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Theodorsson, Elvar, ProfessorORCID iD iconorcid.org/0000-0003-0756-7723
Publications (10 of 192) Show all publications
Jacobsson, S. & Theodorsson, E. (2018). Anemier (10ed.). In: Elvar Theodorsson, Maria Berggren Söderlund (Ed.), Laurells klinisk kemi i praktisk medicin: (pp. 209-264). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Anemier
2018 (Swedish)In: Laurells klinisk kemi i praktisk medicin / [ed] Elvar Theodorsson, Maria Berggren Söderlund, Lund: Studentlitteratur AB, 2018, 10, p. 209-264Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154591 (URN)9789144119748 (ISBN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21Bibliographically approved
Theodorsson, E., Löwbeer, C., Ridefelt, P., Carlson, M., Dahle, C. & Simonsson, P. (2018). Digestionsorganens sjukdomar (10ed.). In: Laurells klinisk kemi i praktisk medicin: (pp. 465-516). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Digestionsorganens sjukdomar
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2018 (Swedish)In: Laurells klinisk kemi i praktisk medicin, Lund: Studentlitteratur AB, 2018, 10, p. 465-516Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154593 (URN)9789144119748 (ISBN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21
Löwbeer, C., Hammarsten, O., Rönnelid, J., Ridefelt, P. & Theodorsson, E. (2018). Energiomsättning, diabetes och lipoproteinrubbningar (10ed.). In: Elvar Theodorsson, Maria Berggren Söderlund (Ed.), Laurells klinisk kemi i praktisk medicin: (pp. 345-414). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Energiomsättning, diabetes och lipoproteinrubbningar
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2018 (Swedish)In: Laurells klinisk kemi i praktisk medicin / [ed] Elvar Theodorsson, Maria Berggren Söderlund, Lund: Studentlitteratur AB, 2018, 10, p. 345-414Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154592 (URN)9789144119748 (ISBN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21Bibliographically approved
Lund, M. L., Egerod, K. L., Engelstoft, M. S., Dmytriyeva, O., Theodorsson, E., Patel, B. A. & Schwartz, T. W. (2018). Enterochromaffin 5-HT cells: A major target for GLP-1 and gut microbial metabolites. MOLECULAR METABOLISM, 11, 70-83
Open this publication in new window or tab >>Enterochromaffin 5-HT cells: A major target for GLP-1 and gut microbial metabolites
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2018 (English)In: MOLECULAR METABOLISM, ISSN 2212-8778, Vol. 11, p. 70-83Article in journal (Refereed) Published
Abstract [en]

Objectives

5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been described to be the major sensors of nutrients in the GI-tract. However, the molecular mechanism through which EC cells sense nutrients and gut microbiota is still unclear.

Methods and results

TPH1, the 5-HT generating enzyme, and chromogranin A, an acidic protein responsible for secretory granule storage of 5-HT, were highly enriched in FACS-purified EC cells from both small intestine and colon using a 5-HT antibody-based method. Surprisingly, EC cells from the small intestine did not express GPCRsensors for lipid and protein metabolites, such as FFAR1, GPR119, GPBAR1(TGR5), CaSR, and GPR142, in contrast to the neighboring GLP-1 storing enteroendocrine cell. However, the GLP-1 receptor was particularly highly expressed and enriched in EC cells as judged both by qPCR and by immunohistochemistryusing a receptor antibody. GLP-1 receptor agonists robustly stimulated 5-HT secretion from intestinal preparations using both HPLC and a specific amperometricmethod. Colonic EC cells expressed many different types of known and potential GPCR sensors of microbial metabolites including three receptors for SCFAs, i.e. FFAR2, OLF78, and OLF558 and receptors for aromatic acids, GPR35; secondary bile acids GPBAR1; and acyl-amides and lactate, GPR132.

Conclusion

Nutrient metabolites apparently do not stimulate EC cells of the small intestine directly but through a paracrine mechanism involving GLP-1 secreted from neighboring enteroendocrine cells. In contrast, colonic EC cells are able to sense a multitude of different metabolites generated by the gut microbiota as well as gut hormones, including GLP-1.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Metabolite GPCR; Nutrient sensing; Gut microbiota; Gut hormone; Enteroendocrine; Afferent vagal nerves
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:liu:diva-150300 (URN)10.1016/j.molmet.2018.03.004 (DOI)000439548700006 ()29576437 (PubMedID)2-s2.0-85044298641 (Scopus ID)
Note

Funding Agencies|Novo Nordisk Foundation [NNF10CC1016515, NNF15CC0018346, NNF15OC0016798, NNF14OC0016798]; Danish Council for Independent Research [7016-00389A]

Available from: 2018-08-16 Created: 2018-08-16 Last updated: 2018-09-07Bibliographically approved
Hedin, C., Sjödahl, R., Aldman, Å., Davidson, T., Kammerlind, A.-S., Nodbrant, P., . . . Theodorsson, E. (2018). Intraoperativ strålbehandling vid primar operation for bröstcancer: TARGIT-A-studien ej konklusiv. Läkartidningen, 115, Article ID EWFF.
Open this publication in new window or tab >>Intraoperativ strålbehandling vid primar operation for bröstcancer: TARGIT-A-studien ej konklusiv
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2018 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, article id EWFFArticle, review/survey (Refereed) Published
Abstract [sv]

The TARGIT-A (TARGeted Intraoperative radioTherapy) multicentre study of early breast cancer compared intraoperative radiotherapy with external radiotherapy. While the intraoperative radiotherapy was standardised, the external postoperative comparison treatment followed established routines in the participating treatment centres resulting in substantial variations in dosages and treatment durations. The uncertainties in the interpretation of the study results created by the design of the TARGIT-A study constitute substantial obstacles to the possible introduction of intraoperative radiotherapy for early breast cancer.

Place, publisher, year, edition, pages
Stockholm, Sweden: Läkartidningen Förlag AB, 2018
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-154595 (URN)29381183 (PubMedID)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-04-18Bibliographically approved
Hedin, C., Sjödahl, R., Aldman, Å., Davidson, T., Kammerlind, A.-S., Agrup, M. & Theodorsson, E. (2018). Intraoperativ strålbehandling vid primär operation för bröstcancer: TARGIT-A-studien ej konklusiv. Läkartidningen, 115
Open this publication in new window or tab >>Intraoperativ strålbehandling vid primär operation för bröstcancer: TARGIT-A-studien ej konklusiv
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2018 (English)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115Article, review/survey (Refereed) Published
Abstract [en]

The TARGIT-A (TARGeted Intraoperative radioTherapy) multicentre study of early breast cancer compared intraoperative radiotherapy with external radiotherapy. While the intraoperative radiotherapy was standardised, the external postoperative comparison treatment followed established routines in the participating treatment centres resulting in substantial variations in dosages and treatment durations. The uncertainties in the interpretation of the study results created by the design of the TARGIT-A study constitute substantial obstacles to the possible introduction of intraoperative radiotherapy for early breast cancer.

Place, publisher, year, edition, pages
Stockholm, Sweden: Läkartidningen Förlag AB, 2018
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:liu:diva-152529 (URN)29381183 (PubMedID)
Available from: 2019-03-28 Created: 2019-03-28 Last updated: 2019-04-05Bibliographically approved
Theodorsson, E. (2018). Labbdiagnostik av sällsynta sjukdomar kan bli bättre: Både metodernas tillförlitlighet och personalens medvetenhet spelar roll - ornitos är ett bra exempel. Läkartidningen, 115, Article ID FDI3.
Open this publication in new window or tab >>Labbdiagnostik av sällsynta sjukdomar kan bli bättre: Både metodernas tillförlitlighet och personalens medvetenhet spelar roll - ornitos är ett bra exempel
2018 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, article id FDI3Article in journal, Editorial material (Refereed) Published
Abstract [en]

Psittacosis (parrot fever) is underdiagnosed in Sweden, possibly due to lack of awareness, and the fact that only five out of 24 clinical microbiology laboratories routinely perform the PCR test for Chlamydia psittaci. The test has shown 100% sensitivity and 100% sensitivity for the pathogen in samples from the lower part of the respiratory tract which caters for a high predictive value in patients with symptoms and signs of community-acquired atypical pneumonias, provided optimal patient selection. Knowledge and awareness of treatable rare diseases amongst healthcare personnel combined with conveniently available cost-effective diagnostic techniques is essential for improvements in the handling of rare diseases.

Place, publisher, year, edition, pages
Stockholm, Sweden: Läkartidningen Förlag AB, 2018
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154588 (URN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-28Bibliographically approved
Grankvist, K., Hammarsten, O., Maria, B. S. & Theodorsson, E. (2018). Laboratoriernas verksamhet (10ed.). In: Elvar Theodorsson, Maria Berggren Söderlund (Ed.), Laurells klinisk kemi i praktisk medicin: (pp. 13-30). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Laboratoriernas verksamhet
2018 (Swedish)In: Laurells klinisk kemi i praktisk medicin / [ed] Elvar Theodorsson, Maria Berggren Söderlund, Lund: Studentlitteratur AB, 2018, 10, p. 13-30Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154589 (URN)9789144119748 (ISBN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21Bibliographically approved
Theodorsson, E. & Berggren Söderlund, M. (2018). Laurells klinisk kemi i praktisk medicin (10ed.). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Laurells klinisk kemi i praktisk medicin
2018 (Swedish)Book (Other academic)
Abstract [sv]

Denna tionde upplaga av Laurells Klinisk kemi i praktisk medicin utgör en grundlig bearbetning av det populära verket. Samtliga kapitel har reviderats och kapitlen om tolkning av analysresultat, vatten, elektrolyter, blodgaser, mag–tarmkanalen och immunologi har skrivits om från grunden; allt i samarbete mellan verksamma inom klinisk farmakologi, klinisk immunologi och klinisk kemi.?

Kunskapsfragment inom medicin, inklusive klinisk kemi, är lättillgängliga på nätet men ger sällan den helhetsbild som behövs för en djupare förståelse och därmed optimal användning av laboratorie­analyser. Denna bok ger en sådan helhetsbild och kan användas såväl för att slå upp fakta om specifika analyser som för att förstå de sjukdomsmekanismer som är av betydelse för beställning och tolkning av laboratorieresultat.?

Texten är organiserad utifrån kliniska problemområden och i balansgången mellan inslagen av laboratorium och medicin har tonvikten lagts på det medicinskt-diagnostiska snarare än på det laboratorietekniska. Fokus ligger på förståelsen av preanalytiska och analytiska faktorer vid tolkningen av laboratorieresultat samt av förståelsen av prevalens, sensitivitet, specificitet och liknande begrepp i det diagnostiska arbetet.?

Föreliggande bok förväntas även fortsatt komma till god användning på avdelningar, mottagningar och vårdcentraler – överallt där man behöver ta laboratorieprover och tolka provsvar – men också bland studenter i medicin, biomedicin, biomedicinsk laboratorievetenskap och besläktade kunskapsområden.

Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018. p. 763 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154581 (URN)9789144119748 (ISBN)
Available from: 2019-02-20 Created: 2019-02-20 Last updated: 2019-03-08Bibliographically approved
Lundin, C., Malmborg, A., Slezak, J., Gemzell-Danielsson, K., Bixo, M., Bengtsdotter, H., . . . Sundström-Poromaa, I. (2018). Sexual function and combined oral contraceptives: a randomised, placebo-controlled trial. Endocrine Connections, 7(11), 1208-1216
Open this publication in new window or tab >>Sexual function and combined oral contraceptives: a randomised, placebo-controlled trial
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2018 (English)In: Endocrine Connections, ISSN 2049-3614, E-ISSN 2049-3614, Vol. 7, no 11, p. 1208-1216Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The effect of combined oral contraceptives (COC) on female sexuality has long been a matter of discussion, but placebo-controlled studies are lacking. Thus, the aim of the present study was to investigate if an estradiol-containing COC influences sexual function.

DESIGN: Investigator-initiated, randomised, double-blinded, placebo-controlled clinical trial where 202 healthy women were randomized to a combined oral contraceptive (1.5 mg estradiol and 2.5 mg nomegestrol acetate) or placebo for three treatment cycles.

METHODS: Sexual function at baseline and during the last week of the final treatment cycle was evaluated by the McCoy Female Sexuality Questionnaire. Serum and hair testosterone levels were assessed at the same time points.

RESULTS: Compared to placebo, COC use was associated with a small decrease in sexual interest (COC median change score: -2.0; interquartile range (IQR): -5.0-0.5 vs. placebo: -1.0; IQR: -3.0-2.0, p = 0.019), which remained following adjustment for change in self-rated depressive symptoms B = -0.80 ± 0.30, Wald = 7.08, p = 0.008. However, the proportion of women who reported a clinically relevant deterioration in sexual interest did not differ between COC or placebo users (COC 18 (22.2%) vs. placebo 16 (17.8%), p = 0.47). Change in other measured aspects of sexual function as well as total score of sexual function did not differ between the two treatments.

CONCLUSIONS: This study suggests that use of estradiol-based combined oral contraceptives is associated with reduced sexual interest. However, the changes are minute, and probably not of clinical relevance.

Place, publisher, year, edition, pages
Bioscientifica, 2018
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-154597 (URN)10.1530/EC-18-0384 (DOI)000456843800012 ()30352399 (PubMedID)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-03-15Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-0756-7723

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