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Hammar, Mats
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Publications (10 of 141) Show all publications
Nilsson, S., Henriksson, M., Berin, E., Engblom, D., Holm, A.-C. S. & Hammar, M. (2022). Resistance training reduced luteinising hormone levels in postmenopausal women in a substudy of a randomised controlled clinical trial: A clue to how resistance training reduced vasomotor symptoms. PLOS ONE, 17(5), Article ID e0267613.
Open this publication in new window or tab >>Resistance training reduced luteinising hormone levels in postmenopausal women in a substudy of a randomised controlled clinical trial: A clue to how resistance training reduced vasomotor symptoms
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2022 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 17, no 5, article id e0267613Article in journal (Refereed) Published
Abstract [en]

Background: Vasomotor symptoms (VMS) are common around menopause. Menopausal hormone therapy is the most effective treatment for VMS. Physical exercise has been proposed as an alternative treatment since physically active women have previously been found to experience fewer VMS than inactive women. In our randomised controlled trial on resistance training to treat VMS, sympoms were reduced by 50% in the intervention group compared with the control group.

Objectives: To propose a mechanism to explain how resistance training reduced VMS and to assess if luteinizing hormone (LH) and follicle stimulating hormone (FSH) were affected in accordance with the proposed mechanism.

Trial design and methods: A substudy of a randomized controlled trial on 65 postmenopausal women with VMS and low physical activity who were randomised to 15 weeks of resistance training three times per week (n = 33) or to a control group (n = 32). To be regarded compliant to the intervention we predecided a mean of two training sessions per week. The daily number of VMS were registered before and during the 15 weeks. Blood samples were drawn for analysis of LH and FSH at baseline and after 15 weeks.

Results: LH decreased significantly in the compliant intervention group compared with the control group (-4.0±10.6 versus 2.9±9.0, p = 0.028 with Mann-Whitney U test). FSH also decreased in the compliant intervention group compared with the control group, however not enough to reach statistical significance (-3.5±16.3 versus 3.2±18.2, p = 0.063 with Mann-Whitney U test). As previously published the number of hot flushes decreased significantly more in the intervention group than in the control group but there was no association between change in LH or FSH and in number of VMS.

Conclusions: We propose that endogenous opiods such as β-endorphin or dynorphin produced during resistance training decreased VMS by stimulating KNDγ-neurons to release neurokinin B to the hypothalamic thermoregulatory centre. Through effects on KNDγ-neurons, β-endorphin could also inhibit GnRH and thereby decrease the production of LH and FSH. The significanty decreased LH in the compliant intervention group compared with the control group was in accordance with the proposed mechanism.

Place, publisher, year, edition, pages
Public Library of Science (PLoS), 2022
National Category
Gynaecology, Obstetrics and Reproductive Medicine Cardiology and Cardiovascular Disease
Identifiers
urn:nbn:se:liu:diva-192233 (URN)10.1371/journal.pone.0267613 (DOI)000951362800009 ()35617333 (PubMedID)2-s2.0-85130785420 (Scopus ID)
Funder
Swedish Research Council, 2014-02781
Note

Funding: Swedish Research Council [2014-2781]; ALF-grants from the County Council of Ostergotland [RO-602001, RO-884981]

Available from: 2023-03-07 Created: 2023-03-07 Last updated: 2025-03-27
Leijon, I., Bladh, M., Finnström, O., Gäddlin, P.-O., Hammar, M., Nelson, N., . . . Sydsjö, G. (2020). God prognos för unga vuxna med mycket låg födelsevikt [Follow-up study of very low birthweight children in Sweden at the age of 27-28]. Läkartidningen, 117
Open this publication in new window or tab >>God prognos för unga vuxna med mycket låg födelsevikt [Follow-up study of very low birthweight children in Sweden at the age of 27-28]
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2020 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 117Article in journal (Refereed) Published
Abstract [en]

Studies show that very low birthweight can be an important risk factor for mental problems, disturbed fertility and neuroendocrine dysregulation. In a regional long-term study 56 of 86 adult individuals 27 to 28 years of age with a very low birthweight were compared with normal birthweight controls. Analyses of self-reported mental health, socio-demographic factors, sex hormone levels, and hair cortisol levels showed no significant differences between the groups. However, in order to analyse subgroups with different risk factors from the newborn period or children with a variety of social background factors, larger patient groups are needed.

Place, publisher, year, edition, pages
Stockholm, Sweden: Sveriges Läkarförbund, 2020
National Category
Pediatrics
Identifiers
urn:nbn:se:liu:diva-174497 (URN)33259050 (PubMedID)
Note

Självskattning av mental hälsa, psykosociala förhållanden och könshormonnivåer hos unga vuxna kvinnoroch män med mycket låg födelsevikt skilde sig inte från respektive kontroller med normal födelsevikt.

Kvinnorna med mycket låg födelsevikt undersökta i tonåren hade mindre grad av utagerande beteende än kontrollerna, skillnader som var utjämnade i vuxen ålder.

Kvinnorna med mycket låg födelsevikt uppvisade högre koncentrationer av morgonkortisol i saliv än kvinnorna i kontrollgruppen. Den kliniska relevansen är osäker, då inget samband med beteendeskalorna kunde påvisas och på grund av att spridningen av kortisolnivåerna var stor.

Available from: 2021-03-22 Created: 2021-03-22 Last updated: 2024-01-10Bibliographically approved
Leijon, I., Bladh, M., Finnström, O., Gäddlin, P.-O., Nelson, N., Hammar, M., . . . Sydsjö, G. (2020). Self-reported mental health and cortisol activity at 27-28 years of age in individuals born with very low birthweight. Acta Paediatrica, 109(5), 948-958
Open this publication in new window or tab >>Self-reported mental health and cortisol activity at 27-28 years of age in individuals born with very low birthweight
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2020 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 109, no 5, p. 948-958Article in journal (Refereed) Published
Abstract [en]

Aim

To assess mental health outcomes of very low birthweight (VLBW, <1500 g) subjects to adulthood and to examine salivary cortisol and hair cortisol levels and their relation to birth characteristics and mental health.

Methods

A Swedish regional cohort of 56 VLBW subjects and 55 full‐term controls were assessed at the ages 27‐28 with adult self‐reported scales and the mean of 2 days diurnal salivary cortisol and hair cortisol. The cohorts had been assessed at 15 years of age with youth self‐reported scales.

Results

There were no differences between the groups in youth self‐reported scales and adult self‐reported scores. The 24 participating VLBW girls scored lower on youth self‐reported scales externalising and total problem scores than the control girls. In adulthood, the 21 participating VLBW women had significantly higher morning concentrations of salivary cortisol than control women, P = .014. No significant associations were found between cortisol concentrations and adult self‐reported scales internalising, externalising and total scores.

Conclusion

Self‐reported mental health in VLBW subjects was comparable with normal birthweight controls indicating a satisfying transition from adolescence to adulthood. VLBW females had higher morning salivary cortisol concentrations, suggesting a gender difference. We found no correlations between cortisol and mental health.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2020
Keywords
adults; cortisol; longitudinal; low birthweight; mental health
National Category
Public Health, Global Health and Social Medicine
Identifiers
urn:nbn:se:liu:diva-162725 (URN)10.1111/apa.15093 (DOI)000500499300001 ()31732987 (PubMedID)2-s2.0-85076315484 (Scopus ID)
Note

Funding Agencies|County Council of Ostergotland; Futurum-the Academy for Health and Care, Region Jonkoping County, Sweden

Available from: 2019-12-19 Created: 2019-12-19 Last updated: 2025-02-20Bibliographically approved
Malmborg, A., Brynhildsen, J. & Hammar, M. (2019). A survey of young womens perceptions of the influence of the Levonorgestrel-Intrauterine System or copper-intrauterine device on sexual desire. Sexual & Reproductive HealthCare, 21, 75-80
Open this publication in new window or tab >>A survey of young womens perceptions of the influence of the Levonorgestrel-Intrauterine System or copper-intrauterine device on sexual desire
2019 (English)In: Sexual & Reproductive HealthCare, ISSN 1877-5756, E-ISSN 1877-5764, Vol. 21, p. 75-80Article in journal (Refereed) Published
Abstract [en]

Objectives: Few studies, with contradictory results, evaluate intrauterine contraceptives (IUC) and sexual function specifically. This study compares perception of sexual desire related to IUC use and aspects of sexual function in women who use the Lng-IUS with those using the Cu-IUD. Study design: A secondary analysis regarding IUC use based on a larger cross-sectional survey of contraceptive use in Sweden, conducted in 2013. In total, 153 IUC users (103 Cu-IUD and 50 Lng-IUS users) answered the questionnaire. The only inclusion criterion was intrauterine contraceptive use. Main outcome measures: Were self-reported sexual desire changes related to contraceptive method. We also analysed aspects of sexual functioning; sexual desire level, sexual activity, orgasm frequency, satisfaction with sex life and satisfaction of desire level. Results: A negative effect on sexual desire due to contraceptive method was reported by 28% of the Lng-IUS users and by 10.1% of the Cu-IUD users (p amp;lt; 0.05). Results were more marked after adjusting for age, body mass index, depression, parity, switching behaviour, and partnership (OR 5.0; CI: 1.8-13.8). The adjusted odds of reporting low sexual desire level (never or almost never feeling sexual desire) (OR 3.5; CI: 1.1-11.2) as well as low satisfaction with sex life (OR 2.7; CI: 1.2-6.3) was higher in the Lng-IUS group (adjusted for same confounders as above). Conclusions: The women in this study using the Lng-IUS more often report negative sexual desire effects of their contraception as well as lower sexual desire level compared with women using the Cu-IUD.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD, 2019
Keywords
Contraception; Intrauterine contraceptives; Lng-IUS; Cu IUD; Sexual desire; Sexual function
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-161009 (URN)10.1016/j.srhc.2019.06.007 (DOI)000485335500013 ()31395237 (PubMedID)
Note

Funding Agencies|Region of Ostergotland

Available from: 2019-10-16 Created: 2019-10-16 Last updated: 2025-02-11
Hammar, M., Larsson, E., Bladh, M., Finnström, O., Gäddlin, P.-O., Leijon, I., . . . Sydsjö, G. (2018). A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile. Systems biology in reproductive medicine, 64(3), 207-215
Open this publication in new window or tab >>A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile
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2018 (English)In: Systems biology in reproductive medicine, ISSN 1939-6376, Vol. 64, no 3, p. 207-215Article in journal (Refereed) Published
Abstract [en]

Environmental factors during the fetal period may adversely affect reproductive functions in men being born with very low birth weight (VLBW, <1500 g). The objective of this prospective, controlled cohort study was to investigate if VLBW men have an altered reproductive hormone profile compared with men born at term. The study group initially consisted of all VLBW boys live-born between 1 February 1987 and 30 April 1988 in the south-east region of Sweden (n = 47). A control child was chosen born at term, at the same hospital, with the same parity, without malformations, and next in order after each VLBW child who survived the first four weeks (n = 45). The present follow-up was performed when the men were 26-28 years of age and included measurements of serum hormone levels, hair testosterone concentration, and anthropometric data. Also life-style questionnaires were collected from 26 VLBW men and 19 controls. The VLBW group (n = 26) had higher median levels of serum estradiol, 84.5 pmol/L than controls (n = 19), 57.5 pmol/L (p = 0.008). There was no significant correlation between serum estradiol and BMI (r = 0.06, p = 0.74). There were no differences in other hormone levels or the reproductive pattern between the groups. In conclusion, even though there was a statistically significant difference in estradiol levels between the groups, both groups had low normal mean levels of questionable clinical significance. The reproductive pattern was similar in the two groups and in this study being born VLBW does not seem to affect these measured aspects of reproduction.

ABBREVIATIONS: ADHD: attention deficit hyperactive disorder; AGA: average for gestational age; BMI: body mass index; CP: cerebral palsy; DHT: dihydrotestosterone; FSH: follicle stimulating hormone; LBW: low birth weight; LH: luteinizing hormone; SAD: sagittal abdominal diameter; SGA: small for gestational age; SHBG: sex hormone binding globulin; TSH: thyroid stimulating hormone; T3: triiodothyronine; T4: thyroxin; VLBW: very low birth weight.

Place, publisher, year, edition, pages
Taylor & Francis, 2018
Keywords
Very low birth weight, follow-up study, preterm, reproduction
National Category
Pediatrics
Identifiers
urn:nbn:se:liu:diva-148117 (URN)10.1080/19396368.2018.1448901 (DOI)000432658800007 ()29583035 (PubMedID)2-s2.0-85044443280 (Scopus ID)
Note

Funding agencies: County Council of Ostergotland (ALF grants); Futurum-the Academy for Health and Care, Region Jonkoping County, Sweden

Available from: 2018-05-30 Created: 2018-05-30 Last updated: 2024-01-10Bibliographically approved
Liffner, S., Hammar, M., Bladh, M., Nedstrand, E., Rodriguez-Martinez, H. & Sydsjö, G. (2017). Men becoming fathers by intracytoplasmic sperm injection were more often born small for gestational to age. Asian Journal of Andrology, 19(1), 103-106
Open this publication in new window or tab >>Men becoming fathers by intracytoplasmic sperm injection were more often born small for gestational to age
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2017 (English)In: Asian Journal of Andrology, ISSN 1008-682X, E-ISSN 1745-7262, Vol. 19, no 1, p. 103-106Article in journal (Refereed) Published
Abstract [en]

Being born with nonoptimal birth characteristics decreases the chance of becoming a father. Urogenital malformations as well as metabolic syndrome are more common in men born small for gestational age (SGA) and could be contributing factors to the reduced fertility rate seen in these men. It could imply that men becoming fathers by assisted reproductive technology (ART) more often are born with low birth weight (LBW), preterm, and/or SGA than men conceiving without treatment and also that men where intracytoplasmic sperm injection (ICSI) had to be performed more often are born with nonoptimal birth characteristics than men where conventional in vitro fertilization (IVF) successfully could be used. In this retrospective, case-control study using Swedish national registers, we compared the birth characteristics of 1206 men who have become fathers by ART with a control group consisting of age-matched men who became fathers without treatment. The differences in birth characteristics between men becoming fathers by IVF and ICSI were also assessed. For men becoming fathers by ART, OR of being born with LBW was 1.66 (95% CI = 1.17-2.36) compared with fathers who conceived without treatment. OR of being born prematurely was 1.32 (95% CI = 1.00-1.77). Men becoming fathers via ICSI had a doubled increased likelihood of being born SGA compared with men who became fathers via IVF (OR = 2.12; 95% CI = 1.17-3.83). In conclusion, we have found that men becoming fathers by ICSI treatments had more often been born SGA than men becoming fathers by conventional IVF.

Place, publisher, year, edition, pages
MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2017
Keywords
infertility; intracytoplasmic sperm injection; in vitro fertilization; low birth weight; preterm; small for gestational age
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-134486 (URN)10.4103/1008-682X.178848 (DOI)000392108300018 ()27184547 (PubMedID)
Note

Funding Agencies|County Council of Ostergotland

Available from: 2017-02-15 Created: 2017-02-15 Last updated: 2025-02-11
Enblom, A., Steineck, G., Hammar, M. & Börjeson, S. (2017). Reduced Need for Rescue Antiemetics and Improved Capacity to Eat in Patients Receiving Acupuncture Compared to Patients Receiving Sham Acupuncture or Standard Care during Radiotherapy.. Evidence-based Complementary and Alternative Medicine, 2017, Article ID 5806351.
Open this publication in new window or tab >>Reduced Need for Rescue Antiemetics and Improved Capacity to Eat in Patients Receiving Acupuncture Compared to Patients Receiving Sham Acupuncture or Standard Care during Radiotherapy.
2017 (English)In: Evidence-based Complementary and Alternative Medicine, ISSN 1741-427X, E-ISSN 1741-4288, Vol. 2017, article id 5806351Article in journal (Refereed) Published
Abstract [en]

Objective. To evaluate if consumption of emesis-related care and eating capacity differed between patients receiving verum acupuncture, sham acupuncture, or standard care only during radiotherapy. Methods. Patients were randomized to verum (n = 100) or sham (n = 100) acupuncture (telescopic blunt sham needle) (median 12 sessions) and registered daily their consumption of antiemetics and eating capacity. A standard care group (n = 62) received standard care only and delivered these data once. Results. More patients in the verum (n = 73 of 89 patients still undergoing radiotherapy; 82%, Relative Risk (RR) 1.23, 95% Confidence Interval (CI) 1.01-1.50) and the sham acupuncture group (n = 79 of 95; 83%, RR 1.24, CI 1.03-1.52) did not need any antiemetic medications, as compared to the standard care group (n = 42 out of 63; 67%) after receiving 27 Gray dose of radiotherapy. More patients in the verum (n = 50 of 89; 56%, RR 1.78, CI 1.31-2.42) and the sham acupuncture group (n = 58 of 94 answering patients; 62%, RR 1.83, CI 1.20-2.80) were capable of eating as usual, compared to the standard care group (n = 20 of 63; 39%). Conclusion. Patients receiving acupuncture had lower consumption of antiemetics and better eating capacity than patients receiving standard antiemetic care, plausible by nonspecific effects of the extra care during acupuncture.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2017
National Category
Nursing
Identifiers
urn:nbn:se:liu:diva-136008 (URN)10.1155/2017/5806351 (DOI)000394876600001 ()28270851 (PubMedID)
Note

Funding agencies: Swedish Cancer Society; Region of Ostergotland; University of Linkoping; Cancer Rehabilitation Foundation; Swedish Institute of Health Research; Vardal Foundation for Healthcare Sciences and Allergy Research; Osher Center for Integrative Research, Karolin

Available from: 2017-03-24 Created: 2017-03-24 Last updated: 2018-12-19Bibliographically approved
Vikström, J., Sydsjö, G., Hammar, M., Bladh, M. & Josefsson, A. (2017). Risk of postnatal depression or suicide after in vitro fertilisation treatment: a nationwide case–control study. British Journal of Obstetrics and Gynecology, 124(3), 435-442
Open this publication in new window or tab >>Risk of postnatal depression or suicide after in vitro fertilisation treatment: a nationwide case–control study
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2017 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 124, no 3, p. 435-442Article in journal (Refereed) Published
Abstract [en]

Objective

To examine whether women who undergo in vitro fertilisation (IVF) treatment are at greater risk of postnatal suicide or postnatal depression (PND) requiring psychiatric care, compared with women who conceive spontaneously.

Design

Case–control study using data from national registers.

Setting

Sweden during the period 2003–2009.

Population

Cases were 3532 primiparous women who had given birth following IVF treatment. An aged-matched control group of 8553 mothers was randomly selected from the medical birth register.

Methods

Logistic regression analyses were performed with PND as the outcome, and with known risk factors of PND as well as IVF/spontaneous birth as covariates.

Main outcome measures

Postnatal depression (PND), defined as diagnoses F32–F39 of the tenth edition of the International Classification of Diseases (ICD–10), within 12 months of childbirth.

Results

Initial analyses showed that PND was more common in the control group than in the IVF group (0.8 versus 0.4%; P = 0.04); however, these differences disappeared when confounding factors were controlled for. A history of any psychiatric illness (P = 0.000; odds ratio, OR = 25.5; 95% confidence interval, 95% CI = 11.7–55.5), any previous affective disorder (P = 0.000; OR = 26.0; 95% CI = 10.5–64.0), or specifically a personality disorder (P = 0.028; OR = 3.8; 95% CI = 1.2–12.7) increased the risk of PND. No woman in either group committed suicide during the first year after childbirth.

Conclusions

Whereas mothers who receive IVF treatment are not at increased risk of PND, the risk is increased among mothers with a history of mental illness. Tweetable abstract A Swedish study on 3532 women showed that IVF treatment does not increase the risk of postnatal depression.

Place, publisher, year, edition, pages
Chichester: Wiley-Blackwell Publishing Inc., 2017
Keywords
In vitro fertilisation, infertility treatment, postnatal depression, postnatal mental illness
National Category
Gynaecology, Obstetrics and Reproductive Medicine Public Health, Global Health and Social Medicine Geriatrics General Practice
Identifiers
urn:nbn:se:liu:diva-132763 (URN)10.1111/1471-0528.13788 (DOI)000397007500016 ()26663705 (PubMedID)2-s2.0-84983109530 (Scopus ID)
Available from: 2016-11-23 Created: 2016-11-23 Last updated: 2025-05-23Bibliographically approved
Malmborg, A., Persson, E., Brynhildsen, J. & Hammar, M. (2016). Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women. European journal of contraception & reproductive health care, 21(2), 158-167
Open this publication in new window or tab >>Hormonal contraception and sexual desire: A questionnaire-based study of young Swedish women
2016 (English)In: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 21, no 2, p. 158-167Article in journal (Refereed) Published
Abstract [en]

Objectives The aim of the study was to determine whether a decrease in sexual desire is more prevalent among women using hormonal contraception than among women using hormone-free contraception, and whether a decrease increases the risk of changing to another contraceptive method. Methods A validated questionnaire was posted to 3740 women (aged 22, 25 or 28 years) living in Sweden. Descriptive statistics were used to present the results; differences between groups were tested using χ(2) analyses. A multiple logistic regression model was used for analysis of possible confounders. Results The response rate was 50%. The majority (81%) of respondents used some kind of contraception, and 88% were generally satisfied with the method used. Regardless of the type of method, 27% of hormonal contraceptive users reported a decrease in sexual desire that they attributed to their use of hormonal contraception, whereas only 12% of women using hormone-free contraception reported a decrease in sexual desire (p<0.01). This twofold risk of a decrease in sexual desire was shown in the multiple regression analysis to be independent of age group, depression, BMI, educational level and parity. However, having a partner was found to be a factor of equal importance: women with partners experienced reduced desire twice as often as women without partners. The observed odds ratio for planning to stop hormonal contraception or to change to a different type due to reduced desire was 8.16 (95% confidence interval 6.65-10.1) among women who had had the same experience during a previous period of hormonal contraceptive use. Conclusions Women using hormonal contraception were more likely to experience reduced sexual desire compared with women using hormone-free contraception. Experiencing reduced desire was a strong predictive factor for women to change contraceptive method.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2016
Keywords
Cross-sectional study; Hormonal contraceptives; Intrauterine devices; Progestin; Sexual desire
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-126286 (URN)10.3109/13625187.2015.1079609 (DOI)000375025700007 ()26406399 (PubMedID)
Available from: 2016-03-22 Created: 2016-03-21 Last updated: 2025-02-11
Berin, E., Hammar, M., Lindblom, H., Lindh Åstrand, L. & Spetz, A.-C. (2016). Resistance training for hot flushes in postmenopausal women: Randomized controlled trial protocol. Maturitas, 85, 96-103
Open this publication in new window or tab >>Resistance training for hot flushes in postmenopausal women: Randomized controlled trial protocol
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2016 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 85, p. 96-103Article in journal (Refereed) Published
Abstract [en]

Objectives: Hot flushes and night sweats affect 75% of all women after menopause and is a common reason for decreased quality of life in mid-aged women. Hormone therapy is effective in ameliorating symptoms but cannot be used by all women due to contraindications and side effects. Engagement in regular exercise is associated with fewer hot flushes in observational studies, but aerobic exercise has not proven effective in randomized controlled trials. It remains to be determined whether resistance training is effective in reducing hot flushes and improves quality of life in symptomatic postmenopausal women. The aim of this study is to investigate the effect of standardized resistance training on hot flushes and other health parameters in postmenopausal women. Study design: This is an open, parallel-group, randomized controlled intervention study conducted in Linkoping, Sweden. Sixty symptomatic and sedentary postmenopausal women with a mean of at least four moderate to severe hot flushes per day or 28 per week will be randomized to an exercise intervention or unchanged physical activity (control group). The intervention consists of 15 weeks of standardized resistance training performed three times a week under supervision of a physiotherapist. Main outcome measures: The primary outcome is hot flush frequency assessed by self-reported hot flush diaries, and the difference in change from baseline to week 15 will be compared between the intervention group and the control group. Conclusion: The intention is that this trial will contribute to the evidence base regarding effective treatment for hot flushes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD, 2016
Keywords
Menopause; Hot flashes; Resistance training; Vasomotor symptoms; Exercise; Study protocol
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-126250 (URN)10.1016/j.maturitas.2015.12.015 (DOI)000370897300016 ()26857887 (PubMedID)
Note

Funding Agencies|Swedish Research Council [2014-2781]; Region Ostergotland, Sweden

Available from: 2016-03-21 Created: 2016-03-21 Last updated: 2024-03-22
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