Open this publication in new window or tab >>Show others...
2021 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 64, no 5, p. 1113-1120Article in journal (Refereed) Published
Abstract [en]
Aim/hypothesis Environmental factors are believed to contribute to the risk of developing type 1 diabetes. The aim of this study was to investigate how size for gestational age affects the risk of developing childhood type 1 diabetes.
Methods Using the Swedish paediatric diabetes quality register and the Swedish medical birth register, children with type 1 diabetes diagnosed between 2000 and 2012 (n = 9376) were matched with four control children (n = 37,504). Small for gestational age (SGA) and large for gestational age (LGA) were defined according to Swedish national standards. Data were initially analysed using Pearsons chi(2) and thereafter by single and multiple logistic regression models.
Results An equal proportion of children were born appropriate for gestational age, but children with type 1 diabetes were more often born LGA and less often born SGA than control children (4.7% vs 3.5% and 2.0% vs 2.6%, respectively, p < 0.001). In the multiple logistic regression analysis, being born LGA increased (adjusted OR 1.16 [95% CI 1.02, 1.32]) and SGA decreased (adjusted OR 0.76 [95% CI 0.63, 0.92]) the risk for type 1 diabetes, regardless of maternal BMI and diabetes.
Conclusions/interpretation Size for gestational age of Swedish children affects the risk of type 1 diabetes, with increased risk if the child is born LGA and decreased risk if the child is born SGA. Being born LGA is an independent risk factor for type 1 diabetes irrespective of maternal BMI and diabetes. Thus, reducing the risk for a child being born LGA might to some extent reduce the risk for type 1 diabetes.
Place, publisher, year, edition, pages
Springer, 2021
Keywords
Age at onset, Children, Epidemiology, Large for gestational age, Risk factor, Small for gestational age, Type 1 diabetes
National Category
Pediatrics
Identifiers
urn:nbn:se:liu:diva-173695 (URN)10.1007/s00125-021-05381-y (DOI)000615218500003 ()33544169 (PubMedID)2-s2.0-85100553941 (Scopus ID)
Note
Funding Agencies: Linköping University; Association of Local Authorities and Regions (SALAR); ALF Grants, Region Ostergotland
2021-03-022021-03-022024-01-10Bibliographically approved