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Sherrell, Peter
Publikasjoner (2 av 2) Visa alla publikasjoner
Sherrell, P., Cieślar-Pobuda, A., Silverå Ejneby, M., Sammalisto, L., Gelmi, A., de Muinck, E., . . . Rafat, M. (2017). Rational Design of a Conductive Collagen Heart Patch. Macromolecular Bioscience, 17(7), Article ID 1600446.
Åpne denne publikasjonen i ny fane eller vindu >>Rational Design of a Conductive Collagen Heart Patch
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2017 (engelsk)Inngår i: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 17, nr 7, artikkel-id 1600446Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Cardiovascular diseases, including myocardial infarction, are the cause of significant morbidity and mortality globally. Tissue engineering is a key emerging treatment method for supporting and repairing the cardiac scar tissue caused by myocardial infarction. Creating cell supportive scaffolds that can be directly implanted on a myocardial infarct is an attractive solution. Hydrogels made of collagen are highly biocompatible materials that can be molded into a range of shapes suitable for cardiac patch applications. The addition of mechanically reinforcing materials, carbon nanotubes, at subtoxic levels allows for the collagen hydrogels to be strengthened, up to a toughness of 30 J m-1 and a two to threefold improvement in Youngs' modulus, thus improving their viability as cardiac patch materials. The addition of carbon nanotubes is shown to be both nontoxic to stem cells, and when using single-walled carbon nanotubes, supportive of live, beating cardiac cells, providing a pathway for the further development of a cardiac patch.

sted, utgiver, år, opplag, sider
Wiley-VCH Verlagsgesellschaft, 2017
Carbon nanotube, Collagen, Hydrogel, Myocardial infarction, Stem cell
HSV kategori
urn:nbn:se:liu:diva-136817 (URN)10.1002/mabi.201600446 (DOI)000405566300004 ()28322510 (PubMedID)2-s2.0-85016390421 (Scopus ID)

Funding agencies: Linkoping Initiative in Life Science Technologies (LIST); Central ALF Matching Grant from Landstinget i Ostergotland [LIO-344071]; European Research Agency [304209]; GeCONiI [POIG.02.03.01-24-099/13]

Tilgjengelig fra: 2017-04-27 Laget: 2017-04-27 Sist oppdatert: 2024-01-10bibliografisk kontrollert
Rafat, M., Xeroudaki, M., Koulikovska, M., Sherrell, P., Groth, F., Fagerholm, P. & Lagali, N. (2016). Composite core-and-skirt collagen hydrogels with differential degradation for corneal therapeutic applications. Biomaterials, 83, 142-155
Åpne denne publikasjonen i ny fane eller vindu >>Composite core-and-skirt collagen hydrogels with differential degradation for corneal therapeutic applications
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2016 (engelsk)Inngår i: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 83, s. 142-155Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Scarcity of donor tissue to treat corneal blindness and the need to deliver stem cells or pharmacologic agents to ensure corneal graft survival are major challenges. Here, new composite collagen-based hydrogels are developed as implants to restore corneal transparency while serving as a possible reservoir for cells and drugs. The composite hydrogels have a centrally transparent core and embedded peripheral skirt of adjustable transparency and degradability, with the skirt exhibiting faster degradation in vitro. Both core and skirt supported human epithelial cell populations in vitro and the skirt merged homogeneously with the core material to smoothly distribute a mechanical load in vitro. After in vivo transplantation in rabbit corneas over three months, composites maintained overall corneal shape and integrity, while skirt degradation could be tracked in vivo and non-invasively due to partial opacity. Skirt degradation was associated with partial collagen breakdown, thinning, and migration of host stromal cells and macrophages, while the central core maintained integrity and transparency as host cells migrated and nerves regenerated.


This study indicates the feasibility of a collagen-based composite hydrogel to maintain corneal stability and transparency while providing a degradable peripheral reservoir for cell or substance release.

Composite; Cornea; Degradation; Femtosecond laser; Keratoplasty; Porcine collagen
HSV kategori
urn:nbn:se:liu:diva-125229 (URN)10.1016/j.biomaterials.2016.01.004 (DOI)000371651700012 ()26773670 (PubMedID)

Funding agencies:  Abbott Medical Optics Inc, Solna, Sweden

Tilgjengelig fra: 2016-02-16 Laget: 2016-02-16 Sist oppdatert: 2022-10-27