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Gerdle, Björn
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Publications (10 of 165) Show all publications
Lindbäck, Y., Tropp, H., Enthoven, P., Gerdle, B., Abbott, A. & Öberg, B. (2017). Association between pain sensitivity in the hand and outcomes after surgery in patients with lumbar disc herniation or spinal stenosis.. European spine journal, 26(10), 2581-2588
Open this publication in new window or tab >>Association between pain sensitivity in the hand and outcomes after surgery in patients with lumbar disc herniation or spinal stenosis.
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2017 (English)In: European spine journal, ISSN 0940-6719, E-ISSN 1432-0932, Vol. 26, no 10, p. 2581-2588Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To investigate the association between pain sensitivity in the hand pre-surgery, and patient-reported outcomes (PROs) in function, pain and health pre- and post-surgery in patients with disc herniation or spinal stenosis.

METHODS: This is a prospective cohort study with 82 patients. Associations between pressure-, cold- and heat pain threshold (PPT, CPT, HPT) in the hand pre-surgery and Oswestry, VAS pain, EQ-5D, HADS, and Self-Efficacy Scale, pre- and three months post-surgery; were investigated with linear regression.

RESULTS: Patients with disc herniation more sensitive to pressure pain pre-surgery showed lower function and self-efficacy, and higher anxiety and depression pre-surgery, and lower function, and self-efficacy, and higher pain post-surgery. Results for cold pain were similar. In patients with spinal stenosis few associations with PROs were found and none for HPT and PROs.

CONCLUSIONS: Altered pain response in pressure- and cold pain in the hand, as a sign of widespread pain pre-surgery had associations with higher pain, lower function and self-efficacy post-surgery in patients with disc herniation.

Place, publisher, year, edition, pages
Springer, 2017
Keywords
Disc herniation, Quantitative sensory testing, Spinal stenosis, Spinal surgery, Widespread pain
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-136688 (URN)10.1007/s00586-017-4979-9 (DOI)000412841000013 ()28168345 (PubMedID)2-s2.0-85011710070 (Scopus ID)
Note

Funding agencies: Swedish Research Council [521-2019-3578]; Faculty of Medicine and Health, Linkoping University; County Council of Ostergotland, Linkoping, Sweden

Available from: 2017-05-12 Created: 2017-05-12 Last updated: 2018-05-03Bibliographically approved
Lemming, D., Börsbo, B., Sjörs, A., Lind, E.-B., Arendt-Nielsen, L., Graven-Nielsen, T. & Gerdle, B. (2017). Cuff Pressure Pain Detection Is Associated with Both Sex and Physical Activity Level in Nonathletic Healthy Subjects. Pain medicine (Malden, Mass.), 18(8), 1573-1581
Open this publication in new window or tab >>Cuff Pressure Pain Detection Is Associated with Both Sex and Physical Activity Level in Nonathletic Healthy Subjects
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2017 (English)In: Pain medicine (Malden, Mass.), ISSN 1526-2375, E-ISSN 1526-4637, Vol. 18, no 8, p. 1573-1581Article in journal (Refereed) Published
Abstract [en]

Purpose. The aim of this study was to evaluate pressure pain sensitivity on leg and arm in 98 healthy persons (50 women) using cuff algometry. Furthermore, associations with sex and physical activity level were investigated.

Method. Normal physical activity level was defined as Godin Leisure-Time Exercise Questionnaire (GLTEQ) score ≤ 45 and high activity level as GLTEQ > 45. A pneumatic double-chamber cuff was placed around the arm or leg where a single chamber was inflated. The cuff inflation rate (1 kPa/s) was constant, and pain intensity was registered continuously on a 10 cm electronic visual analogue scale (VAS). The pain detection threshold (PDT) was defined as when the pressure was perceived as painful, and pain tolerance (PTT) was when the subject terminated the cuff inflation. For PTT, the corresponding VAS score was recorded (VAS-PTT). The protocol was repeated with two chambers inflated.

Result. Only single cuff results are given. For women compared with men, the PDT was lower when assessed in the arm (P = 0.002), PTTs were lower in the arm and leg (P < 0.001), and the VAS-PTT was higher in the arm and leg (P < 0.033). Highly active participants compared with less active had higher PDT (P = 0.027) in the leg. Women showed facilitated spatial summation (P < 0.014) in the arm and leg and a steeper VAS slope (i.e., the slope of the VAS pressure curve between PDT and PPT) in the arm and leg (P < 0.003).

Conclusion. This study indicates that reduced pressure pain sensitivity is associated both with male sex and physical activity level.

Place, publisher, year, edition, pages
Oxford: Oxford University Press, 2017
Keywords
Experimental Pain, Pain Assessment, Cuff Pressure Sensitivity, Physical Activity, Sex, Gender
National Category
Physiotherapy Sport and Fitness Sciences Occupational Health and Environmental Health
Identifiers
urn:nbn:se:liu:diva-140496 (URN)10.1093/pm/pnw309 (DOI)000409845200018 ()
Note

Funding agencies: Swedish Research Council [K2011-69X-21874-01-6]; FORTE The Swedish Research Council for Health, Working life and Welfare [2010-0913]

Available from: 2017-09-05 Created: 2017-09-05 Last updated: 2018-04-16Bibliographically approved
Ståhl, C., Seing, I., Gerdle, B. & Sandqvist, J. (2017). Fair or square? Experiences of introducing a new method for assessing general work ability in a sickness insurance context. Disability and Rehabilitation, 1-10
Open this publication in new window or tab >>Fair or square? Experiences of introducing a new method for assessing general work ability in a sickness insurance context
2017 (English)In: Disability and Rehabilitation, ISSN 0963-8288, E-ISSN 1464-5165, p. 1-10Article in journal (Refereed) Epub ahead of print
Abstract [en]

PURPOSE: To study social validity and perceived fairness of a new method for assessing general work ability in a sickness insurance context. Assessments are based on self-reports, combined with examinations by physicians, and, if needed, occupational therapists, physiotherapists and/or psychologists.

MATERIALS AND METHODS: Interviews with 36 insurance officials, 10 physicians, and 36 sick-listed persons, which were analysed through a qualitative content analysis.

RESULTS: Insurance officials and physicians considered the method useful and that it facilitated benefit decisions. The experiences of persons who had undergone the assessment differed, where the dialog with insurance officials seemed to have had an influence on experiences of the assessment and the decisions it led to.

CONCLUSIONS: The perceived fairness and social validity of the assessment depended on how it was carried out; organisational conditions and priorities; communication skills; and decision outcomes. Professionals have an important pedagogical task in explaining the purpose and procedure of the assessment in order for the sick-listed to perceive it as fair rather than square, i.e., too standardised and not considering individual conditions. If the assessment could be used also for rehabilitative purposes, it could possibly be perceived as more acceptable also in cases where it leads to denied benefits. Implications for rehabilitation The perceived fairness of work ability assessments is dependent on procedures for the assessment, communication with the person, and the outcome. What is considered fair differs between assessing professionals and persons being assessed. Professionals may influence the perceptions of fairness through their way of communication. Assessments need to be coupled with rehabilitation measures in order to perceived as relevant and acceptable.

Place, publisher, year, edition, pages
Taylor & Francis, 2017
Keywords
Sweden, Work ability, return to work; assessment, sickness insurance, work disability
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:liu:diva-146118 (URN)10.1080/09638288.2017.1401675 (DOI)29145740 (PubMedID)2-s2.0-85034264041 (Scopus ID)
Available from: 2018-03-28 Created: 2018-03-28 Last updated: 2018-05-09Bibliographically approved
Järemo, P., Arman, M., Gerdle, B., Larsson, B. & Gottberg, K. (2017). Illness beliefs among patients with chronic widespread pain - associations with self-reported health status, anxiety and depressive symptoms and impact of pain. BMC Psychology, 5(24)
Open this publication in new window or tab >>Illness beliefs among patients with chronic widespread pain - associations with self-reported health status, anxiety and depressive symptoms and impact of pain
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2017 (English)In: BMC Psychology, E-ISSN 2050-7283, Vol. 5, no 24Article in journal (Refereed) Published
Abstract [en]

Chronic widespread pain (CWP) is a disabling condition associated with a decrease in health. Illness beliefs are individual and are acquired during life. Constraining beliefs may prevent patients from regaining health. Understanding these patients’ illness beliefs may be a way to improve the health care they are offered. The aim of this study was to describe illness beliefs among patients with CWP and associations with self-reported health, anxiety and depressive symptoms, and impact of pain.

Place, publisher, year, edition, pages
BioMed Central, 2017
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-146264 (URN)10.1186/s40359-017-0192-1 (DOI)28679446 (PubMedID)
Available from: 2018-04-05 Created: 2018-04-05 Last updated: 2018-04-26
Tseli, E., Grooten, W. J., Stålnacke, B.-M., Boersma, K., Enthoven, P., Gerdle, B. & Äng, B. O. (2017). Predictors of multidisciplinary rehabilitation outcomes in patients with chronic musculoskeletal pain: protocol for a systematic review and meta-analysis. Systematic Reviews, 6(1), Article ID 199.
Open this publication in new window or tab >>Predictors of multidisciplinary rehabilitation outcomes in patients with chronic musculoskeletal pain: protocol for a systematic review and meta-analysis
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2017 (English)In: Systematic Reviews, E-ISSN 2046-4053, Vol. 6, no 1, article id 199Article in journal (Refereed) Published
Abstract [en]

Background

Chronic musculoskeletal pain is a major public health problem. Early prediction for optimal treatment results has received growing attention, but there is presently a lack of evidence regarding what information such proactive management should be based on. This study protocol, therefore, presents our planned systematic review and meta-analysis on important predictive factors for health and work-related outcomes following multidisciplinary rehabilitation (MDR) in patients with chronic musculoskeletal pain.

Methods

We aim to perform a synthesis of the available evidence together with a meta-analysis of published peer-reviewed original research that includes predictive factors preceding MDR. Included are prospective studies of adults with benign, chronic (> 3 months) musculoskeletal pain diagnoses who have taken part in MDR. In the studies, associations between personal and rehabilitation-based factors and the outcomes of interest are reported. Outcome domains are pain, physical functioning including health-related quality of life, and work ability with follow-ups of 6 months or more. We will use a broad, explorative approach to any presented predictive factors (demographicsymptoms-relatedphysicalpsychosocialwork-related, and MDR-related) and these will be analyzed through (a) narrative synthesis for each outcome domain and (b) if sufficient studies are available, a quantitative synthesis in which variance-weighted pooled proportions will be computed using a random effects model for each outcome domain. The strength of the evidence will be evaluated using the Grading of Recommendations, Assessment, Development and Evaluation.

Discussion

The strength of this systematic review is that it aims for a meta-analysis of prospective cohort or randomized controlled studies by performing an extensive search of multiple databases, using an explorative study approach to predictive factors, rather than building on single predictor impact on the outcome or on predefined hypotheses. In this way, an overview of factors central to MDR outcome can be made and will help strengthen the evidence base and inform a wide readership including health care practitioners and policymakers.

Place, publisher, year, edition, pages
BioMed Central, 2017
Keywords
Chronic musculoskeletal pain; Literature review; Meta-analysis; Multidisciplinary rehabilitation; Prognostic factors; Treatment outcome
National Category
Neurology
Identifiers
urn:nbn:se:liu:diva-146339 (URN)10.1186/s13643-017-0598-0 (DOI)29020989 (PubMedID)2-s2.0-85030844165 (Scopus ID)
Available from: 2018-04-07 Created: 2018-04-07 Last updated: 2018-04-27Bibliographically approved
Jöud, A., Björk, J., Gerdle, B., Grimby-Ekman, A. & Larsson, B. (2017). The association between pain characteristics, pain catastrophizing and health care use: Baseline results from the SWEPAIN cohort. Scandinavian Journal of Pain, 16, 122-128, Article ID S1877-8860(17)30122-2.
Open this publication in new window or tab >>The association between pain characteristics, pain catastrophizing and health care use: Baseline results from the SWEPAIN cohort
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2017 (English)In: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 16, p. 122-128, article id S1877-8860(17)30122-2Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND AIM: Pain is common and adds to the global burden of disease. However, individuals suffering from pain are a heterogeneous group in terms of pain spreading, intensity and duration. While pain influences overall health care consultation not everyone with pain consult health care. To be able to provide health care matching the patients' needs increased knowledge about what factors determines the decision to consult health care is essential. The aim of this study was to explore the combined importance of pain spreading, intensity, duration and pain catastrophizing for consulting health care.

METHODS: In this cross-sectional study we used population based survey data from southeast Sweden (SWEPAIN) including 7792 individuals' aged 16-85 reporting pain. We used Modified Poisson regressions to analyse factors of importance related to the decision to consult health care.

RESULTS: High and moderate pain intensity, as compared to low, increases the probability of consulting health care (High PR=1.7 [95% CI 1.51-1.88], moderate PR=1.2 [1.15-1.41]). Having widespread pain, as compared to localised pain, increased the probability of consulting health (PR=1.2 [1.03-1.36). Pain duration was not associated with increased probability of consulting health care (PR=1.0 CI0.88-1.07). However an interaction (p=0.05) between pain duration and pain catastrophizing beliefs was seen indicating a combined importance of the two when consulting health care.

CONCLUSION: Our result suggests that pain intensity, pain spreading and pain catastrophizing independently influence the decision to consult health care while there is an interaction effect between pain duration and pain catastrophizing beliefs where the importance of pain catastrophizing believes differ with pain duration; the importance of pain catastrophizing believes differ with pain duration.

IMPLICATIONS: Treatment and rehabilitation strategies should incorporate this finding in order to meet the individual's needs focusing on the biopsychosocial model within health care focusing not only on actual pain reliefs but also on for example acceptance and behavioural changes.

Place, publisher, year, edition, pages
Walter de Gruyter, 2017
Keywords
Chronic pain, Health care utilisation, Pain catastrophizing
National Category
Other Health Sciences
Identifiers
urn:nbn:se:liu:diva-146111 (URN)10.1016/j.sjpain.2017.04.071 (DOI)28850387 (PubMedID)2-s2.0-85019552538 (Scopus ID)
Available from: 2018-03-28 Created: 2018-03-28 Last updated: 2018-05-04Bibliographically approved
Peterson, A., Carlfjord, S., Schaller, A., Gerdle, B. & Larsson, B. (2017). Using education and support strategies to improve the way nurses assess regular and transient pain: A quality improvement study of three hospitals. Scandinavian Journal of Pain, 16(1), 15-21
Open this publication in new window or tab >>Using education and support strategies to improve the way nurses assess regular and transient pain: A quality improvement study of three hospitals
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2017 (English)In: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 16, no 1, p. 15-21Article in journal (Refereed) Published
Abstract [en]

Background and aims

Systematic and regular pain assessment has been shown to improve pain management. Well-functioning pain assessments require using strategies informed by well-established theory. This study evaluates documented pain assessments reported in medical records and by patients, including reassessment using a Numeric Rating Scale (NRS) after patients receive rescue medication.

Methods

Documentation surveys (DS) and patient surveys (PS) were performed at baseline (BL), after six months, and after 12 months in 44 in-patient wards at the three hospitals in Östergötland County, Sweden. Nurses and nurse assistants received training on pain assessment and support. The Knowledge to Action Framework guided the implementation of new routines.

Results

According to DS pain assessment using NRS, pain assessment increased significantly: from 7% at baseline to 36% at 12 months (p < 0.001). For PS, corresponding numbers were 33% and 50% (p < 0.001). According to the PS, the proportion of patients who received rescue medication and who had been reassessed increased from 73% to 86% (p = 0.003). The use of NRS to document pain assessment after patients received rescue medication increased significantly (4% vs. 17%; p < 0.001).

Conclusions

After implementing education and support strategies, systematic pain assessment increased, an encouraging finding considering the complex contexts of in-patient facilities. However, the achieved assessment levels and especially reassessments related to rescue medication were clinically unsatisfactory. Future studies should include nursing staff and physicians and increase interactivity such as providing online education support. A discrepancy between documented and reported reassessment in association with given rescue medication might indicate that nurses need better ways to provide pain relief.

Implications

The fairly low level of patient-reported pain via NRS and documented use of NRS before and 12 months after the educational programme stresses the need for education on pain management in nursing education. Implementations differing from traditional educational attempts such as interactive implementations might complement educational programmes given at the work place. Standardized routines for pain management that include the possibility for nurses to deliver pain medication within well-defined margins might improve pain management and increase the use of pain assessments. Further research is needed that examines the large discrepancy between patient-reported pain management and documentation in the medical recording system of transient pain.

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
Assessment; Documentation; Implementation; Observation; Pain
National Category
Nursing
Identifiers
urn:nbn:se:liu:diva-145287 (URN)10.1016/j.sjpain.2017.01.013 (DOI)28850394 (PubMedID)2-s2.0-85013638729 (Scopus ID)
Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-03-01Bibliographically approved
Ertzgaard, P., Ohberg, F., Gerdle, B. & Grip, H. (2016). A new way of assessing arm function in activity using kinematic Exposure Variation Analysis and portable inertial sensors - A validity study. Manual Therapy, 21, 241-249
Open this publication in new window or tab >>A new way of assessing arm function in activity using kinematic Exposure Variation Analysis and portable inertial sensors - A validity study
2016 (English)In: Manual Therapy, ISSN 1356-689X, E-ISSN 1532-2769, Vol. 21, p. 241-249Article in journal (Refereed) Published
Abstract [en]

Portable motion systems based on inertial motion sensors are promising methods, with the advantage compared to optoelectronic cameras of not being confined to a laboratory setting. A challenge is to develop relevant outcome measures for clinical use. The aim of this study was to characterize elbow and shoulder motion during functional tasks, using portable motion sensors and a modified Exposure Variation Analysis (EVA) and evaluate system accuracy with optoelectronic cameras. Ten healthy volunteers and one participant with sequel after stroke performed standardised functional arm tasks. Motion was registered simultaneously with a custom developed motion sensor system, including gyroscopes and accelerometers, and an optoelectronic camera system. The EVA was applied on elbow and shoulder joints, and angular and angular velocity EVA plots was calculated. The EVA showed characteristic patterns for each arm task in the healthy controls and a distinct difference between the affected and unaffected arm in the participant with sequel after stroke. The accuracy of the portable system was high with a systematic error ranging between -1.2 degrees and 2.0 degrees. The error was direction specific due to a drift component along the gravity vector. Portable motion sensor systems have high potential as clinical tools for evaluation of arm function. EVA effectively illustrates joint angle and joint angle velocity patterns that may capture deficiencies in arm function and movement quality. Next step will be to manage system drift by including magnetometers, to further develop clinically relevant outcome variables and apply this for relevant patient groups. (C) 2015 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
CHURCHILL LIVINGSTONE, 2016
Keywords
Upper extremity motion analysis; Portable motion sensors; Exposure Variation Analysis; Validity
National Category
Basic Medicine
Identifiers
urn:nbn:se:liu:diva-127585 (URN)10.1016/j.math.2015.09.004 (DOI)000373615100033 ()26456185 (PubMedID)
Available from: 2016-05-03 Created: 2016-05-03 Last updated: 2018-01-10
Palstam, A., Larsson, A., Lofgren, M., Ernberg, M., Bjersing, J., Bileviciute-Ljungar, I., . . . Mannerkorpi, K. (2016). Decrease of fear avoidance beliefs following person-centered progressive resistance exercise contributes to reduced pain disability in women with fibromyalgia: secondary exploratory analyses from a randomized controlled trial. Arthritis Research & Therapy, 18(116)
Open this publication in new window or tab >>Decrease of fear avoidance beliefs following person-centered progressive resistance exercise contributes to reduced pain disability in women with fibromyalgia: secondary exploratory analyses from a randomized controlled trial
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2016 (English)In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 18, no 116Article in journal (Refereed) Published
Abstract [en]

Background: Fibromyalgia (FM) is characterized by persistent widespread pain, increased pain sensitivity and tenderness. Women with FM also report disability, in terms of negative consequences on activities of daily living. Our recent randomized controlled trial (RCT) is the first study of resistance exercise to show positive effects on pain disability. The resistance exercise program of our RCT emphasized active involvement of participants in planning and progression of the exercise, using the principles of person-acenteredness, to support each participants ability to manage the exercise and the progress of it. The aim of this sub-astudy was to investigate explanatory factors for reduced pain disability in women with FM participating in a 15-aweek person-acentered progressive resistance exercise program. Methods: A total of 67 women with FM were included in this sub-astudy of an RCT examining the effects of person-acentered progressive resistance exercise performed twice a week for 15 weeks. Tests of physical capacity and health-arelated questionnaires were assessed at baseline and after the intervention period. Multivariable stepwise regression was used to analyze explanatory factors for improvements in pain disability. Results: Reduced pain disability was explained by higher pain disability at baseline together with decreased fear avoidance beliefs about physical activity (R-2 = 28, p = 0.005). The improvements in the disability domains of recreation and social activity were explained by decreased fear avoidance beliefs about physical activity together with higher baseline values of each disability domain respectively (R-2 = 32, p = 0.025 and R-2 = 30, p = 0.017). The improvement in occupational disability was explained by higher baseline values of occupational disability (R-2 = 19, p = 0.001). Conclusion: The person-centered resistance exercise intervention, based on principles of self-efficacy, had a positive effect on recreational, social and occupational disability. The reduced pain disability seemed to be mediated by decreased fear avoidance beliefs. Age, symptom duration, pain intensity, and muscle strength at baseline had no explanatory value for reduced pain disability, indicating that the person-centered resistance exercise program has the potential to work for anyone with FM who has interest in physical exercise.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD, 2016
Keywords
Fibromyalgia; Pain; Disability; Resistance exercise; Person-centered
National Category
General Practice
Identifiers
urn:nbn:se:liu:diva-129153 (URN)10.1186/s13075-016-1007-0 (DOI)000376372300006 ()27209068 (PubMedID)
Note

Funding Agencies|Swedish Rheumatism Association; Swedish Research Council; Health and Medical Care Executive Board of Vastra Gotaland Region; Renee Eander foundation; The Norrbacka Eugenia foundation; Gothenburg Center for Person Centered Care (GPCC), FA insurance; ALF-LUA at Sahlgrenska University Hospital; Stockholm County Council (ALF)

Available from: 2016-06-13 Created: 2016-06-13 Last updated: 2018-01-10
Ernberg, M., Christidis, N., Ghafouri, B., Bileviciute-Ljungar, I., Löfgren, M., Larsson, A., . . . Gerdle, B. (2016). Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia. Arthritis Research & Therapy, 18(137)
Open this publication in new window or tab >>Effects of 15 weeks of resistance exercise on pro-inflammatory cytokine levels in the vastus lateralis muscle of patients with fibromyalgia
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2016 (English)In: Arthritis Research & Therapy, ISSN 1478-6354, E-ISSN 1478-6362, Vol. 18, no 137Article in journal (Refereed) Published
Abstract [en]

Background: This study aimed at investigating the effect of a resistance exercise intervention on the interstitial muscle levels of pro-inflammatory cytokines in fibromyalgia (FMS) and healthy controls (CON). Methods: Twenty-four female patients with FMS (54 +/- 8 years) and 27 female CON (54 +/- 9 years) were subjected to intramuscular microdialysis of the most painful vastus lateralis muscle before and after 15 weeks of progressive resistance exercise twice per week. Baseline dialysates were sampled in the resting muscle 140 min after insertion of the microdialysis catheter. The participants then performed repetitive dynamic contractions (knee extension) for 20 min, followed by 60 min rest. Pain intensity was assessed with a 0-100 mm visual analogue scale (VAS), and fatigue was assessed with Borgs RPE throughout microdialysis. Dialysates were sampled every 20 min and analyzed with Luminex for interleukin (IL)-1 beta, tumor necrosis factor (TNF) alpha, IL-6, and IL-8. Results: At both sessions and for both groups the dynamic contractions increased pain (P amp;lt; 0.012) and fatigue (P amp;lt; 0.001). The levels of TNF were lower in the FMS group than the CON group at both sessions (P amp;lt; 0.05), but none of the other cytokines differed between the groups. IL-6 and IL-8 increased after the dynamic contractions in both groups (P amp;lt; 0.010), while TNF increased only in CON (P amp;lt; 0.05) and IL-1 beta did not change. Overall pain intensity was reduced after the 15 weeks of resistance exercise in FMS (P amp;lt; 0.05), but there was no changes in fatigue or cytokine levels. Conclusion: Progressive resistance exercise for 15 weeks did not affect the interstitial levels of IL-1 beta, TNF, IL-6, and IL-8 in the vastus lateralis muscle of FMS patients or CON.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD, 2016
Keywords
Cytokines; Dynamic contractions; Exercise; Fibromyalgia; Microdialysis; Quadriceps
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:liu:diva-130286 (URN)10.1186/s13075-016-1041-y (DOI)000377977300001 ()27296860 (PubMedID)
Note

Funding Agencies|Swedish Rheumatism Association; Swedish Research Council [K2009-52P-20943-03-2, K2011-69X-21874-01-6, K2015-99X-21874-05-05]; Stockholm County Council (ALF); County Council of Ostergotland (ALF); AFA insurance; Norrbacka-Eugenia foundation; Health and Medical Care Executive Board of Vastra Gotaland Region; ALF-LUA at Sahlgrenska University Hospital; Gothenburg Center for Person Centered Care (GPCC)

Available from: 2016-08-01 Created: 2016-07-28 Last updated: 2017-11-28
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