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Eriksson, Ola
Publications (10 of 38) Show all publications
Johansson, J. D., Blomstedt, P., Haj-Hosseini, N., Bergenheim, T., Eriksson, O. & Wårdell, K. (2009). Combined diffuse light reflectance and electric impedance measurements for navigation aid in deep brain surgery. Stereotactic and Functional Neurosurgery, 87(2), 105-113
Open this publication in new window or tab >>Combined diffuse light reflectance and electric impedance measurements for navigation aid in deep brain surgery
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2009 (English)In: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 87, no 2, p. 105-113Article in journal (Refereed) Published
Abstract [en]

Aim: The aim of this study is to investigate reflected light intensity combined with impedance for navigation aid during stereotactic neurosurgery.

Methods: During creation of 21 trajectories for stereotactic implantation of deep brain stimulation electrodes in the globus pallidus internus or subthalamus (zona incerta or subthalamic nucleus), impedance at 512 kHz and reflected light intensity at 780 nm were measured continuously and simultaneously with a radio frequency electrode containing optical fibres. The signals were compared with anatomy determined from pre- and postoperative MRI and CT. The measurements were performed within minutes and signal analysis was done post-operatively.

Results: Reflected light intensity was low from cortex, lateral ventricle, caudate nucleus and putamen. It was intermediate from globus pallidus and thalamus while it was high from subcortical white matter, internal capsule and the subthalamus. The electric impedance was less consistent but generally low in the cortex, intermediate in subcortical white matter, the putamen, the globus pallidus and the thalamus and high in the internal capsule and the subthalamus.

Conclusion: Reflected light intensity and electric impedance give complementary information about passed tissue and the combination seems promising for navigation aid during stereotactic neurosurgery.

Keywords
Stereotactic surgery, navigation, electric impedance, light reflectance
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-15929 (URN)10.1159/000202977 (DOI)
Note

Original Publication: Johannes D. Johansson, Patric Blomstedt, Neda Haj-Hosseini, Tommy Bergenheim, Ola Eriksson and Karin Wårdell, Combined diffuse light reflectance and electric impedance measurements for navigation aid in deep brain surgery, 2009, Stereotactic and Functional Neurosurgery, (87), 2, 105-113. http://dx.doi.org/10.1159/000202977 Copyright: S. Karger AG http://www.karger.com/

Available from: 2008-12-16 Created: 2008-12-16 Last updated: 2017-12-14Bibliographically approved
Johansson, J. D., Fredriksson, I., Wårdell, K. & Eriksson, O. (2009). Simulation of reflected light intensity changes during navigation and radio frequency lesioning in the brain. Journal of Biomedical Optics, 14(044040)
Open this publication in new window or tab >>Simulation of reflected light intensity changes during navigation and radio frequency lesioning in the brain
2009 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 14, no 044040Article in journal (Refereed) Published
Abstract [en]

An electrode with adjacent optical fibers for measurements during navigation and radio frequency lesioning in the brain was modeled for Monte Carlo simulations of light transport in brain tissue. Relative reflected light intensity at 780 nm, I780, from this electrode and probes with identical fiber configuration were simulated using the intensity from native white matter as reference. Models were made of homogeneousnative and coagulated gray, thalamus, and white matter as well as blood. Dual layermodels, including models with a layer of cerebrospinal fluid between the fibers andthe brain tissue, were also made. Simulated I780 was 0.16 for gray matter, 0.67 forcoagulate gray matter, 0.36 for thalamus, 0.39 for coagulated thalamus, unity forwhite matter, 0.70 for coagulated white matter and 0.24 for blood. Thalamic matterhas also been found to reflect more light than gray matter and less than white matterin clinical studies. In conclusion the reflected light intensity can be used todifferentiate between gray and white matter during navigation. Furthermore,coagulation of light gray tissue, such as the thalamus, might be difficult to detectusing I780, but coagulation in darker gray tissue should result in a rapid increase of I780.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2009
Keywords
Brain, Monte Carlo simulations, diffuse reflectance, navigation, radio-frequency lesioning
National Category
Bioengineering Equipment
Identifiers
urn:nbn:se:liu:diva-15930 (URN)10.1117/1.3210781 (DOI)000270540100046 ()19725751 (PubMedID)2-s2.0-73349106860 (Scopus ID)
Note

Original Publication: Johannes D. Johansson, Ingemar Fredriksson, Karin Wårdell and Ola Eriksson, Simulation of reflected light intensity changes during navigation and radio frequency lesioning in the brain, Journal of Biomedical Optics, (14), 044040, (2009). http://dx.doi.org/10.1117/1.3210781 Copyright 2009 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.

Available from: 2008-12-16 Created: 2008-12-16 Last updated: 2017-12-14Bibliographically approved
Johansson, J., Blomstedt, P., Haj-Hosseini, N., Bergenheim, A. T., Hariz, M. I., Eriksson, O. & Wårdell, K. (2008). Combined electric impedance and optical diffuse reflectance measurements for navigation aid in deep brain surgery. In: XVIII Congress of the European Society for Stereotactic and Functional Neurosurgery,2008: . Paper presented at ESSFN, Rimini, 5-8 Oktober, 2008.
Open this publication in new window or tab >>Combined electric impedance and optical diffuse reflectance measurements for navigation aid in deep brain surgery
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2008 (English)In: XVIII Congress of the European Society for Stereotactic and Functional Neurosurgery,2008, 2008Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-44408 (URN)76546 (Local ID)76546 (Archive number)76546 (OAI)
Conference
ESSFN, Rimini, 5-8 Oktober, 2008
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-02-17Bibliographically approved
Antonsson, J., Eriksson, O., Blomstedt, P., Bergenheim, T., Hariz, M., Richter, J., . . . Wårdell, K. (2008). Diffuse reflectance spectroscopy measurements for tissue type discrimination during deep brain stimulation. Journal of neural engineering, 5(2), 185-190
Open this publication in new window or tab >>Diffuse reflectance spectroscopy measurements for tissue type discrimination during deep brain stimulation
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2008 (English)In: Journal of neural engineering, ISSN 1741-2560, Vol. 5, no 2, p. 185-190Article in journal (Refereed) Published
Abstract [en]

Diffuse reflectance spectroscopy as a method for improving intracerebral guidance during functional neurosurgery has been investigated. An optical probe was developed for measurements during stereotactic and functional neurosurgery in man. The aim of the study was to investigate the spectral differences between white and grey matter and between white matter and functional targets. Diffuse reflectance spectroscopy measurements in ten patients were recorded at incremental steps towards and in three different functional targets (STN, GPi and Zi). The recorded spectra along the trajectory were sorted into white or grey matter, based on preoperative MRI images or the recorded spectral shape and intensity. The difference between tissue types was calculated as a quotient. Significant intensity differences between white and grey matter were found to be at least 14% (p < 0.05) and 20% (p < 0.0001) for MRI and spectral-sorted data respectively. The reflectance difference between white matter and the functional targets of GPi was higher than for STN and Zi. The results indicate that diffuse reflectance spectroscopy has a potential to be developed to a suitable complement to other intracerebral guidance methods.

National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-14235 (URN)10.1088/1741-2560/5/2/009 (DOI)000257253800009 ()18460743 (PubMedID)2-s2.0-48949118315 (Scopus ID)
Available from: 2007-01-26 Created: 2007-01-26 Last updated: 2017-02-10Bibliographically approved
Johansson, J., Fredriksson, I., Eriksson, O. & Wårdell, K. (2008). Simulering av ljusreflektion i hjärnan under navigation och radiofrekvensablation. In: Medicinteknikdagarna 2008,2008: . Paper presented at Medicinteknikdagarna, Göteborg, 14-15 Oktober 2008 (pp. 70-70).
Open this publication in new window or tab >>Simulering av ljusreflektion i hjärnan under navigation och radiofrekvensablation
2008 (Swedish)In: Medicinteknikdagarna 2008,2008, 2008, p. 70-70Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-44327 (URN)76339 (Local ID)76339 (Archive number)76339 (OAI)
Conference
Medicinteknikdagarna, Göteborg, 14-15 Oktober 2008
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-02-17Bibliographically approved
Wårdell, K., Fors, C., Antonsson, J. & Eriksson, O. (2007). A laser Doppler system for intracerebral measurements during stereotactic neurosurgery. In: Engineering in Medicine and Biology Society, 2007. EMBS 2007: . Paper presented at 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2007), 22-26 August 2007, Lyon, France (pp. 4083-4086). IEEE
Open this publication in new window or tab >>A laser Doppler system for intracerebral measurements during stereotactic neurosurgery
2007 (English)In: Engineering in Medicine and Biology Society, 2007. EMBS 2007, IEEE , 2007, p. 4083-4086Conference paper, Published paper (Refereed)
Abstract [en]

A laser Doppler system for intracerebral measurements during stereotactic and functional neurosurgery is presented. The system comprises a laser Doppler perfusion monitor, an optical probe adapted for the Leksellreg stereotactic system and a personal computer with software for acquisition, data analysis and presentation. The software makes it possible to present both the perfusion and the total backscattered light intensity (TLI) in real-time. During intracerebral measurements, the perfusion signal records the tissue's microcirculation whereas the TLI signal may be used to distinguish between grey and white matter. Evaluation of the system has been done during stereotactic neurosurgery in relation to implantation of deep brain stimulation electrodes. Measurements were made along trajectories towards targets in the deep brain structure as well as in pre-calculated target areas. The measurements show that the system has a potential to be used for intracerebral guidance but further evaluation of the technique is needed.

Place, publisher, year, edition, pages
IEEE, 2007
Series
IEEE Engineering in Medicine and Biology Society. Conference Proceedings, ISSN 1557-170X
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-38409 (URN)10.1109/IEMBS.2007.4353231 (DOI)44245 (Local ID)9781424407873 (ISBN)9781424407880 (ISBN)44245 (Archive number)44245 (OAI)
Conference
29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2007), 22-26 August 2007, Lyon, France
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-02-17Bibliographically approved
Wårdell, K., Blomstedt, P., Richter, J., Antonsson, J., Eriksson, O., Zsigmond, P., . . . Hariz, M. (2007). Intracerebral microvascular measurements during deep brain stimulation implantation using laser doppler perfusion monitoring. Stereotactic and Functional Neurosurgery, 85(6), 279-286
Open this publication in new window or tab >>Intracerebral microvascular measurements during deep brain stimulation implantation using laser doppler perfusion monitoring
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2007 (English)In: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 85, no 6, p. 279-286Article in journal (Refereed) Published
Abstract [en]

The aim of the study was to investigate if laser Doppler perfusion monitoring (LDPM) can be used in order to differentiate between gray and white matter and to what extent microvascular perfusion can be recorded in the deep brain structures during stereotactic neurosurgery. An optical probe constructed to fit in the Leksell® Stereotactic System was used for measurements along the trajectory and in the targets (globus pallidus internus, subthalamic nucleus, zona incerta, thalamus) during the implantation of deep brain stimulation leads (n = 22). The total backscattered light intensity (TLI) reflecting the grayness of the tissue, and the microvascular perfusion were captured at 128 sites. Heartbeat-synchronized pulsations were found at all perfusion recordings. In 6 sites the perfusion was more than 6 times higher than the closest neighbor indicating a possible small vessel structure. TLI was significantly higher (p < 0.005) and the perfusion significantly lower (p < 0.005) in positions identified as white matter in the respective MRI batch. The measurements imply that LDPM has the potential to be used as an intracerebral guidance tool.

Place, publisher, year, edition, pages
S. Karger, 2007
Keywords
Deep brain stimulation, Laser Doppler perfusion monitoring, Microcirculation
National Category
Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:liu:diva-48444 (URN)10.1159/000107360 (DOI)000249535300004 ()17709980 (PubMedID)2-s2.0-35348889232 (Scopus ID)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12Bibliographically approved
Johansson, J., Blomstedt, P., Hariz, M., Bergenheim, T., Eriksson, O. & Wårdell, K. (2007). Simultan jämförande mätning av elektrisk impedans och reflekterat ljus för guidning vid stereotakisk neurokirurgi. In: Medicinteknikdagarna,2007: . Paper presented at Medicinteknikdagarna, Örebro, 2-3 Oktober, 2007.
Open this publication in new window or tab >>Simultan jämförande mätning av elektrisk impedans och reflekterat ljus för guidning vid stereotakisk neurokirurgi
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2007 (Swedish)In: Medicinteknikdagarna,2007, 2007Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-38830 (URN)45806 (Local ID)45806 (Archive number)45806 (OAI)
Conference
Medicinteknikdagarna, Örebro, 2-3 Oktober, 2007
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-02-17Bibliographically approved
Wårdell, K., Blomstedt, P., Antonsson, J., Eriksson, O., Richter, J. & Hariz, M. (2006). Intracerebral measurements during DBS-implatation using optical methods. In: Congress of the European Society for Stereotactic and Funktional Neurosurgery,2006: . New York: Springer
Open this publication in new window or tab >>Intracerebral measurements during DBS-implatation using optical methods
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2006 (English)In: Congress of the European Society for Stereotactic and Funktional Neurosurgery,2006, New York: Springer , 2006Conference paper, Published paper (Other academic)
Abstract [en]

   

Place, publisher, year, edition, pages
New York: Springer, 2006
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-35238 (URN)25847 (Local ID)25847 (Archive number)25847 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-02-17Bibliographically approved
Johansson, J., Wren, J., Loyd, D., Eriksson, O. & Wårdell, K. (2006). Konvektiva flöden och deras termiska inverkan vid Radiofrekvenslesionering i hjärna. In: Medicinteknikdagarna 2006,2006: .
Open this publication in new window or tab >>Konvektiva flöden och deras termiska inverkan vid Radiofrekvenslesionering i hjärna
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2006 (English)In: Medicinteknikdagarna 2006,2006, 2006Conference paper, Published paper (Other academic)
Abstract [en]

   

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-36217 (URN)30572 (Local ID)30572 (Archive number)30572 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-02-17Bibliographically approved
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