liu.seSearch for publications in DiVA
Endre søk
Link to record
Permanent link

Direct link
BETA
Alternativa namn
Publikasjoner (10 av 12) Visa alla publikasjoner
Simon, D. T., Gabrielsson, E., Tybrandt, K. & Berggren, M. (2016). Organic Bioelectronics: Bridging the Signaling Gap between Biology and Technology. Chemical Reviews, 116(21), 13009-13041
Åpne denne publikasjonen i ny fane eller vindu >>Organic Bioelectronics: Bridging the Signaling Gap between Biology and Technology
2016 (engelsk)Inngår i: Chemical Reviews, ISSN 0009-2665, E-ISSN 1520-6890, Vol. 116, nr 21, s. 13009-13041Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

The electronics surrounding us in our daily lives rely almost exclusively on electrons as the dominant charge carrier. In stark contrast, biological systems rarely use electrons but rather use ions and molecules of varying size. Due to the unique combination of both electronic and ionic/molecular conductivity in conducting and semiconducting organic polymers and small molecules, these materials have emerged in recent decades as excellent tools for translating signals between these two realms and, therefore, providing a means to effectively interface biology with conventional electronics-thus, the field of organic bioelectronics. Today, organic bioelectronics defines a generic platform with unprecedented biological recording and regulation tools and is maturing toward applications ranging from life sciences to the clinic. In this Review, we introduce the field, from its early breakthroughs to its current results and future challenges.

sted, utgiver, år, opplag, sider
American Chemical Society (ACS), 2016
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-130629 (URN)10.1021/acs.chemrev.6b00146 (DOI)000387625200006 ()27367172 (PubMedID)
Merknad

Funding agencies: Knut and Alice Wallenberg Foundation; Swedish Foundation for Strategic Research; VINNOVA; Swedish Research Council; EU Seventh Framework Programme; Onnesjo Foundation; Linkoping Universitys Forum Scientium; Advanced Functional Materials Center at Linkopin

Tilgjengelig fra: 2016-08-19 Laget: 2016-08-19 Sist oppdatert: 2017-11-28
Gabrielsson, E., Armgarth, A., Hammarström, P., Nilsson, P. & Berggren, M. (2016). Spatiotemporal Control of Amyloid-Like A Plaque Formation Using a Multichannel Organic Electronic Device. Macromolecular materials and engineering (Print), 301(4), 359-363
Åpne denne publikasjonen i ny fane eller vindu >>Spatiotemporal Control of Amyloid-Like A Plaque Formation Using a Multichannel Organic Electronic Device
Vise andre…
2016 (engelsk)Inngår i: Macromolecular materials and engineering (Print), ISSN 1438-7492, E-ISSN 1439-2054, Vol. 301, nr 4, s. 359-363Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We herein report on an iontronic device to drive and control A1-40 and A1-42 fibril formation. This system allows kinetic control of A aggregation by regulation of H+ flows. The formed aggregates show both nanometer-sized fibril structure and microscopic growth, thus mimicking senile plaques, at the H+-outlet. Mechanistically we observed initial accumulation of A1-40 likely driven by electrophoretic migration which preceded nucleation of amyloid structures in the accumulated peptide cluster.

sted, utgiver, år, opplag, sider
WILEY-V C H VERLAG GMBH, 2016
Emneord
amyloid; Alzheimers disease; bioelectronics; fibrils; luminescent conjugated oligothiophene; optical probes
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-127750 (URN)10.1002/mame.201500428 (DOI)000374030400001 ()
Merknad

Funding Agencies|VINNOVA [2010-00507]; Swedish research council [2011-5804, 621-2011-3517]; Advanced Functional Materials Center at Linkoping University; Onnesjo foundation; ERC Starting Independent Researcher Grant (Project: MUMID) from the European Research Council

Tilgjengelig fra: 2016-05-12 Laget: 2016-05-12 Sist oppdatert: 2018-04-25
Malti, A., Gabrielsson, E., Crispin, X. & Berggren, M. (2015). An Electrochromic Bipolar Membrane Diode. Advanced Materials, 27(26), 3909-+
Åpne denne publikasjonen i ny fane eller vindu >>An Electrochromic Bipolar Membrane Diode
2015 (engelsk)Inngår i: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 27, nr 26, s. 3909-+Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Conducting polymers with bipolar membranes (a complementary stack of selective membranes) may be used to rectify current. Integrating a bipolar membrane into a polymer electrochromic display obviates the need for an addressing backplane while increasing the devices bistability. Such devices can be made from solution-processable materials.

sted, utgiver, år, opplag, sider
Wiley-VCH Verlag, 2015
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-120341 (URN)10.1002/adma.201500891 (DOI)000357688900008 ()26016815 (PubMedID)
Merknad

Funding Agencies|Swedish foundation for strategic research; Knut and Alice Wallenberg foundation; VINNOVA; Advanced Functional Materials Center at Linkoping University; European Research Council [307596]

Tilgjengelig fra: 2015-07-31 Laget: 2015-07-31 Sist oppdatert: 2017-12-04
Gabrielsson, E. O., Janson, P., Tybrandt, K., Simon, D. T. & Berggren, M. (2014). A Four-Diode Full-Wave Ionic Current Rectifier Based on Bipolar Membranes: Overcoming the Limit of Electrode Capacity. Advanced Materials, 26(30), 5143-5147
Åpne denne publikasjonen i ny fane eller vindu >>A Four-Diode Full-Wave Ionic Current Rectifier Based on Bipolar Membranes: Overcoming the Limit of Electrode Capacity
Vise andre…
2014 (engelsk)Inngår i: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 26, nr 30, s. 5143-5147Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Full-wave rectification of ionic currents is obtained by constructing the typical four-diode bridge out of ion conducting bipolar membranes. Together with conjugated polymer electrodes addressed with alternating current, the bridge allows for generation of a controlled ionic direct current for extended periods of time without the production of toxic species or gas typically arising from electrode side-reactions.

sted, utgiver, år, opplag, sider
Wiley-VCH Verlagsgesellschaft, 2014
Emneord
bioelectronics, ionics, ion transport, bipolar membranes, conjugated polymer electrodes
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-110403 (URN)10.1002/adma.201401258 (DOI)000340546300010 ()24863171 (PubMedID)
Forskningsfinansiär
Vinnova, 2010–00507EU, FP7, Seventh Framework Programme, iONE-FP7Swedish Research Council, 621–2011–3517EU, FP7, Seventh Framework Programme, OrgBIO
Tilgjengelig fra: 2014-09-10 Laget: 2014-09-10 Sist oppdatert: 2017-12-05bibliografisk kontrollert
Gabrielsson, E. O. (2014). Monopolar and Bipolar Membranes in Organic Bioelectronic Devices. (Doctoral dissertation). Linköping: Linköping University Electronic Press
Åpne denne publikasjonen i ny fane eller vindu >>Monopolar and Bipolar Membranes in Organic Bioelectronic Devices
2014 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

In the 1970s it was discovered that organic polymers, a class of materials otherwise best know as insulating plastics, could be made electronically conductive. As an alternative to silicon semiconductors, organic polymers offer many novel features, characteristics, and opportunities, such as producing electronics at low costs using printing techniques, using organic chemistry to tune optical and electronic properties, and mechanical flexibility. The conducting organic polymers have been used in a vast array of devices, exemplified by organic transistors, light-emitting diodes, and solar cells. Due to their softness, biocompatibility, and combined electronic and ionic transport, organic electronic materials are also well suited as the active material in bioelectronic applications, a scientific and engineering area in which electronics interface with biology. The coupling of ions and electrons is especially interesting, as ions serve as signal carriers in all living organisms, thus offering a direct translation of electronic and ionic signals. To further enable complex control of ionic fluxes, organic electronic materials can be integrated with various ionic components, such as ion-conducting diodes and transistors.

This thesis reports a background to the field of organic bioelectronic and ionic devices, and also presents the integration of ionic functions into organic bioelectronic devices. First, an electrophoretic drug delivery device is presented, capable of delivering ions at high spatiotemporal resolution. The device, called the organic electronic ion pump, is used to electronically control amyloid-like aggregation kinetics and morphology of peptides, and offers an interesting method for studying amyloids in vitro. Second, various ion-conducting diodes based on bipolar membranes are described. These diodes show high rectification ratio, i.e. conduct ions better for positive than for negative applied voltage. Simple ion diode based circuits, such as an AND gate and a full-wave rectifier, are also reported. The AND gate is intended as an addressable pH pixel to regulate for example amyloid aggregation, while the full-wave rectifier decouples the electrochemical capacity of an electrode from the amount of ionic charge it can generate. Third, an ion transistor, also based on bipolar membranes, is presented. This transistor can amplify and control ionic currents, and is suitable for building complex ionic logic circuits. Together, these results provide a basic toolbox of ionic components that is suitable for building more complex and/or implantable organic bioelectronic devices.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2014. s. 76
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1620
Emneord
bioelectronics, ionic, ion transport;bipolar membrane, conjugated polymer, amyloid, self-assembly
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-110406 (URN)10.3384/diss.diva-110406 (DOI)978-91-7519-244-4 (ISBN)
Disputas
2014-10-10, K2, Kåkenhus, Campus Norrköping, Linköpings Universitet, Norrköping, 10:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2014-09-10 Laget: 2014-09-10 Sist oppdatert: 2017-02-03bibliografisk kontrollert
Gabrielsson, E. O., Tybrandt, K. & Berggren, M. (2014). Polyphosphonium-Based Ion Bipolar Junction Transistors. Biomicrofluidics, 8(6), 064116
Åpne denne publikasjonen i ny fane eller vindu >>Polyphosphonium-Based Ion Bipolar Junction Transistors
2014 (engelsk)Inngår i: Biomicrofluidics, ISSN 1932-1058, E-ISSN 1932-1058, Vol. 8, nr 6, s. 064116-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Advancements in the field of electronics during the past few decades have inspired the use of transistors in a diversity of research fields, including biology and medicine. However, signals in living organisms are not only carried by electrons, but also through fluxes of ions and biomolecules. Thus, in order to implement the transistor functionality to control biological signals, devices that can modulate currents of ions and biomolecules, i.e. ionic transistors and diodes, are needed. One successful approach for modulation of ionic currents is to use oppositely charged ion-selective membranes to form so called ion bipolar junction transistors (IBJTs). Unfortunately, overall IBJT device performance has been hindered due to the typical low mobility of ions, large geometries of the ion bipolar junction materials, and the possibility of electric field enhanced (EFE) water dissociation in the junction. Here, we introduce a novel polyphosphonium-based anion-selective material into npn-type IBJTs. The new material does not show EFE water dissociation and therefore allows for a reduction of junction length down to 2 μm, which significantly improves the switching performance of the ion transistor to 2 s. The presented improvement in speed as well the simplified design will be useful for future development of advanced iontronic circuits employing IBJTs, for example addressable drug-delivery devices.

Emneord
WATER DISSOCIATION; NANOFLUIDIC DIODE; MEMBRANES; CIRCUITS
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-110400 (URN)10.1063/1.4902909 (DOI)000347160400018 ()
Merknad

This research was financed by VINNOVA (OBOE Miljo and AFM), the Swedish Research Council, and the Onnesjo foundation.

Tilgjengelig fra: 2014-09-10 Laget: 2014-09-10 Sist oppdatert: 2017-12-05bibliografisk kontrollert
Gabrielsson, E. & Berggren, M. (2013). Polyphosphonium-based bipolar membranes for rectification of ionic currents. Biomicrofluidics, 7(6), 064117
Åpne denne publikasjonen i ny fane eller vindu >>Polyphosphonium-based bipolar membranes for rectification of ionic currents
2013 (engelsk)Inngår i: Biomicrofluidics, ISSN 1932-1058, E-ISSN 1932-1058, Vol. 7, nr 6, s. 064117-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Bipolar membranes (BMs) have interesting applications within the field of bioelectronics, as they may be used to create non-linear ionic components (e. g., ion diodes and transistors), thereby extending the functionality of, otherwise linear, electrophoretic drug delivery devices. However, BM based diodes suffer from a number of limitations, such as narrow voltage operation range and/or high hysteresis. In this work, we circumvent these problems by using a novel polyphosphonium-based BM, which is shown to exhibit improved diode characteristics. We believe that this new type of BM diode will be useful for creating complex addressable ionic circuits for delivery of charged biomolecules.

sted, utgiver, år, opplag, sider
American Institute of Physics (AIP), 2013
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-103883 (URN)10.1063/1.4850795 (DOI)000329292200020 ()
Tilgjengelig fra: 2014-01-30 Laget: 2014-01-30 Sist oppdatert: 2017-12-06
Gabrielsson, E. O., Tybrandt, K. & Berggren, M. (2012). Ion diode logics for pH control. Lab on a Chip, 12(14), 2507-2513
Åpne denne publikasjonen i ny fane eller vindu >>Ion diode logics for pH control
2012 (engelsk)Inngår i: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 12, nr 14, s. 2507-2513Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Electronic control over the generation, transport, and delivery of ions is useful in order to regulate reactions, functions, and processes in various chemical and biological systems. Different kinds of ion diodes and transistors that exhibit non-linear current versus voltage characteristics have been explored to generate chemical gradients and signals. Bipolar membranes (BMs) exhibit both ion current rectification and water splitting and are thus suitable as ion diodes for the regulation of pH. To date, fast switching ion diodes have been difficult to realize due to accumulation of ions inside the device structure at forward bias – charges that take a long time to deplete at reverse bias. Water splitting occurs at elevated reverse voltage bias and is a feature that renders high ion current rectification impossible. This makes integration of ion diodes in circuits difficult. Here, we report three different designs of micro-fabricated ion bipolar membrane diodes (IBMDs). The first two designs consist of single BM configurations, and are capable of either splitting water or providing high current rectification. In the third design, water-splitting BMs and a highly-rectifying BM are connected in series, thus suppressing accumulation of ions. The resulting IBMD shows less hysteresis, faster off-switching, and also a high ion current rectification ratio as compared to the single BM devices. Further, the IBMD was integrated in a diode-based AND gate, which is capable of controlling delivery of hydroxide ions into a receiving reservoir.

sted, utgiver, år, opplag, sider
Cambridge, UK: Royal Society of Chemistry, 2012
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-78002 (URN)10.1039/C2LC40093F (DOI)000305532600009 ()
Tilgjengelig fra: 2012-06-04 Laget: 2012-06-04 Sist oppdatert: 2017-12-07
Tybrandt, K., Gabrielsson, E. & Berggren, M. (2011). Toward Complementary Ionic Circuits: The npn Ion Bipolar Junction Transistor. Journal of the American Chemical Society, 133(26), 10141-10145
Åpne denne publikasjonen i ny fane eller vindu >>Toward Complementary Ionic Circuits: The npn Ion Bipolar Junction Transistor
2011 (engelsk)Inngår i: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 133, nr 26, s. 10141-10145Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Many biomolecules are charged and may therefore be transported with ionic currents. As a step toward addressable ionic delivery circuits, we report on the development of a npn ion bipolar junction transistor (npn-IBJT) as an active control element of anionic currents in general, and specifically, demonstrate actively modulated delivery of the neurotransmitter glutamic acid. The functional materials of this transistor are ion exchange layers and conjugated polymers. The npn-IBJT shows stable transistor characteristics over extensive time of operation and ion current switch times below 10 s. Our results promise complementary chemical circuits similar to the electronic equivalence, which has proven invaluable in conventional electronic applications.

sted, utgiver, år, opplag, sider
ACS American Chemical Society, 2011
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-69799 (URN)10.1021/ja200492c (DOI)000292715600041 ()
Tilgjengelig fra: 2011-08-10 Laget: 2011-08-08 Sist oppdatert: 2017-12-08
Malti, A., Gabrielsson, E., Berggren, M. & Crispin, X. (2011). Ultra-low voltage air-stable polyelectrolyte gated n-type organic thin film transistors. Applied Physics Letters, 99(6), 063305
Åpne denne publikasjonen i ny fane eller vindu >>Ultra-low voltage air-stable polyelectrolyte gated n-type organic thin film transistors
2011 (engelsk)Inngår i: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 99, nr 6, s. 063305-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Complementary circuits, processing digital signals, are a cornerstone of modern electronics. Such circuits require both p-and n-type transistors. Polyelectrolytes are used as gate insulators in organic thin film transistors (OTFTs) to establish an electric double layer capacitor upon gate bias that allows low operational voltages (andlt;1 V). However, stable and low-voltage operating n-channel organic transistors have proven difficult to construct. Here, we report ultra-low voltage n-channel organic polymer-based transistors that are stable in ambient atmosphere. Our n-type OTFTs exhibit on/off ratios around 10(3) for an applied drain potential as low as 0.1 V. Since small ions are known to promote electrochemical reactions within the semiconductors channel bulk and typically slow down the transistor, we use a solid polycationic gate insulator that suppresses penetration of anions into the n-channel semiconductor. As a result, our n-channel OTFTs switch on in under 5 ms and off in less than 1 ms.

sted, utgiver, år, opplag, sider
American Institute of Physics (AIP), 2011
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-70331 (URN)10.1063/1.3626587 (DOI)000293857700076 ()
Merknad
|Swedish Government||Swedish Foundation for Strategic Research (OPEN)||Knut and Alice Wallenberg Foundation||Onnesjo Foundation||Tilgjengelig fra: 2011-09-02 Laget: 2011-09-02 Sist oppdatert: 2017-12-08
Organisasjoner
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0002-0302-226X