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Abtahi, J., Malakuti, I. & Ajan, A. (2019). Surgical Management of Granular Cell Tumor of the Orbit: Case Report and Literature Review. Open Dentistry Journal, 13, 33-40
Öppna denna publikation i ny flik eller fönster >>Surgical Management of Granular Cell Tumor of the Orbit: Case Report and Literature Review
2019 (Engelska)Ingår i: Open Dentistry Journal, ISSN 1874-2106, E-ISSN 1874-2106, Vol. 13, s. 33-40Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Introduction: Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the literature. The treatment of the choice is total excision. Early diagnosis prior to surgery is valuable for the distinction of malignant from benign tumor.

Case presentation: We report a case of a 55-year-old woman with a solitary slow-growing mass in the right orbit with the involvement of the rectus inferior muscle, and present a review of the recent literature. The lesion had a diameter of 1 cm and was noticed 2 years before the examination. Excisional biopsy confirmed the diagnosis of GCT. The tumor was resected through a retroseptal transconjunctival approach. The final histological examination revealed findings characteristic of GCT, including positive reaction for protein S-100, SOX10, and calcitonin and negative reaction for desmin, myogenin, Smooth Muscle Antigen (SMA), Melan-A, and HMB-45. There were no signs of malignancy in this sample. Disturbance of motility was not noted by the patient after surgery.

Conclusion: GCT should be included in the differential diagnosis of intraorbital lesions, particularly those that involve the orbit muscles. A biopsy is recommended before surgical resection, to exclude malignancy and prevent radical resection.

Ort, förlag, år, upplaga, sidor
Sharjah, United Arab Emirates: Bentham Open, 2019
Nyckelord
Granular cell tumor, Orbit, Protein S-100, Inferior rectus muscle, Magnetic resonance imaging, Biopsy
Nationell ämneskategori
Kirurgi
Identifikatorer
urn:nbn:se:liu:diva-154508 (URN)10.2174/1874210601913010033 (DOI)
Tillgänglig från: 2019-02-19 Skapad: 2019-02-19 Senast uppdaterad: 2019-02-26Bibliografiskt granskad
Abtahi, J. & Ajan, A. (2018). Malignant Transformation of Ossifying Fibroma into Parosteal Osteosarcoma with High-grade Component: Presentation of an Unusual Case and Review of the Literature. The Open Dentistry Journal, 12, 1059-1068
Öppna denna publikation i ny flik eller fönster >>Malignant Transformation of Ossifying Fibroma into Parosteal Osteosarcoma with High-grade Component: Presentation of an Unusual Case and Review of the Literature
2018 (Engelska)Ingår i: The Open Dentistry Journal, E-ISSN 1874-2106, Vol. 12, s. 1059-1068Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Parosteal Osteosarcoma of the Jaw (POSJ) is a rare entity that is associated with a high survival rate. Several case reports and case series of POSJ have been published in the literature, but few authors have described development of this tumor by possible transformation from a fibro-osseous neoplasm. Objective: We present a rare occurrence of parosteal osteosarcoma with involvement of the posterior maxilla, orbit floor, and infra-temporal fossa in a 20-year-old man. Furthermore, we performed a literature review regarding clinical, radiological, and histological features; treatment strategies; and etiology/pathophysiology. Methods: A PubMed search yielded a total of 74 articles and the articles were sorted according to their corresponding key area of focus. Results: This was a case of POSJ with high-grade component in the maxillofacial region of a 20-year old male. Co-expression of MDM2 and CDK4 was confirmed. At 2.5-year follow-up, the patient had died. The literature review revealed 18 articles including 20 cases of POSJ. Four cases represent the possible development of this tumor by transformation from a fibro-osseous neoplasm: Two cases of fibrous dysplasia, one case of cemento-ossifying fibroma, and the case of Ossifying Fibroma (OF) in the present study. Conclusion: In conclusion, we found an unusual case of POSJ of the midface in a patient with a previous diagnosis of OF in the same region. To our knowledge, there have been no previous reports of development of POSJ in OF. Furthermore, this is the first described case of high-grade surface osteosarcoma in the craniofacial region.

Ort, förlag, år, upplaga, sidor
Bentham Open, 2018
Nyckelord
Facial bone;Jaw, Malignant tumor;Neoplasm;Osteosarcoma;Parosteal
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
urn:nbn:se:liu:diva-153632 (URN)10.2174/1874210601812011059 (DOI)
Tillgänglig från: 2019-01-06 Skapad: 2019-01-06 Senast uppdaterad: 2019-01-06
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