(5), 261-267
Åpne denne publikasjonen i ny fane eller vindu >>Functional evaluation of regenerated and misrouted low threshold mechanoreceptors and polymodal nociceptors in the skin of rat hindfeet after crush lesions to the sciatic nerve
2005 (engelsk)Inngår i: Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, ISSN 2000-656X, E-ISSN 2000-6764, Vol. 39, nr 5, s. 261-267Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Tracer studies on motor axons after nerve crush injuries have indicated that misrouting may occur even when the endoneurium is intact. Misrouting of regenerated polymodal nociceptive C-fibres and low threshold mechanoreceptive axons have been studied functionally in 50 rats three months after unilateral crush lesions to the sciatic nerve. Two weeks before evaluation the tibial fascicle (or the peroneal fascicle) above the lesion was cut and tied off. In this way only functional regeneration of misrouted axons was tested. Misrouted low threshold mechanoreceptive axons and polymodal nociceptor C-fibres were found after regeneration in both glabrous and hairy skin. We conclude that functional misdirection of both myelinated and unmyelinated sensory axons innervating either glabrous or hairy skin can occur after a crush lesion to a peripheral nerve in rats. © 2005 Taylor & Francis.

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-31882 (URN)10.1080/0284431051006420 (DOI)17713 (Lokal ID)17713 (Arkivnummer)17713 (OAI)
Tilgjengelig fra: 2009-10-09 Laget: 2009-10-09 Sist oppdatert: 2017-12-13
Hansson, T. & Brismar, T. (2003). Loss of sensory discrimination after median nerve injury and activation in the primary somatosensory cortex on functional magnetic resonance imaging. Journal of Neurosurgery, 99(1), 100-105
Åpne denne publikasjonen i ny fane eller vindu >>Loss of sensory discrimination after median nerve injury and activation in the primary somatosensory cortex on functional magnetic resonance imaging
2003 (engelsk)Inngår i: Journal of Neurosurgery, ISSN 0022-3085, E-ISSN 1933-0693, Vol. 99, nr 1, s. 100-105Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Object. The aim of this study was to assess the effects of median nerve injury and regeneration on neuronal activation in the somatosensory cortex by means of functional magnetic resonance (fMR) imaging and somatosensory evoked potentials (SSEPs). Methods. Ten injured male patients (mean age 26 years) were examined 15 to 58 months after a total transection of the median nerve at the wrist that was repaired with epineural sutures. Two-point discrimination was lost in Digit II-III and sensory nerve conduction displayed decreased velocity (-29%) and amplitude (-84%) in the median nerve at the wrist. The fMR images were obtained during tactile stimulation (gentle strokes) performed separately on the volar surface of either Digit II-III or Digit IV-V (eight patients: two were excluded because of movement artifacts). The SSEPs were obtained using electrical stimulation proximal to the median nerve lesion. Conclusions. Patients with loss of sensory discrimination after median nerve damage and regeneration had larger areas of activation in fMR imaging near the contralateral central sulcus during tactile stimulation of the injured compared with the noninjured hand. The increase relative to the unaffected hand was 43% (p < 0.02) for Digit II-III stimulation and 46% (p < 0.02) for Digit IV-V stimulation. The SSEP data showed normal latency and amplitude. The enlarged area of cortical activation may be the result of reorganization, and it may indicate that larger cortical areas are involved in the discriminatory task after a derangement of the peripheral input.

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-25068 (URN)9498 (Lokal ID)9498 (Arkivnummer)9498 (OAI)
Tilgjengelig fra: 2009-10-07 Laget: 2009-10-07 Sist oppdatert: 2017-12-13
Organisasjoner