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Nielsen, Niels Erik
Alternative names
Publications (10 of 42) Show all publications
Rinnstrom, D., Dellborg, M., Thilen, U., Sorensson, P., Nielsen, N. E., Christersson, C. & Johansson, B. (2016). Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; association with systolic blood pressure in the high normal range. International Journal of Cardiology, 218, 59-64
Open this publication in new window or tab >>Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; association with systolic blood pressure in the high normal range
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2016 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 218, p. 59-64Article in journal (Refereed) Published
Abstract [en]

Background: Arterial hypertension is common in adults with repaired coarctation of the aorta (CoA). The associations between the diagnosis of hypertension, actual blood pressure, other factors affecting left ventricular overload, and left ventricular hypertrophy (LVH) are not yet fully explored in this population. Material and results: From the national register for congenital heart disease, 506 adult patients (amp;gt;= 18 years old) with previous repair of CoA were identified (37.0% female, mean age 35.7 +/- 13.8 years, with an average of 26.8 +/- 12.4 years post repair). Echocardiographic data were available for all patients, and showed LVH in 114 (22.5%) of these. Systolic blood pressure (SBP) (mm Hg) (OR 1.02, CI 1.01-1.04), aortic valve disease, (OR 2.17, CI 1.33-3.53), age (years) (OR 1.03, CI 1.01-1.05), diagnosis of arterial hypertension (OR 3.02, CI 1.81-5.02), and sex (female) (OR 0.41, CI 0.24-0.72) were independently associated with LVH. There was an association with LVH at SBP within the upper reference limits [ 130, 140] mm Hg (OR 2.23, CI 1.05-4.73) that further increased for SBP amp;gt; 140 mm Hg (OR 8.02, CI 3.76-17.12). Conclusions: LVH is common post repair of CoA and is associated with SBP even below the currently recommended target level. Lower target levels may therefore become justified in this population. ORCID Id: 0000-0003-0976-6910 (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD, 2016
Keywords
CoA; Hypertension; Left ventricular hypertrophy; Adult congenital heart disease
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-130115 (URN)10.1016/j.ijcard.2016.05.033 (DOI)000377856300010 ()27232912 (PubMedID)
Note

Funding Agencies|Swedish Heart and Lung Foundation [2013074, 20150579]; Heart Foundation of Northern Sweden; Umea University; County Council of Vasterbotten

Available from: 2016-07-12 Created: 2016-07-11 Last updated: 2017-11-28
Ahn, H. C., Baranowski, J., Dahlin, L.-G. & Nielsen, N. E. (2016). Transvenous Implantation of a Stent Valve in Patients With Degenerated Mitral Prostheses and Native Mitral Stenosis. Annals of Thoracic Surgery, 101(6), 2279-2284
Open this publication in new window or tab >>Transvenous Implantation of a Stent Valve in Patients With Degenerated Mitral Prostheses and Native Mitral Stenosis
2016 (English)In: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 101, no 6, p. 2279-2284Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The purpose of this study was to report the use of a transvenous transseptal approach using a stent valve in patients with degenerated biological mitral valve prostheses, regurgitation after mitral repair, and native mitral stenosis.

METHODS: Ten patients (median age, 74 years; range, 20-89 years; 5 men and 5 women) with degenerated mitral bioprosthetic valves (n = 7), failed mitral repair (n = 1), or calcified native stenotic valves (n = 2) underwent transvenous implantation of a stent valve.

RESULTS: The procedure was initially successful in all patients. Predilation was performed for balloon sizing only in the 2 patients with native mitral stenosis. The stent valve was deployed during 1 period of rapid pacing. A guidewire, as a loop from the right femoral vein and through the left ventricular apex, facilitated a good angle and secure positioning of the stent valve. An ultrasonographically guided puncture of the apex was carried out in 6 patients, and in the other 4 we performed a minithoracotomy before apical puncture. All valves were implanted in a good position with improved function and without significant paravalvular leakage (PVL). There were no periprocedural deaths. The 30-day survival was 80% (8 of 10 patients), and 60% (6 of 10) of patients were still alive a median time of 290 days after the procedure.

CONCLUSIONS: Transvenous transseptal implantation of a stent valve was performed in 10 patients with mitral valve disease, with good early functional results. These high-risk patients must be carefully selected by a multidisciplinary team because the procedure carries a high mortality.

Place, publisher, year, edition, pages
Elsevier, 2016
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-128915 (URN)10.1016/j.athoracsur.2015.11.019 (DOI)000376502600041 ()26897322 (PubMedID)
Available from: 2016-06-07 Created: 2016-06-07 Last updated: 2018-03-19Bibliographically approved
Nielsen, N. E., Baranowski, J. & Casimir Ahn, H. (2015). Editorial Material: Transvenous Implantation of a Stent Valve for Calcified Native Mitral Stenosis in ANNALS OF THORACIC SURGERY, vol 100, issue 1, pp E21-E23. Annals of Thoracic Surgery, 100(1), E21-E23
Open this publication in new window or tab >>Editorial Material: Transvenous Implantation of a Stent Valve for Calcified Native Mitral Stenosis in ANNALS OF THORACIC SURGERY, vol 100, issue 1, pp E21-E23
2015 (English)In: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 100, no 1, p. E21-E23Article in journal, Editorial material (Other academic) Published
Abstract [en]

We used a modified combination of the transseptal and transapical methods to facilitate the controlled delivery and use of a stent valve in a patient with calcified native mitral stenosis. A loop from the right femoral vein passing transseptally and then through the apex of the left ventricle was created, enabling highly controlled positioning and deployment of the stent valve.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 2015
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-120877 (URN)10.1016/j.athoracsur.2015.03.114 (DOI)000358796800007 ()26140803 (PubMedID)
Available from: 2015-08-28 Created: 2015-08-28 Last updated: 2017-12-04
Sandberg, C., Rinnstrom, D., Dellborg, M., Thilen, U., Sorensson, P., Nielsen, N. E., . . . Johansson, B. (2015). Height, weight and body mass index in adults with congenital heart disease. International Journal of Cardiology, 187, 219-226
Open this publication in new window or tab >>Height, weight and body mass index in adults with congenital heart disease
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2015 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754, Vol. 187, p. 219-226Article in journal (Refereed) Published
Abstract [en]

Background: High BMI is a risk factor for cardiovascular disease and, in contrast, low BMI is associated with worse prognosis in heart failure. The knowledge on BMI and the distribution in different BMI-classes in adults with congenital heart disease (CHD) are limited. Methods and results: Data on 2424 adult patients was extracted from the Swedish Registry on Congenital Heart Disease and compared to a reference population (n = 4605). The prevalence of overweight/obesity (BMI greater than= 25) was lower in men with variants of the Fontan procedure, pulmonary atresia (PA)/double outlet right ventricle (DORV) and aortic valve disease (AVD) (Fontan 22.0% and PA/DORV 15.1% vs. 43.0%, p = 0.048 and p less than 0.001) (AVD 37.5% vs. 49.3%, p less than 0.001). Overt obesity (BMI greater than= 30) was only more common in women with AVD (12.8% vs. 9.0%, p = 0.005). Underweight (BMI less than 18.5) was generally more common in men with CHD (complex lesions 4.9% vs. 0.9%, p less than 0.001 and simple lesions 3.2% vs. 0.6%, less than0.001). Men with complex lesions were shorter than controls in contrast to females that in general did not differ from controls. Conclusion: Higher prevalence of underweight in men with CHD combined with a lower prevalence of over-weight/obesity in men with some complex lesions indicates that men with CHD in general has lower BMI compared to controls. In women, only limited differences between those with CHD and the controls were found. The complexity of the CHD had larger impact on height in men. The cause of these gender differences as well as possible significance for prognosis is unknown. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2015
Keywords
Congenital heart disease; Body mass index; Height; Weight; Adult
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-119591 (URN)10.1016/j.ijcard.2015.03.153 (DOI)000354905600063 ()25838217 (PubMedID)
Note

Funding Agencies|Swedish Heart-Lung Foundation [20100355, 20130472]; Heart Foundation of Northern Sweden; research foundation of The Swedish Heart and Lung Association [E116/12, E115/13]; research foundation of Healthcare Professions within Cardiology; Umea University and Vasterbottens lans landsting (the County of Vasterbotten) [316351]

Available from: 2015-06-23 Created: 2015-06-22 Last updated: 2017-12-04
Hansson, N. C., Norgaard, B. L., Barbanti, M., Nielsen, N. E., Yang, T.-H., Tamburino, C., . . . Leipsic, J. (2015). The impact of calcium volume and distribution in aortic root injury related to balloon-expandable transcatheter aortic valve replacement. JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, 9(5), 382-392
Open this publication in new window or tab >>The impact of calcium volume and distribution in aortic root injury related to balloon-expandable transcatheter aortic valve replacement
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2015 (English)In: JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, ISSN 1934-5925, Vol. 9, no 5, p. 382-392Article in journal (Refereed) Published
Abstract [en]

Background: A detailed assessment of calcium within the aortic root may provide important additional information regarding the risk of aortic root injury during transcatheter heart valve replacement (TAVR). Objective: We sought to delineate the effect of calcium volume and distribution on aortic root injury during TAVR. Methods: Thirty-three patients experiencing aortic root injury during TAVR with a balloon-expandable valve were compared with a control group of 153 consecutive TAVR patients without aortic root injury (as assessed by post-TAVR multidetector CT). Using commercial software to analyze contrast-enhanced pre-TAVR CT scans, caltium volume was determined in 3 regions: (1) the overall left ventricular outflow tract (LVOT), extending 10 mm down from the aortic annulus plane; (2) the upper LVOT, extending 2 mm down from the annulus plane; and (3) the aortic valve region. Results: Calcium volumes in the upper LVOT (median, 29 vs 0 mm(3); P less than .0001) and overall LVOT (median, 74 vs 3 mm(3); P = .0001) were higher in patients who experienced aortic root injury compared with the control group. Calcium in the aortic valve region did not differ between groups. Upper LVOT calcium volume was more predictive of aortic root injury than overall LVOT calcium volume (area under receiver operating curve [AUG]; 0.78; 95% confidence interval, 0.69-0.86 vs AUC, 0.71; 95% confidence interval, 0.62-0.82; P = .010). Upper LVOT calcium below the noncoronary cusp was significantly more predictive of aortic root injury compared to calcium underneath the right coronary cusp or the left coronary cusp (AUC, 0.81 vs 0.68 vs 0.64). Prosthesis oversizing greater than20% (likelihood ratio test, P = .028) and redilatation (likelihood ratio test, P = .015) improved prediction of aortic root injury by upper LVOT calcium volume. Conclusion: Calcification of the LVOT, especially in the upper LVOT, located below the noncoronary cusp and extending from the annular region, is predictive of aortic root injury during TAVR with a balloon-expandable valve. (C) 2015 Society of Cardiovascular Computed Tomography. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 2015
Keywords
Aortic root calcification; Aortic root injury; Multidetector computed tomography; Transcatheter aortic valve replacement
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-122215 (URN)10.1016/j.jcct.2015.04.002 (DOI)000361930700002 ()26164109 (PubMedID)
Note

Funding Agencies|Edwards Lifesciences; Danish Heart Foundation

Available from: 2015-10-26 Created: 2015-10-23 Last updated: 2015-10-26
Kernell, K., Sydsjö, G., Bladh, M., Nielsen, N.-E. & Josefsson, A. (2014). Congenital heart disease in men - birth characteristics and reproduction: a national cohort study.. BMC pregnancy and childbirth, 14, 187
Open this publication in new window or tab >>Congenital heart disease in men - birth characteristics and reproduction: a national cohort study.
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2014 (English)In: BMC pregnancy and childbirth, ISSN 1471-2393, Vol. 14, p. 187-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Women with congenital heart disease (CHD) are more often born preterm or small-for-gestational age and with a caesarean section. This pattern together with an increased risk of congenital anomalies seems to be repeated in the next generation. Information on the effect of paternal CHD on their offspring is sparse. In this study we investigated if men with CHD differ from those who do not have CHD with respect to characteristics related to their own births, their reproductive patterns and the neonatal outcomes of their children.

METHODS: In this national cohort study data were derived from Swedish population-based registries. The population consists of all men born in 1973-1983 who were alive and living in Sweden at 13 years of age (n = 522 216). The index group is men with CHD (n = 2689). Men diagnosed with CHD were compared with men without CHD. The CHD were also divided into two groups, complex and simple CHD and comparisons between the groups were made.

RESULTS: Men with CHD are more likely to have been born preterm (p < 0.001), small-for gestational-age (p < 0.001) or large-for-gestational-age (p < 0.001) than men without CHD. They are also more likely to have been the result of a twin pregnancy (p < 0.001) and to have been delivered by caesarean section (p < 0.001). Men with CHD have a decreased likelihood to become fathers compared to non-CHD men and in this study their offspring do not have a higher incidence of CHD than offspring to non-CHD fathers. The neonatal outcomes of children of men with CHD do not differ from the outcomes of children of non-CHD men.

CONCLUSIONS: Men with CHD were more often born with non-optimal characteristics compared to men without the condition. However, the increased risk does not repeat itself in the next generation. This knowledge can lead to improved preconception counselling for couples in which the father has a CHD.

Place, publisher, year, edition, pages
BioMed Central, 2014
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-115269 (URN)10.1186/1471-2393-14-187 (DOI)000338566400002 ()24890365 (PubMedID)2-s2.0-84905053219 (Scopus ID)
Available from: 2015-03-11 Created: 2015-03-11 Last updated: 2017-02-27Bibliographically approved
Baranowski, J., Wallby, L., Nylander, E., Boano, G., Vanky, F., Löfstöm, L., . . . Nielsen, N.-E. (2014). MitraClip after myocardial infarction with papillary muscle rupture and as treatment of systolic anterior motion of the mitral valve.. In: : . Paper presented at ICI&CSI 2014, Frankfurt, Tyskland.
Open this publication in new window or tab >>MitraClip after myocardial infarction with papillary muscle rupture and as treatment of systolic anterior motion of the mitral valve.
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2014 (English)Conference paper, Oral presentation only (Refereed)
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-114081 (URN)
Conference
ICI&CSI 2014, Frankfurt, Tyskland
Available from: 2015-02-07 Created: 2015-02-07 Last updated: 2015-03-30
Baranowski, J., Wallby, L., Ahn, H., Dahlin, L.-G., Nylander, E., Lindgren, B., . . . Nielsen, N.-E. (2014). TAVI without balloon predilation. A ramdomized single centre study.. In: : . Paper presented at ICI&CSI 2014, Frankfurt, Tyskland.
Open this publication in new window or tab >>TAVI without balloon predilation. A ramdomized single centre study.
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2014 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-114078 (URN)
Conference
ICI&CSI 2014, Frankfurt, Tyskland
Available from: 2015-02-07 Created: 2015-02-07 Last updated: 2015-03-30
Baranowski, J. & Nielsen, N.-E. (2014). TAVI without BAV. In: : . Paper presented at Nordic/Baltic TAVI implanters educational meeting. Riga, Latvia. 6-7 February 2014.
Open this publication in new window or tab >>TAVI without BAV
2014 (English)Conference paper, Oral presentation only (Refereed)
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-114074 (URN)
Conference
Nordic/Baltic TAVI implanters educational meeting. Riga, Latvia. 6-7 February 2014
Available from: 2015-02-07 Created: 2015-02-07 Last updated: 2015-03-30
Nielsen, N.-E., Wallby, L., Wolfgang, F., Ahn, H. & Baranowski, J. (2014). Total percutaneous transcatheter valve implantation in native mitral stenosis in a patinent with previous transapical TACI. In: : . Paper presented at ICI&CSI 2014, Frankfurt, Tyskland.
Open this publication in new window or tab >>Total percutaneous transcatheter valve implantation in native mitral stenosis in a patinent with previous transapical TACI
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2014 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-114083 (URN)
Conference
ICI&CSI 2014, Frankfurt, Tyskland
Available from: 2015-02-07 Created: 2015-02-07 Last updated: 2015-03-31
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