liu.seSearch for publications in DiVA
Change search
Link to record
Permanent link

Direct link
Brudin, Lars
Alternative names
Publications (10 of 87) Show all publications
Lans, C., Cider, Å., Nylander, E. & Brudin, L. (2022). The relationship between six-minute walked distance and health-related quality of life in patients with chronic heart failure. Scandinavian Cardiovascular Journal, 56(1), 310-315
Open this publication in new window or tab >>The relationship between six-minute walked distance and health-related quality of life in patients with chronic heart failure
2022 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 56, no 1, p. 310-315Article in journal (Refereed) Published
Abstract [en]

Objectives. To assess the relationship between the six-minute walk test (6MWT) and health-related quality of life (HRQL) in patients with chronic heart failure. Methods. Forty-six patients (37 men and 9 women) with chronic heart failure, mean age 68 (SD 9), NYHA II-III and EF 29 (9) % were included. They performed 6MWT and assessed HRQL using two tools, a Swedish version of the 36-item Short Form (SF-36) and the Minnesota Living with Heart Failure Questionnaire (MLHFQ). This was performed repeatedly during a study period of one year. Results. Patients with a walking distance lower than median experienced a lower HRQL than the higher performing half of the cohort, in four dimensions of the SF-36 and the summary of physical and mental components, but not in the dimensions of MLHFQ. Conclusion. Patients with heart failure with a short walking distance assessed their quality of life as inferior in half of the dimensions in the SF-36 but not in the dimensions measured with the MLHFQ. Thus, different aspects of the symptomatology are uncovered using the 6MWT and the different HRQL tools.

Place, publisher, year, edition, pages
Taylor & Francis Ltd, 2022
Keywords
Walk test; quality of life; cardiac failure; cardiac rehabilitation
National Category
General Practice
Identifiers
urn:nbn:se:liu:diva-187263 (URN)10.1080/14017431.2022.2107234 (DOI)000836477600001 ()35929855 (PubMedID)
Available from: 2022-08-16 Created: 2022-08-16 Last updated: 2023-05-04
Nordqvist, O., Björneld, O., Brudin, L., Wanby, P., Nobin, R. & Carlsson, M. (2021). A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs. PLOS ONE, 16(8), Article ID e0256093.
Open this publication in new window or tab >>A novel index to assess low energy fracture risks in patients prescribed antiepileptic drugs
Show others...
2021 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 16, no 8, article id e0256093Article in journal (Refereed) Published
Abstract [en]

Objective To develop an index assessing the risks of low energy fractures (LEF) in patients prescribed antiepileptic drugs (AED) by exploring five previously suggested risk factors; age, gender, AED-type, epilepsy diagnosis and BMI. Methods In a population-based retrospective open cohort study we used real world data from the Electronic Health Register (EHR) in Region Kalmar County, Sweden. 23 209 patients prescribed AEDs at any time from January 2008 to November 2018 and 23 281 matching controls were followed from first registration in the EHR until the first documented LEF, disenrollment (or death) or until the end of the study period, whichever came first. Risks of LEF measured as hazard rate ratios in relation to the suggested risk factors and in comparison to matched controls were analyzed using Cox regression. The index was developed using a linear combination of the statistically significant variables multiplied by the corresponding regression coefficients. Results Data from 23 209 patients prescribed AEDs and 2084 documented LEFs during a follow-up time of more than 10 years resulted in the Kalmar Epilepsy Fracture Risk Index (KEFRI). KEFRI = Age-category x (1.18) + Gender x (-0.51) + AED-type x (0.29) + Epilepsy diagnosis-category x (0.31) + BMI-category x (-0.35). All five previously suggested risk factors were confirmed. Women aged 75 years and older treated with an inducing AED against epilepsy and BMIs of 25 kg/m(2) or below had 48 times higher LEF rates compared to men aged 50 years or younger, treated with a non-inducing AED for a condition other than epilepsy and BMIs above 25 kg/m(2). Conclusion The KEFRI is the first weighted multifactorial assessment tool estimating risks of LEF in patients prescribed AEDs and could serve as a feasible guide within clinical practice.

Place, publisher, year, edition, pages
Public Library of Science, 2021
National Category
General Practice
Identifiers
urn:nbn:se:liu:diva-180309 (URN)10.1371/journal.pone.0256093 (DOI)000697186000031 ()34437569 (PubMedID)
Available from: 2021-10-15 Created: 2021-10-15 Last updated: 2022-05-24
Hedman, K., Lindow, T., Elmberg, V., Brudin, L. & Ekstrom, M. (2021). Age- and gender-specific upper limits and reference equations for workload-indexed systolic blood pressure response during bicycle ergometry. European Journal of Preventive Cardiology, 28(12), 1360-1369
Open this publication in new window or tab >>Age- and gender-specific upper limits and reference equations for workload-indexed systolic blood pressure response during bicycle ergometry
Show others...
2021 (English)In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881, Vol. 28, no 12, p. 1360-1369Article in journal (Refereed) Published
Abstract [en]

Background Guidelines recommend considering workload in interpretation of the systolic blood pressure (SBP) response to exercise, but reference values are lacking. Design This was a retrospective, consecutive cohort study. Methods From 12,976 subjects aged 18-85 years who performed a bicycle ergometer exercise test at one centre in Sweden during the years 2005-2016, we excluded those with prevalent cardiovascular disease, comorbidities, cardiac risk factors or medications. We extracted SBP, heart rate and workload (watt) from >= 3 time points from each test. The SBP/watt-slope and the SBP/watt-ratio at peak exercise were calculated. Age- and sex-specific mean values, standard deviations and 90th and 95th percentiles were determined. Reference equations for workload-indexed and peak SBP were derived using multiple linear regression analysis, including sex, age, workload, SBP at rest and anthropometric variables as predictors. Results A final sample of 3839 healthy subjects (n = 1620 female) were included. While females had lower mean peak SBP than males (188 +/- 24 vs 202 +/- 22 mmHg, p < 0.001), workload-indexed SBP measures were markedly higher in females; SBP/watt-slope: 0.52 +/- 0.21 versus 0.41 +/- 0.15 mmHg/watt (p < 0.001); peak SBP/watt-ratio: 1.35 +/- 0.34 versus 0.90 +/- 0.21 mmHg/watt (p < 0.001). Age, sex, exercise capacity, resting SBP and height were significant predictors of the workload-indexed SBP parameters and were included in the reference equations. Conclusions These novel reference values can aid clinicians and exercise physiologists in interpreting the SBP response to exercise and may provide a basis for future research on the prognostic impact of exercise SBP. In females, a markedly higher SBP in relation to workload could imply a greater peripheral vascular resistance during exercise than in males.

Place, publisher, year, edition, pages
SAGE PUBLICATIONS LTD, 2021
Keywords
Exercise testing; reference values; hypertension
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-165242 (URN)10.1177/2047487320909667 (DOI)000523812500001 ()32153202 (PubMedID)
Note

Funding Agencies|County Council of Ostergotland, Sweden [LIO822461]; Scientific Committee of Blekinge County Council, Sweden

Available from: 2020-04-20 Created: 2020-04-20 Last updated: 2022-03-10
Ingemansson Hultquist, A., Brudin, L. & Bågesund, M. (2021). Early childhood caries risk assessment in 1-year-olds evaluated at 6-years of age. Acta Odontologica Scandinavica, 79(2), 103-111
Open this publication in new window or tab >>Early childhood caries risk assessment in 1-year-olds evaluated at 6-years of age
2021 (English)In: Acta Odontologica Scandinavica, ISSN 0001-6357, E-ISSN 1502-3850, Vol. 79, no 2, p. 103-111Article in journal (Refereed) Published
Abstract [en]

Objectives The aim was to identify caries risk factors in 1-year-olds predicting dentine caries in 6-year-olds. Materials and methods Caries risk assessment was performed in 804 one-year-olds. Their parents answered a questionnaire, regarding family factors, general health, food habits and oral hygiene. Clinical examinations and caries risk assessments at 1, 3 and 6 years of age were performed. Simple and multiple regression analyses were used for identification of caries-associated factors. Results Caries risk was found in 5% of the 1-year-olds, and 12% of the 3-year-olds. Dentine caries was found in 3% of the 3-year-olds and in 16% of the 6-year-olds. Caries risk assessment was associated with caries at 6 years of age (OR = 5.1,p < .001). Multiple logistic regression analysis found the following variables associated with caries at 6 years of age: Caries in sibling (OR = 2.1,p = .012), Beverage other than water (OR = 2.1,p < .001), Night meal (OR = 1.9,p = .002), Presence of mutans streptococci (MS) (OR = 1.6,p = .033) and Male gender (OR = 1.5,p = .053). An overall caries risk assessment was more reliable than any single caries risk factor. Conclusions Caries risk assessment for 1-year-olds in a region with low caries prevalence has limited accuracy to predict dental caries at 6 years of age. Caries risk often changes over time and should be reassessed on a regularly basis. The presence of MS in 1-year-olds did not increase the prognostic accuracy at 6 years of age.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD, 2021
Keywords
Risk factors; dental caries; children
National Category
Dentistry
Identifiers
urn:nbn:se:liu:diva-168553 (URN)10.1080/00016357.2020.1795247 (DOI)000550962600001 ()32697607 (PubMedID)
Available from: 2020-08-28 Created: 2020-08-28 Last updated: 2022-05-24
Goransson, I., Brudin, L., Irbe, A. & Turesson, C. (2021). Hand function 5 years after treatment with collagenase Clostridium histolyticum injection for Dupuytrens disease. Journal of Hand Surgery, European Volume, 46(9), 985-994
Open this publication in new window or tab >>Hand function 5 years after treatment with collagenase Clostridium histolyticum injection for Dupuytrens disease
2021 (English)In: Journal of Hand Surgery, European Volume, ISSN 1753-1934, E-ISSN 2043-6289, Vol. 46, no 9, p. 985-994Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to report hand function, disability and satisfaction and patients perception of functionally troublesome contractures 5 years after injection with collagenase Clostridium histolyticum and hand therapy for Dupuytrens disease. Data from 79 patients were collected before and at 3, 12 and 60 months after treatment. Hand function was significantly improved, and 70% achieved a functional range of motion in the treated hand. QuickDASH scores and range of motion were best at 3 months follow-up. At 60 months, mean total extension deficit was 48 degrees, which was 57% of the deficit before treatment. Thirty-seven patients (47%) had developed recurrent contractures in treated finger(s) meeting the criteria for new treatment. The threshold for functionally troublesome contractures was found to be 30 degrees-60 degrees in the finger joints. Treatment was experienced as painful, but few hand function problems occurred. Most patients would choose this treatment method again.

Place, publisher, year, edition, pages
Sage Publications, 2021
Keywords
Dupuytrens disease; collagenase; long-term follow-up; hand function; satisfaction; activities of daily living
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-176881 (URN)10.1177/17531934211002383 (DOI)000660936800001 ()33757325 (PubMedID)
Note

Funding Agencies|Orthopaedic Clinic at Kalmar County Hospital; Department of Occupational Therapy at Kalmar County Hospital; Department of Hand Surgery, Plastic Surgery and Burns, Linkoping University Hospital

Available from: 2021-06-23 Created: 2021-06-23 Last updated: 2022-05-26
Petersson, S., Birgegård, A., Brudin, L., Mantilla, E. F., Monell, E., Clinton, D. & Björck, C. (2021). Initial self-blame predicts eating disorder remission after 9 years. Journal of Eating Disorders, 9(1), Article ID 81.
Open this publication in new window or tab >>Initial self-blame predicts eating disorder remission after 9 years
Show others...
2021 (English)In: Journal of Eating Disorders, E-ISSN 2050-2974, Vol. 9, no 1, article id 81Article in journal (Refereed) Published
Abstract [en]

Background Research into predictors of outcome in eating disorders (ED) has shown conflicting results, with few studies of long-term predictors and the possible importance of psychological variables that may act as risk- and maintenance factors. Aim To identify baseline predictors of ED remission nine years after initial clinical assessment using self-report measures of ED psychopathology, psychiatric symptoms, and self-image in a sample of adult ED patients (N = 104) treated at specialist units in Stockholm, Sweden. Sixty patients participated in the follow-up, of whom 41 patients (68%) had achieved remission. Results Results suggested that the only significant predictor of diagnostic remission after nine years was initial levels of self-blame. Conclusion In order to ensure long-term recovery in ED it may be important for clinicians to widen their therapeutic repertoire and utilise techniques that reduce self-blame and increase self-compassion. Plain English summary It is difficult to predict how an eating disorder will develop, and research has found varying factors that affect the outcome of the condition. Recovery rates vary from nearly nil to over 90%. This variation could be explained by different research factors, but are more likely due to varying definitions of recovery, with less stringent definitions yielding high recovery rates and more stringent definitions yielding lower rates. The present study investigated whether the severity of eating disorder symptoms and other psychiatric symptoms could predict recovery nine years from first admission to specialised eating disorder care. Sixty patients at three eating disorder treatment units participated, and their scores on self-report measures of symptoms were used as predictor variables. Forty-one participants had no eating disorder diagnosis at nine-year follow-up. Most participants with binge-eating disorder had recovered, while the poorest outcome was found for anorexia nervosa with slightly over half of patients recovered after nine years. The only predictor for the nine-year outcome was a higher initial rating of self-blame, measured with the Structural Analysis of the Social Behavior. It was concluded that it may be important for clinicians to detect and address self-blame early in the treatment of eating disorders in order to enhance the possibility of recovery. Treatment should focus on reducing self-blame and increasing self-acceptance.

Place, publisher, year, edition, pages
BMC, 2021
Keywords
Eating disorders; Outcome; Prediction; Self-image
National Category
Psychiatry
Identifiers
urn:nbn:se:liu:diva-180010 (URN)10.1186/s40337-021-00435-3 (DOI)000671327600001 ()34233765 (PubMedID)
Note

Funding Agencies|Kalmar Regional Council, Sweden

Available from: 2021-10-08 Created: 2021-10-08 Last updated: 2022-05-24
Svenvik, M., Raffetseder, J., Brudin, L., Lindberg, R., Blomberg, M., Axelsson, D., . . . Nording, M. L. (2021). Plasma oxylipin levels associated with preterm birth in preterm labor✰. Prostaglandins, Leukotrienes and Essential Fatty Acids, 166, Article ID 102251.
Open this publication in new window or tab >>Plasma oxylipin levels associated with preterm birth in preterm labor✰
Show others...
2021 (English)In: Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, E-ISSN 1532-2823, Vol. 166, article id 102251Article in journal (Refereed) Published
Abstract [en]

Introduction

Preterm labor is a common clinical problem in obstetrics. Since the majority of women with preterm labor eventually deliver at full term, biomarkers are needed to more accurately predict who will deliver preterm. Oxylipins, given their importance in inflammation regulation, are highly interesting in this respect since labor is an inflammatory process.

Methods

Eighty women with preterm labor before 34 weeks of gestation were enrolled in a prospective observational multi-center cohort study. Oxylipin levels of 67 analytes in plasma samples were analyzed by liquid chromatography coupled to tandem mass spectrometry.

Results

Twenty-one (26%) of the women delivered before 34 weeks of gestation, and of those women, fourteen delivered within 48 h of admission. Logistic multivariate regression showed that lower levels of 9,10-DiHODE were associated with delivery before 34 weeks of gestation (aOR 0.12 (0.024–0.62)) and within 48 h ((aOR 0.13 (0.019–0.93)). Furthermore, higher levels of 11,12-DiHETrE were associated with delivery before 34 weeks of gestation ((aOR 6.19 (1.17–32.7)) and higher levels of 8-HETE were associated with delivery within 48 h ((aOR 5.01 (1.13–22.14)).

Conclusions

The oxylipin 9,10-DiHODE may be protective in preterm labor, both for delivery after 34 weeks of gestation and for delivery later than 48 h of admission, whereas 11,12-DiHETrE and 8-HETE display the opposite effect. Larger studies are needed to validate these mediators as biomarkers for prediction of preterm birth following preterm labor.

Place, publisher, year, edition, pages
Elsevier, 2021
Keywords
Preterm labor, Preterm birth, Oxylipins, Eicosanoids, Biomarker, Prediction
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-174827 (URN)10.1016/j.plefa.2021.102251 (DOI)000633428800004 ()33626402 (PubMedID)2-s2.0-85101321594 (Scopus ID)
Note

Medical Research Council of Southeast Sweden (FORSS) [FORSS-931816]; Region Kalmar County; ALF grants; Region Ostergotland

Available from: 2021-04-06 Created: 2021-04-06 Last updated: 2022-01-23Bibliographically approved
Engvall, J., Brudin, L., Maret, E., Nylander, E. & Åström Aneq, M. (2021). Recalibration of calculated VO2max against measured VO2max. Linkoping: Linköping University Electronic Press
Open this publication in new window or tab >>Recalibration of calculated VO2max against measured VO2max
Show others...
2021 (English)Data set
Alternative title[en]
Calculated vs measured VO2max
Place, publisher, year
Linkoping: Linköping University Electronic Press, 2021
Keywords
Cardiac adaptation, remodelling, strain, functional measurement
National Category
Physiology
Identifiers
urn:nbn:se:liu:diva-173319 (URN)10.48360/zf9r-j510 (DOI)
Funder
Futurum - Academy for Health and Care, Jönköping County Council, Sweden, 81951, 157681Linköpings universitet, LIO-900161
Available from: 2021-02-15 Created: 2021-02-15 Last updated: 2021-12-28Bibliographically approved
Carlsson, H., Sandholm, K., Haddish, H. W., Brudin, L., Ekdahl, K. N. & Tjernberg, I. (2020). Complement activation in individuals with previous subclinical Lyme borreliosis and patients with previous Lyme neuroborreliosis. European Journal of Clinical Microbiology and Infectious Diseases, 39(5), 855-862
Open this publication in new window or tab >>Complement activation in individuals with previous subclinical Lyme borreliosis and patients with previous Lyme neuroborreliosis
Show others...
2020 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 39, no 5, p. 855-862Article in journal (Refereed) Published
Abstract [en]

Lyme borreliosis (LB) is caused by Borrelia burgdorferi and infection may lead to not only a large variety of clinical manifestations but also a subclinical outcome. The aim of the present study was to investigate if there is a constitutional difference in complement activation between individuals with previous subclinical Lyme borreliosis (SB) and patients previously diagnosed with Lyme neuroborreliosis (LNB). Lepirudin plasma for activation studies was collected from 60 SB individuals and from 22 patients pre-diagnosed with LNB. The plasma was incubated with live Borrelia spirochetes of two strains (complement sensitive B. garinii Lu59 and complement resistant B. afzelii ACA1). Complement factor C3 was measured in non-activated lepirudin plasma with immune-nephelometry and C3a and sC5b-9 generated during complement activation were measured by enzyme-linked immunosorbent assay. We found that the complement sensitive Lu59 induced higher complement activation than the complement resistant ACA1 when measuring activation products C3a and sC5b-9 in SB and LNB patients, p < 0.0001. No significant difference was found between SB and LNB patients in systemic levels of C3. Furthermore, SB individuals generated a higher activation of C3 cleavage to C3a (C3a/C3 ratio) than LNB patients after activation with ACA1, p < 0.001, but no significant differences were found in response to Lu59. In conclusion, Lu59 induced higher complement activation than ACA1 and individuals with previous SB showed increased generation of C3a compared with patients with previous LNB. In our study population, this mechanism could lead to less elimination of spirochetes in LNB patients and thereby be a factor contributing to the clinical outcome.

Place, publisher, year, edition, pages
SPRINGER, 2020
Keywords
Complement activation; Subclinical Lyme borreliosis; Lyme neuroborreliosis; Lyme borreliosis; Innate immune system; C3a
National Category
Infectious Medicine
Identifiers
urn:nbn:se:liu:diva-165640 (URN)10.1007/s10096-019-03807-5 (DOI)000528380400006 ()31893341 (PubMedID)
Note

Funding Agencies|Swedish Research Council (VR)Swedish Research Council [2016-2075-5.1]; Medical Research Council of Southeast Sweden (FORSS) [217821]

Available from: 2020-05-11 Created: 2020-05-11 Last updated: 2023-03-15
Moen, V., Brudin, L., Ebberyd, A., Sennstrom, M., Ekman-Ordeberg, G., Rundgren, M. & Irestedt, L. (2020). Hyponatraemia reversibly affects human myometrial contractility. An in vitro pilot study. PLOS ONE, 15(1), Article ID e0220020.
Open this publication in new window or tab >>Hyponatraemia reversibly affects human myometrial contractility. An in vitro pilot study
Show others...
2020 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 15, no 1, article id e0220020Article in journal (Refereed) Published
Abstract [en]

Background In a previous study we found a significant correlation between dystocia and hyponatraemia that developed during labour. The present study examined a possible causal relationship. In vitro studies often use area under the curve (AUC) determined by frequency and force of contractions as a measure of myometrial contractility. However, a phase portrait plot of isometric contraction, obtained by plotting the first derivate of contraction against force of contraction, could indicate that bi-or multiphasic contractions might be less effective compared to the smooth contractions. Material and methods Myometrial biopsies were obtained from 17 women undergoing elective caesarean section at term. Each biopsy was divided into 8 strips and mounted isometrically in a force transducer. Seven biopsies were used in the first part of the study when half of the strips were immersed in the hyponatraemic study solution S containing Na+ 120 mmol/L and observed for 1 hour, followed by 1 hour in normonatraemic control solution C containing Na+ 136 mmol/L, then again in S for 1 hour, and finally 1 hour in C. The other half of the strips were studied in reverse order, C-S-C-S. The remaining ten biopsies were included in the second part of the study. Response to increasing doses of oxytocin (OT) in solutions S and C was studied. In the first part of the study we calculated AUC, and created phase portrait plots of two different contractions from the same strip, one smooth and one biphasic. In both parts of the study we registered frequency and force of contractions, and described appearance of the contractions. Results First part of the study: Mean (median) contractions per hour in C: 8.7 (7.6), in S 14,3 (13). Mean (SD) difference between groups 5.6 (4.2), p = 0.018. Force of contractions in C: 11.8 (10.2) mN, in S: 10.8 (9.2) mN, p = 0.09, AUC increased in S; p = 0.018. Bi-/multiphasic contractions increased from 8% in C to 18% in S, p = 0.001. All changes were reversible in C. Second part of the study: Frequency after OT 1.65 x 10-(9) M in C:3.4 (2.9), in S: 3.8 (3.2), difference between groups: p = 0.48. After OT 1.65 x 10-(7) M in C: 7.8 (8.9), increase from previous OT administration: p = 0.09, in S: 8.7 (9.0), p = 0.04, difference between groups, p = 0.32. Only at the highest dose of OT dose was there an increase in force of contraction in S, p = 0.05, difference between groups, p = 0.33. Initial response to OT was more frequently bi/multiphasic in S, reaching significance at the highest dose of OT(1.65 x 10-(7) M), p = 0.015. when almost all contractions were bi/multiphasic. Conclusion Hyponatraemia reversibly increased frequency of contractions and appearance of bi-or multiphasic contractions, that could reduce myometrial contractility. This could explain the correlation of hyponatraemia and instrumental delivery previously observed. Contractions in the hyponatraemic solution more frequently showed initial multiphasic contractions when OT was added in increasing doses. Longer lasting labours carry the risk both of hyponatraemia and OT administration, and their negative interaction could be significant. Further studies should address this possibility.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE, 2020
National Category
Physiology
Identifiers
urn:nbn:se:liu:diva-166514 (URN)10.1371/journal.pone.0220020 (DOI)000534374400001 ()31971939 (PubMedID)
Note

Funding Agencies|Patient Insurance Claims in Sweden [VIMO20120207]

Available from: 2020-06-18 Created: 2020-06-18 Last updated: 2021-06-14
Organisations

Search in DiVA

Show all publications