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Brudin, Lars
Alternative names
Publications (10 of 73) Show all publications
Lundgren, C., Brudin, L., Wanby, A.-S. & Cedergren, M. (2018). Ante- and intrapartum risk factors for neonatal hypoxic ischemic encephalopathy. The Journal of Maternal-Fetal & Neonatal Medicine, 31(12), 1595-1601
Open this publication in new window or tab >>Ante- and intrapartum risk factors for neonatal hypoxic ischemic encephalopathy
2018 (English)In: The Journal of Maternal-Fetal & Neonatal Medicine, ISSN 1476-7058, E-ISSN 1476-4954, Vol. 31, no 12, p. 1595-1601Article in journal (Refereed) Published
Abstract [en]

To identify obstetrical risk factors for the diagnosis of neonatal hypoxic ischemic encephalopathy (HIE). A secondary aim was to determine the incidence of HIE.

Place, publisher, year, edition, pages
Taylor & Francis, 2018
Keywords
CTG; Hypoxic ischemic encephalopathy; acute obstetrical events; nulliparity; risk factor
National Category
Pediatrics
Identifiers
urn:nbn:se:liu:diva-146142 (URN)10.1080/14767058.2017.1321628 (DOI)000427953800009 ()28486858 (PubMedID)
Available from: 2018-03-29 Created: 2018-03-29 Last updated: 2018-12-07
Lans, C., Cider, Å., Nylander, E. & Brudin, L. (2018). Peripheral muscle training with resistance exercise bands in patients with chronic heart failure. Long-term effects on walking distance and quality of life; a pilot study. ESC Heart Failure, 5(2), 241-248
Open this publication in new window or tab >>Peripheral muscle training with resistance exercise bands in patients with chronic heart failure. Long-term effects on walking distance and quality of life; a pilot study
2018 (English)In: ESC Heart Failure, E-ISSN 2055-5822, Vol. 5, no 2, p. 241-248Article in journal (Refereed) Published
Abstract [en]

This study aimed to describe a method of peripheral muscle training with resistance bands in patients with chronic heart failure (CHF) and to evaluate its effects on the 6 min walk test and quality of life up to 12 months using a home-based programme.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018
Keywords
6 min walk test; Cardiac rehabilitation; Heart failure; Home rehabilitation; Long time follow-up; Quality of life
National Category
Physiotherapy
Identifiers
urn:nbn:se:liu:diva-155853 (URN)10.1002/ehf2.12230 (DOI)000428992300004 ()29168621 (PubMedID)
Available from: 2019-03-29 Created: 2019-03-29 Last updated: 2019-03-29
Almroth, G., Lönn, J., Uhlin, F., Brudin, L., Andersson, B. A. & Hahn-Zoric, M. (2016). Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients. Scandinavian Journal of Immunology, 83(1), 58-63
Open this publication in new window or tab >>Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients
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2016 (English)In: Scandinavian Journal of Immunology, ISSN 0300-9475, E-ISSN 1365-3083, Vol. 83, no 1, p. 58-63Article in journal (Refereed) Published
Abstract [en]

Patients with chronic renal failure are known to have renal osteodystrophy (bone disease) and increased calcification of vessels. A new marker of bone disease, sclerostin, the two pro-inflammatory cytokines tumour necrosis factor-alpha (TNF-alpha) and interleukin-18 (IL-18), and the fibroblast growth factor-23 (FGF-23) receptor-associated marker Klotho were tested in 84 haemodialysis (HD) patients and in healthy controls. The patients had significantly higher levels of the three former markers than of the controls while Klotho was significantly higher in the controls. Low level, but significant, correlations were observed in the patient group when the levels of these four markers were compared to each other and to those of 5 cytokines and growth factors tested earlier; high-sensitive CRP (hsCRP), interleukin-6 (IL-6), hepatocyte growth factor (HGF), fibroblast growth factor-23 (FGF-23) and soluble urokinase plasminogen activator (suPAR). Ln sclerostin correlated positively to Ln hsTNF-alpha, Ln HGF and Ln suPAR. Ln hsTNF-alpha correlated positively to Ln sclerostin, Ln hsCRP, Ln IL-6, Ln FGF-23, Ln suPAR and Ln IL-18. Ln IL-18 correlated positively to Ln suPAR and Ln TNF-alpha. Ln Klotho correlated negatively to Ln hsCRP but did not correlate to Ln FGF-23. The markers studied here may be involved in the calcification of vessels seen in HD patients due to a combination of inflammation and bone disease. The mechanisms are still not fully known but may be of importance for future therapeutic possibilities in this group of patients.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:liu:diva-124013 (URN)10.1111/sji.12392 (DOI)000366927600009 ()26448366 (PubMedID)
Note

Funding agencies: County Council of ostergotland; Research Council of South Eastern Sweden (FORSS)

Available from: 2016-01-18 Created: 2016-01-18 Last updated: 2017-04-24
Hedman, K., Tamás, É., Bjarnegård, N., Brudin, L. & Nylander, E. (2015). Cardiac systolic regional function and synchrony in endurance trained and untrained females. BMJ Open Sport & Exercise Medicine, 25(1), Article ID :e000015.
Open this publication in new window or tab >>Cardiac systolic regional function and synchrony in endurance trained and untrained females
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2015 (English)In: BMJ Open Sport & Exercise Medicine, ISSN 2055-7647, Vol. 25, no 1, article id :e000015Article in journal (Refereed) Published
Abstract [en]

Background Most studies on cardiac function in athletes describe overall heart function in predominately male participants. We aimed to compare segmental, regional and overall myocardial function and synchrony in female endurance athletes (ATH) and in age-matched sedentary females (CON).

Methods In 46 ATH and 48 CON, echocardiography was used to measure peak longitudinal systolic strain and myocardial velocities in 12 left ventricular (LV) and 2 right ventricular (RV) segments. Regional and overall systolic function were calculated together with four indices of dyssynchrony.

Results There were no differences in regional or overall LV systolic function between groups, or in any of the four dyssynchrony indices. Peak systolic velocity (s′) was higher in the RV of ATH than in CON (9.7±1.5 vs 8.7±1.5 cm/s, p=0.004), but not after indexing by cardiac length (p=0.331). Strain was similar in ATH and CON in 8 of 12 LV myocardial segments. In septum and anteroseptum, basal and mid-ventricular s′ was 6–7% and 17–19% higher in ATH than in CON (p<0.05), respectively, while s′ was 12% higher in CON in the basal LV lateral wall (p=0.013). After indexing by cardiac length, s′ was only higher in ATH in the mid-ventricular septum (p=0.041).

Conclusions We found differences between trained and untrained females in segmental systolic myocardial function, but not in global measures of systolic function, including cardiac synchrony. These findings give new insights into cardiac adaptation to endurance training and could also be of use for sports cardiologists evaluating female athletes.

National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-122839 (URN)10.1136/bmjsem-2015-000015 (DOI)
Available from: 2015-11-26 Created: 2015-11-26 Last updated: 2016-04-24Bibliographically approved
Wågström, P., Bengnér, M., Dahle, C., Nilsdotter-Augustinsson, Å., Neumark, T., Brudin, L. & Björkander, J. (2015). Does the frequency of respiratory tract infections help to identify humoral immunodeficiencies in a primary health-care cohort?. Scandinavian Journal of Infectious Diseases, 47(1), 13-19
Open this publication in new window or tab >>Does the frequency of respiratory tract infections help to identify humoral immunodeficiencies in a primary health-care cohort?
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2015 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 47, no 1, p. 13-19Article in journal (Refereed) Published
Abstract [en]

Background: Primary immune deficiency (PID) due to humoral defects is associated with recurrent respiratory tract infections (RTIs). Reliable clinical warning signs of PID would facilitate early diagnosis and thereby reduce long-term complications. The aim of the present study was to evaluate the accuracy of the warning sign, 'four or more antibiotic-treated RTIs annually for 3 or more consecutive years,' for detecting PID among adults in a primary health-care setting. Methods: Fifty-three cases with 'four or more antibiotic-treated RTIs annually for 3 or more consecutive years' were selected from a Swedish primary health-care registry of RTIs. In addition, 66 age- and sex-matched controls were selected having a maximum of one antibiotic-treated RTI during the period covered by the study. Levels of immunoglobulin (Ig) IgG, IgA, IgM, IgG subclasses, and IgG antibodies against Haemophilus influenzae and Streptococcus pneumoniae as well as the inflammatory markers, C-reactive protein, interleukin (IL)-6 and IL-8 were determined. Results: IgG subclass deficiencies (IgGsd) were found in 5/53 (9.4%) of the cases and in 7/66 (10.6%) controls. The most frequent deficiency was IgG3sd and this was found in three participants in the case group and seven in the control group. The mean level of IgG3 was lower in the control group (p = 0.02). The mean level of IL-8 was lower in the case group (p = 0.02). Conclusion: The results show that physicians working in primary health care cannot solely rely on the frequency of antibiotic-treated RTIs as a warning sign for the detection of common humoral immune deficiencies.

Place, publisher, year, edition, pages
Informa Healthcare, 2015
Keywords
Clinical warning sign; immunoglobulin deficiency; primary health care; respiratory tract infections
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-112726 (URN)10.3109/00365548.2014.956330 (DOI)000350052400003 ()25378084 (PubMedID)
Available from: 2014-12-10 Created: 2014-12-10 Last updated: 2017-12-05
Hedman, K., Tamás, E., Henriksson, J., Bjarnegård, N., Brudin, L. & Nylander, E. (2015). Female athlete's heart: Systolic and diastolic function related to circulatory dimensions. Scandinavian Journal of Medicine and Science in Sports, 25(3), 372-381
Open this publication in new window or tab >>Female athlete's heart: Systolic and diastolic function related to circulatory dimensions
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2015 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 25, no 3, p. 372-381Article in journal (Refereed) Published
Abstract [en]

There are relatively few studies on female athletes examining cardiac size and function and how these measures relate to maximal oxygen uptake (VO2max ). When determining sports eligibility, it is important to know what physiological adaptations and characteristics may be expected in female athletes, taking body and cardiac size into account. The purposes of this study were (a) to compare right and left heart dimensions and function in female endurance athletes (ATH) and in non-athletic female controls of similar age (CON); and (b) to explore how these measures related to VO2max . Forty-six ATH and 48 CON underwent a maximal bicycle exercise test and an echocardiographic examination at rest, including standard and color tissue Doppler investigation. All heart dimensions indexed for body size were larger in ATH (all P < 0.01). The diastolic mitral E/A ratio was 27% higher in ATH (P < 0.001) while systolic left and right atrio-ventricular longitudinal displacement was 7% (P = 0.002) and 15% (P < 0.001) larger in ATH, respectively. Half (50.3%) of the variability in VO2max could be explained by left ventricular end-diastolic volume. Our results could be useful in evaluating female endurance athletes with suspected cardiac disease and contribute to understanding differences between female athletes and non-athletes.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-113770 (URN)10.1111/sms.12246 (DOI)000354568800021 ()24840312 (PubMedID)
Available from: 2015-01-30 Created: 2015-01-30 Last updated: 2017-12-05
De Geer, J., Gjerde, M., Brudin, L., Olsson, E., Persson, A. & Engvall, J. (2015). Large variation in blood flow between left ventricular segments, as detected by adenosine stress dynamic CT perfusion.. Clinical Physiology and Functional Imaging, 35(4), 291-300
Open this publication in new window or tab >>Large variation in blood flow between left ventricular segments, as detected by adenosine stress dynamic CT perfusion.
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2015 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 35, no 4, p. 291-300Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Dynamic cardiac CT perfusion (CTP) is based on repeated imaging during the first-pass contrast agent inflow. It is a relatively new method that still needs validation.

PURPOSE: To evaluate the variation in adenosine stress dynamic CTP blood flow as compared to (99m) Tc SPECT. Secondarily, to compare manual and automatic segmentation.

METHODS: Seventeen patients with manifest coronary artery disease were included. Nine were excluded from evaluation for various reasons. All patients were examined with dynamic stress CTP and stress/rest SPECT. CTP blood flow was compared with SPECT on a per segment basis. Results for manual and automated AHA segmentation were compared.

RESULTS: CTP showed a positive correlation with SPECT, with correlation coefficients of 0·38 and 0·41 for manual and automatic segmentation, respectively (P<0·0001). There was no significant difference between the correlation coefficients of the manual and automated segmentation procedures (P = 0·75). The average per individual global CTP blood flow value for normal segments varied by a factor of 1·9 (manual and automatic segmentation). For the whole patient group, the CTP blood flow value in normal segments varied by a factor of 2·9/2·7 (manual/automatic segmentation). Within each patient, the average per segment blood flow in normal segments varied by a factor of 1·3-2·0/1·2-2·1 (manual/automatic segmentation).

CONCLUSION: A positive but rather weak correlation was found between CTP and (99m) Tc SPECT. Large variations in CTP blood flow suggest that a cut-off value for stress myocardial blood flow is inadequate to detect ischaemic segments. Dynamic CTP is hampered by a limited coverage.

National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-113400 (URN)10.1111/cpf.12163 (DOI)000356312800007 ()24842265 (PubMedID)
Available from: 2015-01-17 Created: 2015-01-17 Last updated: 2017-12-05
Maret, E., Liehl, M., Brudin, L., Tödt, T., Edvardsen, T. & Engvall, J. (2015). Phase analysis detects heterogeneity of myocardial deformation on cine MRI. Scandinavian Cardiovascular Journal, 49(3), 149-158
Open this publication in new window or tab >>Phase analysis detects heterogeneity of myocardial deformation on cine MRI
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2015 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 49, no 3, p. 149-158Article in journal (Refereed) Published
Abstract [en]

Abstract Objectives. Myocardial scar will lead to heterogeneous left ventricular deformation. We hypothesized that a myocardial scar will display an elevated standard deviation of phase and that this effect could be compared with mechanical dispersion. Design. Thirty patients (3 women and 27 men) were investigated 4-8 weeks after ST-elevation myocardial infarction treated with percutaneous coronary intervention. Seventeen had a scar area >75% in at least one antero- or inferoseptal segment (scar) and 13 had scar <1% (non-scar). The phase delays of velocity, displacement and strain were measured in the longitudinal direction, tangential to the endocardial outline, and in the radial direction, perpendicular to the tangent. Results. The standard deviation of phase in radial measurements differentiated scar patients from those without scar (p<0.01), while longitudinal measurements did so only for longitudinal strain. Likewise, the standard deviation for radial measurements of time to peak for segmental velocity, displacement and strain performed better than longitudinal measurements and equal to the results of phase. Conclusion. Phase dispersion in deformation imaging may be used for detecting heterogeneous left ventricular contraction.

Place, publisher, year, edition, pages
Informa Healthcare, 2015
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-115752 (URN)10.3109/14017431.2015.1023343 (DOI)000354402500007 ()25752486 (PubMedID)
Available from: 2015-03-18 Created: 2015-03-18 Last updated: 2017-12-04
Svenvik, M., Brudin, L. & Blomberg, M. (2015). Preterm Birth: A Prominent Risk Factor for Low Apgar Scores. BioMed Research International, Article ID 978079.
Open this publication in new window or tab >>Preterm Birth: A Prominent Risk Factor for Low Apgar Scores
2015 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 978079Article in journal (Refereed) Published
Abstract [en]

Objective. To determine predictive risk factors for Apgar scores less than 7 at 5 minutes at two hospitals providing tertiary care and secondary care, respectively. Methods. A retrospective registry cohort study of 21126 births (2006-2010) using data from digital medical records. Risk factors were analyzed by logistic regression analyses. Results. AS(5min) less than 7 was multivariately associated with the following: preterm birth; gestational week 32 + 0-36 + 6, OR = 3.9 (95% CI 2.9-5.3); week 28 + 0-31 + 6, OR = 8 (5-12); week less than 28 + 0, OR = 15 (8-29); postterm birth, OR = 2.0 (1.7-2.3); multiple pregnancy, OR = 3.53 (1.79-6.96); previous cesarean section, OR = 3.67 (2.31-5.81); BMI 25-29, OR = 1.30 (1.09-1.55); BMI greater than= 30 OR = 1.70 (1.20-2.41); nonnormal CTG at admission, OR = 1.98 (1.48-2.66). greater than= 1-para was associated with a decreased risk for AS(5min) less than 7, OR = 0.34 (0.25-0.47). In the univariate logistic regression analysis AS(5min) less than 7 was associated with tertiary level care, OR = 1.48 (1.17-1.87); however, in the multivariate analysis there was no significant difference. Conclusion. A number of partially preventable risk factors were identified, preterm birth being the most evident. Further, no significant difference between the two hospital levels regarding the risk for low Apgar scores was detected.

Place, publisher, year, edition, pages
HINDAWI PUBLISHING CORPORATION, 2015
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-122075 (URN)10.1155/2015/978079 (DOI)000360755200001 ()26413554 (PubMedID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden

Available from: 2015-12-18 Created: 2015-10-19 Last updated: 2017-12-01
Jansson, I., Birgitta Gunnarsson, A., Bjorklund, A., Brudin, L. & Perseius, K.-I. (2015). Problem-Based Self-care Groups Versus Cognitive Behavioural Therapy for Persons on Sick Leave Due to Common Mental Disorders: A Randomised Controlled Study. Journal of occupational rehabilitation, 25(1), 127-140
Open this publication in new window or tab >>Problem-Based Self-care Groups Versus Cognitive Behavioural Therapy for Persons on Sick Leave Due to Common Mental Disorders: A Randomised Controlled Study
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2015 (English)In: Journal of occupational rehabilitation, ISSN 1053-0487, E-ISSN 1573-3688, Vol. 25, no 1, p. 127-140Article in journal (Refereed) Published
Abstract [en]

Purpose To evaluate the interventional capacity of problem based method groups (PBM) regarding mental health and work ability compared to cognitive behavioural therapy (CBT) for persons on sick leave due to common mental disorders. Methods In a randomised controlled design the experimental group received PBM and the control group received CBT. Outcomes were measured by the Hospital Anxiety and Depression Scale (HADS), the Stress and Crisis Inventory 93 (SCI-93) and the Dialogue about Working Ability instrument (DOA). Results Twenty-two participants in the PBM group and 28 in the CBT group completed intervention. Both groups showed significant lower scores on the two HADS subscales. Regarding stress the PBM group showed significant decrease in one (out of three) subscales of SCI-93. The CBT group showed significant decrease on all subscales of SCI-93. Regarding work ability the PBM group showed significant higher scores on one of five subscales of DOA. The CBT group showed significant higher scores on four of five subscales of DOA. Between groups there were significant differences to the favour of CBT on one of two subscales of HADS, all three subscales of SCI-93 and on two of the five subscales of DOA. Conclusion PBM seem to be able to reduce anxiety- and depression symptoms. CBT showed to be superior to PBM in reducing symptoms in all aspects of mental health, except for anxiety, in which they seem equally effective. Regarding work ability CBT showed to be superior, with significant effect on more aspects compared to PBM.

Place, publisher, year, edition, pages
Springer Verlag (Germany), 2015
Keywords
Anxiety; Depression; Intervention; Primary health care; Return to work; Sickness absence; Stress
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-116515 (URN)10.1007/s10926-014-9530-9 (DOI)000349971100013 ()24972663 (PubMedID)
Note

Funding Agencies|REHSAM-programme (the Swedish Social Insurance Agency); REHSAM-programme (Vardal Foundation); FORSS (the Medical Research Council of Southeast Sweden); County Council in Jonkoping; County Council in Kalmar, Sweden

Available from: 2015-03-27 Created: 2015-03-27 Last updated: 2017-12-04
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