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Sherrell, Peter
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Sherrell, P., Cieślar-Pobuda, A., Silverå Ejneby, M., Sammalisto, L., Gelmi, A., de Muinck, E., . . . Rafat, M. (2017). Rational Design of a Conductive Collagen Heart Patch. Macromolecular Bioscience, 17(7), Article ID 1600446.
Öppna denna publikation i ny flik eller fönster >>Rational Design of a Conductive Collagen Heart Patch
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2017 (Engelska)Ingår i: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 17, nr 7, artikel-id 1600446Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Cardiovascular diseases, including myocardial infarction, are the cause of significant morbidity and mortality globally. Tissue engineering is a key emerging treatment method for supporting and repairing the cardiac scar tissue caused by myocardial infarction. Creating cell supportive scaffolds that can be directly implanted on a myocardial infarct is an attractive solution. Hydrogels made of collagen are highly biocompatible materials that can be molded into a range of shapes suitable for cardiac patch applications. The addition of mechanically reinforcing materials, carbon nanotubes, at subtoxic levels allows for the collagen hydrogels to be strengthened, up to a toughness of 30 J m-1 and a two to threefold improvement in Youngs' modulus, thus improving their viability as cardiac patch materials. The addition of carbon nanotubes is shown to be both nontoxic to stem cells, and when using single-walled carbon nanotubes, supportive of live, beating cardiac cells, providing a pathway for the further development of a cardiac patch.

Ort, förlag, år, upplaga, sidor
Wiley-VCH Verlagsgesellschaft, 2017
Nyckelord
Carbon nanotube, Collagen, Hydrogel, Myocardial infarction, Stem cell
Nationell ämneskategori
Medicinteknik
Identifikatorer
urn:nbn:se:liu:diva-136817 (URN)10.1002/mabi.201600446 (DOI)000405566300004 ()28322510 (PubMedID)2-s2.0-85016390421 (Scopus ID)
Anmärkning

Funding agencies: Linkoping Initiative in Life Science Technologies (LIST); Central ALF Matching Grant from Landstinget i Ostergotland [LIO-344071]; European Research Agency [304209]; GeCONiI [POIG.02.03.01-24-099/13]

Tillgänglig från: 2017-04-27 Skapad: 2017-04-27 Senast uppdaterad: 2024-01-10Bibliografiskt granskad
Rafat, M., Xeroudaki, M., Koulikovska, M., Sherrell, P., Groth, F., Fagerholm, P. & Lagali, N. (2016). Composite core-and-skirt collagen hydrogels with differential degradation for corneal therapeutic applications. Biomaterials, 83, 142-155
Öppna denna publikation i ny flik eller fönster >>Composite core-and-skirt collagen hydrogels with differential degradation for corneal therapeutic applications
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2016 (Engelska)Ingår i: Biomaterials, ISSN 0142-9612, E-ISSN 1878-5905, Vol. 83, s. 142-155Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Scarcity of donor tissue to treat corneal blindness and the need to deliver stem cells or pharmacologic agents to ensure corneal graft survival are major challenges. Here, new composite collagen-based hydrogels are developed as implants to restore corneal transparency while serving as a possible reservoir for cells and drugs. The composite hydrogels have a centrally transparent core and embedded peripheral skirt of adjustable transparency and degradability, with the skirt exhibiting faster degradation in vitro. Both core and skirt supported human epithelial cell populations in vitro and the skirt merged homogeneously with the core material to smoothly distribute a mechanical load in vitro. After in vivo transplantation in rabbit corneas over three months, composites maintained overall corneal shape and integrity, while skirt degradation could be tracked in vivo and non-invasively due to partial opacity. Skirt degradation was associated with partial collagen breakdown, thinning, and migration of host stromal cells and macrophages, while the central core maintained integrity and transparency as host cells migrated and nerves regenerated.

IMPACT:

This study indicates the feasibility of a collagen-based composite hydrogel to maintain corneal stability and transparency while providing a degradable peripheral reservoir for cell or substance release.

Nyckelord
Composite; Cornea; Degradation; Femtosecond laser; Keratoplasty; Porcine collagen
Nationell ämneskategori
Cell- och molekylärbiologi
Identifikatorer
urn:nbn:se:liu:diva-125229 (URN)10.1016/j.biomaterials.2016.01.004 (DOI)000371651700012 ()26773670 (PubMedID)
Anmärkning

Funding agencies:  Abbott Medical Optics Inc, Solna, Sweden

Tillgänglig från: 2016-02-16 Skapad: 2016-02-16 Senast uppdaterad: 2022-10-27
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