liu.seSearch for publications in DiVA
Change search
Link to record
Permanent link

Direct link
BETA
Ludvigsson, Johnny
Alternative names
Publications (10 of 359) Show all publications
Beam, C. A., MacCallum, C., Herold, K. C., Wherrett, D. K., Palmer, J. & Ludvigsson, J. (2017). GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis. Diabetologia, 60(1), 43-49
Open this publication in new window or tab >>GAD vaccine reduces insulin loss in recently diagnosed type 1 diabetes: findings from a Bayesian meta-analysis
Show others...
2017 (English)In: Diabetologia, ISSN 0012-186X, E-ISSN 1432-0428, Vol. 60, no 1, p. 43-49Article in journal (Refereed) Published
Abstract [en]

GAD is a major target of the autoimmune response that occurs in type 1 diabetes mellitus. Randomised controlled clinical trials of a GAD + alum vaccine in human participants have so far given conflicting results. In this study, we sought to see whether a clearer answer to the question of whether GAD65 has an effect on C-peptide could be reached by combining individual-level data from the randomised controlled trials using Bayesian meta-analysis to estimate the probability of a positive biological effect (a reduction in C-peptide loss compared with placebo approximately 1 year after the GAD vaccine). We estimate that there is a 98% probability that 20 mu g GAD with alum administered twice yields a positive biological effect. The effect is probably a 15-20% reduction in the loss of C-peptide at approximately 1 year after treatment. This translates to an annual expected loss of between -0.250 and -0.235 pmol/ml in treated patients compared with an expected 2 h AUC loss of -0.294 pmol/ml at 1 year for untreated newly diagnosed patients. The biological effect of this vaccination should be developed further in order to reach clinically desirable reductions in insulin loss in patients recently diagnosed with type 1 diabetes.

Place, publisher, year, edition, pages
SPRINGER, 2017
Keywords
Bayes methods; Glutamic acid decarboxylase (GAD); Meta-analysis; Type 1 diabetes; Vaccine
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:liu:diva-133724 (URN)10.1007/s00125-016-4122-1 (DOI)000389634000007 ()27704166 (PubMedID)
Note

Funding Agencies|JDRF [1-INO-20140170-A-V]

Available from: 2017-01-11 Created: 2017-01-09 Last updated: 2018-05-02
Klingberg, S., Ludvigsson, J. & Brekke, H. K. (2017). Introduction of complementary foods in Sweden and impact of maternal education on feeding practices.. Public Health Nutrition, 20(6), 1054-1062
Open this publication in new window or tab >>Introduction of complementary foods in Sweden and impact of maternal education on feeding practices.
2017 (English)In: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 20, no 6, p. 1054-1062Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To describe the introduction of complementary foods in a population-based cohort in relation to recommendations and explore the possible impact of maternal education on infant feeding practices.

DESIGN: Prospective data from the All Babies in Southeast Sweden (ABIS) cohort study were used. The ABIS study invited all infants born in south-east Sweden during October 1997-October 1999 (n 21 700) to participate. A questionnaire was completed for 16 022 infants. During the infants' first year parents continuously filed in a diary covering introduction of foods.

SETTING: Sweden.

SUBJECTS: Infants (n 9727) with completed food diaries.

RESULTS: Potatoes, vegetables, fruits/berries and porridge were the foods first introduced, with a median introduction between 19 and 22 weeks, followed by introduction of meat, cow's milk, follow-on formula and sour milk/yoghurt between 24 and 27 weeks. Early introduction of any food, before 16 weeks, occurred for 27 % of the infants and was more common in infants of mothers with low education. Overall, potatoes (14·7 %), vegetables (11·1 %), fruits/berries (8·5 %), porridge (7·4 %) and follow-on formula (2·7 %) were the foods most frequently introduced early. The majority of infants (≥70 %) were introduced to potatoes, vegetables, fruits/berries and porridge during concurrent breast-feeding, but introduction during concurrent breast-feeding was less common in infants of mothers with low education.

CONCLUSIONS: Most infants were introduced to complementary foods timely in relation to recommendations. Low maternal education was associated with earlier introduction of complementary foods and less introduction during concurrent breast-feeding. Still, the results indicated exposure to fewer foods at 12 months in infants of mothers with low education.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
National Category
Health Sciences
Identifiers
urn:nbn:se:liu:diva-134865 (URN)10.1017/S1368980016003104 (DOI)000399398300011 ()27917749 (PubMedID)
Note

Funding agencies: Swedish Child Diabetes Foundation (Barndiabetesfonden); Novo Nordisk Foundation; Research Council of Southeast Sweden (FORSS); Swedish Research Council [K2005-72X-11242-11A]; ALF/County Council of Ostergotland

Available from: 2017-02-27 Created: 2017-02-27 Last updated: 2018-05-02Bibliographically approved
Ludvigsson, J., Wahlberg Topp, J. & Casas, R. (2017). Letter: Intralymphatic Injection of Autoantigen in Type 1 Diabetes in NEW ENGLAND JOURNAL OF MEDICINE, vol 376, issue 7, pp 697-699 [Letter to the editor]. New England Journal of Medicine, 376(7), 697-699
Open this publication in new window or tab >>Letter: Intralymphatic Injection of Autoantigen in Type 1 Diabetes in NEW ENGLAND JOURNAL OF MEDICINE, vol 376, issue 7, pp 697-699
2017 (English)In: New England Journal of Medicine, ISSN 0028-4793, E-ISSN 1533-4406, Vol. 376, no 7, p. 697-699Article in journal, Letter (Other academic) Published
Abstract [en]

n/a

Place, publisher, year, edition, pages
MASSACHUSETTS MEDICAL SOC, 2017
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-136061 (URN)10.1056/NEJMc1616343 (DOI)000396402700022 ()28199812 (PubMedID)
Note

Funding Agencies|Barndiabetesfonden (the Swedish Child Diabetes Foundation); Diabetesfonden (the Swedish Diabetes Foundation); Forskningsradet i Sydostra Sverige (the Research Council of Southeast Sweden); Diamyd Medical

Available from: 2017-03-27 Created: 2017-03-27 Last updated: 2018-05-02
Jonsdottir, B., Larsson, C., Carlsson, A., Forsander, G., Ivarsson, S. A., Lernmark, Å., . . . Elding Larsson, H. (2017). Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis.. Journal of Clinical Endocrinology and Metabolism, 102(4), 1277-1285
Open this publication in new window or tab >>Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis.
Show others...
2017 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 102, no 4, p. 1277-1285Article in journal (Refereed) Published
Abstract [en]

CONTEXT: Screening of autoimmune thyroid disease in children and young adults with Type 1 diabetes is important but vary greatly between clinics.

OBJECTIVE: The aim was to determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA- DQ at diagnosis of Type 1 diabetes for autoimmune thyroid disease during subsequent follow-up.

SETTING: 43 Paediatric Endocrinology units Sweden. Design, patients and main outcome measures: At diagnosis of Type 1 diabetes, samples from 2433 children were analysed for autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated protein-2 (IA-2A), and the three variants of the zinc transporter 8 (ZnT8W/R/QA) as well as HLA-DQA1-B1 genotypes and thyroid function. After 5.1-9.5 years disease duration, children treated with thyroxine were identified in the Swedish National Board of Health and Welfare Prescribed Drug Register.

RESULTS: Thyroxine had been prescribed to 6% (147/2433; 66% girls). In patients below 5 years, female gender (HR=4.60, p=0.008) and GADA (HR=5.80, p=0.02) were significant predictors. In patients 5-10 years, TPOAb (HR=20.56, p<0.0001), TGAb (HR=3.40, p=0.006) and TSH outside the reference limit (HR=3.64, p<0.001) were predictors while in the 10-15 year olds, TPOAb (HR=17.00, p<0.001) and TSH outside the reference limit (HR=4.11, p<0.001) predicted future thyroxine prescription.

CONCLUSION: In addition to TPOAb and TSH, positive GADA tested at the diagnosis of type 1 diabetes is important for the prediction of autoimmune thyroid disease in children below 5 years of age.

Place, publisher, year, edition, pages
Oxford University Press, 2017
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-134863 (URN)10.1210/jc.2016-2335 (DOI)000402195300021 ()27740884 (PubMedID)
Note

Funding agencies: Swedish Research Council [14064]; Swedish Child Diabetes Foundation; Swedish Diabetes Association; National Institutes of Health [DK26190]; SUS Fund; Knut and Alice Wallenberg Foundation; Skane County Council for Research and Development

Available from: 2017-02-27 Created: 2017-02-27 Last updated: 2018-05-03
Rewers, M. & Ludvigsson, J. (2016). Environmental risk factors for type 1 diabetes. The Lancet, 387(10035), 2340-2348
Open this publication in new window or tab >>Environmental risk factors for type 1 diabetes
2016 (English)In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 387, no 10035, p. 2340-2348Article, review/survey (Refereed) Published
Abstract [en]

The incidence of type 1 diabetes has risen considerably in the past 30 years due to changes in the environment that have been only partially identified. In this Series paper, we critically discuss candidate triggers of islet autoimmunity and factors thought to promote progression from autoimmunity to overt type 1 diabetes. We revisit previously proposed hypotheses to explain the growth in the incidence of type 1 diabetes in light of current data. Finally, we suggest a unified model in which immune tolerance to beta cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 2016
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:liu:diva-129471 (URN)10.1016/S0140-6736(16)30507-4 (DOI)000376969100037 ()
Note

Funding Agencies|National Institutes of Health [DK32493]; Juvenile Diabetes Research Foundation [17-2013-535]; Swedish Child Diabetes Foundation (Barndiabetesfonden); JDF-Wallenberg [K98-99JD-12813-01A]; Swedish Medical Research Council (MFR) [K99-72X-11242-05A]; Research Council of Southeast Sweden

Available from: 2016-06-21 Created: 2016-06-20 Last updated: 2017-06-09
Carlsson, E., Ludvigsson, J., Huus, K. & Faresjö, M. (2016). High physical activity in young children suggests positive effects by altering autoantigen-induced immune activity. Scandinavian Journal of Medicine and Science in Sports, 26(4), 441-450
Open this publication in new window or tab >>High physical activity in young children suggests positive effects by altering autoantigen-induced immune activity
2016 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 26, no 4, p. 441-450Article in journal (Refereed) Published
Abstract [en]

Physical activity in children is associated with several positive health outcomes such as decreased cardiovascular risk factors, improved lung function, enhanced motor skill development, healthier body composition, and also improved defense against inflammatory diseases. We examined how high physical activity vs a sedentary lifestyle in young children influences the immune response with focus on autoimmunity. Peripheral blood mononuclear cells, collected from 55 5-year-old children with either high physical activity (n = 14), average physical activity (n = 27), or low physical activity (n = 14), from the All Babies In Southeast Sweden (ABIS) cohort, were stimulated with antigens (tetanus toxoid and beta-lactoglobulin) and autoantigens (GAD65 , insulin, HSP60, and IA-2). Immune markers (cytokines and chemokines), C-peptide and proinsulin were analyzed. Children with high physical activity showed decreased immune activity toward the autoantigens GAD65 (IL-5, P < 0.05), HSP60 and IA-2 (IL-10, P < 0.05) and also low spontaneous pro-inflammatory immune activity (IL-6, IL-13, IFN-γ, TNF-α, and CCL2 (P < 0.05)) compared with children with an average or low physical activity. High physical activity in young children seems to have positive effects on the immune system by altering autoantigen-induced immune activity.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016
Keywords
Physical activity, Autoimmunity, Cytokines. Immune response, Young children
National Category
Physiotherapy Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-126414 (URN)10.1111/sms.12450 (DOI)000373356600009 ()25892449 (PubMedID)
Note

Funding agencies:  Swedish Council for Working Life and Social Research [2008-0284]; Swedish Research Council [K2009-70X-21086-01-3]; Medical Research Council of Southeast Sweden; Swedish Child Diabetes Foundation; Academy for Health and Care Jonkoping County Council

Available from: 2016-03-23 Created: 2016-03-23 Last updated: 2018-03-20Bibliographically approved
Ruiz, M., Goldblatt, P., Morrison, J., Porta, D., Forastiere, F., Hryhorczuk, D., . . . Pikhart, H. (2016). Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe. Paediatric and Perinatal Epidemiology, 30(3), 274-284
Open this publication in new window or tab >>Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe
Show others...
2016 (English)In: Paediatric and Perinatal Epidemiology, ISSN 0269-5022, E-ISSN 1365-3016, Vol. 30, no 3, p. 274-284Article in journal (Refereed) Published
Abstract [en]

BackgroundComparable evidence on adiposity inequalities in early life is lacking across a range of European countries. This study investigates whether low maternal education is associated with overweight and obesity risk in children from distinct European settings during early childhood. MethodsProspective data of 45 413 children from 11 European cohorts were used. Childrens height and weight obtained at ages 4-7 years were used to assess prevalent overweight and obesity according to the International Obesity Task Force definition. The Relative/Slope Indices of Inequality (RII/SII) were estimated within each cohort and by gender to investigate adiposity risk among children born to mothers with low education as compared to counterparts born to mothers with high education. Individual-data meta-analyses were conducted to obtain aggregate estimates and to assess heterogeneity between cohorts. ResultsLow maternal education yielded a substantial risk of early childhood adiposity across 11 European countries. Low maternal education yielded a mean risk ratio of 1.58 (95% confidence interval (CI) 1.34, 1.85) and a mean risk difference of 7.78% (5.34, 10.22) in early childhood overweight, respectively, measured by the RII and SII. Early childhood obesity risk by low maternal education was as substantial for all cohorts combined (RII = 2.61 (2.10, 3.23)) and (SII = 4.01% (3.14, 4.88)). Inequalities in early childhood adiposity were consistent among boys, but varied among girls in a few cohorts. ConclusionsConsiderable inequalities in overweight and obesity are evident among European children in early life. Tackling early childhood adiposity is necessary to promote childrens immediate health and well-being and throughout the life course.

Place, publisher, year, edition, pages
WILEY-BLACKWELL, 2016
Keywords
child; preschool; child development; cohort studies; comparative study; Czech Republic; epidemiology; Europe; Finland; France; Greece; health inequalities; Italy; maternal educational status; meta-analysis; Netherlands; obesity; overweight; Portugal; Spain; Sweden; United Kingdom; Ukraine
National Category
Clinical Medicine Basic Medicine
Identifiers
urn:nbn:se:liu:diva-127547 (URN)10.1111/ppe.12285 (DOI)000373623800008 ()26945670 (PubMedID)
Note

Funding Agencies|European Union [278350]; Ministry of Education of the Czech Republic [LM2011028, LO1214]; Grant Agency of the Masaryk University [MUNI/M/1075/2013]; Academy of Finland; Biocenter, University of Oulu, Finland; European Commission (EUROBLCS) [QLG1-CT-2000-01643]; EU [EurHEALTHAgeing-277849]; Medical Research Council, UK (PrevMetSyn/SALVE); MRC; Netherlands Organization for Health Research and Development (ZonMw) [40-00812-98-11010]; Juvenile Diabetes Research Foundation; Swedish Child Diabetes Foundation; Research Council of Southeast Sweden

Available from: 2016-05-04 Created: 2016-05-03 Last updated: 2018-01-10
Ludvigsson, J. (2016). Letter: Authors Reply to Dayal: "Therapies to Preserve beta-Cell Function in Type 1 Diabetes in DRUGS, vol 76, issue 5, pp 627-627 [Letter to the editor]. Drugs, 76(5), 627-627
Open this publication in new window or tab >>Letter: Authors Reply to Dayal: "Therapies to Preserve beta-Cell Function in Type 1 Diabetes in DRUGS, vol 76, issue 5, pp 627-627
2016 (English)In: Drugs, ISSN 0012-6667, E-ISSN 1179-1950, Vol. 76, no 5, p. 627-627Article in journal, Letter (Other academic) Published
Abstract [en]

n/a

Place, publisher, year, edition, pages
ADIS INT LTD, 2016
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-128752 (URN)10.1007/s40265-016-0561-8 (DOI)000375052300009 ()26979969 (PubMedID)
Available from: 2016-05-31 Created: 2016-05-30 Last updated: 2017-11-30
Ping Zhao, L., Alshiekh, S., Zhao, M., Carlsson, A., Elding Larsson, H., Forsander, G., . . . Lernmark, A. (2016). Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes. Diabetes, 65(3), 710-718
Open this publication in new window or tab >>Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes
Show others...
2016 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 65, no 3, p. 710-718Article in journal (Refereed) Published
Abstract [en]

The possible contribution of HLA-DRB3, -DRB4, and -DRB5 alleles to type 1 diabetes risk and to insulin autoantibody (IAA), GAD65 (GAD autoantibody [GADA]), IA-2 antigen (IA-2A), or ZnT8 against either of the three amino acid variants R, W, or Q at position 325 (ZnT8RA, ZnT8WA, and ZnT8QA, respectively) at clinical diagnosis is unclear. Next-generation sequencing (NGS) was used to determine all DRB alleles in consecutively diagnosed patients ages 1-18 years with islet autoantibody-positive type 1 diabetes (n = 970) and control subjects (n = 448). DRB3, DRB4, or DRB5 alleles were tested for an association with the risk of DRB1 for autoantibodies, type 1 diabetes, or both. The association between type 1 diabetes and DRB1*03:01:01 was affected by DRB3*01:01:02 and DRB3*02:02:01. These DRB3 alleles were associated positively with GADA but negatively with ZnT8WA, IA-2A, and IAA. The negative association between type 1 diabetes and DRB1*13:01:01 was affected by DRB3*01:01:02 to increase the risk and by DRB3*02:02:01 to maintain a negative association. DRB4*01:03:01 was strongly associated with type 1 diabetes (P = 10(-36)), yet its association was extensively affected by DRB1 alleles from protective (DRB1*04:03:01) to high (DRB1*04:01:01) risk, but its association with DRB1*04:05:01 decreased the risk. HLA-DRB3, -DRB4, and -DRB5 affect type 1 diabetes risk and islet autoantibodies. HLA typing with NGS should prove useful to select participants for prevention or intervention trials.

Place, publisher, year, edition, pages
AMER DIABETES ASSOC, 2016
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-126246 (URN)10.2337/db15-1115 (DOI)000370961000024 ()26740600 (PubMedID)
Note

Funding Agencies|European Foundation for the Study of Diabetes Clinical Research Grants Programme; Swedish Child Diabetes Foundation; National Institutes of Health [DK-63861, DK-26190]; Swedish Research Council; Linne grant; Skane County Council for Research and Development; Swedish Association of Local Authorities and Regions; Knut and Alice Wallenberg Foundation

Available from: 2016-03-21 Created: 2016-03-21 Last updated: 2017-11-30
Granfors, M., Augustin, H., Ludvigsson, J. & Brekke, H. K. (2016). No association between use of multivitamin supplement containing vitamin D during pregnancy and risk of Type 1 Diabetes in the child. Pediatric Diabetes, 17(7), 525-530
Open this publication in new window or tab >>No association between use of multivitamin supplement containing vitamin D during pregnancy and risk of Type 1 Diabetes in the child
2016 (English)In: Pediatric Diabetes, ISSN 1399-543X, E-ISSN 1399-5448, Vol. 17, no 7, p. 525-530Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Sweden has the second highest incidence of type 1 diabetes in the world. Nutritional aspects in utero and in infancy affect the development. We conducted a survey to determine whether reported maternal use of vitamin D-containing micronutrient supplements during pregnancy was associated with the risk of developing type 1 diabetes in the child.

METHODS:

This report was based on data from the ABIS (All Babies In Southeast Sweden) study, with questionnaire data on 16 339 mother and infant pairs at birth and at 1-yr of age (n = 10 879), of whom 108 children were registered with type 1 diabetes before 14-16 yr of age. The questions 'during pregnancy, did you take any vitamin/mineral supplements?' and 'if yes, which? (open answer)' in addition to other lifestyle questions were answered. Logistic regression was performed with onset of type 1 diabetes as the dependent variable and vitamin D supplementation use as the independent variable, adjusted for relevant factors.

RESULTS:

Vitamin D supplementation during pregnancy was consumed by 9.3% of mothers whose children later got type1 diabetes and among 11.3% of those mothers whose children did not get type 1 diabetes (p = 0.532). No significant association was found between reported supplement intake of vitamin D during pregnancy and risk of type 1 diabetes, even when adjusting for factors which could influence the association.

CONCLUSION:

Maternal use of vitamin D-containing multivitamin supplements during pregnancy was not related to the risk of developing type 1 diabetes in children before 14-16 yr of age in Southeast of Sweden.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016
Keywords
Child, Micronutrient, Pregnancy, Supplementation, Type 1 diabetes, Vitamin D
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:liu:diva-126408 (URN)10.1111/pedi.12334 (DOI)000388303400008 ()26552946 (PubMedID)
Note

Funding agencies: Juvenile Diabetes Research Foundation; International-Wallenberg Foundations [K 98-99D-12813-01A]; Swedish Medical Research Council [K99-72X- 11242-05A]; Swedish Child Diabetes Foundation (Barndiabetesfonden); Swedish Diabetes Association; Swedish Diary As

Available from: 2016-03-23 Created: 2016-03-23 Last updated: 2017-11-30Bibliographically approved
Organisations

Search in DiVA

Show all publications