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Wranne, Bengt
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Bolger, A. F., Heiberg, E., Karlsson, M., Wigström, L., Engvall, J., Sigfridsson, A., . . . Wranne, B. (2007). Transit of blood flow through thehuman left ventricle mapped by cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 9(5), 741-747
Öppna denna publikation i ny flik eller fönster >>Transit of blood flow through thehuman left ventricle mapped by cardiovascular magnetic resonance
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2007 (Engelska)Ingår i: Journal of Cardiovascular Magnetic Resonance, ISSN 1097-6647, E-ISSN 1532-429X, Vol. 9, nr 5, s. 741-747Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND:

The transit of blood through the beating heart is a basic aspect of cardiovascular physiology which remains incompletely studied. Quantification of the components of multidirectional flow in the normal left ventricle (LV) is lacking, making it difficult to put the changes observed with LV dysfunction and cardiac surgery into context.

METHODS:

Three dimensional, three directional, time resolved magnetic resonance phase-contrast velocity mapping was performed at 1.5 Tesla in 17 normal subjects, 6 female, aged 44+/-14 years (mean+/-SD). We visualized and measured the relative volumes of LV flow components and the diastolic changes in inflowing kinetic energy (KE). Of total diastolic inflow volume, 44+/-11% followed a direct, albeit curved route to systolic ejection (videos 1 and 2), in contrast to 11% in a subject with mildly dilated cardiomyopathy (DCM), who was included for preliminary comparison (video 3). In normals, 16+/-8% of the KE of inflow was conserved to the end of diastole, compared with 5% in the DCM patient. Blood following the direct route lost or transferred less of its KE during diastole than blood that was retained until the next beat (1.6+/-1.0 millijoules vs 8.2+/-1.9 millijoules, p<0.05); whereas, in the DCM patient, the reduction in KE of retained inflow was 18-fold greater than that of the blood tracing the direct route.

CONCLUSION:

Multidimensional flow mapping can measure the paths, compartmentalization and kinetic energy changes of blood flowing into the LV, demonstrating differences of KE loss between compartments, and potentially between the flows in normal and dilated left ventricles.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-41889 (URN)10.1080/10976640701544530 (DOI)17891610 (PubMedID)59319 (Lokalt ID)59319 (Arkivnummer)59319 (OAI)
Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Hult, P., Fjällbrant, T., Hildén, K., Dahlström, U., Wranne, B. & Ask, P. (2005). Detection of the third heart sound using a tailored wavelet approach: Method verification. Medical and Biological Engineering and Computing, 43(2), 212-217
Öppna denna publikation i ny flik eller fönster >>Detection of the third heart sound using a tailored wavelet approach: Method verification
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2005 (Engelska)Ingår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 43, nr 2, s. 212-217Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Heart sounds can be considered as mechanical fingerprints of myocardial function. The third heart sound normally occurs in children but disappears with maturation. The sound can also appear in patients with heart failure. The sound is characterised by its low-amplitude and low-frequency content, which makes it difficult to identify by the traditional use of the stethoscope. A wavelet-based method has recently been developed for detection of the third heart sound. This study investigated if the third heart sound could be identified in patients with heart failure using this detection method. The method was also compared with auscultation using conventional phonocardiography and with characterisation of the patients with echocardiography. In the first study, 87% of the third heart sounds were detected using the wavelet method, 12% were missed, and 6% were false positive. In study 2, the wavelet-detection method identified 87% of the patients using the third heart sound, and regular phonocardiography identified two (25%) of the subjects. © IFMBE: 2005.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-28715 (URN)10.1007/BF02345957 (DOI)13884 (Lokalt ID)13884 (Arkivnummer)13884 (OAI)
Tillgänglig från: 2009-10-09 Skapad: 2009-10-09 Senast uppdaterad: 2017-12-13
Lindström, L., Nylander, E., Larsson, H. & Wranne, B. (2005). Left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy: A scintigraphic and echocardiographic study. Clinical Physiology and Functional Imaging, 25(3), 171-177
Öppna denna publikation i ny flik eller fönster >>Left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy: A scintigraphic and echocardiographic study
2005 (Engelska)Ingår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 25, nr 3, s. 171-177Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background:  Left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy (ARVC) is a common finding in autopsy studies. In clinical studies using myocardial scintigraphy, MRI and echocardiography, contradictory results have been reported. In this study, we therefore investigated a group of 15 patients with ARVC using thallium-201 (Tl) single-photon emission tomography (SPECT) and echocardiography including assessment of mitral annular motion with M-mode and pulsed tissue Doppler.

Methods:  Exercise and rest Tl-201 SPECT were performed in 15 patients with ARVC. The time from diagnosis of the disease varied from less than 1–16 years. All patients fulfilled the established diagnostic criteria for ARVC. An echocardiographic examination, including assessment of left and right ventricular motion and measurements of the mitral annulus motion with M-mode and pulsed tissue Doppler was performed in the patients and in 25 normal subjects.

Results:  Tl-201 uptake defects in the left ventricular myocardium were present in all except one patient (93%). The uptake defects were predominantly located to the anteroseptal and basal posterior segments. Wall motion abnormalities were seen in the same segments, and in addition to this, in the septal area. In line with this, the total amplitude and the peak systolic velocity of mitral annular motion at the septal point were significantly decreased in the patients compared with the control group.

Conclusions:  Our data show that left ventricular involvement is common in ARVC. Tl-201 SPECT and echocardiographic abnormalities were seen not only in patients with long-lasting symptoms but also in asymptomatic patients and in those with short duration of symptoms.

Nyckelord
annular motion, pulsed tissue Doppler, T1-201 scintigraphy, wall motion abnormalities
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-28426 (URN)10.1111/j.1475-097X.2005.00607.x (DOI)13565 (Lokalt ID)13565 (Arkivnummer)13565 (OAI)
Tillgänglig från: 2009-10-09 Skapad: 2009-10-09 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Walker, A., Olsson, E., Wranne, B., Ringqvist, I. & Ask, P. (2004). Accuracy of spectral Doppler flow and tissue velocity measurements in ultrasound systems. Ultrasound in Medicine and Biology, 30(1), 127-132
Öppna denna publikation i ny flik eller fönster >>Accuracy of spectral Doppler flow and tissue velocity measurements in ultrasound systems
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2004 (Engelska)Ingår i: Ultrasound in Medicine and Biology, ISSN 0301-5629, E-ISSN 1879-291X, Vol. 30, nr 1, s. 127-132Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Blood and tissue velocity are measured and analysed in cardiac, vascular and other applications of diagnostic ultrasound (US). An error in system calibration is a potential risk for misinterpretation of the measurements. To determine the accuracy in velocity calibration, we tested three common commercial US systems using a Doppler string phantom. We tested pulsed and continuous-wave Doppler modes for velocities relevant to both cardiac blood flow and tissue-velocity estimation. The US systems were tested with settings and transducers commonly used in cardiac applications. One system consistently overestimated velocity by about 5%, whereas the other two systems were quite accurate in velocity estimation. These findings emphasize the importance of continuous quality control of US equipment.

Nyckelord
Ultrasound system, Doppler, Velocity, Accuracy, Doppler phantom, Calibration, Echocardiography
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-22168 (URN)10.1016/j.ultrasmedbio.2003.08.020 (DOI)1295 (Lokalt ID)1295 (Arkivnummer)1295 (OAI)
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Hult, P., Fjällbrant, T., Wranne, B., Engdahl, O. & Ask, P. (2004). An improved bioacoustic method for monitoring of respiration. Technology and Health Care, 12(4), 323-332
Öppna denna publikation i ny flik eller fönster >>An improved bioacoustic method for monitoring of respiration
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2004 (Engelska)Ingår i: Technology and Health Care, ISSN 0928-7329, E-ISSN 1878-7401, Vol. 12, nr 4, s. 323-332Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Reliable monitoring of respiration plays an important role in a broad spectrum of applications. Today, there are several methods for monitoring respiration, but none of them has proved to be satisfactory in all respects. We have recently developed a bioacoustic method that can accurately time respiration from tracheal sounds. The aim of this study is to tailor this bioacoustic method for monitoring purposes by introducing dedicated signal processing. The method was developed on a material of ten patients and then tested in another ten patients treated in an intensive care unit. By studying the differences in the variation of the spectral content between the different phases of respiration, the described method can distinguish between inspiration and expiration and can extract respiration frequency, and respiration pause periods. The system detected 98% of the inspirations and 99% of the expirations. This method for respiration monitoring has the advantage of being simple, robust and the sensor does not need to be placed closed to the face. A commercial heart microphone was used and we anticipate that further improvement in performance can be achieved trough optimization of sensor design.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-22249 (URN)1416 (Lokalt ID)1416 (Arkivnummer)1416 (OAI)
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13
Hult, P., Fjällbrant, T., Wranne, B. & Ask, P. (2004). Detection of the third heart sound using a tailored wavelet approach.. Medical and Biological Engineering and Computing, 42(2), 253-258
Öppna denna publikation i ny flik eller fönster >>Detection of the third heart sound using a tailored wavelet approach.
2004 (Engelska)Ingår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 42, nr 2, s. 253-258Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The third heart sound is normally heard during auscultation of younger individuals but disappears with increasing age. However, this sound can appear in patients with heart failure and is thus of potential diagnostic use in these patients. Auscultation of the heart involves a high degree of subjectivity. Furthermore, the third heart sound has low amplitude and a low-frequency content compared with the first and second heart sounds, which makes it difficult for the human ear to detect this sound. It is our belief that it would be of great help to the physician to receive computer-based support through an intelligent stethoscope, to determine whether a third heart sound is present or not. A precise, accurate and low-cost instrument of this kind would potentially provide objective means for the detection of early heart failure, and could even be used in primary health care. In the first step, phonocardiograms from ten children, all known to have a third heart sound, were analysed, to provide knowledge about the sound features without interference from pathological sounds. Using this knowledge, a tailored wavelet analysis procedure was developed to identify the third heart sound automatically, a technique that was shown to be superior to Fourier transform techniques. In the second step, the method was applied to phonocardiograms from heart patients known to have heart failure. The features of the third heart sound in children and of that in patients were shown to be similar. This resulted in a method for the automatic detection of third heart sounds. The method was able to detect third heart sounds effectively (90%), with a low false detection rate (3.7%), which supports its clinical use. The detection rate was almost equal in both the children and patient groups. The method is therefore capable of detecting, not only distinct and clearly visible/audible third heart sounds found in children, but also third heart sounds in phonocardiograms from patients suffering from heart failure.

Nationell ämneskategori
Medicinsk laboratorie- och mätteknik
Identifikatorer
urn:nbn:se:liu:diva-116913 (URN)15125157 (PubMedID)
Tillgänglig från: 2015-04-09 Skapad: 2015-04-09 Senast uppdaterad: 2017-12-04
Hult, P., Ask, P., Fjällbrant, T. & Wranne, B. (2004). Detection of the third heart sound using a tailored wavelet approach. Medical and Biological Engineering and Computing, 42(2), 253-258
Öppna denna publikation i ny flik eller fönster >>Detection of the third heart sound using a tailored wavelet approach
2004 (Engelska)Ingår i: Medical and Biological Engineering and Computing, ISSN 0140-0118, E-ISSN 1741-0444, Vol. 42, nr 2, s. 253-258Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The third heart sound is normally heard during auscultation of younger individuals but disappears with increasing age. However, this sound can appear in patients with heart failure and is thus of potential diagnostic use in these patients. Auscultation of the heart involves a high degree of subjectivity. Furthermore, the third heart sound has low amplitude and a low-frequency content compared with the first and second heart sounds, which makes it difficult for the human ear to detect this sound. It is our belief that it would be of great help to the physician to receive computer-based support through an intelligent stethoscope, to determine whether a third heart sound is present or not. A precise, accurate and low-cost instrument of this kind would potentially provide objective means for the detection of early heart failure, and could even be used in primary health care. In the first step, phonocardiograms from ten children, all known to have a third heart sound, were analysed, to provide knowledge about the sound features without interference from pathological sounds. Using this knowledge, a tailored wavelet analysis procedure was developed to identify the third heart sound automatically, a technique that was shown to be superior to Fourier transform techniques. In the second step, the method was applied to phonocardiograms from heart patients known to have heart failure. The features of the third heart sound in children and of that in patients were shown to be similar. This resulted in a method for the automatic detection of third heart sounds. The method was able to detect third heart sounds effectively (90%), with a low false detection rate (3.7%), which supports its clinical use. The detection rate was almost equal in both the children and patient groups. The method is therefore capable of detecting, not only distinct and clearly visible/audible third heart sounds found in children, but also third heart sounds in phonocardiograms from patients suffering from heart failure.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-22211 (URN)10.1007/BF02344639 (DOI)1369 (Lokalt ID)1369 (Arkivnummer)1369 (OAI)
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13
Escobar Kvitting, J.-P., Ebbers, T., Engvall, J., Sutherland, G. R., Wranne, B. & Wigström, L. (2004). Three-directional myocardial motion assessed using 3D phase contrast MRI. Journal of Cardiovascular Magnetic Resonance, 6(3), 627-636
Öppna denna publikation i ny flik eller fönster >>Three-directional myocardial motion assessed using 3D phase contrast MRI
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2004 (Engelska)Ingår i: Journal of Cardiovascular Magnetic Resonance, ISSN 1097-6647, E-ISSN 1532-429X, Vol. 6, nr 3, s. 627-636Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Regional myocardial function is a complex entity consisting of motion in three dimensions (3D). Besides magnetic resonance imaging (MRI), no other noninvasive technique can give a true 3D description of cardiac motion. Using a time‐resolved 3D phase contrast technique, three‐dimensional image volumes containing myocardial velocity data in six normal volunteers were acquired. Coordinates and velocity information were extracted from nine points placed in different myocardial segments in the left ventricle (LV), and decomposed into longitudinal (VL), radial (VR), and circumferential (VC) velocity components. Our findings confirm a longitudinal apex‐to‐base gradient for the LV, with only a small motion of the apex. The mean velocity for VL for all the basal segments was higher compared to the midsegments during systole [3.5 ± 1.2 vs. 2.5 ± 1.7 cm/s (p < 0.01)], early filling [− 6.9 ± 1.8 vs. − 4.9 ± 1.8 cm/s (p < 0.001)], and during atrial contraction [− 2.2 ± 1.4 vs. − 1.6 ± 1.3 cm/s (p < 0.05)]. A similar pattern was observed when comparing velocities from the midsegments to the apex. Radial velocity was higher during early filling in the midportion of the lateral [− 4.9 ± 2.7 vs. − 3.2 ± 1.6 cm/s (p < 0.05)] wall compared to the basal segments, no difference was observed for the septal [− 2.0 ± 1.5 vs. − 0.3 ± 2.5 cm/s (p = 0.15)], anterior [− 5.8 ± 3.3 vs. − 4.0 ± 1.7 cm/s (p = 0.17)], and posterior [− 2.3 ± 2.1 vs. − 2.5 ± 1.0 cm/s (p = 0.78)] walls. When observing the myocardial velocity in a single point and visualizing the movement of the main direction of the velocities in this point as vectors in velocity vector plots like planes, it is clear that myocardial movement is by no means one dimensional. In conclusion, our time‐resolved 3D, phase contrast MRI technique makes it feasible to extract myocardial velocities from anywhere in the myocardium, including all three velocity components without the need for positioning any slices at the time of acquisition.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-24306 (URN)10.1081/JCMR-120038692 (DOI)3929 (Lokalt ID)3929 (Arkivnummer)3929 (OAI)
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13
Carlhäll, C., Wranne, B. & Jurkevicius, R. (2003). Is left ventricular postsystolic long-axis shortening a marker for severity of hypertensive heart disease?. American Journal of Cardiology, 91(12), 1490-1493
Öppna denna publikation i ny flik eller fönster >>Is left ventricular postsystolic long-axis shortening a marker for severity of hypertensive heart disease?
2003 (Engelska)Ingår i: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 91, nr 12, s. 1490-1493Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

No abstract available.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-26833 (URN)10.1016/S0002-9149(03)00407-7 (DOI)11448 (Lokalt ID)11448 (Arkivnummer)11448 (OAI)
Tillgänglig från: 2009-10-08 Skapad: 2009-10-08 Senast uppdaterad: 2017-12-13Bibliografiskt granskad
Bech-Hanssen, O., Gjertsson, P., Houltz, E., Wranne, B., Ask, P., Loyd, D. & Caidahl, K. (2003). Net Pressure Gradients in Aortic Prosthetic Valves can be Estimated by Doppler. Journal of the American Society of Echocardiography, 16(8), 858-866
Öppna denna publikation i ny flik eller fönster >>Net Pressure Gradients in Aortic Prosthetic Valves can be Estimated by Doppler
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2003 (Engelska)Ingår i: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 16, nr 8, s. 858-866Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: In aortic prosthetic valves, both the Doppler-estimated gradients and orifice areas are misleading in the assessment of hemodynamic performance. The parameter of major interest is the net pressure gradient after pressure recovery (PR). We, therefore, investigated, in vitro, our ability to predict the net pressure gradient and applied the formulas in a representative patient population with 2 different valve designs. Methods: We studied the St Jude Medical (SJM) standard valve (size 19-27) and SJM Biocor (size 21-27) in an in vitro steady-flow model with simultaneous Doppler-estimated pressure and catheter pressure measurements. Using echocardiography, we also studied patients who received the SJM (n = 66) and SJM Biocor (n = 45). Results: In the SJM, we observed PR both within the prosthesis and aorta, whereas in the SJM Biocor, PR was only present in the aorta. We estimated the PR within the valve and within the aorta separately from echocardiographic in vitro data, combining a regression equation (valve) with an equation on the basis of fluid mechanics theory (aorta). The difference between estimated and catheter-obtained net gradients (mean ± SD) was 0.6 ± 1.6 mm Hg in the SJM and - 0.2 ± 1.9 mm Hg in the SJM Biocor. When these equations were applied in vivo, we found that PR had an overall value of 57 ± 7% of the peak Doppler gradient in the SJM and 33 ± 9% in the SJM Biocor. Conclusions: The in vitro results indicate that it is possible to predict the net pressure gradient by Doppler in bileaflet and stented biologic valves. Our data indicate that important PR is also present in stented biologic valves.

Nationell ämneskategori
Teknik och teknologier
Identifikatorer
urn:nbn:se:liu:diva-46533 (URN)10.1067/S0894-7317(03)00422-X (DOI)12878995 (PubMedID)
Tillgänglig från: 2009-10-11 Skapad: 2009-10-11 Senast uppdaterad: 2017-12-13
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