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Hammar, Mats
Publications (10 of 138) Show all publications
Hammar, M., Larsson, E., Bladh, M., Finnström, O., Gäddlin, P. O., Leijon, I., . . . Sydsjö, G. (2018). A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile. Systems biology in reproductive medicine, 64(3), 207-215
Open this publication in new window or tab >>A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile
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2018 (English)In: Systems biology in reproductive medicine, ISSN 1939-6376, Vol. 64, no 3, p. 207-215Article in journal (Refereed) Published
Abstract [en]

Environmental factors during the fetal period may adversely affect reproductive functions in men being born with very low birth weight (VLBW, <1500 g). The objective of this prospective, controlled cohort study was to investigate if VLBW men have an altered reproductive hormone profile compared with men born at term. The study group initially consisted of all VLBW boys live-born between 1 February 1987 and 30 April 1988 in the south-east region of Sweden (n = 47). A control child was chosen born at term, at the same hospital, with the same parity, without malformations, and next in order after each VLBW child who survived the first four weeks (n = 45). The present follow-up was performed when the men were 26-28 years of age and included measurements of serum hormone levels, hair testosterone concentration, and anthropometric data. Also life-style questionnaires were collected from 26 VLBW men and 19 controls. The VLBW group (n = 26) had higher median levels of serum estradiol, 84.5 pmol/L than controls (n = 19), 57.5 pmol/L (p = 0.008). There was no significant correlation between serum estradiol and BMI (r = 0.06, p = 0.74). There were no differences in other hormone levels or the reproductive pattern between the groups. In conclusion, even though there was a statistically significant difference in estradiol levels between the groups, both groups had low normal mean levels of questionable clinical significance. The reproductive pattern was similar in the two groups and in this study being born VLBW does not seem to affect these measured aspects of reproduction.

ABBREVIATIONS: ADHD: attention deficit hyperactive disorder; AGA: average for gestational age; BMI: body mass index; CP: cerebral palsy; DHT: dihydrotestosterone; FSH: follicle stimulating hormone; LBW: low birth weight; LH: luteinizing hormone; SAD: sagittal abdominal diameter; SGA: small for gestational age; SHBG: sex hormone binding globulin; TSH: thyroid stimulating hormone; T3: triiodothyronine; T4: thyroxin; VLBW: very low birth weight.

Place, publisher, year, edition, pages
Taylor & Francis, 2018
Keywords
Very low birth weight, follow-up study, preterm, reproduction
National Category
Pediatrics
Identifiers
urn:nbn:se:liu:diva-148117 (URN)10.1080/19396368.2018.1448901 (DOI)000432658800007 ()29583035 (PubMedID)2-s2.0-85044443280 (Scopus ID)
Note

Funding agencies: County Council of Ostergotland (ALF grants); Futurum-the Academy for Health and Care, Region Jonkoping County, Sweden

Available from: 2018-05-30 Created: 2018-05-30 Last updated: 2018-08-30Bibliographically approved
Liffner, S., Hammar, M., Bladh, M., Nedstrand, E., Rodriguez-Martinez, H. & Sydsjö, G. (2017). Men becoming fathers by intracytoplasmic sperm injection were more often born small for gestational to age. Asian Journal of Andrology, 19(1), 103-106
Open this publication in new window or tab >>Men becoming fathers by intracytoplasmic sperm injection were more often born small for gestational to age
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2017 (English)In: Asian Journal of Andrology, ISSN 1008-682X, E-ISSN 1745-7262, Vol. 19, no 1, p. 103-106Article in journal (Refereed) Published
Abstract [en]

Being born with nonoptimal birth characteristics decreases the chance of becoming a father. Urogenital malformations as well as metabolic syndrome are more common in men born small for gestational age (SGA) and could be contributing factors to the reduced fertility rate seen in these men. It could imply that men becoming fathers by assisted reproductive technology (ART) more often are born with low birth weight (LBW), preterm, and/or SGA than men conceiving without treatment and also that men where intracytoplasmic sperm injection (ICSI) had to be performed more often are born with nonoptimal birth characteristics than men where conventional in vitro fertilization (IVF) successfully could be used. In this retrospective, case-control study using Swedish national registers, we compared the birth characteristics of 1206 men who have become fathers by ART with a control group consisting of age-matched men who became fathers without treatment. The differences in birth characteristics between men becoming fathers by IVF and ICSI were also assessed. For men becoming fathers by ART, OR of being born with LBW was 1.66 (95% CI = 1.17-2.36) compared with fathers who conceived without treatment. OR of being born prematurely was 1.32 (95% CI = 1.00-1.77). Men becoming fathers via ICSI had a doubled increased likelihood of being born SGA compared with men who became fathers via IVF (OR = 2.12; 95% CI = 1.17-3.83). In conclusion, we have found that men becoming fathers by ICSI treatments had more often been born SGA than men becoming fathers by conventional IVF.

Place, publisher, year, edition, pages
MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2017
Keywords
infertility; intracytoplasmic sperm injection; in vitro fertilization; low birth weight; preterm; small for gestational age
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-134486 (URN)10.4103/1008-682X.178848 (DOI)000392108300018 ()27184547 (PubMedID)
Note

Funding Agencies|County Council of Ostergotland

Available from: 2017-02-15 Created: 2017-02-15 Last updated: 2018-05-02
Enblom, A., Steineck, G., Hammar, M. & Börjeson, S. (2017). Reduced Need for Rescue Antiemetics and Improved Capacity to Eat in Patients Receiving Acupuncture Compared to Patients Receiving Sham Acupuncture or Standard Care during Radiotherapy.. Evidence-based Complementary and Alternative Medicine, 2017, Article ID 5806351.
Open this publication in new window or tab >>Reduced Need for Rescue Antiemetics and Improved Capacity to Eat in Patients Receiving Acupuncture Compared to Patients Receiving Sham Acupuncture or Standard Care during Radiotherapy.
2017 (English)In: Evidence-based Complementary and Alternative Medicine, ISSN 1741-427X, E-ISSN 1741-4288, Vol. 2017, article id 5806351Article in journal (Refereed) Published
Abstract [en]

Objective. To evaluate if consumption of emesis-related care and eating capacity differed between patients receiving verum acupuncture, sham acupuncture, or standard care only during radiotherapy. Methods. Patients were randomized to verum (n = 100) or sham (n = 100) acupuncture (telescopic blunt sham needle) (median 12 sessions) and registered daily their consumption of antiemetics and eating capacity. A standard care group (n = 62) received standard care only and delivered these data once. Results. More patients in the verum (n = 73 of 89 patients still undergoing radiotherapy; 82%, Relative Risk (RR) 1.23, 95% Confidence Interval (CI) 1.01-1.50) and the sham acupuncture group (n = 79 of 95; 83%, RR 1.24, CI 1.03-1.52) did not need any antiemetic medications, as compared to the standard care group (n = 42 out of 63; 67%) after receiving 27 Gray dose of radiotherapy. More patients in the verum (n = 50 of 89; 56%, RR 1.78, CI 1.31-2.42) and the sham acupuncture group (n = 58 of 94 answering patients; 62%, RR 1.83, CI 1.20-2.80) were capable of eating as usual, compared to the standard care group (n = 20 of 63; 39%). Conclusion. Patients receiving acupuncture had lower consumption of antiemetics and better eating capacity than patients receiving standard antiemetic care, plausible by nonspecific effects of the extra care during acupuncture.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2017
National Category
Nursing
Identifiers
urn:nbn:se:liu:diva-136008 (URN)10.1155/2017/5806351 (DOI)000394876600001 ()28270851 (PubMedID)
Note

Funding agencies: Swedish Cancer Society; Region of Ostergotland; University of Linkoping; Cancer Rehabilitation Foundation; Swedish Institute of Health Research; Vardal Foundation for Healthcare Sciences and Allergy Research; Osher Center for Integrative Research, Karolin

Available from: 2017-03-24 Created: 2017-03-24 Last updated: 2018-05-02Bibliographically approved
Vikström, J., Sydsjö, G., Hammar, M., Bladh, M. & Josefsson, A. (2017). Risk of postnatal depression or suicide after in vitro fertilisation treatment: a nationwide case–control study. British Journal of Obstetrics and Gynecology, 124(3), 435-442
Open this publication in new window or tab >>Risk of postnatal depression or suicide after in vitro fertilisation treatment: a nationwide case–control study
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2017 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 124, no 3, p. 435-442Article in journal (Refereed) Published
Abstract [en]

Objective

To examine whether women who undergo in vitro fertilisation (IVF) treatment are at greater risk of postnatal suicide or postnatal depression (PND) requiring psychiatric care, compared with women who conceive spontaneously.

Design

Case–control study using data from national registers.

Setting

Sweden during the period 2003–2009.

Population

Cases were 3532 primiparous women who had given birth following IVF treatment. An aged-matched control group of 8553 mothers was randomly selected from the medical birth register.

Methods

Logistic regression analyses were performed with PND as the outcome, and with known risk factors of PND as well as IVF/spontaneous birth as covariates.

Main outcome measures

Postnatal depression (PND), defined as diagnoses F32–F39 of the tenth edition of the International Classification of Diseases (ICD–10), within 12 months of childbirth.

Results

Initial analyses showed that PND was more common in the control group than in the IVF group (0.8 versus 0.4%; P = 0.04); however, these differences disappeared when confounding factors were controlled for. A history of any psychiatric illness (P = 0.000; odds ratio, OR = 25.5; 95% confidence interval, 95% CI = 11.7–55.5), any previous affective disorder (P = 0.000; OR = 26.0; 95% CI = 10.5–64.0), or specifically a personality disorder (P = 0.028; OR = 3.8; 95% CI = 1.2–12.7) increased the risk of PND. No woman in either group committed suicide during the first year after childbirth.

Conclusions

Whereas mothers who receive IVF treatment are not at increased risk of PND, the risk is increased among mothers with a history of mental illness. Tweetable abstract A Swedish study on 3532 women showed that IVF treatment does not increase the risk of postnatal depression.

Place, publisher, year, edition, pages
Chichester: Wiley-Blackwell Publishing Inc., 2017
Keywords
In vitro fertilisation, infertility treatment, postnatal depression, postnatal mental illness
National Category
Obstetrics, Gynecology and Reproductive Medicine Public Health, Global Health, Social Medicine and Epidemiology Geriatrics General Practice
Identifiers
urn:nbn:se:liu:diva-132763 (URN)10.1111/1471-0528.13788 (DOI)000397007500016 ()26663705 (PubMedID)2-s2.0-84983109530 (Scopus ID)
Available from: 2016-11-23 Created: 2016-11-23 Last updated: 2018-05-02Bibliographically approved
Malmborg, A., Persson, E., Brynhildsen, J. & Hammar, M. (2016). Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women. European journal of contraception & reproductive health care, 21(2), 158-167
Open this publication in new window or tab >>Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women
2016 (English)In: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 21, no 2, p. 158-167Article in journal (Refereed) Published
Abstract [en]

Objectives The aim of the study was to determine whether a decrease in sexual desire is more prevalent among women using hormonal contraception than among women using hormone-free contraception, and whether a decrease increases the risk of changing to another contraceptive method. Methods A validated questionnaire was posted to 3740 women (aged 22, 25 or 28 years) living in Sweden. Descriptive statistics were used to present the results; differences between groups were tested using χ(2) analyses. A multiple logistic regression model was used for analysis of possible confounders. Results The response rate was 50%. The majority (81%) of respondents used some kind of contraception, and 88% were generally satisfied with the method used. Regardless of the type of method, 27% of hormonal contraceptive users reported a decrease in sexual desire that they attributed to their use of hormonal contraception, whereas only 12% of women using hormone-free contraception reported a decrease in sexual desire (p<0.01). This twofold risk of a decrease in sexual desire was shown in the multiple regression analysis to be independent of age group, depression, BMI, educational level and parity. However, having a partner was found to be a factor of equal importance: women with partners experienced reduced desire twice as often as women without partners. The observed odds ratio for planning to stop hormonal contraception or to change to a different type due to reduced desire was 8.16 (95% confidence interval 6.65-10.1) among women who had had the same experience during a previous period of hormonal contraceptive use. Conclusions Women using hormonal contraception were more likely to experience reduced sexual desire compared with women using hormone-free contraception. Experiencing reduced desire was a strong predictive factor for women to change contraceptive method.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2016
Keywords
Cross-sectional study; Hormonal contraceptives; Intrauterine devices; Progestin; Sexual desire
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-126286 (URN)10.3109/13625187.2015.1079609 (DOI)000375025700007 ()26406399 (PubMedID)
Available from: 2016-03-22 Created: 2016-03-21 Last updated: 2018-03-26
Berin, E., Hammar, M., Lindblom, H., Lindh Åstrand, L. & Spetz, A.-C. (2016). Resistance training for hot flushes in postmenopausal women: Randomized controlled trial protocol. Maturitas, 85, 96-103
Open this publication in new window or tab >>Resistance training for hot flushes in postmenopausal women: Randomized controlled trial protocol
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2016 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 85, p. 96-103Article in journal (Refereed) Published
Abstract [en]

Objectives: Hot flushes and night sweats affect 75% of all women after menopause and is a common reason for decreased quality of life in mid-aged women. Hormone therapy is effective in ameliorating symptoms but cannot be used by all women due to contraindications and side effects. Engagement in regular exercise is associated with fewer hot flushes in observational studies, but aerobic exercise has not proven effective in randomized controlled trials. It remains to be determined whether resistance training is effective in reducing hot flushes and improves quality of life in symptomatic postmenopausal women. The aim of this study is to investigate the effect of standardized resistance training on hot flushes and other health parameters in postmenopausal women. Study design: This is an open, parallel-group, randomized controlled intervention study conducted in Linkoping, Sweden. Sixty symptomatic and sedentary postmenopausal women with a mean of at least four moderate to severe hot flushes per day or 28 per week will be randomized to an exercise intervention or unchanged physical activity (control group). The intervention consists of 15 weeks of standardized resistance training performed three times a week under supervision of a physiotherapist. Main outcome measures: The primary outcome is hot flush frequency assessed by self-reported hot flush diaries, and the difference in change from baseline to week 15 will be compared between the intervention group and the control group. Conclusion: The intention is that this trial will contribute to the evidence base regarding effective treatment for hot flushes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD, 2016
Keywords
Menopause; Hot flashes; Resistance training; Vasomotor symptoms; Exercise; Study protocol
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-126250 (URN)10.1016/j.maturitas.2015.12.015 (DOI)000370897300016 ()26857887 (PubMedID)
Note

Funding Agencies|Swedish Research Council [2014-2781]; Region Ostergotland, Sweden

Available from: 2016-03-21 Created: 2016-03-21 Last updated: 2018-03-22
Boström, A., Thulin, K., Fredriksson, M., Reese, D., Rockborn, P. & Hammar, M. (2016). Risk factors for acute and overuse sport injuries in Swedish children 11 to 15 years old: What about resistance training with weights?. Scandinavian Journal of Medicine and Science in Sports, 26(3), 317-323
Open this publication in new window or tab >>Risk factors for acute and overuse sport injuries in Swedish children 11 to 15 years old: What about resistance training with weights?
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2016 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 26, no 3, p. 317-323Article in journal (Refereed) Published
Abstract [en]

To determine the 1-year self-reported incidence of overuse and traumatic sport injuries and risk factors for injuries in children participating in a summer sports camp representing seven different sports. 4363 children, 11 to 15 years old participating in a summer camp in seven different sports answered a questionnaire. Injury in this cross-sectional study was defined as a sport-related trauma or overload leading to pain and dysfunction preventing the person from participation in training or competition for at least 1 week. A number of risk factors for injury were investigated such as sex, age, number of hours spent on training in general, and on resistance training with weights. Nearly half [49%, 95% confidence interval (CI) 48–51%] of the participants had been injured as a result of participation in a sport during the preceding year, significantly more boys than girls (53%, 95% CI 50–55% vs 46%, 95% CI 43–48%; P < 0.001). Three factors contributed to increased incidence of sport injuries: age, sex, and resistance training with weights. Time spent on resistance training with weights was significantly associated with sport injuries in a logistic regression analysis. In children age 11 to 15 years, the risk of having a sport-related injury increased with age and occurred more often in boys than in girls. Weight training was the only modifiable risk factor that contributed to a significant increase in the incidence of sport injuries.

Place, publisher, year, edition, pages
John Wiley & Sons, 2016
Keywords
Sport injuries, adolescents, overuse injury, traumatic injury, sex, resistance training, weight training, children
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:liu:diva-125262 (URN)10.1111/sms.12432 (DOI)000371247200009 ()25727791 (PubMedID)
Note

Funding agency:  County Council of Ostergotland

Available from: 2016-02-18 Created: 2016-02-18 Last updated: 2017-11-30Bibliographically approved
Romu, T., West, J., Spetz, A.-C., Lindblom, H., Lindh Åstrand, L., Hammar, M., . . . Dahlqvist Leinhard, O. (2016). The effect of flip-angle on body composition using calibrated water-fat MRI.. In: : . Paper presented at International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Singapore, May 7-13, 2016.
Open this publication in new window or tab >>The effect of flip-angle on body composition using calibrated water-fat MRI.
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2016 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

This study tested how the flip angle affects body composition analysis by MRI, if adipose tissue is used as an internal intensity reference. Whole-body water-fat images with flip angle 5° and 10° were collected from 29 women in an ongoing study. The images were calibrated based on the adipose tissue signal and whole-body total adipose, lean and soft tissue volumes were measured. A mean difference of 0.29 L, or 0.90 % of the average volume, and a coefficient of variation of 0.40 % was observed for adipose tissue.

National Category
Radiology, Nuclear Medicine and Medical Imaging Medical Image Processing
Identifiers
urn:nbn:se:liu:diva-128989 (URN)
Conference
International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Singapore, May 7-13, 2016
Available from: 2016-06-07 Created: 2016-06-07 Last updated: 2016-06-22Bibliographically approved
West, J., Romu, T., Spetz, A.-C., Lindblom, H., Lindh Åstrand, L., Borga, M., . . . Dahlqvist Leinhard, O. (2015). Automatic combined whole-body muscle and fat volume quantification using water-fat separated MRI in postmenopausal women. In: International Society for Magnetic Resonance in Medicine Annual Meeting: Proceedings. Paper presented at 23rd International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Toronto, Ontario, Canada, May 30 - June 5, 2015.
Open this publication in new window or tab >>Automatic combined whole-body muscle and fat volume quantification using water-fat separated MRI in postmenopausal women
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2015 (English)In: International Society for Magnetic Resonance in Medicine Annual Meeting: Proceedings, 2015Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Quantitative and exact measurements of fat and muscle in the body are important when addressing some of the greatest health-challenges today. In this study whole-body combined regional muscle and fat volume quantification was validated in a group of postmenopausal women, where the body composition is changing. Twelve subjects were scanned with a 4-echo 3D gradient-echo sequence. Water and fat image volumes were calculated using IDEAL, and image intensity correction was performed. Subsequently, automatic tissue segmentation was established using non-rigid morphon based registration. Whole-body regional fat and muscle segmentation could be performed with excellent test-retest reliability, in a single 7-minutes MR-scan.

National Category
Radiology, Nuclear Medicine and Medical Imaging Medical Image Processing
Identifiers
urn:nbn:se:liu:diva-128992 (URN)
Conference
23rd International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Toronto, Ontario, Canada, May 30 - June 5, 2015
Available from: 2016-06-07 Created: 2016-06-07 Last updated: 2016-06-23Bibliographically approved
Lindh Falk, A., Hammar, M. & Nyström, S. (2015). Does gender matter?: Differences between students at an interprofessional training ward. Journal of Interprofessional Care, 29(6), 616-621
Open this publication in new window or tab >>Does gender matter?: Differences between students at an interprofessional training ward
2015 (English)In: Journal of Interprofessional Care, ISSN 1356-1820, E-ISSN 1469-9567, Vol. 29, no 6, p. 616-621Article in journal (Refereed) Published
Abstract [en]

Studies on graduates’ transitions from education into clinical work highlight inequalities concerning how women and men experience their professional learning and development. This study explores how female and male students from different programs within the health care education system, i.e. medicine, nursing, occupational therapy and physiotherapy programmes, experience an IPTW as a part of their professional identity formation.

Students from the medicine, nursing, physiotherapy, and occupational therapy programmes collaborate in teams during two weeks at one of three IPTWs at the medical school, Linköping University. They together take the responsibility for diagnosis, treatment and rehabilitation of the patients, albeit with professional supervisors as support. During 2010 to 2011 454 (93%) of the 488 students who practiced at the IPTWs answered a questionnaire on their experiences of the IPTW. The students stated that the IPTW had positively influenced their professional development. The female and male medical students were significantly less positive than other female and male students, respectively, concerning the value of IPTW. The male students from all programmes were slightly, but significantly, less positive than all the female students. These findings show that students “do gender” as an integral part of the educational practice. It is important to scrutinize the IPTW as an educational practice, influencing students’ preparation for future work. Gender should be discussed during the IPTW rotation but also in general during the curriculum for all healthcare programmes.

 

Place, publisher, year, edition, pages
Taylor & Francis, 2015
Keywords
IPTW, professional development, gender, questionnaire
National Category
Pedagogical Work
Identifiers
urn:nbn:se:liu:diva-121056 (URN)10.3109/13561820.2015.1047491 (DOI)000366450200017 ()
Available from: 2015-09-04 Created: 2015-09-04 Last updated: 2017-12-04
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