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Sydsjö, Gunilla
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Publications (10 of 151) Show all publications
Tordön, R., Svedin, C. G., Fredlund, C., Jonsson, L., Pribe, G. & Sydsjö, G. (2019). Background, experience of abuse, and mental health among adolescents in out-of-home care: a cross-sectional study of a Swedish high school national sample. Nordic Journal of Psychiatry, 73(1), 16-23
Open this publication in new window or tab >>Background, experience of abuse, and mental health among adolescents in out-of-home care: a cross-sectional study of a Swedish high school national sample
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2019 (English)In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 73, no 1, p. 16-23Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To compare experiences for adverse events, especially sexual abuse, and mental health in a group of high school students in out-of-home care with a representative sample of peers of the same age and similar educational attainment living with their parents.

MATERIALS AND METHODS: A sample of 5839 students in the third year of Swedish high school, corresponding to a response rate of 59.7%, answered a study specific questionnaire. Data from 41 students living in out-of-home care were compared with data from peers not in out-of-home care in a cross-sectional analyze.

RESULTS: Students in out-of-home care had more often an immigrant background and a non-heterosexual orientation, had more often experienced physical and penetrative sexual abuse, and more often sought healthcare for mental problems. Disclosure of sexual abuse was less common, and acts of persuasion or adults' use of their social position was more common among students in out-of-home care.

CONCLUSIONS: Even where the protective factor 'senior educational attainment' is present, risks for abuse and poor mental health are evident for adolescents in out-of-home care. Disclosure of adversity, when it has occurred, ought to be higher among these adolescents with regular contact with social services, but our findings indicate tendencies for the opposite. We therefore suggest routines to be established to screen for adverse life events and mental health actively, along with general and systematic assessments of adversity and mental health during care.

Place, publisher, year, edition, pages
Taylor & Francis, 2019
Keywords
Out-of-home care, child sexual abuse, foster home care, mental health, residential care
National Category
Psychiatry
Identifiers
urn:nbn:se:liu:diva-159924 (URN)10.1080/08039488.2018.1527397 (DOI)000466445300003 ()30561234 (PubMedID)2-s2.0-85058791083 (Scopus ID)
Available from: 2019-08-28 Created: 2019-08-28 Last updated: 2019-09-03Bibliographically approved
Sydsjö, G., Lindell Pettersson, M., Bladh, M., Skoog Svanberg, A., Lampic, C. & Nedstrand, E. (2019). Evaluation of risk factors’ importance on adverse pregnancy and neonatal outcomes in women aged 40 years or older. BMC Pregnancy and Childbirth, 19, Article ID 92.
Open this publication in new window or tab >>Evaluation of risk factors’ importance on adverse pregnancy and neonatal outcomes in women aged 40 years or older
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2019 (English)In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 19, article id 92Article in journal (Refereed) Published
Abstract [en]

Background

Women of advanced age (40 years or older) are generally, at risk for pregnancy and delivery related problems. In addition, there is limited knowledge on being of advanced age and having been given Assisted Reproductive Treatment (ART) and its association with negative obstetric outcomes. Therefore, data from the Swedish Medical Birth Register was used to investigate pregnancy and neonatal outcomes for women aged 40 or more who had given birth. The secondary aim was to compare the obstetric outcomes of women who had used ART and women who had not undergoneART while adjusting for marital status across the age groups.

Method

Women of advanced age who had given birth in Sweden during 2007–2012 formed the index group, n = 37,558; a reference group of women comprised 71,472 women under the age of 40. An additional subgroup of women aged 45 or older when giving birth was also formed, n = 2229. The obstetric and neonatal data for all the women was derived from national register data.

Results

Women of advanced age were more often single, had undergone ART, and more often experienced adverse obstetric outcomes than did younger women. The neonate’s health was also more often adversely affected expressed as being born with low birth weight and Small for Gestational Age (SGA), having lower Apgar scores, and having more health problems during the first week compared to the reference group.

Conclusions

Women who are approaching the upper limit of fecundity are at greater risk for having children who are preterm and SGA. The adverse effects of being preterm and SGA may have negative long-term effects, not only on the children but also on the mothers. This needs to be addressed more frequently in a clinical setting when advising women of all ages on pregnancy and ART treatment.

Place, publisher, year, edition, pages
BioMed Central, 2019
Keywords
Advanced maternal age; Pregnancy; Delivery; Neonate status
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-155894 (URN)10.1186/s12884-019-2239-1 (DOI)000461291500002 ()30866838 (PubMedID)2-s2.0-85062845776 (Scopus ID)
Note

Funding Agencies|Research Council in the southeast of Sweden, FORSS

Available from: 2019-04-03 Created: 2019-04-03 Last updated: 2019-07-01Bibliographically approved
Hammar, M., Larsson, E., Bladh, M., Finnström, O., Gäddlin, P.-O., Leijon, I., . . . Sydsjö, G. (2018). A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile. Systems biology in reproductive medicine, 64(3), 207-215
Open this publication in new window or tab >>A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile
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2018 (English)In: Systems biology in reproductive medicine, ISSN 1939-6376, Vol. 64, no 3, p. 207-215Article in journal (Refereed) Published
Abstract [en]

Environmental factors during the fetal period may adversely affect reproductive functions in men being born with very low birth weight (VLBW, <1500 g). The objective of this prospective, controlled cohort study was to investigate if VLBW men have an altered reproductive hormone profile compared with men born at term. The study group initially consisted of all VLBW boys live-born between 1 February 1987 and 30 April 1988 in the south-east region of Sweden (n = 47). A control child was chosen born at term, at the same hospital, with the same parity, without malformations, and next in order after each VLBW child who survived the first four weeks (n = 45). The present follow-up was performed when the men were 26-28 years of age and included measurements of serum hormone levels, hair testosterone concentration, and anthropometric data. Also life-style questionnaires were collected from 26 VLBW men and 19 controls. The VLBW group (n = 26) had higher median levels of serum estradiol, 84.5 pmol/L than controls (n = 19), 57.5 pmol/L (p = 0.008). There was no significant correlation between serum estradiol and BMI (r = 0.06, p = 0.74). There were no differences in other hormone levels or the reproductive pattern between the groups. In conclusion, even though there was a statistically significant difference in estradiol levels between the groups, both groups had low normal mean levels of questionable clinical significance. The reproductive pattern was similar in the two groups and in this study being born VLBW does not seem to affect these measured aspects of reproduction.

ABBREVIATIONS: ADHD: attention deficit hyperactive disorder; AGA: average for gestational age; BMI: body mass index; CP: cerebral palsy; DHT: dihydrotestosterone; FSH: follicle stimulating hormone; LBW: low birth weight; LH: luteinizing hormone; SAD: sagittal abdominal diameter; SGA: small for gestational age; SHBG: sex hormone binding globulin; TSH: thyroid stimulating hormone; T3: triiodothyronine; T4: thyroxin; VLBW: very low birth weight.

Place, publisher, year, edition, pages
Taylor & Francis, 2018
Keywords
Very low birth weight, follow-up study, preterm, reproduction
National Category
Pediatrics
Identifiers
urn:nbn:se:liu:diva-148117 (URN)10.1080/19396368.2018.1448901 (DOI)000432658800007 ()29583035 (PubMedID)2-s2.0-85044443280 (Scopus ID)
Note

Funding agencies: County Council of Ostergotland (ALF grants); Futurum-the Academy for Health and Care, Region Jonkoping County, Sweden

Available from: 2018-05-30 Created: 2018-05-30 Last updated: 2019-04-10Bibliographically approved
Johansson, T., Lindblad, M., Bladh, M., Josefsson, A. & Sydsjö, G. (2017). Incidence of Perthes disease in children born between 1973 and 1993: A Swedish nationwide cohort study of 2.1 million individuals. Acta Orthopaedica, 88(1), 96-100
Open this publication in new window or tab >>Incidence of Perthes disease in children born between 1973 and 1993: A Swedish nationwide cohort study of 2.1 million individuals
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2017 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 88, no 1, p. 96-100Article in journal (Refereed) Published
Abstract [en]

Background and purpose - The incidence of Perthes disease as reported in the literature varies widely between and within countries. The etiology of the disease is still unknown. Both environmental and genetic factors have been suggested to play a part in either causing the disease or increasing the susceptibility of an individual. We determined the incidence of Perthes disease in Sweden and investigated possible relationships to parental socioeconomic status, ethnicity, marital status, mothers age when giving birth, parity, number of siblings, and smoking habits. Patients and methods - Six Swedish population-based registers were used, together covering all children born in Sweden from 1973 through 1993. Results - The incidence of Perthes disease in Sweden was 9.3 per 100,000 subjects. The ratio between boys and girls was 3.1:1. The educational level of the father and the mother of a child with Perthes disease was lower than in the controls. The incidence was lower when the fathers were in the highest income bracket (above the 90(th) percentile). A higher proportion of parents of Nordic lineage had children with Perthes disease than parental pairs with one or both who were not of such lineage. Interpretation - This study confirms that there is an association between the incidence of Perthes disease and the socioeconomic status of the parents.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD, 2017
National Category
General Practice
Identifiers
urn:nbn:se:liu:diva-134798 (URN)10.1080/17453674.2016.1227055 (DOI)000392736200016 ()27587239 (PubMedID)
Available from: 2017-02-24 Created: 2017-02-24 Last updated: 2019-06-28
Liffner, S., Hammar, M., Bladh, M., Nedstrand, E., Rodriguez-Martinez, H. & Sydsjö, G. (2017). Men becoming fathers by intracytoplasmic sperm injection were more often born small for gestational to age. Asian Journal of Andrology, 19(1), 103-106
Open this publication in new window or tab >>Men becoming fathers by intracytoplasmic sperm injection were more often born small for gestational to age
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2017 (English)In: Asian Journal of Andrology, ISSN 1008-682X, E-ISSN 1745-7262, Vol. 19, no 1, p. 103-106Article in journal (Refereed) Published
Abstract [en]

Being born with nonoptimal birth characteristics decreases the chance of becoming a father. Urogenital malformations as well as metabolic syndrome are more common in men born small for gestational age (SGA) and could be contributing factors to the reduced fertility rate seen in these men. It could imply that men becoming fathers by assisted reproductive technology (ART) more often are born with low birth weight (LBW), preterm, and/or SGA than men conceiving without treatment and also that men where intracytoplasmic sperm injection (ICSI) had to be performed more often are born with nonoptimal birth characteristics than men where conventional in vitro fertilization (IVF) successfully could be used. In this retrospective, case-control study using Swedish national registers, we compared the birth characteristics of 1206 men who have become fathers by ART with a control group consisting of age-matched men who became fathers without treatment. The differences in birth characteristics between men becoming fathers by IVF and ICSI were also assessed. For men becoming fathers by ART, OR of being born with LBW was 1.66 (95% CI = 1.17-2.36) compared with fathers who conceived without treatment. OR of being born prematurely was 1.32 (95% CI = 1.00-1.77). Men becoming fathers via ICSI had a doubled increased likelihood of being born SGA compared with men who became fathers via IVF (OR = 2.12; 95% CI = 1.17-3.83). In conclusion, we have found that men becoming fathers by ICSI treatments had more often been born SGA than men becoming fathers by conventional IVF.

Place, publisher, year, edition, pages
MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2017
Keywords
infertility; intracytoplasmic sperm injection; in vitro fertilization; low birth weight; preterm; small for gestational age
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-134486 (URN)10.4103/1008-682X.178848 (DOI)000392108300018 ()27184547 (PubMedID)
Note

Funding Agencies|County Council of Ostergotland

Available from: 2017-02-15 Created: 2017-02-15 Last updated: 2018-05-02
Vikström, J., Sydsjö, G., Hammar, M., Bladh, M. & Josefsson, A. (2017). Risk of postnatal depression or suicide after in vitro fertilisation treatment: a nationwide case–control study. British Journal of Obstetrics and Gynecology, 124(3), 435-442
Open this publication in new window or tab >>Risk of postnatal depression or suicide after in vitro fertilisation treatment: a nationwide case–control study
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2017 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 124, no 3, p. 435-442Article in journal (Refereed) Published
Abstract [en]

Objective

To examine whether women who undergo in vitro fertilisation (IVF) treatment are at greater risk of postnatal suicide or postnatal depression (PND) requiring psychiatric care, compared with women who conceive spontaneously.

Design

Case–control study using data from national registers.

Setting

Sweden during the period 2003–2009.

Population

Cases were 3532 primiparous women who had given birth following IVF treatment. An aged-matched control group of 8553 mothers was randomly selected from the medical birth register.

Methods

Logistic regression analyses were performed with PND as the outcome, and with known risk factors of PND as well as IVF/spontaneous birth as covariates.

Main outcome measures

Postnatal depression (PND), defined as diagnoses F32–F39 of the tenth edition of the International Classification of Diseases (ICD–10), within 12 months of childbirth.

Results

Initial analyses showed that PND was more common in the control group than in the IVF group (0.8 versus 0.4%; P = 0.04); however, these differences disappeared when confounding factors were controlled for. A history of any psychiatric illness (P = 0.000; odds ratio, OR = 25.5; 95% confidence interval, 95% CI = 11.7–55.5), any previous affective disorder (P = 0.000; OR = 26.0; 95% CI = 10.5–64.0), or specifically a personality disorder (P = 0.028; OR = 3.8; 95% CI = 1.2–12.7) increased the risk of PND. No woman in either group committed suicide during the first year after childbirth.

Conclusions

Whereas mothers who receive IVF treatment are not at increased risk of PND, the risk is increased among mothers with a history of mental illness. Tweetable abstract A Swedish study on 3532 women showed that IVF treatment does not increase the risk of postnatal depression.

Place, publisher, year, edition, pages
Chichester: Wiley-Blackwell Publishing Inc., 2017
Keywords
In vitro fertilisation, infertility treatment, postnatal depression, postnatal mental illness
National Category
Obstetrics, Gynecology and Reproductive Medicine Public Health, Global Health, Social Medicine and Epidemiology Geriatrics General Practice
Identifiers
urn:nbn:se:liu:diva-132763 (URN)10.1111/1471-0528.13788 (DOI)000397007500016 ()26663705 (PubMedID)2-s2.0-84983109530 (Scopus ID)
Available from: 2016-11-23 Created: 2016-11-23 Last updated: 2019-06-28Bibliographically approved
Agnafors, S., Svedin, C. G., Oreland, L., Bladh, M., Comasco, E. & Sydsjö, G. (2016). A biopsychosocial approach to risk and resilience on behavior in children followed from birth to age twelve.
Open this publication in new window or tab >>A biopsychosocial approach to risk and resilience on behavior in children followed from birth to age twelve
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2016 (English)Manuscript (preprint) (Other academic)
Abstract [en]

An increasing prevalence of mental health problems calls for more knowledge into factors associated with resilience in the context of child behavior. Biological factors are seldom considered in psychosocial models of resilience. The present study used multiple statistical methodologies to examine a biopsychosocial model of risk and resilience on behavior at preadolescence. Data from 889 children and their mothers were used. A cumulative adversity score was created by combining maternal symptoms of depression, psychosocial risk and children’s experiences of life events. The proposed resilience factors investigated were candidate genetic polymorphisms, child temperament and social functioning, and maternal sense of coherence. Results show that the l/l genotype of the serotonin transporter linked polymorphic region (5-HTTLPR) was associated with lower internalizing scores, especially for children exposed to low adversity. An easy temperament was associated with resilient outcomes for children exposed to high adversity. Child social functioning was found to be more of a general resource variable buffering risk in both high and low adversity groups. The results support a multiple level model of resilience indicating effects, though small, of both biological and psychosocial factors. The present findings call for both preventive actions and further studies on biopsychosocial models in resilience research.

Keywords
Child, genotype, longitudinal, mental health, resilience
National Category
Psychiatry
Identifiers
urn:nbn:se:liu:diva-124208 (URN)
Available from: 2016-01-22 Created: 2016-01-22 Last updated: 2016-01-22Bibliographically approved
Skoog Svanberg, A., Sydsjö, G., Bladh, M. & Lampic, C. (2016). Attitudes about donor information differ greatly between IVF couples using their own gametes and those receiving or donating oocytes or sperm. Journal of Assisted Reproduction and Genetics, 33(6), 703-710
Open this publication in new window or tab >>Attitudes about donor information differ greatly between IVF couples using their own gametes and those receiving or donating oocytes or sperm
2016 (English)In: Journal of Assisted Reproduction and Genetics, ISSN 1058-0468, E-ISSN 1573-7330, Vol. 33, no 6, p. 703-710Article in journal (Refereed) Published
Abstract [en]

The objective of the study is to examine attitudes towards aspects of donation treatment based on a national Swedish sample of gamete donors and couples undergoing assisted reproductive techniques (ART). The present study was part of the Swedish study on gamete donation, a prospective longitudinal cohort study including all fertility clinics performing gamete donation in Sweden. The sample comprised 164 oocyte donors, 89 sperm donors, 251 people treated with their own gametes (in vitro fertilisation (IVF)), 213 oocyte recipients and 487 sperm recipients. A study-specific questionnaire was used. Attitudes vary widely between couples using their own gametes for IVF and those receiving or donating oocyte or sperm. The groups differed in their responses to most questions. Oocyte and sperm donors were more likely to agree with the statements "The donor should be informed if the donation results in a child" and "Offspring should receive some information about the donor during mature adolescence" than recipients of donated gametes and couples treated with their own gametes. Donor recipients, IVF couples and donors expressed different attitudes towards openness and information when it came to gamete donation, and those differences seemed to depend on their current reproductive situation.

Place, publisher, year, edition, pages
SPRINGER/PLENUM PUBLISHERS, 2016
Keywords
Attitudes; Gamete donation; Embryo donation
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-130068 (URN)10.1007/s10815-016-0694-4 (DOI)000377242000004 ()27059774 (PubMedID)
Note

Funding Agencies|Merck Serono; Uppsala/Orebro Research Council; Marianne and Marcus Wallenberg Foundation

Available from: 2016-07-06 Created: 2016-07-06 Last updated: 2017-11-28
Kastbom, Å., Sydsjö, G., Bladh, M., Priebe, G. & Svedin, C. G. (2016). Differences in sexual behavior, health, and history of child abuse among school students who had and had not engaged in sexual activity by the age of 18 years: a cross-sectional study. Adolescent Health, Medicine and Therapeutics, 7, 1-11
Open this publication in new window or tab >>Differences in sexual behavior, health, and history of child abuse among school students who had and had not engaged in sexual activity by the age of 18 years: a cross-sectional study
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2016 (English)In: Adolescent Health, Medicine and Therapeutics, ISSN 1179-318X, Vol. 7, p. 1-11Article in journal (Refereed) Published
Abstract [en]

Background: Empirical research about late sexual debut and its consequences is limited, and further research is needed.

Objective: To explore how students who had not had intercourse by the age of 18 years differed in terms of sociodemographic factors, physical and psychological health, sexual behavior, and history of sexual abuse from those who had.

Materials and methods: This is a cross-sectional survey involving 3,380 Swedish 18-year-olds. Descriptive analyses were used to investigate different types of sexual behavior. Ordinal data concerning alcohol consumption, self-esteem, sexual and physical abuse, parental relationships, sense of coherence, and health were analyzed, and multiple regression was carried out to identify the most important factors associated with no sexual debut.

Results: Just under a quarter of the adolescents had not had oral, anal, or vaginal sex by the age of 18 years, and they comprised the index group. They were characterized by being more likely to have caring fathers, parents born outside Europe, lower pornography consumption, lower alcohol and tobacco consumption, less antisocial behavior, and above all lower sexual desire (sometimes, adjusted odds ratio [aOR] 3.8; never/seldom, aOR 13.3) and fewer experiences of sexual abuse (aOR 25.5). Family structure and culture matters when it comes to the age of sexual debut.

Conclusion: Adolescents with no sexual debut at 18 years of age seemed to live a more stable and cautious life than more sexual experienced peers, exemplified by fewer antisocial acts, less smoking and alcohol/drug consumption, less sexual desire, and less experience of sexual abuse.

Place, publisher, year, edition, pages
Dove Medical Press Ltd.(Dovepress), 2016
Keywords
Adolescents, sexual abuse, sexual behavior, late sexual debut
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-123026 (URN)10.2147/AHMT.S95493 (DOI)26811695 (PubMedID)
Funder
Swedish Agency for Youth and Civil Society (MUCF)
Note

At the time for thesis presentation publication was in status: Manuscript

Available from: 2015-12-02 Created: 2015-12-02 Last updated: 2017-12-01Bibliographically approved
Agnafors, S., Sydsjö, G., Comasco, E., Bladh, M., Oreland, L. & Svedin, C. G. (2016). Early predictors of behavioural problems in pre-schoolers: a longitudinal study of constitutional and environmental main and interaction effects. BMC Pediatrics, 16
Open this publication in new window or tab >>Early predictors of behavioural problems in pre-schoolers: a longitudinal study of constitutional and environmental main and interaction effects
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2016 (English)In: BMC Pediatrics, ISSN 1471-2431, E-ISSN 1471-2431, Vol. 16Article in journal (Refereed) Published
Abstract [en]

Background: The early environment is important for child development and wellbeing. Gene-by-environment studies investigating the impact of the serotonin transporter genelinked polymorphic region (5-HTTLPR) and the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphisms by life events on mental health and behaviour problems have been inconclusive. Methodological differences regarding sample sizes, study population, definitions of adversities and measures of mental health problems obstacle their comparability. Furthermore, very few studies included children. The aim of this study was to examine the associations between a broad range of risk factors covering pregnancy and birth, genetic polymorphism, experience of multiple life events and psychosocial environment, and child behaviour at age three, using a comparably large, representative, population-based sample.

Methods: A total of 1,106 children, and their mothers, were followed from pregnancy to age three. Information on pregnancy and birth-related factors was retrieved from the Medical Birth Register. Questionnaires on depressive symptoms, child behaviour and child experiences of life events were filled in by the mothers. Child saliva samples were used for genotyping the 5-HTTLPR and BDNF Val66Met polymorphisms. Multiple logistic regression was used to investigate the association between psychological scales and genetic polymorphisms.

Results: Symptoms of postpartum depression increased the risk of both internalizing and externalizing problems. Experience of multiple life events was also a predictor of behavioural problems across the scales. No gene-by-environment or gene-bygene-by-environment interactions were found. Children of immigrants had an increased risk of internalizing problems and parental unemployment was significantly associated with both internalizing and externalizing type of problems.

Conclusion: This study shows the importance of the psychosocial environment for psychosocial health in preschool children, and adds to  the literature of null-findings of gene-by-environment effects of 5-HTTLPR and BDNF in children

National Category
Psychiatry
Identifiers
urn:nbn:se:liu:diva-124207 (URN)10.1186/s12887-016-0614-x (DOI)000377535800002 ()
Note

Funding agencies:Funding was obtained from the Swedish Council for Working Life and Social Research (FAS), the Swedish Research Council (VR), the Clas Groschinsky Memorial Foundation, Stockholm, Samariten Foundation, Stockholm, the Hallsten Research Foundation and ALF, County Council of Ostergotland.

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Available from: 2016-01-22 Created: 2016-01-22 Last updated: 2017-11-30Bibliographically approved
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