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Theodorsson, Elvar, ProfessorORCID iD iconorcid.org/0000-0003-0756-7723
Publications (10 of 192) Show all publications
Sauveroche, M., Henriksson, J., Theodorsson, E., Svensson Holm, A.-C. B. & Roth, L. (2020). Hair cortisol in horses (Equus caballus) in relation to management regimes, personality and breed. Journal of Veterinary Behavior
Open this publication in new window or tab >>Hair cortisol in horses (Equus caballus) in relation to management regimes, personality and breed
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2020 (English)In: Journal of Veterinary Behavior, ISSN 1558-7878Article in journal (Refereed) Published
Abstract [en]

Hair cortisol is a promising biomarker to measure long-term stress since cortisol is incorporated into the hair shaft as it grows. However, few studies have previously assessed hair cortisol concentrations (HCC) in horses. In this study, HCC was evaluated in both mane hair from the neck and body hair from the withers in 153 horses of different breeds, from seven different stables with three different management regimes (Free-roaming horses, Riding school horses, Trotter horses). In addition, 4 hours of behavioral observations were performed at each stable, and for 43 of the horses, a personality survey was completed. Mane and withers HCC correlated moderately, but significantly (rs=0.48, p<0.001). Differences between the stables were found for both mane and withers hair (both p<0.01) and the stable with lowest HCC also showed highest occurrences of positive social and resting behaviors (both p<0.01). There were no significant differences in HCC between the management regimes even though Free-roaming horses showed less negative social behavior compared to Riding school horses (p=0.041) and Trotter horses (p=0.055). The personality traits Dominance, Anxiousness, and Excitability revealed weak to moderate correlations with mane HCC (rs=-0.34, p=0.027; rs=-0.46, p=0.002; rs=-0.31, p=0.043 respectively) which might suggest that personality could also be related to long-term stress levels in horses.

Place, publisher, year, edition, pages
Elsevier, 2020
Keywords
Horse; Cortisol; Behavior; Stress; Welfare; Management; Personality
National Category
Other Veterinary Science
Identifiers
urn:nbn:se:liu:diva-163937 (URN)10.1016/j.jveb.2019.12.002 (DOI)
Available from: 2020-02-27 Created: 2020-02-27 Last updated: 2020-02-27Bibliographically approved
Kristoffersen, L., Støen, R., Bergseng, H., Follestad, T., Theodorsson, E., Vederhus, B., . . . Austeng, D. (2019). Skin-to-skin contact during eye examination did not reduce pain compared to standard care with parental support in preterm infants. Acta Paediatrica, 108(8), 1434-1440
Open this publication in new window or tab >>Skin-to-skin contact during eye examination did not reduce pain compared to standard care with parental support in preterm infants
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2019 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 108, no 8, p. 1434-1440Article in journal (Refereed) Published
Abstract [en]

AIM: We compared the pain relieving effect of skin-to-skin contact versus standard care in the incubator during screening for retinopathy of prematurity.

METHODS: This randomised crossover study included 35 preterm infants of less than 32 weeks of gestational age admitted to St Olavs University Hospital, Trondheim, Norway, between January 2014 and June 2016. Randomisation was for skin-to-skin with one of the parents or standard care with supportive positioning by parents for the first of two consecutive eye examinations. The pain score was measured twice using the Premature Infant Pain Profile (PIPP) during and after the eye examination. The infants' movement activity was video recorded after the examination.

RESULTS: There was no difference in mean pain scores with skin-to-skin contact versus standard care during (10.2 vs. 10.3, p = 0.91) or after (7.0 vs. 6.8, p = 0.76) the procedure. Independent of the randomisation group, PIPP scores were lower than previous comparable studies have found. Bouts of movement activity were also the same whether the examination was conducted in skin-to-skin position or in the incubator (p = 0.91).

CONCLUSION: Skin-to-skin contact during the eye examination did not provide additional pain relief compared to standard care where the parents were already a part of the multidimensional approach.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2019
Keywords
Pain assessment, Pain relief, Preterm infant, Retinopathy of prematurity, Skin-to-skin contact
National Category
Pediatrics
Identifiers
urn:nbn:se:liu:diva-154598 (URN)10.1111/apa.14699 (DOI)000474935600012 ()30561825 (PubMedID)2-s2.0-85060225339 (Scopus ID)
Note

Funding agencies: Norwegian University of Science and Technology; Central Norway Regional Health Authority

Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-07-30Bibliographically approved
Jacobsson, S. & Theodorsson, E. (2018). Anemier (10ed.). In: Elvar Theodorsson, Maria Berggren Söderlund (Ed.), Laurells klinisk kemi i praktisk medicin: (pp. 209-264). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Anemier
2018 (Swedish)In: Laurells klinisk kemi i praktisk medicin / [ed] Elvar Theodorsson, Maria Berggren Söderlund, Lund: Studentlitteratur AB, 2018, 10, p. 209-264Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154591 (URN)9789144119748 (ISBN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21Bibliographically approved
Theodorsson, E., Löwbeer, C., Ridefelt, P., Carlson, M., Dahle, C. & Simonsson, P. (2018). Digestionsorganens sjukdomar (10ed.). In: Laurells klinisk kemi i praktisk medicin: (pp. 465-516). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Digestionsorganens sjukdomar
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2018 (Swedish)In: Laurells klinisk kemi i praktisk medicin, Lund: Studentlitteratur AB, 2018, 10, p. 465-516Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154593 (URN)9789144119748 (ISBN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21
Löwbeer, C., Hammarsten, O., Rönnelid, J., Ridefelt, P. & Theodorsson, E. (2018). Energiomsättning, diabetes och lipoproteinrubbningar (10ed.). In: Elvar Theodorsson, Maria Berggren Söderlund (Ed.), Laurells klinisk kemi i praktisk medicin: (pp. 345-414). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Energiomsättning, diabetes och lipoproteinrubbningar
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2018 (Swedish)In: Laurells klinisk kemi i praktisk medicin / [ed] Elvar Theodorsson, Maria Berggren Söderlund, Lund: Studentlitteratur AB, 2018, 10, p. 345-414Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154592 (URN)9789144119748 (ISBN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21Bibliographically approved
Lund, M. L., Egerod, K. L., Engelstoft, M. S., Dmytriyeva, O., Theodorsson, E., Patel, B. A. & Schwartz, T. W. (2018). Enterochromaffin 5-HT cells: A major target for GLP-1 and gut microbial metabolites. MOLECULAR METABOLISM, 11, 70-83
Open this publication in new window or tab >>Enterochromaffin 5-HT cells: A major target for GLP-1 and gut microbial metabolites
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2018 (English)In: MOLECULAR METABOLISM, ISSN 2212-8778, Vol. 11, p. 70-83Article in journal (Refereed) Published
Abstract [en]

Objectives

5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been described to be the major sensors of nutrients in the GI-tract. However, the molecular mechanism through which EC cells sense nutrients and gut microbiota is still unclear.

Methods and results

TPH1, the 5-HT generating enzyme, and chromogranin A, an acidic protein responsible for secretory granule storage of 5-HT, were highly enriched in FACS-purified EC cells from both small intestine and colon using a 5-HT antibody-based method. Surprisingly, EC cells from the small intestine did not express GPCRsensors for lipid and protein metabolites, such as FFAR1, GPR119, GPBAR1(TGR5), CaSR, and GPR142, in contrast to the neighboring GLP-1 storing enteroendocrine cell. However, the GLP-1 receptor was particularly highly expressed and enriched in EC cells as judged both by qPCR and by immunohistochemistryusing a receptor antibody. GLP-1 receptor agonists robustly stimulated 5-HT secretion from intestinal preparations using both HPLC and a specific amperometricmethod. Colonic EC cells expressed many different types of known and potential GPCR sensors of microbial metabolites including three receptors for SCFAs, i.e. FFAR2, OLF78, and OLF558 and receptors for aromatic acids, GPR35; secondary bile acids GPBAR1; and acyl-amides and lactate, GPR132.

Conclusion

Nutrient metabolites apparently do not stimulate EC cells of the small intestine directly but through a paracrine mechanism involving GLP-1 secreted from neighboring enteroendocrine cells. In contrast, colonic EC cells are able to sense a multitude of different metabolites generated by the gut microbiota as well as gut hormones, including GLP-1.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Metabolite GPCR; Nutrient sensing; Gut microbiota; Gut hormone; Enteroendocrine; Afferent vagal nerves
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:liu:diva-150300 (URN)10.1016/j.molmet.2018.03.004 (DOI)000439548700006 ()29576437 (PubMedID)2-s2.0-85044298641 (Scopus ID)
Note

Funding Agencies|Novo Nordisk Foundation [NNF10CC1016515, NNF15CC0018346, NNF15OC0016798, NNF14OC0016798]; Danish Council for Independent Research [7016-00389A]

Available from: 2018-08-16 Created: 2018-08-16 Last updated: 2018-09-07Bibliographically approved
Hedin, C., Sjödahl, R., Aldman, Å., Davidson, T., Kammerlind, A.-S., Nodbrant, P., . . . Theodorsson, E. (2018). Intraoperativ strålbehandling vid primar operation for bröstcancer: TARGIT-A-studien ej konklusiv. Läkartidningen, 115, Article ID EWFF.
Open this publication in new window or tab >>Intraoperativ strålbehandling vid primar operation for bröstcancer: TARGIT-A-studien ej konklusiv
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2018 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, article id EWFFArticle, review/survey (Refereed) Published
Abstract [sv]

The TARGIT-A (TARGeted Intraoperative radioTherapy) multicentre study of early breast cancer compared intraoperative radiotherapy with external radiotherapy. While the intraoperative radiotherapy was standardised, the external postoperative comparison treatment followed established routines in the participating treatment centres resulting in substantial variations in dosages and treatment durations. The uncertainties in the interpretation of the study results created by the design of the TARGIT-A study constitute substantial obstacles to the possible introduction of intraoperative radiotherapy for early breast cancer.

Place, publisher, year, edition, pages
Stockholm, Sweden: Läkartidningen Förlag AB, 2018
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-154595 (URN)29381183 (PubMedID)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-04-18Bibliographically approved
Theodorsson, E. (2018). Labbdiagnostik av sällsynta sjukdomar kan bli bättre: Både metodernas tillförlitlighet och personalens medvetenhet spelar roll - ornitos är ett bra exempel. Läkartidningen, 115, Article ID FDI3.
Open this publication in new window or tab >>Labbdiagnostik av sällsynta sjukdomar kan bli bättre: Både metodernas tillförlitlighet och personalens medvetenhet spelar roll - ornitos är ett bra exempel
2018 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115, article id FDI3Article in journal, Editorial material (Refereed) Published
Abstract [en]

Psittacosis (parrot fever) is underdiagnosed in Sweden, possibly due to lack of awareness, and the fact that only five out of 24 clinical microbiology laboratories routinely perform the PCR test for Chlamydia psittaci. The test has shown 100% sensitivity and 100% sensitivity for the pathogen in samples from the lower part of the respiratory tract which caters for a high predictive value in patients with symptoms and signs of community-acquired atypical pneumonias, provided optimal patient selection. Knowledge and awareness of treatable rare diseases amongst healthcare personnel combined with conveniently available cost-effective diagnostic techniques is essential for improvements in the handling of rare diseases.

Place, publisher, year, edition, pages
Stockholm, Sweden: Läkartidningen Förlag AB, 2018
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154588 (URN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-28Bibliographically approved
Grankvist, K., Hammarsten, O., Maria, B. S. & Theodorsson, E. (2018). Laboratoriernas verksamhet (10ed.). In: Elvar Theodorsson, Maria Berggren Söderlund (Ed.), Laurells klinisk kemi i praktisk medicin: (pp. 13-30). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Laboratoriernas verksamhet
2018 (Swedish)In: Laurells klinisk kemi i praktisk medicin / [ed] Elvar Theodorsson, Maria Berggren Söderlund, Lund: Studentlitteratur AB, 2018, 10, p. 13-30Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154589 (URN)9789144119748 (ISBN)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-02-21Bibliographically approved
Theodorsson, E. & Berggren Söderlund, M. (2018). Laurells klinisk kemi i praktisk medicin (10ed.). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Laurells klinisk kemi i praktisk medicin
2018 (Swedish)Book (Other academic)
Abstract [sv]

Denna tionde upplaga av Laurells Klinisk kemi i praktisk medicin utgör en grundlig bearbetning av det populära verket. Samtliga kapitel har reviderats och kapitlen om tolkning av analysresultat, vatten, elektrolyter, blodgaser, mag–tarmkanalen och immunologi har skrivits om från grunden; allt i samarbete mellan verksamma inom klinisk farmakologi, klinisk immunologi och klinisk kemi.?

Kunskapsfragment inom medicin, inklusive klinisk kemi, är lättillgängliga på nätet men ger sällan den helhetsbild som behövs för en djupare förståelse och därmed optimal användning av laboratorie­analyser. Denna bok ger en sådan helhetsbild och kan användas såväl för att slå upp fakta om specifika analyser som för att förstå de sjukdomsmekanismer som är av betydelse för beställning och tolkning av laboratorieresultat.?

Texten är organiserad utifrån kliniska problemområden och i balansgången mellan inslagen av laboratorium och medicin har tonvikten lagts på det medicinskt-diagnostiska snarare än på det laboratorietekniska. Fokus ligger på förståelsen av preanalytiska och analytiska faktorer vid tolkningen av laboratorieresultat samt av förståelsen av prevalens, sensitivitet, specificitet och liknande begrepp i det diagnostiska arbetet.?

Föreliggande bok förväntas även fortsatt komma till god användning på avdelningar, mottagningar och vårdcentraler – överallt där man behöver ta laboratorieprover och tolka provsvar – men också bland studenter i medicin, biomedicin, biomedicinsk laboratorievetenskap och besläktade kunskapsområden.

Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2018. p. 763 Edition: 10
National Category
Clinical Laboratory Medicine
Identifiers
urn:nbn:se:liu:diva-154581 (URN)9789144119748 (ISBN)
Available from: 2019-02-20 Created: 2019-02-20 Last updated: 2019-03-08Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-0756-7723

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