liu.seSearch for publications in DiVA
Change search
Link to record
Permanent link

Direct link
Alternative names
Publications (10 of 91) Show all publications
Martinez Serrano, C., Marteinsdottir, I., Josefsson, A., Sydsjö, G., Theodorsson, E. & Rodriguez-Martinez, H. (2023). Epigenetic modifications appear in the human placenta following anxiety and depression during pregnancy. Placenta, 140, 72-79
Open this publication in new window or tab >>Epigenetic modifications appear in the human placenta following anxiety and depression during pregnancy
Show others...
2023 (English)In: Placenta, ISSN 0143-4004, E-ISSN 1532-3102, Vol. 140, p. 72-79Article in journal (Refereed) Published
Abstract [en]

Introduction: The future health of the offspring can be influenced by longstanding maternal anxiety and depression disorders during pregnancy. The present study aimed to explore the effect of psychiatric disorders during pregnancy on placental epigenetics. Methods: We measured DNA methylation patterns in term-placentas of women either suffering longstanding anxiety and depression symptoms (Index group, with overt symptoms), or a healthy population (Control, none/ only mild symptoms). Whole genome DNA methylation profiling was performed using the TruSeq (R) Methyl Capture EPIC Library Prep Kit (Illumina, San Diego, CA, USA) for library preparation and NGS technology for genomic DNA sequencing.Results: The results of high-throughput DNA methylation analysis revealed that the Index group had differential DNA methylation at epigenome-wide significance (p < 0.05) in 226 genes in the placenta. Targeted enrichment analyses identified hypermethylation of genes associated with psychiatric disorders (BRINP1, PUM1), and ion homeostasis (COMMD1), among others. The ECM (extracellular matrix)-receptor interaction pathway was significantly dysregulated in the Index group compared to the Control. In addition, DNA methylation/mRNA integration analyses revealed that four genes with key roles in neurodevelopment and other important processes (EPB41L4B, BMPR2, KLHL18, and UBAP2) were dysregulated at both, DNA methylation and transcriptome levels in the Index group compared to Control.Discussion: The presented results increase our understanding of how maternal psychiatric disorders may affect the newborn through placental differential epigenome, suggesting DNA methylation status as a biomarker when aiming to design new preventive techniques and interventions.

Place, publisher, year, edition, pages
W B SAUNDERS CO LTD, 2023
Keywords
Antenatal anxiety; Term-placentae; Methylation; Human
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-197856 (URN)10.1016/j.placenta.2023.07.298 (DOI)001055059200001 ()37549439 (PubMedID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden [392061, 472721, 891663]; European Union [2017-00946]; Swedish Research Council FORMAS, Stockholm, Sweden [2019-00288]; [661011]

Available from: 2023-09-18 Created: 2023-09-18 Last updated: 2025-02-11
Martinez-Serrano, C., Marteinsdottir, I., Josefsson, A., Sydsjö, G., Theodorsson, E. & Rodriguez-Martinez, H. (2022). Prenatal stress, anxiety and depression alter transcripts, proteins and pathways associated with immune responses at the maternal-fetal interface. Biology of Reproduction, 106(3), 449-462
Open this publication in new window or tab >>Prenatal stress, anxiety and depression alter transcripts, proteins and pathways associated with immune responses at the maternal-fetal interface
Show others...
2022 (English)In: Biology of Reproduction, ISSN 0006-3363, E-ISSN 1529-7268, Vol. 106, no 3, p. 449-462Article in journal (Refereed) Published
Abstract [en]

During pregnancy, the immune system is modified to allow developmental tolerance of the semi-allogeneic fetus and placenta to term. Pregnant women suffering from stress, anxiety, and depression show dysfunctions of their immune system that may be responsible for fetal and/or newborn disorders, provided that placental gene regulation is compromised. The present study explored the effects of maternal chronic self-perceived stress, anxiety, and depression during pregnancy on the expression of immune-related genes and pathways in term placenta. Pregnancies were clinically monitored with the Beck Anxiety Inventory (BAI) and Edinburgh Postnatal Depression Scale (EPDS). A cutoff threshold for BAI/EPDS of 10 divided patients into two groups: Index group (>10, n = 11) and a Control group (<10, n = 11), whose placentae were sampled at delivery. The placental samples were subjected to RNA-Sequencing, demonstrating that stress, anxiety, and depression during pregnancy induced a major downregulation of placental transcripts related to immune processes such as T-cell regulation, interleukin and cytokine signaling, or innate immune responses. Expression differences of main immune-related genes, such as CD46, CD15, CD8 alpha & beta ILR7 alpha, and CCR4 among others, were found in the Index group (P < 0.05). Moreover, the key immune-like pathway involved in humoral and cellular immunity named "Primary immunodeficiency" was significantly downregulated in the Index group compared with Controls. Our results show that mechanisms ruling immune system functions are compromised at the maternal-fetal interface following self-perceived depressive symptoms and anxiety during pregnancy. These findings may help unveil mechanisms ruling the impact of maternal psychiatric symptoms and lead to new prevention/intervention strategies in complicated pregnancies. Summary Sentence Mechanisms ruling immune system functions are compromised at the maternal-fetal interface following self-perceived depressive symptoms and anxiety during pregnancy.

Place, publisher, year, edition, pages
Oxford University Press, 2022
Keywords
antenatal stress; immune system; term-placentae; RNA-Seq; human
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-183253 (URN)10.1093/biolre/ioab232 (DOI)000756755300001 ()34935902 (PubMedID)
Available from: 2022-03-04 Created: 2022-03-04 Last updated: 2025-02-11Bibliographically approved
Stålberg, V., Krevers, B., Lingetun, L., Eriksson, T., Josefsson, A. & Lilliecreutz, C. (2022). Study protocol for a modified antenatal care program for pregnant women with a low risk for adverse outcomes - a stepped wedge cluster non-inferiority randomized trial. BMC Pregnancy and Childbirth, 22(1), Article ID 999.
Open this publication in new window or tab >>Study protocol for a modified antenatal care program for pregnant women with a low risk for adverse outcomes - a stepped wedge cluster non-inferiority randomized trial
Show others...
2022 (English)In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 22, no 1, article id 999Article in journal (Refereed) Published
Abstract [en]

Background: It is crucial to provide care based on individual needs. Swedish health care is obliged to give care on equal conditions for the entire population. The person with the greatest need should be given the most care, and the health care system should strive to be cost-efficient. Medical and technical advances have been significant during the last decades and the recent Covid-19 pandemic has caused a shift in health care, from in-person visits to virtual visits. The majority of pregnant women with a low risk assessment have an uncomplicated antenatal course without adverse events. These women probably receive excessive and unnecessary antenatal care. This study will investigate if an antenatal care program for healthy pregnant women with a low risk for adverse outcomes could be safely monitored with fewer in-person visits to a midwife, and with some of them replaced by virtual visits.

Methods: This is a non-inferiority trial where a stepped wedge cluster randomized controlled design will be used. Data collection includes register data and questionnaires that concern antenatal, obstetric and neonatal outcomes, patient- and caregiver-reported experiences, healthcare-economy, and implementation aspects. The modified antenatal care (MAC) study is performed in parts of the southeast of Sweden, which has approximately 8200 childbirths annually. At the start of the study, all antenatal care centers included in the study will use the same standard antenatal care (SAC) program. In the MAC program the in-person visits to a midwife will be reduced to four instead of eight, with two additional virtual meetings compared with the SAC program.

Discussion: This presented study protocol is informed by research knowledge. The protocol is expected to provide a good structure for future studies on changed antenatal care programs that introduce virtual visits for healthy pregnant women with a low risk for adverse outcomes, without risking quality, safety, and increased costs.

Place, publisher, year, edition, pages
London, United Kingdom: BioMed Central, 2022
Keywords
Antenatal care; Risk assessment; Low risk pregnancy; Maternal outcomes; Neonatal outcomes; Virtual care; Patient satisfaction; Caregiver satisfaction; Health economics; e-health
National Category
Nursing
Identifiers
urn:nbn:se:liu:diva-184559 (URN)10.1186/s12884-022-04406-7 (DOI)000779606500003 ()35395741 (PubMedID)2-s2.0-85127637021 (Scopus ID)
Note

Funding Agencies: county council of Östergötland, Sweden; Medical Research Council of Southeast Sweden (FORSS); Linköping University; ALF

Available from: 2022-05-03 Created: 2022-05-03 Last updated: 2022-05-30Bibliographically approved
Lilliecreutz, C., Josefsson, A., Mohammed, H., Josefsson, A. & Sydsjö, G. (2021). Mental disorders and risk factors among pregnant women with depressive symptoms in Sweden: A case-control study. Acta Obstetricia et Gynecologica Scandinavica, 100(6), 1068-1074
Open this publication in new window or tab >>Mental disorders and risk factors among pregnant women with depressive symptoms in Sweden: A case-control study
Show others...
2021 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 100, no 6, p. 1068-1074Article in journal (Refereed) Published
Abstract [en]

Introduction Identification of pregnant women suffering from depression or other mental disorders is a challenge for antenatal caregivers. The purpose of this case-control study was to describe mental disorders and the risk factors for mental disorders in women with depressive symptoms assessed with the Edinburgh Postnatal Depression Scale during the first trimester and to compare them with pregnant women without depressive symptoms. Material and methods In total, 2271 women answered the Edinburgh Postnatal Depression Scale at the first antenatal visit with a midwife. An Edinburgh Postnatal Depression Scale score of 13 or higher was considered to be screen-positive and these women were further assessed. Screen-negative pregnant women, matched for age and parity, were chosen as controls. Results In total, 149 (6.6%) women were found to be screen-positive. The majority (126, 85%) had at least one mental disorder or risk factor for mental disorder, such as depression (36.0%), anxiety (14.8%), or severe fear of childbirth (20.8%). The screen-positive women were more often smokers (16.1% vs 1.3%), unemployed (19.9% vs 1.3%), or on sick leave (25.3% vs 14.1%) during pregnancy and more often used selective serotonin reuptake inhibitor during pregnancy (14.2% vs 2.7%) compared with the screen-negative women (P<.001). Among the screen-negative women (n = 150) only three (2%) presented with symptoms of depression during pregnancy. Conclusions The Edinburgh Postnatal Depression Scale seems to be a valuable screening tool to detect depressive symptoms as well as other mental disorders during early pregnancy.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021
Keywords
depression; Edinburgh Postnatal Depression Scale; mental health; midwife; pregnancy
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-173477 (URN)10.1111/aogs.14051 (DOI)000609027800001 ()33474752 (PubMedID)2-s2.0-85100157605 (Scopus ID)
Note

Funding Agencies|ALF, Region Ostergotland [LIO-35 9731]

Available from: 2021-02-20 Created: 2021-02-20 Last updated: 2025-02-11Bibliographically approved
Marteinsdottir, I., Sydsjö, G., Olsen Faresjö, Å., Theodorsson, E. & Josefsson, A. (2021). Parity-related variation in cortisol concentrations in hair during pregnancy. British Journal of Obstetrics and Gynecology, 128(4), 637-644
Open this publication in new window or tab >>Parity-related variation in cortisol concentrations in hair during pregnancy
Show others...
2021 (English)In: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 128, no 4, p. 637-644Article in journal (Refereed) Published
Abstract [en]

Objective To investigate hair cortisol concentrations (HCC) monthly in pregnant women and to explore the effect of parity. Design Prospective cohort study from gestational week (GW) 26, at childbirth and postpartum. Setting An antenatal care clinic in southeast Sweden. Sample 390 pregnant women. Methods Cortisol was measured using radioimmunoassay in methanol extracts of ground hair samples. Main outcome measures Hair cortisol concentrations. Results Both primi- and multiparae exhibited an increase in HCC throughout pregnancy. Primiparae had significantly higher HCC in the latter part of the last trimester compared with multiparae (1 month P = 0.003, 2 months P = 0.038). The use of psychotropic medication in the first trimester correlated to HCC postpartum (P < 0.001). HCC in GW 14-17 was associated with HCC in GW 18-21 (primiparae and multiparae, P < 0.001), GW 22-25 (primiparae P = 0.036, multiparae P = 0.033), and 2 months postpartum (primiparae P = 0.049). HCC in GW 18-21 was associated with GW 22-25 in both primiparae (P < 0.001) and multiparae (P < 0.001) as well as 2 months prior to childbirth among primiparae (<0.037). In general, all estimates of HCC in pregnancy and postpartum showed a significant association between HCC for a specific month and the HCC in the previous month (all P < 0.001), except for the association of HCC among primiparae in GW 22-25 and 3 months prior to childbirth. Conclusions Increased cortisol concentrations in hair were observed during pregnancy, which decreased 3 months prior to childbirth in multiparae. The results indicate a quicker suppression of the hypothalamic CRH (corticotropin-releasing hormone) production by placenta CRH in multiparous women.

Place, publisher, year, edition, pages
WILEY, 2021
Keywords
Cortisol; hair; hypothalamic-pituitary-adrenal pregnancy axis; women
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-171401 (URN)10.1111/1471-0528.16542 (DOI)000583801200001 ()32985075 (PubMedID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden

Available from: 2020-11-30 Created: 2020-11-30 Last updated: 2025-02-11
Lindell, N., Bladh, M., Carlsson, A., Josefsson, A., Åkesson, K. & Samuelsson, U. (2021). Size for gestational age affects the risk for type 1 diabetes in children and adolescents: a Swedish national case-control study. Diabetologia, 64(5), 1113-1120
Open this publication in new window or tab >>Size for gestational age affects the risk for type 1 diabetes in children and adolescents: a Swedish national case-control study
Show others...
2021 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 64, no 5, p. 1113-1120Article in journal (Refereed) Published
Abstract [en]

Aim/hypothesis Environmental factors are believed to contribute to the risk of developing type 1 diabetes. The aim of this study was to investigate how size for gestational age affects the risk of developing childhood type 1 diabetes.

Methods Using the Swedish paediatric diabetes quality register and the Swedish medical birth register, children with type 1 diabetes diagnosed between 2000 and 2012 (n = 9376) were matched with four control children (n = 37,504). Small for gestational age (SGA) and large for gestational age (LGA) were defined according to Swedish national standards. Data were initially analysed using Pearsons chi(2) and thereafter by single and multiple logistic regression models.

Results An equal proportion of children were born appropriate for gestational age, but children with type 1 diabetes were more often born LGA and less often born SGA than control children (4.7% vs 3.5% and 2.0% vs 2.6%, respectively, p < 0.001). In the multiple logistic regression analysis, being born LGA increased (adjusted OR 1.16 [95% CI 1.02, 1.32]) and SGA decreased (adjusted OR 0.76 [95% CI 0.63, 0.92]) the risk for type 1 diabetes, regardless of maternal BMI and diabetes.

Conclusions/interpretation Size for gestational age of Swedish children affects the risk of type 1 diabetes, with increased risk if the child is born LGA and decreased risk if the child is born SGA. Being born LGA is an independent risk factor for type 1 diabetes irrespective of maternal BMI and diabetes. Thus, reducing the risk for a child being born LGA might to some extent reduce the risk for type 1 diabetes.

Place, publisher, year, edition, pages
Springer, 2021
Keywords
Age at onset, Children, Epidemiology, Large for gestational age, Risk factor, Small for gestational age, Type 1 diabetes
National Category
Pediatrics
Identifiers
urn:nbn:se:liu:diva-173695 (URN)10.1007/s00125-021-05381-y (DOI)000615218500003 ()33544169 (PubMedID)2-s2.0-85100553941 (Scopus ID)
Note

Funding Agencies: Linköping University; Association of Local Authorities and Regions (SALAR); ALF Grants, Region Ostergotland

Available from: 2021-03-02 Created: 2021-03-02 Last updated: 2024-01-10Bibliographically approved
Wolgast, E., Lilliecreutz, C., Sydsjö, G., Bladh, M. & Josefsson, A. (2021). The impact of major depressive disorder and antidepressant medication before and during pregnancy on obstetric and neonatal outcomes: A nationwide population-based study. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 257, 42-50
Open this publication in new window or tab >>The impact of major depressive disorder and antidepressant medication before and during pregnancy on obstetric and neonatal outcomes: A nationwide population-based study
Show others...
2021 (English)In: European Journal of Obstetrics, Gynecology, and Reproductive Biology, ISSN 0301-2115, E-ISSN 1872-7654, Vol. 257, p. 42-50Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the impact of major depressive disorder (MDD) and antidepressant medication before and during pregnancy on obstetric and neonatal outcomes. Study design: A national register-based cohort study of pregnant women born in Sweden, and their first child born in 2012-2015 (n = 262 329). Women diagnosed with MDD and who had redeemed an antidepressant one year before becoming pregnant ("before pregnancy") and women who were diagnosed with MDD and who had redeemed an antidepressant both before and during pregnancy ("before and during pregnancy") were compared with each other and with women who had neither been diagnosed with MDD nor been prescribed antidepressants (population controls). Results: In comparison to population controls, the "before pregnancy" and the "before and during pregnancy" groups had increased likelihoods of operative childbirth (aOR = 1.19, 95 % CI 1.12-1.27, aOR = 1.38, 95 % CI 1.28-1.48 respectively), and with an increased likelihood for the child being admitted to a neonatal intensive care unit (NICU) (aOR = 1.51, 95 % CI 1.17-1.95, aOR = 1.55, 95 % CI 1.14-2.11). Children born to mothers in the "before and during pregnancy" group had an increased likelihood of preterm birth (aOR = 1.72, 95 % CI 1.52-1.95,), while children to mothers in the "before pregnancy" group had an increased likelihood of low birthweight (aOR = 1.15, 95 % CI 1.00-1.33) compared to population controls. Women in the "before and during pregnancy" group had an increased likelihood for hyperemesis during pregnancy (aOR =1.93, 95 % CI = 1.60-2.32), having an operative childbirth (aOR =1.17, 95 % CI = 1.06-1.29) or a preterm birth (aOR = 1.53, 95 % CI = 1.28-1.81) compared to the "before pregnancy" group. Conclusions: Women with MDD and antidepressant medication prior to becoming pregnant are at increased risk for adverse obstetric and neonatal outcomes compared to women without an MDD. Continuation of antidepressant medication during pregnancy somewhat increased the risk for adverse obstetric and neonatal outcomes. (C) 2020 Published by Elsevier B.V.

Place, publisher, year, edition, pages
Elsevier, 2021
Keywords
Pregnancy; Antidepressant medication; Selective serotonin reuptake inhibitors; Antenatal; Depression; Discontinuation
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-173395 (URN)10.1016/j.ejogrb.2020.11.062 (DOI)000609227800007 ()33359923 (PubMedID)2-s2.0-85097915102 (Scopus ID)
Note

Funding Agencies|FORSS Grants, Region Ostergotland, Sweden [FORSS-385451]; ALF, Region Ostergotland, Sweden [LIO-35 9731]

Available from: 2021-02-20 Created: 2021-02-20 Last updated: 2025-02-11Bibliographically approved
Stålberg, V., Josefsson, A., Bladh, M. & Lilliecreutz, C. (2021). The risk of postpartum hemorrhage when lowering the oxytocin dose in planned cesarean section, a pilot study. Sexual & Reproductive HealthCare, 29, Article ID 100641.
Open this publication in new window or tab >>The risk of postpartum hemorrhage when lowering the oxytocin dose in planned cesarean section, a pilot study
2021 (English)In: Sexual & Reproductive HealthCare, ISSN 1877-5756, E-ISSN 1877-5764, Vol. 29, article id 100641Article in journal (Refereed) Published
Abstract [en]

Objectives: Oxytocin is the drug of choice in preventing postpartum hemorrhage (PPH). The aim was to compare the peroperative- and total blood loss within two hours and PPH after planned cesarean section (CS) when receiving 2.5 IU vs 5.0 IU of oxytocin in different risk groups for PPH. Study design: A pilot study including 927 women undergoing planned CS where women receiving 2.5 IU of oxytocin were compared to women receiving 5.0 IU of oxytocin. Main outcome measures: Data comparing peroperative blood loss, total blood loss within two hours and PPH were analyzed. Results: The women receiving 2.5 IU of oxytocin had a slightly higher peroperative blood loss, compared to the 5.0 IU group (476 ml vs 426 ml, p = 0.029). The total blood loss two hours after surgery showed no significant difference between the groups (626 ml vs 595 ml, p = 0.230). In the 2.5 IU group 13% had a blood loss > 1000 ml vs 10% in the 5 IU group (aOR 1.64, 95% CI = 1.05-2.56). When the women considered to be at high risk for postpartum hemorrhage were excluded, we found no difference in the likelihood for postpartum hemorrhage between the groups (aOR 1.13, 95% CI = 0.64-1.99). Conclusions: Women undergoing planned CS and receiving 2.5 IU of oxytocin had a slightly higher risk for postpartum hemorrhage in this study. However, a lower dose of 2.5 IU of oxytocin seems to be a safe option in planned CS for women without known risk factors for postpartum hemorrhage, but further research is needed to confirm these findings.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD, 2021
Keywords
Oxytocin; Oxytocin dose; Planned cesarean section; Postpartum hemorrhage; Uterine atony; Uterine contractility
National Category
Gynaecology, Obstetrics and Reproductive Medicine
Identifiers
urn:nbn:se:liu:diva-179832 (URN)10.1016/j.srhc.2021.100641 (DOI)000696626800009 ()34174496 (PubMedID)
Note

Funding Agencies|ALF grants, Region Odstergodtland, Sweden

Available from: 2021-10-04 Created: 2021-10-04 Last updated: 2025-02-11
Martinez Serrano, C., Marteinsdottir, I., Josefsson, A., Sydsjö, G., Theodorsson, E. & Rodriguez-Martinez, H. (2020). Expression of Stress-Mediating Genes is Increased in Term Placentas of Women with Chronic Self-Perceived Anxiety and Depression. Genes, 11(8), Article ID 869.
Open this publication in new window or tab >>Expression of Stress-Mediating Genes is Increased in Term Placentas of Women with Chronic Self-Perceived Anxiety and Depression
Show others...
2020 (English)In: Genes, E-ISSN 2073-4425, Vol. 11, no 8, article id 869Article in journal (Refereed) Published
Abstract [en]

Anxiety, chronical stress, and depression during pregnancy are considered to affect the offspring, presumably through placental dysregulation. We have studied the term placentae of pregnancies clinically monitored with the Becks Anxiety Inventory (BAI) and Edinburgh Postnatal Depression Scale (EPDS). A cutoff threshold for BAI/EPDS of 10 classed patients into an Index group (>10,n= 23) and a Control group (<10,n= 23). Cortisol concentrations in hair (HCC) were periodically monitored throughout pregnancy and delivery. Expression differences of main glucocorticoid pathway genes, i.e., corticotropin-releasing hormone (CRH), 11 beta-hydroxysteroid dehydrogenase (HSD11B2), glucocorticoid receptor (NR3C1), as well as other key stress biomarkers (Arginine Vasopressin, AVP and O-GlcNAc transferase, OGT) were explored in medial placentae using real-time qPCR and Western blotting. Moreover, gene expression changes were considered for their association with HCC, offspring, gender, and birthweight. A significant dysregulation of gene expression for CRH, AVP, and HSD11B2 genes was seen in the Index group, compared to controls, while OGT and NR3C1 expression remained similar between groups. Placental gene expression of the stress-modulating enzyme 11 beta-hydroxysteroid dehydrogenase (HSD11B2) was related to both hair cortisol levels (Rho = 0.54;p< 0.01) and the sex of the newborn in pregnancies perceived as stressful (Index,p< 0.05). Gene expression of CRH correlated with both AVP (Rho = 0.79;p< 0.001) and HSD11B2 (Rho = 0.45;p< 0.03), and also between AVP with both HSD11B2 (Rho = 0.6;p< 0.005) and NR3C1 (Rho = 0.56;p< 0.03) in the Control group but not in the Index group; suggesting a possible loss of interaction in the mechanisms of action of these genes under stress circumstances during pregnancy.

Place, publisher, year, edition, pages
MDPI, 2020
Keywords
antenatal stress; hair cortisol; term-placentae; RT-qPCR; human
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:liu:diva-171010 (URN)10.3390/genes11080869 (DOI)000578897900001 ()32752005 (PubMedID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden (FORSS) [661011, 392061, 472721]; European Unions Horizon 2020 research and innovation program under the MSCA [891663]

Available from: 2020-11-01 Created: 2020-11-01 Last updated: 2024-07-04
Johansson, T., Lindblad, M., Bladh, M., Josefsson, A. & Sydsjö, G. (2017). Incidence of Perthes disease in children born between 1973 and 1993: A Swedish nationwide cohort study of 2.1 million individuals. Acta Orthopaedica, 88(1), 96-100
Open this publication in new window or tab >>Incidence of Perthes disease in children born between 1973 and 1993: A Swedish nationwide cohort study of 2.1 million individuals
Show others...
2017 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 88, no 1, p. 96-100Article in journal (Refereed) Published
Abstract [en]

Background and purpose - The incidence of Perthes disease as reported in the literature varies widely between and within countries. The etiology of the disease is still unknown. Both environmental and genetic factors have been suggested to play a part in either causing the disease or increasing the susceptibility of an individual. We determined the incidence of Perthes disease in Sweden and investigated possible relationships to parental socioeconomic status, ethnicity, marital status, mothers age when giving birth, parity, number of siblings, and smoking habits. Patients and methods - Six Swedish population-based registers were used, together covering all children born in Sweden from 1973 through 1993. Results - The incidence of Perthes disease in Sweden was 9.3 per 100,000 subjects. The ratio between boys and girls was 3.1:1. The educational level of the father and the mother of a child with Perthes disease was lower than in the controls. The incidence was lower when the fathers were in the highest income bracket (above the 90(th) percentile). A higher proportion of parents of Nordic lineage had children with Perthes disease than parental pairs with one or both who were not of such lineage. Interpretation - This study confirms that there is an association between the incidence of Perthes disease and the socioeconomic status of the parents.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD, 2017
National Category
General Practice
Identifiers
urn:nbn:se:liu:diva-134798 (URN)10.1080/17453674.2016.1227055 (DOI)000392736200016 ()27587239 (PubMedID)
Available from: 2017-02-24 Created: 2017-02-24 Last updated: 2025-03-05
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-3238-3811

Search in DiVA

Show all publications