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Lindehammar, Hans
Publikationer (10 of 12) Visa alla publikationer
Huang-Link, Y.-M., Al-Hawasi, A. & Lindehammar, H. (2015). Acute optic neuritis: retinal ganglion cell loss precedes retinal nerve fiber thinning.. Neurological Sciences, 36(4), 617-620
Öppna denna publikation i ny flik eller fönster >>Acute optic neuritis: retinal ganglion cell loss precedes retinal nerve fiber thinning.
2015 (Engelska)Ingår i: Neurological Sciences, ISSN 1590-1874, E-ISSN 1590-3478, Vol. 36, nr 4, s. 617-620Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Optic neuritis (ON) causes axonal loss as reflected by thinning of retinal nerve fiber layer (RNFL) and can be tracked by optical coherence tomography (OCT) about 6 months after ON onset, when swelling of optic nerve head (ONH) has vanished. Changes of macular ganglion cell layer (GCL) thickness provide another window to track the disease process in ON. GCL thinning over time in relation to RNFL change after ON remains elusive. Using OCT, we followed 4 patients with acute unilateral isolated ON for more than 9 months. A diagnosis of multiple sclerosis (MS) was established in all 4 patients. First follow-up was 2-3 weeks after ON onset, and thereafter every 2-3 months. RNFL swelling peaked during first month after acute ON, followed by rapidly reduced swelling (pseudoatrophy) during following 2 months, and thereafter successively vanished 6 months after ON onset. GCL thinning was observed 1-3 months after ON onset, i.e. already during optic disk swelling and before real RNFL thinning. The results imply that quantifying GCL thickness provides opportunities to monitor early axonal loss and ON-to-MS progression, and facilitates distinguishing real atrophy from pseudoatrophy of RNFL after acute ON.

Nationell ämneskategori
Oftalmologi
Identifikatorer
urn:nbn:se:liu:diva-117096 (URN)10.1007/s10072-014-1982-3 (DOI)000351612200017 ()25311917 (PubMedID)
Tillgänglig från: 2015-04-15 Skapad: 2015-04-15 Senast uppdaterad: 2019-02-11
Landtblom, A.-M., Lindehammar, H., Karlsson, H. & Craig, A. D. (2011). Insular cortex activation in a patient with "sensed presence"/ecstatic seizures. EPILEPSY and BEHAVIOR, 20(4), 714-718
Öppna denna publikation i ny flik eller fönster >>Insular cortex activation in a patient with "sensed presence"/ecstatic seizures
2011 (Engelska)Ingår i: EPILEPSY and BEHAVIOR, ISSN 1525-5050, Vol. 20, nr 4, s. 714-718Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: Seizures with an aura of a "sensed presence," a religious emotion, or feelings of euphoria (ecstatic seizures) are characterized by heightened self-awareness. A previous case report on a patient with epilepsy and "sensed presence" as an aura described hypoperfusion in both temporal lobes and a local ictal increase in the left frontoparietal area. A reexamination of the data was suggested by a recent study of patients with ecstatic seizures, which proposed that hyperactivation of the left anterior insula might be a potential cause. Methods: We reanalyzed the laboratory data on the case with "sensed presence" aura using a fusion of SPECT and MR images of the brain, which had not previously been available, and a close examination of the subdural ictal EEG registrations. Results: Examination of the ictal EEG recordings from subdural strip electrodes implanted subtemporally and temporally on both sides showed that seizure activity occurred first at the most medial subtemporal electrode on the left side. From an anatomical point of view, this electrode position is close to the ventral aspect of the left anterior insula, and it is possible that the seizure activity was initiated there. Reexamination of the SPECT data after fusion with contemporary MR images clearly indicated that the region of strong hyperactivation overlies the left anterior insula. Hyperactive regions also appear on the midinsula bilaterally. Together with the neurophysiological ictal EEG, this evidence supports a reinterpretation that this aura of "sensed presence" can be attributed to hyperactivation of the left anterior insula. Conclusion: The present findings support the proposal that ecstatic seizures or "sensed presence" auras can originate from the left anterior insula, a region that has been suggested to engender self-awareness associated with positive feelings.

Ort, förlag, år, upplaga, sidor
Elsevier Science B.V., Amsterdam, 2011
Nyckelord
Seizures, Psychological, Ictal, Single-photon-emission computed tomography, Electroencephalography, Magnetic resonance imaging, Aura, Insula, Ecstatic
Nationell ämneskategori
Teknik och teknologier
Identifikatorer
urn:nbn:se:liu:diva-68226 (URN)10.1016/j.yebeh.2011.01.031 (DOI)000290056200022 ()
Tillgänglig från: 2011-05-13 Skapad: 2011-05-13 Senast uppdaterad: 2012-04-03
Gati, I., Danielsson, O., Vrethem, M., Lindehammar, H., Lindvall, B., Häggqvist, B., . . . Landtblom, A.-M. (2011). SENSORY ATAXIC NEUROPATHY WITH DYSARTHRIA/DYSPHAGIA AND OPHTHALMOPLEGIA (SANDO) - CASE HISTORIES in EUROPEAN JOURNAL OF NEUROLOGY, vol 18, issue SI, pp 282-282. In: EUROPEAN JOURNAL OF NEUROLOGY (pp. 282-282). Wiley-Blackwell, 18(SI)
Öppna denna publikation i ny flik eller fönster >>SENSORY ATAXIC NEUROPATHY WITH DYSARTHRIA/DYSPHAGIA AND OPHTHALMOPLEGIA (SANDO) - CASE HISTORIES in EUROPEAN JOURNAL OF NEUROLOGY, vol 18, issue SI, pp 282-282
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2011 (Engelska)Ingår i: EUROPEAN JOURNAL OF NEUROLOGY, Wiley-Blackwell , 2011, Vol. 18, nr SI, s. 282-282Konferensbidrag, Publicerat paper (Refereegranskat)
Abstract [en]

n/a

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell, 2011
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-71080 (URN)000294806600516 ()
Tillgänglig från: 2011-09-30 Skapad: 2011-09-30 Senast uppdaterad: 2012-04-03
Lindehammar, H. (2004). Muscle function in Juvenile Idiopathic Arthritis: A two-year follow-up. (Doctoral dissertation). Linköping: Linköping University Electronic Press
Öppna denna publikation i ny flik eller fönster >>Muscle function in Juvenile Idiopathic Arthritis: A two-year follow-up
2004 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

This is a study of muscle function in Juvenile Idiopathic Arthritis (JIA). Rheumatoid arthritis (RA) is a disease that primarily affects the synovial membrane of joints. Muscle weakness, atrophy and pain occur in adult RA. This may be a consequence of joint pain, stiffness and immobility. Muscle inflammation and neuropathy occur as complications in adults. Muscle function in JIA has been much less studied.

The aim of the study was to examine whether muscle weakness and atrophy also occur in children with JIA.

This was a longitudinal study over a two-year period, where muscle strength and thickness were measured repeatedly in a group of 20 children and teenagers with JIA. Muscle strength was measured using different methods and in several muscle groups. Muscle biopsies were obtained and nerve conduction velocity studies performed.

The study concludes that, compared to healthy people, children and teenagers with JIA have as a group reduced muscle strength and muscle thickness. For most of these children and teenagers, muscle strength is only slightly lower than expected, but a few have marked muscle weakness. This is most apparent in patients with severe polyarthritis where the weakness seems to be widespread. Patients with isolated arthritis may also have greatly reduced strength and thickness of muscles near the inflamed joint.

There is a risk of decreasing strength in patients with polyarthritis and in muscles near an active arthritis.

Minor changes are common in muscle biopsies, and findings may indicate immunological activity in the muscles.

Atrophy of type II fibres, as in adult RA, was not found in JIA.

No patient had signs of neuropathy.

Ort, förlag, år, upplaga, sidor
Linköping: Linköping University Electronic Press, 2004. s. 97
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 847
Nyckelord
arthritis, juvenile rheumatoid, physiopathology, muscle, skeletal, pathology, physiopathology, Muscular atrophy, etiology, physiopathology, arthritis, juvenile rheumatoid, complications
Nationell ämneskategori
Klinisk vetenskap
Identifikatorer
urn:nbn:se:liu:diva-5195 (URN)91-7373-819-0 (ISBN)
Disputation
2004-05-07, Viktoriasalen, Campus US, Linköpings universitet, Linköping, 13:00 (Engelska)
Handledare
Anmärkning
On the day of the public defence the status of article IV was: Submitted.Tillgänglig från: 2004-05-27 Skapad: 2004-05-27 Senast uppdaterad: 2012-01-25Bibliografiskt granskad
Lindehammar, H. & Lindvall, B. (2004). Muscle involvement in juvenile idiopathic arthritis. Rheumatology, 43(12), 1546-1554
Öppna denna publikation i ny flik eller fönster >>Muscle involvement in juvenile idiopathic arthritis
2004 (Engelska)Ingår i: Rheumatology, ISSN 1462-0324, Vol. 43, nr 12, s. 1546-1554Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: An observational study of changes in muscle structure and the relation to muscle strength in juvenile idiopathic arthritis (JIA).

METHODS: Fifteen children and teenagers (eight girls and seven boys) with JIA, aged 9-19 yr (mean age 16.1), were studied. Muscle biopsies were obtained from the anterior tibial muscle and were examined using histopathological and immunohistochemical methods. Muscle fibre types were classified and fibre areas measured. As markers of inflammation, the major histocompatibility complex (MHC) class I and class II and the membrane attack complex (MAC) were analysed. Results were compared with biopsies from the gastrocnemius muscle in 33 young (19-23 yr) healthy controls. Isometric and isokinetic muscle strengths were measured in ankle dorsiflexion. Strength was compared with reference values for healthy age-matched controls. Nerve conduction velocities were recorded in the peroneal and sural nerves.

RESULTS: Four of the 15 muscle biopsies were morphologically normal. Eleven biopsies showed minor unspecific changes. Two of these also showed minor signs of inflammation. MHC class II expression was found in 4/15 patients, which was significantly more than in the healthy controls (P = 0.0143). The expression of MHC class I and MAC did not differ from that in the controls. The mean area of type I fibres was lower than that of type IIA fibres in 12/13 biopsies. Muscle strength was significantly reduced in the patient group. There was a significant positive correlation between muscle fibre area and muscle strength. Nerve conduction studies were normal in all cases.

CONCLUSIONS: Changes in leg muscle biopsies appear to be common in children and teenagers with JIA. The presence of inflammatory cells in the muscle and expression of MHC class II on muscle fibres may be a sign of inflammatory myopathy. There are no findings of type II muscle fibre hypotrophy or neuropathy, as in adults with RA.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-13647 (URN)10.1093/rheumatology/keh381 (DOI)
Tillgänglig från: 2004-05-27 Skapad: 2004-05-27 Senast uppdaterad: 2009-08-19
Engman, M., Lindehammar, H. & Wijma, B. (2004). Surface electromyography diagnostics in women with partial vaginismus with or without vulvar vestibulitis and in asymptomatic women. Journal of Psychosomatic Obstetrics & Gynecology, 25(3/4), 281-294
Öppna denna publikation i ny flik eller fönster >>Surface electromyography diagnostics in women with partial vaginismus with or without vulvar vestibulitis and in asymptomatic women
2004 (Engelska)Ingår i: Journal of Psychosomatic Obstetrics & Gynecology, ISSN 0167-482X, Vol. 25, nr 3/4, s. 281-294Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The aim of this study was to investigate to what extent women with superficial dyspareunia can be diagnosed for both partial vaginismus (PaV) and vulvar vestibulitis (VVS) and to discover to what extent surface electromyography (sEMG) of the pelvic floor muscles (PFM) can distinguish between women with PaV solely, PaV + VVS, and asymptomatic women. A total of 224 consecutive women with superficial dyspareunia were examined clinically for both PaV and VVS diagnoses. We examined 47 women with PaV ± VVS and 27 asymptomatic women with sEMG of the PFM. The results showed that 102/224 women with superficial dyspareunia and 33/47 women with PaV in the sEMG part of the study had both PaV and VVS. All women with VVS had vaginismus, while 42/224 had PaV but not VVS. sEMG measurements revealed no significant differences between the three groups of women (PaV solely, PaV + VVS, and asymptomatic). Almost half of the women with superficial dyspareunia referred to our clinic have both the diagnosis PaV and VVS. sEMG was not a method of any value to distinguish between women with PaV solely, PaV + VVS, or asymptomatic women. The increased tone found clinically in the PFM of women with PaV ± VVS may be of other origin than electrogenic contractions.

Nyckelord
electromyography, pelvic floor muscles, muscular tone; diagnostic criteria, dyspareunia, vulvar vestibulitis, vaginismus, asymptomatic group
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-12654 (URN)10.1080/01674820400017921 (DOI)
Tillgänglig från: 2007-10-17 Skapad: 2007-10-17 Senast uppdaterad: 2018-11-15
Lindehammar, H. (2003). Hand strength in juvenile chronic arthritis: a two-year follow-up. Acta Paediatrica, 92(11), 1291-1296
Öppna denna publikation i ny flik eller fönster >>Hand strength in juvenile chronic arthritis: a two-year follow-up
2003 (Engelska)Ingår i: Acta Paediatrica, ISSN 0001-656X, Vol. 92, nr 11, s. 1291-1296Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

AIM: To describe changes in muscle strength in the hands of children with juvenile chronic arthritis (JCA) and to examine the relationship between muscle strength, presence of local arthritis and disease subtype.

METHODS: Twenty children (10 girls and 10 boys) with JCA aged 7 to 18 y were followed for two years. Isometric muscle strength in wrist dorsiflexors and handgrip strength were measured repeatedly. The results were compared with reference values for the same methods. Arthritis severity in the hand was scored every third month. Nerve conduction velocities were measured twice.

RESULTS: Seven out of 20 patients had initially low or decreasing strength in one or both of the two tests. Five out of 20 children had reduced strength (more than two standard deviations below the mean of the reference group) in at least one test. Four children showed a significant reduction in muscle strength in at least one test during the observation time. The greatest reduction in strength was measured in four children with polyarticular disease. These children also had local arthritis in the hand. A greater proportion of children with polyarthritis had low or decreasing strength compared with children with oligoarthritis. The same was true for children with active arthritis in the hand. Nerve conduction velocities were normal in all cases and did not change.

CONCLUSION: The majority of children with JCA have normal strength in the hand. Some children, especially those with polyarthritis and hand arthritis, have reduced muscle strength in the hand. Risk factors for low or decreasing strength are polyarthritis and/or active arthritis in the hand.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-13646 (URN)10.1080/08035250310006340 (DOI)
Tillgänglig från: 2004-05-27 Skapad: 2004-05-27 Senast uppdaterad: 2009-08-19
Morren, G., Walter, S., Lindehammar, H., Hallböök, O. & Sjödahl, R. (2001). Evaluation of the sacroanal motor pathway by magnetic and electric stimulation in patients with fecal incontinence. Diseases of the Colon & Rectum, 44(2), 167-172
Öppna denna publikation i ny flik eller fönster >>Evaluation of the sacroanal motor pathway by magnetic and electric stimulation in patients with fecal incontinence
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2001 (Engelska)Ingår i: Diseases of the Colon & Rectum, ISSN 0012-3706, E-ISSN 1530-0358, Vol. 44, nr 2, s. 167-172Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

PURPOSE: The aim of this controlled study was to examine whether it was feasible to use magnetic stimulation as a new diagnostic tool to evaluate the motor function of the sacral roots and the pudendal nerves in patients with fecal incontinence.

PATIENTS AND METHODS: Nineteen consecutive patients (17 females) with a median age of 67 (range, 36-78) years referred for fecal incontinence and 14 healthy volunteers (six females) with a median age of 42 (range, 23-69) years were examined. Latency times of the motor response of the external anal sphincter were measured after electric transrectal stimulation of the pudendal nerve and magnetic stimulation of the sacral roots.

RESULTS: The success rates of pudendal nerve terminal motor latency and sacral root terminal motor latency measurements were 100 and 85 percent, respectively, in the control group and 94 and 81 percent, respectively, in the fecal incontinence group. Median left pudendal nerve terminal motor latency was 1.88 (range, 1.4-2.9) milliseconds in the control group and 2.3 (range, 1.8-4) milliseconds in the fecal incontinence group (P <0.006). Median right pudendal nerve terminal motor latency was 1.7 (range, 1.3-3.4) milliseconds in the control group and 2.5 (range, 1.7-6) milliseconds in the fecal incontinence group (P <0.003). Median left sacral root terminal motor latency was 3.3 (range, 2.1-6) milliseconds in the control group and 3.7 (range, 2.8-4.8) milliseconds in the fecal incontinence group (P <3 0.03). Median right sacral root terminal motor latency was 3 (range, 2.6-5.8) milliseconds in the control group and 3.9 (range, 2.5-7.2) milliseconds in the fecal incontinence group (P =0.15).

CONCLUSIONS: Combined pudendal nerve terminal motor latency and sacral root terminal motor latency measurements may allow us to study both proximal and distal pudendal nerve motor function in patients with fecal incontinence. Values of sacral root terminal motor latency have to be interpreted cautiously because of the uncertainty about the exact site of magnetic stimulation and the limited magnetic field strength.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-25050 (URN)10.1007/BF02234288 (DOI)9478 (Lokalt ID)9478 (Arkivnummer)9478 (OAI)
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Morren, G., Walter, S., Lindehammar, H., Hallböök, O. & Sjödahl, R. (2001). Latency of compound muscle action potentials of the anal sphincter after magnetic sacral stimulation. Muscle and Nerve, 24(9), 1232-1235
Öppna denna publikation i ny flik eller fönster >>Latency of compound muscle action potentials of the anal sphincter after magnetic sacral stimulation
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2001 (Engelska)Ingår i: Muscle and Nerve, ISSN 0148-639X, E-ISSN 1097-4598, Vol. 24, nr 9, s. 1232-1235Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The aim of this study was to present the failure rate and normal values for motor latency of the anal sphincter after magnetic sacral stimulation (LMSS) using a modified recording technique. A bipolar sponge electrode was placed in the anal canal for recording. A ground electrode was placed in the rectum to reduce stimulus artifact. Magnetic stimulation was induced through a twin coil energized by a Maglite-r25 generator. Two groups were examined: 14 healthy volunteers and 14 patients with a spinal cord injury (SCI) above the conus. Nine of 56 studies (16%) failed. There were no significant differences in latency between right- and left-sided stimulation or between the healthy group and the SCI patients. As described, LMSS measurements are minimally invasive and have a low failure rate. They may be used to test the integrity of the distal motor pathway in patients with bladder or bowel dysfunction who may benefit from continuous electrical sacral root stimulation.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-25053 (URN)10.1002/mus.1138 (DOI)9481 (Lokalt ID)9481 (Arkivnummer)9481 (OAI)
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Lindehammar, H. & Sandstedt, P. (1998). Measurement of Quadriceps Muscle Strength and Bulk in Juvenile Chronic Arthritis: A Prospective, Longitudinal, 2 Year Survey. Journal of Rheumatology, 25(11), 2240-2248
Öppna denna publikation i ny flik eller fönster >>Measurement of Quadriceps Muscle Strength and Bulk in Juvenile Chronic Arthritis: A Prospective, Longitudinal, 2 Year Survey
1998 (Engelska)Ingår i: Journal of Rheumatology, ISSN 0315-162X, Vol. 25, nr 11, s. 2240-2248Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: In a prospective survey over a 2-year period we studied strength and bulk of the quadriceps muscle in the thighs of children with juvenile chronic arthritis (JCA). METHODS: Every third month for 2 years we measured isometric muscle strength in knee extensors with a hand-held dynamometer in 20 children with JCA. Ultrasound equipment was used to measure thigh muscle bulk. A joint evaluation was made using a standard severity score. The children had their ordinary medical treatment and physiotherapy during the observation period. RESULTS: Children with high severity scores in the knee or hip had least strength and muscle bulk. In the 4 children with the highest severity scores muscle strength was reduced to half of that expected. In 10 of the children there were clear variations in severity scores during the study period, for either better or worse. In these children an increase in the severity score correlated significantly with reduction in muscle strength and bulk (p < 0.05). The muscle strength and bulk changed in parallel in these children. Other factors, although not independent, such as polyarticular JCA, long duration of disease, and steroid treatment, also reduced muscle strength. CONCLUSION: The presence and intensity of local arthritis is one important factor affecting muscle function in JCA. Normal muscle strength and bulk is rapidly lost near an inflamed joint. It is difficult to maintain or achieve normal muscle function in the presence of active arthritis despite medical and physical treatment. We assume that the muscle weakness is in part caused by atrophy of the muscle, which is influenced by local arthritis.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-13645 (URN)
Tillgänglig från: 2004-05-27 Skapad: 2004-05-27 Senast uppdaterad: 2009-08-19
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