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Nordgren, Johan
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Gunaydin, G., Nordgren, J., Sharma, S. & Hammarstrom, L. (2016). Association of elevated rotavirus-specific antibody titers with HBGA secretor status in Swedish individuals: The FUT2 gene as a putative susceptibility determinant for infection. Virus Research, 211, 64-68
Öppna denna publikation i ny flik eller fönster >>Association of elevated rotavirus-specific antibody titers with HBGA secretor status in Swedish individuals: The FUT2 gene as a putative susceptibility determinant for infection
2016 (Engelska)Ingår i: Virus Research, ISSN 0168-1702, E-ISSN 1872-7492, Vol. 211, s. 64-68Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The histo-blood group antigens (HBGAs) have recently been suggested to serve as attachment factors for rotavirus VP8* (P-genotype) in vitro and associated with susceptibility in vivo. We thus investigated whether rotavirus antibody titers and genotype specific neutralization titers correlate with HBGA status in Swedish individuals. We investigated the effect of inactivating mutations in the secretor FUT2 (rs601338) and Lewis FUT3 genes (rs28362459, rs3894326, rs812936 and rs778986) on serum IgG antibody titers and neutralizing antibody titers to rotavirus strains of the P[8] and P[6] genotypes in Swedish healthy blood donors and patients with IgA deficiency using genotyping, enzyme linked immunosorbent assay and a neutralization assay. Rotavirus-specific serum IgG and neutralizing antibody titers to the Wa strain (G1P[8]), but not to the ST3 (G4P[6]) strain, were significantly higher in secretors (with at least one functional FUT2 gene) than in non-secretors (P<0.001) (with homozygous nonsense mutation in the FUT2 gene). Thus, our results represent that secretors show elevated rotavirus specific serum antibodies, suggesting a higher susceptibility to rotavirus infections, as compared to non-secretors in Sweden. (C) 2015 Elsevier B.V. All rights reserved.

Ort, förlag, år, upplaga, sidor
ELSEVIER SCIENCE BV, 2016
Nyckelord
Rotavirus; Histo-blood group antigen (HBGA); FUT2; Lewis; Secretor; Antibody response
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-124088 (URN)10.1016/j.virusres.2015.10.005 (DOI)000366443500009 ()26454189 (PubMedID)
Anmärkning

Funding Agencies|Swedish Research Council [K2012-56X-05975-32-3]

Tillgänglig från: 2016-01-25 Skapad: 2016-01-19 Senast uppdaterad: 2017-11-30
Nordgren, J., Sharma, S., Kambhampati, A., Lopman, B. & Svensson, L. (2016). Innate Resistance and Susceptibility to Norovirus Infection. PLoS Pathogens, 12(4), e1005385
Öppna denna publikation i ny flik eller fönster >>Innate Resistance and Susceptibility to Norovirus Infection
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2016 (Engelska)Ingår i: PLoS Pathogens, ISSN 1553-7366, E-ISSN 1553-7374, Vol. 12, nr 4, s. e1005385-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

n/a

Ort, förlag, år, upplaga, sidor
PUBLIC LIBRARY SCIENCE, 2016
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-130446 (URN)10.1371/journal.ppat.1005385 (DOI)000378156900003 ()27115484 (PubMedID)
Anmärkning

Funding Agencies|Swedish Foundation for Strategic Research

Tillgänglig från: 2016-08-06 Skapad: 2016-08-05 Senast uppdaterad: 2017-11-28
Gia Phan, T., Charlys da Costa, A., del Valle Mendoza, J., Bucardo-Rivera, F., Nordgren, J., ORyan, M., . . . Delwart, E. (2016). The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin. Archives of Virology, 161(4), 959-966
Öppna denna publikation i ny flik eller fönster >>The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin
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2016 (Engelska)Ingår i: Archives of Virology, ISSN 0304-8608, E-ISSN 1432-8798, Vol. 161, nr 4, s. 959-966Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Viral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with < 35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.

Ort, förlag, år, upplaga, sidor
SPRINGER WIEN, 2016
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-127557 (URN)10.1007/s00705-016-2756-4 (DOI)000373297700017 ()26780893 (PubMedID)
Anmärkning

Funding Agencies|NHLBI [R01 HL105770]; Sao Paulo Research Foundation (FAPESP) [2014/05211-2, 2012/03417-7]

Tillgänglig från: 2016-05-04 Skapad: 2016-05-03 Senast uppdaterad: 2017-11-30
Sharma, S. & Nordgren, J. (2015). Editorial Material: Rotavirus vaccines in developing countries: issues and future considerations in FUTURE VIROLOGY, vol 10, issue 6, pp 663-666. FUTURE VIROLOGY, 10(6), 663-666
Öppna denna publikation i ny flik eller fönster >>Editorial Material: Rotavirus vaccines in developing countries: issues and future considerations in FUTURE VIROLOGY, vol 10, issue 6, pp 663-666
2015 (Engelska)Ingår i: FUTURE VIROLOGY, ISSN 1746-0794, Vol. 10, nr 6, s. 663-666Artikel i tidskrift, Editorial material (Övrigt vetenskapligt) Published
Abstract [en]

n/a

Ort, förlag, år, upplaga, sidor
FUTURE MEDICINE LTD, 2015
Nyckelord
histo-blood group antigen; neonates; P[6]; rotavirus; vaccine efficacy
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-120296 (URN)10.2217/fvl.15.32 (DOI)000357132100002 ()
Tillgänglig från: 2015-07-24 Skapad: 2015-07-24 Senast uppdaterad: 2015-07-24
de Graaf, M., van Beek, J., Vennema, H., Podkolzin, A. T., Hewitt, J., Bucardo, F., . . . Koopmans, M. P. (2015). Emergence of a novel GII.17 norovirus - End of the GII.4 era?. Eurosurveillance, 20(26), 21178
Öppna denna publikation i ny flik eller fönster >>Emergence of a novel GII.17 norovirus - End of the GII.4 era?
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2015 (Engelska)Ingår i: Eurosurveillance, ISSN 1025-496X, E-ISSN 1560-7917, Vol. 20, nr 26, s. 21178-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

In the winter of 2014/15 a novel GII.P17-GII.17 norovirus strain (GII.17 Kawasaki 2014) emerged, as a major cause of gastroenteritis outbreaks in China and Japan. Since their emergence these novel GII.P17-GII.17 viruses have replaced the previously dominant GII.4 genotype Sydney 2012 variant in some areas in Asia but were only detected in a limited number of cases on other continents. This perspective provides an overview of the available information on GII.17 viruses in order to gain insight in the viral and host characteristics of this norovirus genotype. We further discuss the emergence of this novel GII.P17-GII.17 norovirus in context of current knowledge on the epidemiology of noroviruses. It remains to be seen if the currently dominant norovirus strain GII.4 Sydney 2012 will be replaced in other parts of the world. Nevertheless, the public health community and surveillance systems need to be prepared in case of a potential increase of norovirus activity in the next seasons caused by this novel GII.P17-GII.17 norovirus.

Ort, förlag, år, upplaga, sidor
EUR CENTRE DIS PREVENTION and CONTROL, 2015
Nationell ämneskategori
Systemvetenskap, informationssystem och informatik med samhällsvetenskaplig inriktning
Identifikatorer
urn:nbn:se:liu:diva-120345 (URN)10.2807/1560-7917.ES2015.20.26.21178 (DOI)000357663200002 ()
Anmärkning

Funding Agencies|EU H2020 grant COMPARE [643476]; Virgo Consortium - Dutch government [FES0908]; Hungarian Scientific Research Fund [OTKA/NKFIH K111615]

Tillgänglig från: 2015-07-31 Skapad: 2015-07-31 Senast uppdaterad: 2017-12-04
Istrate, C., Sharma, S., Nordgren, J., Videira e Castro, S., Lopes, A., Piedade, J., . . . Esteves, A. (2015). High rate of detection of G8P[6] rotavirus in children with acute gastroenteritis in So Tom, and Principe. Archives of Virology, 160(2), 423-428
Öppna denna publikation i ny flik eller fönster >>High rate of detection of G8P[6] rotavirus in children with acute gastroenteritis in So Tom, and Principe
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2015 (Engelska)Ingår i: Archives of Virology, ISSN 0304-8608, E-ISSN 1432-8798, Vol. 160, nr 2, s. 423-428Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The burden of rotavirus infections greatly affects the low-income African countries. In the absence of epidemiological data on pediatric diarrhea in So Tom, and Principe (STP), a study was conducted from August to December 2011. Rotavirus antigen was detected in 36.7 % of the collected fecal samples (87/237). G8P[6] was identified as the predominant genotype (71.1 % detection rate), while G1P[8] represented only 8.4 %. Phylogenetic analysis of VP7 G8 strains showed clustering within lineage G8d, while VP4 P[6] strains clustered within lineage 1a. Our results represent the first report on rotavirus from STP and show one of the highest detection rates of G8 rotaviruses worldwide.

Ort, förlag, år, upplaga, sidor
Springer Verlag (Germany), 2015
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-115324 (URN)10.1007/s00705-014-2244-7 (DOI)000349433500006 ()25283609 (PubMedID)
Anmärkning

Funding Agencies|Ministry of Health of STP; Calouste Gulbenkian Foundation (Lisbon, Portugal)

Tillgänglig från: 2015-03-13 Skapad: 2015-03-13 Senast uppdaterad: 2017-12-04
Bucardo, F. & Nordgren, J. (2015). Impact of vaccination on the molecular epidemiology and evolution of group A rotaviruses in Latin America and factors affecting vaccine efficacy. Infection, Genetics and Evolution, 34, 106-113
Öppna denna publikation i ny flik eller fönster >>Impact of vaccination on the molecular epidemiology and evolution of group A rotaviruses in Latin America and factors affecting vaccine efficacy
2015 (Engelska)Ingår i: Infection, Genetics and Evolution, ISSN 1567-1348, E-ISSN 1567-7257, Vol. 34, s. 106-113Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Despite high rotavirus (RV) vaccine coverage (similar to 83%) and good effectiveness (similar to 77%) against RV-diarrhea hospitalization, RV is still contributing to the burden of diarrhea that persists in hospital settings in several Latin American countries, where RV vaccination is being implemented. Due to the extensive genomic and antigenic diversity, among co-circulating human RV, a major concern has been that the introduction of RV vaccination could exert selection pressure leading to higher prevalence of strains not included in the vaccines and/or emergence of new strains, thus, reducing the efficacy of vaccination. Here we review the molecular epidemiology of RV in Latin America and explore issues of RV evolution and selection in light of vaccination. We further explore etiologies behind the large burden of diarrhea remaining after vaccination in some countries and discuss plausible reasons for vaccine failures. (C) 2015 Elsevier B.V. All rights reserved.

Ort, förlag, år, upplaga, sidor
ELSEVIER SCIENCE BV, 2015
Nyckelord
Rotavirus; Vaccination; Antigenic sites; Gene reassortment; Host genetics; Molecular epidemiology; Latin America
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-121761 (URN)10.1016/j.meegid.2015.06.013 (DOI)000360902400014 ()26079278 (PubMedID)
Tillgänglig från: 2015-10-06 Skapad: 2015-10-05 Senast uppdaterad: 2017-12-01
Hagbom, M., Nordgren, J., Nybom, R., Hedlund, K.-O., Wigzell, H. & Svensson, L. (2015). Ionizing air affects influenza virus infectivity and prevents airborne-transmission. Scientific Reports, 5(11431)
Öppna denna publikation i ny flik eller fönster >>Ionizing air affects influenza virus infectivity and prevents airborne-transmission
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2015 (Engelska)Ingår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, nr 11431Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

By the use of a modified ionizer device we describe effective prevention of airborne transmitted influenza A (strain Panama 99) virus infection between animals and inactivation of virus (greater than 97%). Active ionizer prevented 100% (4/4) of guinea pigs from infection. Moreover, the device effectively captured airborne transmitted calicivirus, rotavirus and influenza virus, with recovery rates up to 21% after 40 min in a 19 m(3) room. The ionizer generates negative ions, rendering airborne particles/aerosol droplets negatively charged and electrostatically attracts them to a positively charged collector plate. Trapped viruses are then identified by reverse transcription quantitative real-time PCR. The device enables unique possibilities for rapid and simple removal of virus from air and offers possibilities to simultaneously identify and prevent airborne transmission of viruses.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group: Open Access Journals - Option C / Nature Publishing Group, 2015
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-120165 (URN)10.1038/srep11431 (DOI)000356662300002 ()26101102 (PubMedID)
Anmärkning

Funding Agencies|Swedish Research Council [320301]

Tillgänglig från: 2015-07-13 Skapad: 2015-07-13 Senast uppdaterad: 2017-12-04
Bucardo, F., Mercado, J., Reyes, Y., González, F., Balmaseda, A. & Nordgren, J. (2015). Large increase of rotavirus diarrhoea in the hospital setting associated with emergence of G12 genotype in a highly vaccinated population in Nicaragua.. Clinical Microbiology and Infection, 21(6), 603.e1-603.e7
Öppna denna publikation i ny flik eller fönster >>Large increase of rotavirus diarrhoea in the hospital setting associated with emergence of G12 genotype in a highly vaccinated population in Nicaragua.
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2015 (Engelska)Ingår i: Clinical Microbiology and Infection, ISSN 1198-743X, E-ISSN 1469-0691, Vol. 21, nr 6, s. 603.e1-603.e7Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Rotaviruses (RVs) are a major cause of severe diarrhoea in young children. Nicaragua introduced routine immunization with the pentavalent RV vaccine (RV5) in 2006, which greatly reduced the incidence of diarrhoea. A remaining concern has been the possible emergence of new RV strains to which the vaccination has less effect. In this study, 837 children with diarrhoea in hospital settings were investigated for RV between May 2011 and July 2013. RVs were subsequently typed by multiplex PCR and/or sequencing. Fecal anti-RV IgA titres for a subset of RV-infected (n = 137) and noninfected children (n = 52) were determined with an in-house enzyme-linked immunosorbent assay. The RV detection rate was 8% in 2011, followed by a sharp increase to 29% in 2012 and 19% in 2013. This was associated with emergence and predominance of genotype G12 RV, from 0% in 2011 to 66% in 2012 and 82% in 2013, infecting children from 1 month to 10 years of age. Two sequenced G12 strains showed a Wa-like genome with genotype G12-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1, similar to the globally emerging G12 strains. Fecal anti-RV IgA analysis showed that most G12-infected and noninfected children had been in contact with either vaccine or wild RV strains, but such antibodies did not prevent symptomatic G12 infection. A marked increase of RV was evident in the hospital setting associated with a nationwide emergence and predominance of RV G12 genotype in a population with high RV5 vaccine coverage.

Ort, förlag, år, upplaga, sidor
Elsevier, 2015
Nationell ämneskategori
Infektionsmedicin Mikrobiologi inom det medicinska området
Identifikatorer
urn:nbn:se:liu:diva-127979 (URN)10.1016/j.cmi.2015.01.022 (DOI)000209931200002 ()25677631 (PubMedID)
Tillgänglig från: 2016-05-13 Skapad: 2016-05-13 Senast uppdaterad: 2018-04-03
Matussek, A., Dienus, O., Djeneba, O., Simpore, J., Nitiema, L. & Nordgren, J. (2015). Molecular characterization and genetic susceptibility of sapovirus in children with diarrhea in Burkina Faso. Infection, Genetics and Evolution, 32, 396-400
Öppna denna publikation i ny flik eller fönster >>Molecular characterization and genetic susceptibility of sapovirus in children with diarrhea in Burkina Faso
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2015 (Engelska)Ingår i: Infection, Genetics and Evolution, ISSN 1567-1348, E-ISSN 1567-7257, Vol. 32, s. 396-400Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Sapoviruses (Says) are a common cause of gastroenteritis in children. In sub-Saharan Africa, there is a scarcity of information regarding SaV as an etiological agent of diarrhea. Here, we investigated the prevalence, molecular characterization and clinico-epidemiological features of SaV infections in children less than 5 years of age with diarrhea in Burkina Faso. We further investigated the role of type 1 histo blood group antigens as susceptibility factors. In total, 309 fecal and 208 saliva samples from diarrheal children in Ouagadougou, Burkina Faso, were collected between May 2009 and March 2010. Say was detected using real-time PCR, and genogrouped/genotyped by PCR or sequencing. Saliva samples were ABO, Lewis and secretor phenotyped using in house ELISA assays. We found a high prevalence (18%) and large genetic diversity with all 4 human genogroups, and 9 genotypes/genoclusters circulating during the study period. The SaV infections were generally associated with milder symptoms, and neither ABH, Lewis or secretor phenotypes affected susceptibility to Say infections. (C) 2015 Published by Elsevier B.V.

Ort, förlag, år, upplaga, sidor
Elsevier, 2015
Nyckelord
Sapovirus; Burkina Faso; Gastroenteritis; Susceptibility; Histo-blood group antigens
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-119575 (URN)10.1016/j.meegid.2015.03.039 (DOI)000355027300051 ()25847694 (PubMedID)
Anmärkning

Funding Agencies|Swedish Research Council [10392]

Tillgänglig från: 2015-06-23 Skapad: 2015-06-22 Senast uppdaterad: 2017-12-04
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