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Damm, Ole
Publikationer (4 of 4) Visa alla publikationer
Lennernas, B., Majumder, K., Damber, J.-E., Albertsson, P., Holmberg, E., Brandberg, Y., . . . Nilsson, S. (2015). Radical prostatectomy versus high-dose irradiation in localized/locally advanced prostate cancer: A Swedish multicenter randomized trial with patient-reported outcomes. Acta Oncologica, 54(6), 875-881
Öppna denna publikation i ny flik eller fönster >>Radical prostatectomy versus high-dose irradiation in localized/locally advanced prostate cancer: A Swedish multicenter randomized trial with patient-reported outcomes
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2015 (Engelska)Ingår i: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 54, nr 6, s. 875-881Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background . Treatment of localized prostate cancer (PC) is controversial. This is the fi rst randomized study compar-ing an open surgery procedure (radical prostatectomy) with a combination of high-dose rate brachytherapy (2 10 Gy) and external beam radiotherapy (25 2 Gy) in PC patients in Sweden 1996 – 2001. The two randomization arms were compared regarding differences in patients-reported outcomes, such as complications and health-related quality of life (HRQoL). Material and methods . The patients had localized/locally advanced PC, clinical category T1b – T3a, N0, M0 and PSA 50 ng/ml. All underwent total androgen blockade (six months). Self-reported HRQoL and symptoms including urinary, bowel, and sexual side effects were investigated prospectively before randomization and 12 and 24 months after randomization. A total of 89 patients were randomized and completed the EORTC QLQ C-33 and EORTC PR-25 questionnaires. Results . Over the study period, there were no discernible differences in HRQoL, or complications between the two groups. Emotional functioning, however, improved statistically signifi cantly over time, whereas Social functioning decreased, and fi nancial diffi culties increased. No statistically signifi cant differences in group-by-time interactions were found. The survival rate was 76%. Only eight patients (9%) died of PC. Conclusion . Open radical prostatectomy and the combined high-dose rate brachytherapy with external beam radiation appeared to be comparable in the measured outcomes. It was not possible to draw any conclusion on the effi cacy of the two treatments due to insuffi cient power of the study.

Ort, förlag, år, upplaga, sidor
Informa Healthcare, 2015
Nationell ämneskategori
Klinisk medicin
Identifikatorer
urn:nbn:se:liu:diva-118972 (URN)10.3109/0284186X.2014.974827 (DOI)000354479800009 ()25362844 (PubMedID)
Anmärkning

Funding Agencies|Sweden: the King Gustav V Jubilee Clinic Cancer Research Foundation in Gothenburg; Sweden: Swedish Cancer Society; Sweden: Cancer Society Jubilee Fund in Stockholm; Sweden: Schering Plough (Owe Nylander)

Tillgänglig från: 2015-06-08 Skapad: 2015-06-05 Senast uppdaterad: 2017-12-04Bibliografiskt granskad
Jahnson, S., Damm, O., Hellsten, S., Holmang, S., Liedberg, F., Ljungberg, B., . . . Wijkstom, H. (2010). Urinary diversion after cystectomy for bladder cancer: A population-based study in Sweden. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 44(2), 69-75
Öppna denna publikation i ny flik eller fönster >>Urinary diversion after cystectomy for bladder cancer: A population-based study in Sweden
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2010 (Engelska)Ingår i: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, ISSN 0036-5599, Vol. 44, nr 2, s. 69-75Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective. To investigate the type of urinary diversion performed after cystectomy in patients with muscle-invasive bladder cancer in Sweden, using data from a population-based national register. Material and methods. Since 1997, the Swedish Bladder Cancer Register has included more than 90% of all patients with newly diagnosed bladder cancer. The different types of urinary diversion performed in 1997-2003 were analysed, comparing non-continent diversion (ileal conduit) with continent reconstruction (bladder substitution or continent cutaneous diversion). Results. During the study period, 3463 patients were registered with clinical T2-T4 non-metastatic bladder cancer. Cystectomy was performed in 1141 patients with ileal conduit in 732 (64%) and continent reconstruction in 409 (36%). Ileal conduit was used more frequently in females than males (p = 0.019), in patients older than 75 years (p andlt; 0.00001), and in those with less favourable TNM classification. Continent reconstruction was done more often at university hospitals than at county hospitals (p andlt; 0.00001), but rarely in the northern and western healthcare regions compared with other regions (p andlt; 0.00001). Nationwide, the proportion of registered continent reconstructions decreased, although the absolute number was relatively stable (50-60 per year). Conclusions. Continent reconstruction after cystectomy for muscle-invasive bladder cancer is performed more often in some healthcare regions and in patients at university hospitals than in county hospitals, indicating a substantial provider influence on the choice of urinary diversion. Over time, the proportion of these procedures has decreased, while the absolute number has remained low and stable; therefore, concentration in high-volume hospitals specialized in bladder cancer and continent reconstruction seems appropriate.

Nyckelord
Bladder cancer, nationwide register, urinary diversion
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-54767 (URN)10.3109/00365590903449357 (DOI)000275894700001 ()
Tillgänglig från: 2010-04-09 Skapad: 2010-04-09 Senast uppdaterad: 2010-04-09
Jancke, G., Damm, O., Rosell, J. & Jahnson, S. (2008). Risk factors for local recurrence in patients with pTa/pT1 urinary bladder cancer. Scandinavian Journal of Urology and Nephrology, 42(5), 417-421
Öppna denna publikation i ny flik eller fönster >>Risk factors for local recurrence in patients with pTa/pT1 urinary bladder cancer
2008 (Engelska)Ingår i: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 42, nr 5, s. 417-421Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective. This study evaluated risk factors for local tumour recurrence, defined as recurrence at the same location in the bladder within 18 months after primary resection in patients with newly diagnosed pTa or pT1 bladder cancer. Patients and methods. The study included 472 patients with newly diagnosed pTa/T1 bladder cancer between 1992 and 2001. The patients were followed prospectively in accordance with a control programme and possible risk factors for tumour recurrence were registered. Results. Local tumour recurrence was observed in 164 (35%) patients, another 117 (25%) patients had recurrence at other locations in the bladder (non-local recurrence) and 191 (40%) had no recurrence at all. Tumour size and multiple tumours were significantly associated with a higher risk for developing local recurrence as opposed to non-local recurrence. Tumour category was of borderline statistical significance. Gender and tumour grade were not found to be risk factors for developing local recurrence. Conclusion. Tumour size and multiplicity are risk factors for development of recurrence at the same location in the bladder as the primary tumour. Local tumour recurrence may be a result of non-radical primary transurethral resection. One may consider recommending standard re-resection within 6-8 weeks in patients with tumours >3 cm or those with multiple primary tumours. © 2008 Informa UK Ltd. (Informa Healthcare, Taylor & Francis AS).

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-43347 (URN)10.1080/00365590802016302 (DOI)73621 (Lokalt ID)73621 (Arkivnummer)73621 (OAI)
Tillgänglig från: 2009-10-10 Skapad: 2009-10-10 Senast uppdaterad: 2017-12-13
Andius, P., Damm, O. & Holmäng, S. (2004). Prognostic factors in patients with carcinoma in situ treated with intravesical bacille Calmette-Guérin. Scandinavian Journal of Urology and Nephrology, 38(4), 285-290
Öppna denna publikation i ny flik eller fönster >>Prognostic factors in patients with carcinoma in situ treated with intravesical bacille Calmette-Guérin
2004 (Engelska)Ingår i: Scandinavian Journal of Urology and Nephrology, ISSN 0036-5599, E-ISSN 1651-2065, Vol. 38, nr 4, s. 285-290Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: To report prognostic factors and follow-up data for an unselected group of patients with carcinoma in situ (CIS) of the urinary bladder treated with bacille Calmette-Guérin (BCG). Material and Methods: The clinical records of patients with CIS treated with BCG were reviewed. All 173 patients treated between 1986 and 1997 in four hospitals in two Swedish cities were included. The median follow-up period was 72 months (range 6-154 months). The impact of 18 variables on the times to recurrence and progression was studied using multivariate Cox proportional hazard regression and Kaplan-Meier analyses. Results: No pre-treatment variables, including type of CIS and T1G3 tumour, had prognostic value in terms of time to progression. The result of the first cystoscopy had a very strong prognostic importance: 44% of patients with a positive first cystoscopy progressed in stage, 59% were BCG failures and 35% died from urothelial cancer. The corresponding values for patients with a negative first cystoscopy were 11%, 18% and 8%. Fourteen patients (8%) were diagnosed with an upper urinary tract tumour but no variable had prognostic significance. The diagnoses of the upper urinary tract tumours were evenly distributed during follow-up. Conclusions: We were not able to predict which patients would respond favourably to BCG. Cystectomy should be strongly considered even after a positive first cystoscopy. The accumulated incidence of patients with bladder CIS and a subsequent upper urinary tract tumour is rather high but it is questionable whether the prognosis will improve if routine follow-up urographies are performed.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:liu:diva-24313 (URN)10.1080/00365590410028692 (DOI)3936 (Lokalt ID)3936 (Arkivnummer)3936 (OAI)
Tillgänglig från: 2009-10-07 Skapad: 2009-10-07 Senast uppdaterad: 2017-12-13
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