liu.seSearch for publications in DiVA
Endre søk
Link to record
Permanent link

Direct link
BETA
Romu, Thobias
Publikasjoner (10 av 36) Visa alla publikasjoner
Patra, H. K., Azharuddin, M., Islam, M. M., Papapavlou, G., Deb, S., Osterrieth, J., . . . Slater, N. K. H. (2019). Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants. Advanced Functional Materials, Article ID 1903760.
Åpne denne publikasjonen i ny fane eller vindu >>Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants
Vise andre…
2019 (engelsk)Inngår i: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, artikkel-id 1903760Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

Cornea diseases are a leading cause of blindness and the disease burden is exacerbated by the increasing shortage around the world for cadaveric donor corneas. Despite the advances in the field of regenerative medicine, successful transplantation of laboratory‐made artificial corneas is not fully realized in clinical practice. The causes of failure of such artificial corneal implants are multifactorial and include latent infections from viruses and other microbes, enzyme overexpression, implant degradation, extrusion or delayed epithelial regeneration. Therefore, there is an urgent unmet need for developing customized corneal implants to suit the host environment and counter the effects of inflammation or infection, which are able to track early signs of implant failure in situ. This work reports a nanotoolbox comprising tools for protection from infection, promotion of regeneration, and noninvasive monitoring of the in situ corneal environment. These nanosystems can be incorporated within pro‐regenerative biosynthetic implants, transforming them into theranostic devices, which are able to respond to biological changes following implantation.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2019
Emneord
herpes simplex virus type 1 (HSV-1), magnetic resonance imaging (MRI), premedicated cornea implants, pro-regeneration, theranostics
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-159097 (URN)10.1002/adfm.201903760 (DOI)000476281800001 ()2-s2.0-85069940064 (Scopus ID)
Merknad

Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; MIIC Strategic Postdoc Grant; MIIC Seed Grant at Linkoping University (LiU), Sweden

Tilgjengelig fra: 2019-07-24 Laget: 2019-07-24 Sist oppdatert: 2019-11-13bibliografisk kontrollert
Borga, M., West, J., Bell, J., Harvey, N., Romu, T., Heymsfield, S. & Dahlqvist Leinhard, O. (2018). Advanced body composition assessment: From body mass index to body composition profiling. Journal of Investigative Medicine, 66, 887-895
Åpne denne publikasjonen i ny fane eller vindu >>Advanced body composition assessment: From body mass index to body composition profiling
Vise andre…
2018 (engelsk)Inngår i: Journal of Investigative Medicine, ISSN 1081-5589, E-ISSN 1708-8267, Vol. 66, s. 887-895Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

This paper gives a brief overview of common non-invasive techniques for body composition analysis and a more in-depth review of a body composition assessment method based on fat-referenced quantitative magnetic resonance imaging (MRI). Earlier published studies of this method are summarized, and a previously un-published validation study, based on 4.753 subjects from the UK Biobank imaging cohort, comparing the quantitative MRI method with dual-energy x-ray absorptiometry (DXA) is presented. For whole-body measurements of adipose tissue (AT) or fat and lean tissue (LT), DXA and quantitative MRI show excellent agreement with linear correlation of 0.99 and 0.97, and coefficient of variation (CV) of 4.5 % and 4.6 % for fat (computed from AT) and lean tissue respectively, but the agreement was found significantly lower for visceral adipose tissue, with a CV of more than 20 %. The additional ability of MRI to also measure muscle volumes, muscle AT infiltration and ectopic fat in combination with rapid scanning protocols and efficient image analysis tools make quantitative MRI a powerful tool for advanced body composition assessment. 

sted, utgiver, år, opplag, sider
BMJ Publishing Group Ltd, 2018
Emneord
Body-composition-analysis, MRI, UK Biobank
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-145624 (URN)10.1136/jim-2018-00072 (DOI)000435456400001 ()29581385 (PubMedID)
Tilgjengelig fra: 2018-03-08 Laget: 2018-03-08 Sist oppdatert: 2019-06-14bibliografisk kontrollert
Romu, T. (2018). Fat-Referenced MRI: Quanitaive MRI for Tissue Characterizaion and Volume Measurement. (Doctoral dissertation). Linköping: Linköping University Electronic Press
Åpne denne publikasjonen i ny fane eller vindu >>Fat-Referenced MRI: Quanitaive MRI for Tissue Characterizaion and Volume Measurement
2018 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

The amount and distribution of adipose and lean tissues has been shown to be predictive of mortality and morbidity in metabolic disease. Traditionally these risks are assessed by anthropometric measurements based on weight, length, girths or the body mass index (BMI). These measurements are predictive of risks on a population level, where a too low or a too high BMI indicates an increased risk of both mortality and morbidity. However, today a large part of the world’s population belongs to a group with an elevated risk according to BMI, many of which will live long and healthy lives. Thus, better instruments are needed to properly direct health-care resources to those who need it the most.

Medical imaging method can go beyond anthropometrics. Tomographic modalities, such as magnetic resonance imaging (MRI), can measure how we have stored fat in and around organs. These measurements can eventually lead to better individual risk predictions. For instance, a tendency to store fat as visceral adipose tissue (VAT) is associated with an increased risk of diabetes type 2, cardio-vascular disease, liver disease and certain types of cancer. Furthermore, liver fat is associated with liver disease, diabetes type 2. Brown adipose tissue (BAT), is another emerging component of body-composition analysis. While the normal white adipose tissue stores fat, BAT burns energy to produce heat. This unique property makes BAT highly interesting, from a metabolic point of view.

Magnetic resonance imaging can both accurately and safely measure internal adipose tissue compartments, and the fat infiltration of organs. Which is why MRI is often considered the reference method for non-invasive body-composition analysis. The two major challenges of MRI based body-composition analysis are, the between-scanner reproducibility and a cost-effective analysis of the images. This thesis presents a complete implementation of fat-referenced MRI, a technique that produces quantitative images that can increase both inter-scanner and automation of the image analysis.

With MRI, it is possible to construct images where water and fat are separated into paired images. In these images, it easy to depict adipose tissue and lean tissue structures. This thesis takes water-fat MRI one step further, by introducing a quantitative framework called fat-referenced MRI. By calibrating the image using the subjects' own adipose tissue (paper II), the otherwise non-quantitative fat images are made quantitative. In these fat-referenced images it is possible to directly measure the amount of adipose tissue in different compartments. This quantitative property makes image analysis easy and accurate, as lean and adipose tissues can be separated on a sub-voxel level. Fat-referenced MRI further allows the quantification and characterization of BAT.

This thesis work starts by formulating a method to produce water-fat images (paper I) based on two gradient recall images, i.e.\ 2-point Dixon images (2PD). It furthers shows that fat-referenced 2PD images can be corrected for T2*, making the 2PD body-composition measurements comparable with confounder-corrected Dixon measurements (paper III}).

Both the water-fat separation method and fat image calibration are applied to BAT imaging. The methodology is first evaluated in an animal model, where it is shown that it can detect both BAT browning and volume increase following cold acclimatization (paper IV). It is then applied to postmortem imaging, were it is used to locate interscapular BAT in human infants (paper V). Subsequent analysis of biopsies, taken based on the MRI images, showed that the interscapular BAT was of a type not previously believed to exist in humans. In the last study, fat-referenced MRI is applied to BAT imaging of adults. As BAT structures are difficult to locate in many adults, the methodology was also extended with a multi-atlas segmentation methods (paper VI).

In summary, this thesis shows that fat-referenced MRI is a quantitative method that can be used for body-composition analysis. It also shows that fat-referenced MRI can produce quantitative high-resolution images, a necessity for many BAT applications.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2018. s. 85
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1910
Emneord
MRI, water-fat separation, quantitative MRI
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-145316 (URN)10.3384/diss.diva-145316 (DOI)9789176853511 (ISBN)
Disputas
2018-03-21, Grantisalen, Campus US, Linköping, 09:15 (engelsk)
Opponent
Veileder
Merknad

DiVA-länken var felaktig i den tryckta versionen. Den är ändrad i den elektroniska versionen.

Tilgjengelig fra: 2018-02-27 Laget: 2018-02-22 Sist oppdatert: 2019-06-14bibliografisk kontrollert
Agebratt, C., Ström, E., Romu, T., Dahlqvist Leinhard, O., Borga, M., Leandersson, P. & Nyström, F. H. (2016). A Randomized Study of the Effects of Additional Fruit and Nuts Consumption on Hepatic Fat Content, Cardiovascular Risk Factors and Basal Metabolic Rate. PLoS ONE, 11(1), e0147149
Åpne denne publikasjonen i ny fane eller vindu >>A Randomized Study of the Effects of Additional Fruit and Nuts Consumption on Hepatic Fat Content, Cardiovascular Risk Factors and Basal Metabolic Rate
Vise andre…
2016 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, nr 1, s. e0147149-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background

Fruit has since long been advocated as a healthy source of many nutrients, however, the high content of sugars in fruit might be a concern.

Objectives

To study effects of an increased fruit intake compared with similar amount of extra calories from nuts in humans.

Methods

Thirty healthy non-obese participants were randomized to either supplement the diet with fruits or nuts, each at +7 kcal/kg bodyweight/day for two months. Major endpoints were change of hepatic fat content (HFC, by magnetic resonance imaging, MRI), basal metabolic rate (BMR, with indirect calorimetry) and cardiovascular risk markers.

Results

Weight gain was numerically similar in both groups although only statistically significant in the group randomized to nuts (fruit: from 22.15±1.61 kg/m2 to 22.30±1.7 kg/m2, p = 0.24 nuts: from 22.54±2.26 kg/m2 to 22.73±2.28 kg/m2, p = 0.045). On the other hand BMR increased in the nut group only (p = 0.028). Only the nut group reported a net increase of calories (from 2519±721 kcal/day to 2763±595 kcal/day, p = 0.035) according to 3-day food registrations. Despite an almost three-fold reported increased fructose-intake in the fruit group (from 9.1±6.0 gram/day to 25.6±9.6 gram/day, p<0.0001, nuts: from 12.4±5.7 gram/day to 6.5±5.3 gram/day, p = 0.007) there was no change of HFC. The numerical increase in fasting insulin was statistical significant only in the fruit group (from 7.73±3.1 pmol/l to 8.81±2.9 pmol/l, p = 0.018, nuts: from 7.29±2.9 pmol/l to 8.62±3.0 pmol/l, p = 0.14). Levels of vitamin C increased in both groups while α-tocopherol/cholesterol-ratio increased only in the fruit group.

Conclusions

Although BMR increased in the nut-group only this was not linked with differences in weight gain between groups which potentially could be explained by the lack of reported net caloric increase in the fruit group. In healthy non-obese individuals an increased fruit intake seems safe from cardiovascular risk perspective, including measurement of HFC by MRI.

Emneord
Fruits Basal metabolic rate measurement Fats Vitamin C Fructoses Diet Fatty liver Magnetic resonance imaging
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-124605 (URN)10.1371/journal.pone.0147149 (DOI)000368529100062 ()26788923 (PubMedID)
Merknad

Funding agencies: County Council of Ostergotland; Linkoping University, Department of Medical and Health Sciences

Tilgjengelig fra: 2016-02-05 Laget: 2016-02-05 Sist oppdatert: 2019-06-14
Romu, T., Camilla, V., Dahlqvist Leinhard, O., Tallberg, J., Dahlström, N., Persson, A., . . . Nyström, F. (2016). A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans. Metabolism: Clinical and Experimental, 65(6), 926-934
Åpne denne publikasjonen i ny fane eller vindu >>A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans
Vise andre…
2016 (engelsk)Inngår i: Metabolism: Clinical and Experimental, ISSN 0026-0495, E-ISSN 1532-8600, Vol. 65, nr 6, s. 926-934Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective

To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze.

Design

Randomized, open, parallel-group trial.

Methods

Healthy non-selected participants were randomized to achieve cold-exposure 1 hour/day, or to avoid any sense of feeling cold, for 6 weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI).

Results

Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841 ± 199 kCal/24 h to 1795 ± 213 kCal/24 h, p = 0.047 cold-activated MR from 1900 ± 150 kCal/24 h to 1793 ± 215 kCal/24 h, p = 0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p = 0.052). The difference between MR changes by the interventions between groups was statistically significant (p = 0.008 at room temperature, p = 0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported ≥ 8 days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175 ± 0.015 l to 0.0216 ± 0.014 l, p = 0.049).

Conclusions

We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.

sted, utgiver, år, opplag, sider
Elsevier, 2016
Emneord
Brown adipose tissue; Cold exposure; Magnetic resonance imaging; Metabolic rate
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-128200 (URN)10.1016/j.metabol.2016.03.012 (DOI)000376145100013 ()27173471 (PubMedID)
Forskningsfinansiär
Knut and Alice Wallenberg Foundation
Merknad

Funding agencies: Linkoping University; County Council of Ostergotland (LUA-ALF), Sweden; Swedish Research Council [2013-4466, 2012-1652, 2014-2516]; Knut and Alice Wallenberg Foundation; Sahlgrenskas University Hospital (LUA-ALF); European Union grant (DIABAT) [HEALTH-F2-

Tilgjengelig fra: 2016-05-22 Laget: 2016-05-22 Sist oppdatert: 2019-06-14
West, J., Dahlqvist Leinhard, O., Romu, T., Thomas, E. L., Borga, M. & Bell, J. (2016). Body Composition Analysis In Large Scale Population Studies using Dixon Water-Fat Separated Imaging. In: : . Paper presented at International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Singapore, May 7-13, 2016.
Åpne denne publikasjonen i ny fane eller vindu >>Body Composition Analysis In Large Scale Population Studies using Dixon Water-Fat Separated Imaging
Vise andre…
2016 (engelsk)Konferansepaper, Poster (with or without abstract) (Annet vitenskapelig)
Abstract [en]

Water-fat separated MRI, based on Dixon imaging techniques enables high soft-tissue contrast and the separation of fat and muscle compartments. This study investigate the feasibility and success-rate of one recently described method for MR data-acquisition and body composition analysis, in a large-scale population study. The first 1,000 subjects in the UK Biobank imaging cohort were scanned, quality assured and included for body composition analysis. Volumes of visceral adipose tissue, abdominal subcutaneous tissue, and thigh muscles were calculated. This study showed that the rapid MR-examination was sufficiently robust to achieve very high success-rate for body composition analysis. 

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-128987 (URN)
Konferanse
International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Singapore, May 7-13, 2016
Tilgjengelig fra: 2016-06-07 Laget: 2016-06-07 Sist oppdatert: 2019-06-14bibliografisk kontrollert
Peterson, P., Romu, T., Brorson, H., Dahlqvist Leinhard, O. & Mansson, S. (2016). Fat Quantification in Skeletal Muscle Using Multigradient-Echo Imaging: Comparison of Fat and Water References. Journal of Magnetic Resonance Imaging, 43(1), 203-212
Åpne denne publikasjonen i ny fane eller vindu >>Fat Quantification in Skeletal Muscle Using Multigradient-Echo Imaging: Comparison of Fat and Water References
Vise andre…
2016 (engelsk)Inngår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 43, nr 1, s. 203-212Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose: To investigate the precision, accuracy, and repeatability of water/fat imaging-based fat quantification in muscle tissue using a large flip angle (FA) and a fat reference for the calculation of the proton density fat fraction (FF). Comparison is made to a small FA water reference approach. Materials and Methods: An Intralipid phantom and both forearms of six patients suffering from lymphedema and 10 healthy volunteers were investigated at 1.5T. Two multigradient-echo sequences with eight echo times and FAs of 10 degrees and 85 degrees were acquired. For healthy volunteers, the acquisition of the right arm was performed twice with repositioning. From each set, water reference FF and fat reference FF images were reconstructed and the average FF and the standard deviation were calculated within the subfascial compartment. The small FA water reference was considered the reference standard. Results: A high agreement was found between the small FA water reference and large FA fat reference methods (FF bias=0.31%). In this study, the large FA fat reference approach also resulted in higher precision (38% smaller FF standard deviation in homogenous muscle tissue), but no significant difference in repeatability between the various methods was detected (coefficient of repeatability of small FA water reference approach 0.41%). Conclusion: The precision of fat quantification in muscle tissue can be increased with maintained accuracy using a larger flip angle, if a fat reference instead of a water reference is used.

sted, utgiver, år, opplag, sider
WILEY-BLACKWELL, 2016
Emneord
fat quantification; water; fat imaging; skeletal muscle; water reference; internal fat reference
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-125322 (URN)10.1002/jmri.24972 (DOI)000368741400019 ()26095018 (PubMedID)
Merknad

Funding Agencies|Research Council of Southeast Sweden [FORSS-311941]; Knut and Alice Wallenberg Foundation; Stiftelsen for cancerforskning vid Onkologiska kliniken vid Universitetssjukhuset MAS; Skane County Councils Research and Development Foundation; Swedish Cancer Society; Allmanna Sjukhusets i Malmo Stiftelse for bekampande av cancer

Tilgjengelig fra: 2016-02-24 Laget: 2016-02-19 Sist oppdatert: 2019-06-14
Haufe, W., Hooker, J., Schlein, A., Szeverenyi, N., Borga, M., Dahlqvist Leinhard, O., . . . Sirlin, C. B. (2016). Feasibility of an automated tissue segmentation technique in a longitudinal weight loss study. In: : . Paper presented at International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Singapore, May 7-13, 2016.
Åpne denne publikasjonen i ny fane eller vindu >>Feasibility of an automated tissue segmentation technique in a longitudinal weight loss study
Vise andre…
2016 (engelsk)Konferansepaper, Poster (with or without abstract) (Annet vitenskapelig)
Abstract [en]

To address the problems inherent in manual methods, a novel, semi-automated tissue segmentation image analysis technique has been developed. The purpose of this study was to demonstrate the feasibility and describe preliminary observations of applying this technique to quantify and monitor longitudinal changes in abdominal adipose tissue and thigh muscle volume in obese adults during weight loss. Abdominal adipose tissue and thigh muscle volume decreased during weight loss. As a proportion of body weight, adipose tissue volumes decreased during weight loss. By comparison, as a proportion of body weight, thigh muscle volume increased.

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-128990 (URN)
Konferanse
International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Singapore, May 7-13, 2016
Tilgjengelig fra: 2016-06-07 Laget: 2016-06-07 Sist oppdatert: 2019-06-14bibliografisk kontrollert
Middleton, M., Haufe, W., Hooker, J., Borga, M., Dahlqvist Leinhard, O., Romu, T., . . . Sirlin, C. B. (2016). Repeatability and accuracy of a novel, MRI-based, semi-automated analysis method for quantifying abdominal adipose tissue and thigh muscle volumes. In: : . Paper presented at International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Singapore, May 7-13, 2016.
Åpne denne publikasjonen i ny fane eller vindu >>Repeatability and accuracy of a novel, MRI-based, semi-automated analysis method for quantifying abdominal adipose tissue and thigh muscle volumes
Vise andre…
2016 (engelsk)Konferansepaper, Poster (with or without abstract) (Annet vitenskapelig)
Abstract [en]

Current MRI methods to estimate body tissue compartment volumes rely on manual segmentation, which is laborious, expensive, not widely available outside specialized centers, and not standardized. To address these concerns, a novel, semi-automated image analysis method has been developed. Image acquisition takes about six minutes, and uses widely available MRI pulse sequences. We found that this method permits comprehensive body compartment analysis and provides high repeatability and accuracy. Current and future clinical and drug development studies may benefit from this methodology, as may clinical settings where monitoring change in these measures is desired.

HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-128988 (URN)
Konferanse
International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Singapore, May 7-13, 2016
Tilgjengelig fra: 2016-06-07 Laget: 2016-06-07 Sist oppdatert: 2019-06-14bibliografisk kontrollert
Newman, D., Kelly-Morland, C., Dahlqvist Leinhard, O., Kasmai, B., Greenwood, R., Malcolm, P., . . . Toms, A. (2016). Test–retest reliability of rapid whole body and compartmental fat volume quantification on a widebore 3T MR system in normal-weight, overweight, and obese subjects. Journal of Magnetic Resonance Imaging, 44(6), 1464-1473
Åpne denne publikasjonen i ny fane eller vindu >>Test–retest reliability of rapid whole body and compartmental fat volume quantification on a widebore 3T MR system in normal-weight, overweight, and obese subjects
Vise andre…
2016 (engelsk)Inngår i: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 44, nr 6, s. 1464-1473Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Purpose

To measure the test–retest reliability of rapid (<15 min) whole body and visceral fat volume quantification in normal and obese subjects on a widebore 3T MR system and compare it with conventional manual segmentation.

Materials and Methods

Thirty participants (body mass index [BMI] 20.1–48.6 kg/m2) underwent two whole-body magnetic resonance imaging (MRI) examinations on a widebore 3T machine using a 2-point Dixon technique. Phase sensitive reconstruction and intensity inhomogeneity correction produced quantitative datasets of total adipose tissue (TAT), abdominal subcutaneous adipose tissue (ASAT), and visceral adipose tissue (VAT). The quantification was performed automatically using nonrigid atlas-based segmentation and compared with manual segmentation (SliceOmatic).

Results

The mean TAT was 31.74 L with a coefficient of variation (CV) of 0.79% and a coefficient of repeatability (CR) of 0.49 L. The ASAT was 7.92 L with a CV of 2.98% and a CR of 0.46 L. There was no significant difference in the semiautomated and manually segmented VAT (P = 0.73) but there were differences in the reliability of the two techniques. The mean semiautomated VAT was 2.56 L, CV 1.8%, and CR 0.09 L compared to the mean manually segmented VAT of 3.12 L, where the CV was 6.3% and the CR was 0.39 L.

Conclusion

Rapid semiautomated whole body and compartmental fat volume quantification can be derived from a widebore 3T system, for a range of body sizes including obese patients, with “almost perfect” test–retest reliability.

sted, utgiver, år, opplag, sider
Wiley-Blackwell, 2016
Emneord
semiautomated quantification; manual segmentation; MRI; adipose; visceral adipose; reliability
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-128881 (URN)10.1002/jmri.25326 (DOI)000387859600010 ()27249363 (PubMedID)
Tilgjengelig fra: 2016-06-04 Laget: 2016-06-04 Sist oppdatert: 2019-06-14
Organisasjoner