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Flodin, Ulf
Publications (10 of 18) Show all publications
Flodin, U., Paues, J., Åkerlind, B., Leanderson, P. & Sjögren, B. (2017). Svetsare – en riskgrupp för septisk pneumoni [Welders - a risk group for septic pneumonia]: Vaccination mot pneumokocker kan vara motiverat för yrkesgruppen. Läkartidningen, 114(6)
Open this publication in new window or tab >>Svetsare – en riskgrupp för septisk pneumoni [Welders - a risk group for septic pneumonia]: Vaccination mot pneumokocker kan vara motiverat för yrkesgruppen
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2017 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 114, no 6Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Sveriges Läkarförbund, 2017
National Category
Infectious Medicine
Identifiers
urn:nbn:se:liu:diva-145292 (URN)28195626 (PubMedID)
Available from: 2018-03-06 Created: 2018-03-06 Last updated: 2018-03-26Bibliographically approved
Wåhlén, K., Fornander, L., Olausson, P., Ydreborg, K., Flodin, U., Graff, P., . . . Ghafouri, B. (2016). Protein profiles of nasal lavage fluid from individuals with work-related upper airway symptoms associated to moldy and damp buildings. Indoor Air, 26(5), 743-754
Open this publication in new window or tab >>Protein profiles of nasal lavage fluid from individuals with work-related upper airway symptoms associated to moldy and damp buildings
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2016 (English)In: Indoor Air, ISSN 0905-6947, E-ISSN 1600-0668, Vol. 26, no 5, p. 743-754Article in journal (Refereed) Published
Abstract [en]

Upper airway irritation is common among individuals working in moldy and damp buildings. The aim was to investigate effects on the protein composition of the nasal lining fluid. The prevalence of symptoms in relation to work was examined in 37 individuals working in two damp buildings. Microbial growth was confirmed in one of the buildings. Nasal lavage fluid was collected from 29 exposed subjects and 13 controls. Protein profiles were investigated with a proteomic approach and evaluated by multivariate statistical models. Subjects from both workplaces reported upper airway and ocular symptoms. Based on protein profiles, symptomatic subjects in the two workplaces were discriminated from each other and separated from healthy controls. The groups differed in proteins involved in inflammation and host defense. Measurements of innate immunity proteins showed a significant increa e of protein S100-A8 and decrease of SPLUNC1 in subjects from one workplace while alpha-1-antitrypsin was elevated in subjects from the other workplace, compared to healthy controls. The results show that protein profiles in nasal lavage fluid can be used to monitor airway mucosal effects in personnel working in damp buildings and indicate that the profile may be separate when the dampness is associated with the presence of molds.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016
Keywords
Sick building syndrome, proteomics, nasal mucosa, SPLUNC1, alpha-1-antitrypsin, protein S100-A8
National Category
Occupational Health and Environmental Health Infectious Medicine
Identifiers
urn:nbn:se:liu:diva-117339 (URN)10.1111/ina.12257 (DOI)000387348500009 ()
Note

Funding agencies: Research Council of South East Sweden [FORSS-222751, FORSS-389061]; Cancer and Allergy Foundation [150441]

Available from: 2015-04-23 Created: 2015-04-23 Last updated: 2018-01-11Bibliographically approved
Fornander, L., Graff, P., Wåhlén, K., Ydreborg, K., Flodin, U., Leanderson, P., . . . Ghafouri, B. (2013). Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids. PLoS ONE, 8(12), e83089
Open this publication in new window or tab >>Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids
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2013 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 12, p. e83089-Article in journal (Refereed) Published
Abstract [en]

BACKGROUNDS: Occurrence of airway irritation among industrial metal workers was investigated. The aims were to study the association between exposures from water-based metal working fluids (MWF) and the health outcome among the personnel, to assess potential effects on the proteome in nasal mucous membranes, and evaluate preventive actions.

METHODS: The prevalence of airway symptoms related to work were examined among 271 metalworkers exposed to MWF and 24 metal workers not exposed to MWF at the same factory. At the same time, air levels of potentially harmful substances (oil mist, morpholine, monoethanolamine, formaldehyde) generated from MWF was measured. Nasal lavage fluid was collected from 13 workers and 15 controls and protein profiles were determined by a proteomic approach.

RESULTS: Airway symptoms were reported in 39% of the workers exposed to MWF although the measured levels of MWF substances in the work place air were low. Highest prevalence was found among workers handling the MWF machines but also those working in the same hall were affected. Improvement of the ventilation to reduce MWF exposure lowered the prevalence of airway problems. Protein profiling showed significantly higher levels of S100-A9 and lower levels of SPLUNC1, cystatin SN, Ig J and β2-microglobulin among workers with airway symptoms.

CONCLUSIONS: This study confirms that upper airway symptoms among metal workers are a common problem and despite low levels of MWF-generated substances, effects on airway immune proteins are found. Further studies to clarify the role of specific MWF components in connection to airway inflammation and the identified biological markers are warranted.

Place, publisher, year, edition, pages
Public Library of Science, 2013
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-103739 (URN)10.1371/journal.pone.0083089 (DOI)000329325200035 ()24391738 (PubMedID)
Available from: 2014-01-24 Created: 2014-01-24 Last updated: 2019-02-11Bibliographically approved
Graff, P., Fredrikson, M., Jönsson, P. & Flodin, U. (2011). Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium. International Archives of Occupational and Environmental Health, 84(7), 797-804
Open this publication in new window or tab >>Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium
2011 (English)In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 84, no 7, p. 797-804Article in journal (Refereed) Published
Abstract [en]

Purpose: This case-control study was undertaken to elucidate the controversy concerning whether low-level, long-term exposure to non-sensitising air pollution at workplaces may cause asthma. Methods: A case-control study of 192 adult-onset asthma cases aged 20-65 years and 323 controls was conducted in the southeast of Sweden. Cases were identified from computerised registers from the region, diagnosed 2000-2004 and diagnoses were confirmed via medical files. Referents were randomised from the population register of the region. Exposure was monitored by a 16-page questionnaire. Special attention was devoted to identifying and in the final analyses excluding subjects exposed to sensitising agents. Results: Three years or more of occupational exposure to air pollution from dust, smoke, fumes or vapours before the year of diagnosis by analyses adjusting for age yielded an increased risk for asthma (OR = 2.3, 95% CI 1.2-4.2) in men, while in women, no risk was seen. In a multiple logistic regression analysis in men without allergy in childhood, a significant risk was seen (OR = 2.8, 95% CI 1.07-7.4), when subjects exposed to identified allergens were excluded. In women, no excess risk was observed from occupational air pollution. Conclusion: The results of this study support an association between occupational exposure to low level non-sensitising air pollution and adult-onset asthma in men.

Place, publisher, year, edition, pages
Springer Verlag (Germany), 2011
Keywords
Low-level exposure, Non-sensitising, Irritants, Asthma, Workplace
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-72824 (URN)10.1007/s00420-011-0671-2 (DOI)000297135700009 ()
Note

Funding Agencies|Swedish Cancer and Allergy Foundation||Forss (Medical Research Council of Southeast Sweden)|2002-413|

Available from: 2011-12-08 Created: 2011-12-08 Last updated: 2017-12-08
Graff, P., Bozhkov, G., Hedenlof, K., Johannesson, O. & Flodin, U. (2009). Epistaxis in a Low Level Hydrogen Fluoride Exposed Industrial Staff. AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 52(3), 240-245
Open this publication in new window or tab >>Epistaxis in a Low Level Hydrogen Fluoride Exposed Industrial Staff
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2009 (English)In: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, ISSN 0271-3586, Vol. 52, no 3, p. 240-245Article in journal (Refereed) Published
Abstract [en]

Objectives To assess the effect of exposure to hydrogen fluoride (HF) on the airway mucosa in an industrial setting.

Methods A cross-sectional study encompassing 33 industrial workers in a flame soldering plant and 44 assembly workers unexposed to HF was performed by means of a questionnaire on symptoms and diagnosis regarding upper and lower airways as well as through conduct of a clinical examination of the exposed group. Air concentrations of HF that were monitored in winter amounted to 1.0 mg/m(3) and in summer time to 0.15 mg/m(3).

Results A threefold risk for epistaxis (RR = 3.6, 95% confidence interval 1.1-11.0) was observed in the exposed group. Time from the start of exposure to HF until debut of a nose bleeding period varied from 1 month to 6 years. Mean induction (latency) time was 42 months. Mean duration of symptoms was 26 months, range 3-72 months, indicating that the exposure level in summer time was sufficient to maintain the propensity of almost daily, nose bleeding.

Conclusion HF is an irritating vapor, even at relatively low air concentrations. We recommend an 8 hr TLV lower than 1.0 mg/m(3).

Keywords
hydrogen fluoride, nose bleeding, rhinitis, flame soldering, asthma
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-17170 (URN)10.1002/ajim.20667 (DOI)
Available from: 2009-03-07 Created: 2009-03-07 Last updated: 2010-01-09
Graff, P., Elmsjo, L., Bjorkander, J. & Flodin, U. (2008). Occupational rhinitis caused by tolyltriazole in metalworking fluids. Scandinavian Journal of Work, Environment and Health, 34(5), 403-404
Open this publication in new window or tab >>Occupational rhinitis caused by tolyltriazole in metalworking fluids
2008 (English)In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 34, no 5, p. 403-404Article in journal, Editorial material (Other academic) Published
Abstract [en]

Objectives: Exposure to metalworking fluids is known to cause mucous membrane inflammation of the airways. In this case report, the authors attempted to identify responsible components in the metalworking fluids for the rhinitis of an exposed patient.

Methods: The patient underwent two provocation tests. The first provocation was performed with the different metalworking fluids used in the factory, and the second was done double blind for some of the components in the metalworking fluids. The patient was asked to quantify her symptoms before, immediately after, 24 hours after, and finally 96 hours after the exposure.

Results: The patient reacted to tolyltriazole with rhinitis and headache. These symptoms started about 8 hours after the exposure and persisted for 24 hours.

Conclusion: The double-blind provocation exposure to the components of the metalworking fluids showed that the patient reacted to the corrosion inhibitor tolyltriazole. To the authors knowledge, no such reaction to tolyltriazole in the airways has previously been reported.

Place, publisher, year, edition, pages
Nordic Association of Occupational Safety and Health (NOROSH), 2008
Keywords
benzotriazole, case report, rhinitis
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:liu:diva-16194 (URN)10.5271/sjweh.1276 (DOI)000260804200011 ()18853069 (PubMedID)2-s2.0-56249124980 (Scopus ID)
Available from: 2009-01-09 Created: 2009-01-09 Last updated: 2018-01-13Bibliographically approved
Landtblom, A.-M., Tondel, M., Hjalmarsson, P., Flodin, U. & Axelson, O. (2006). The risk for multiple sclerosis in female nurse anaesthetists: A register based study. Occupational and Environmental Medicine, 63(6), 387-389
Open this publication in new window or tab >>The risk for multiple sclerosis in female nurse anaesthetists: A register based study
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2006 (English)In: Occupational and Environmental Medicine, ISSN 1351-0711, E-ISSN 1470-7926, Vol. 63, no 6, p. 387-389Article in journal (Refereed) Published
Abstract [en]

Background: Previous studies have suggested that exposure to organic solvents, including volatile anaesthetic agents, may be a risk factor for multiple sclerosis (MS), possibly in combination with genetic and other environmental factors. Aims: To further investigate the role of volatile anaesthetic agents having similar acute toxic effects to other organic solvents. Methods: Female nurse anaesthetists, other female nurses, and female teachers from middle and upper compulsory school levels were identified and retrieved from the 1985 census, Statistics Sweden. By means of the unique personal identity number in Sweden, these individuals were linked with the disability pension registers at The National Social Insurance Board and also with data on hospital care 1985-2000 at The National Board of Health and Welfare. Results: The cumulative incidence rate ratio of MS was found to be increased in female nurse anaesthetists in relation to other nurses (statistically not significant) and teachers (statistically significant), respectively. Conclusions: These findings give some support to previous findings of an increased risk for MS in nurse anaesthetists. This is interesting in the context of previous observations of organic solvents in general as a potential risk factor in MS.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-34807 (URN)10.1136/oem.2005.024604 (DOI)23305 (Local ID)23305 (Archive number)23305 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Flodin, U. & Jönsson, P. (2004). Non-sensitising air pollution at workplaces and adult onset asthma. International Archives of Occupational and Environmental Health, 77(1), 17-22
Open this publication in new window or tab >>Non-sensitising air pollution at workplaces and adult onset asthma
2004 (English)In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 77, no 1, p. 17-22Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of this study was to elucidate further whether occupational exposure to non-sensitising air pollution at workplaces increases the risk of adult onset asthma. Methods: One hundred and twenty persons with asthma diagnosed by general practitioners, aged 20-65 years, were compared with 446 referents matched for age and gender and living in the same community as the cases. Information about occupation, exposure to specific allergens, smoking habits, dwellings and atopy was obtained from a postal questionnaire. The subjects' occupations were categorised as clean or polluted, based on the judgement of the referents on their respective occupations. Results: Three years or more of work in air-polluted workplaces resulted in an odds ratio of 1.7 (95% confidence interval 1.0-2.7). Stratification of the material on smoking habits, gender or atopy did not alter the results, nor did exclusion of subjects exposed to specific allergens of statistical significance in this material, e.g. flour dust. Smoking per se did not bring any risk of asthma. Working in buildings affected by dampness and mould brought a fourfold significant risk. Conclusion: In this study occupational exposure to unspecific air pollution at workplaces was associated with an increased risk of adult-onset asthma.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-22017 (URN)10.1007/s00420-003-0466-1 (DOI)1045 (Local ID)1045 (Archive number)1045 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Kangoum, A.-A., Flodin, U., Hammar, M. & Sydsjö, G. (2004). Prevalence of female genital mutilation among African women resident in the Swedish county of Östergötland. Acta Obstetricia et Gynecologica Scandinavica, 83(2), 187-190
Open this publication in new window or tab >>Prevalence of female genital mutilation among African women resident in the Swedish county of Östergötland
2004 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 83, no 2, p. 187-190Article in journal (Refereed) Published
Abstract [en]

Objectives. To establish the prevalence of female genital mutilation (FGM) among African women resident in the Swedish County of Östergötland and assess the types of FGM. Material and methods. Three hundred and four African women aged ≥ 18 years were domiciled in Östergötland by the end of 1998. The women were invited by letter. A socio-cultural questionnaire designed to give an overall picture of FGM within a socioeconomic context, and also to invite the women to an interview and examination, was sent to all African women in the county of Östergötland. Women who gave their consent (n = 63) underwent a gynecologic examination. Results. The response rate was 84%. According to the questionnaire, 68% of all the African women were genitally mutilated. The clinical examination revealed that 39 women (62%) were mutilated, 17 of them (44%) had undergone removal of part or all external genitalia and stitching ('infibulation'), 26% had undergone removal of the prepuce of the clitoris ('prepucectomy'), 23% had undergone various cultural practices on the external genitalia, and 7.7% excision of the clitoris with partial or total removal of labia minora ('clitoridectomy'). Conclusion. The influx of immigrants to Sweden and the other Scandinavian countries from cultures where FGM is practiced, requires that physicians and other health professionals familiarize themselves with the practice and the cultural beliefs underlying it. Sensitivity to the needs of these women as well as attention to the potential physical hazards posed by the practice are important factors in care.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-22012 (URN)10.1111/j.0001-6349.2004.0292.x (DOI)1039 (Local ID)1039 (Archive number)1039 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Landtblom, A.-M., Thuomas, K., Sjöqvist, L., Flodin, U., Nyland, H. & Söderfeldt, B. (2003). Hypointensity in T2-weighted images of the basal ganglia in solvent-exposed patients with multiple sclerosis: Clinical, MRI and CSF characteristics. Neurological Sciences, 24(1)
Open this publication in new window or tab >>Hypointensity in T2-weighted images of the basal ganglia in solvent-exposed patients with multiple sclerosis: Clinical, MRI and CSF characteristics
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2003 (English)In: Neurological Sciences, ISSN 1590-1874, E-ISSN 1590-3478, Vol. 24, no 1Article in journal (Refereed) Published
Abstract [en]

Several studies have indicated an association between MS and organic solvent exposure. Our objective was to analyse differences regarding cerebrospinal fluid (CSF) properties, magnetic resonance imaging (MRI) features and cerebral metabolites, measured by proton spectroscopy (1H-MRS), in 20 patients with spontaneous multiple sclerosis (MS) and in 20 patients with MS after solvent exposure, 15 healthy subjects served as controls. CSF examinations were retrospectively reviewed from the medical files. There were no significant differences in the CSF regarding pleocytosis, spinal-serum albumin ratio or mean extended IgG index. However, T2-weighted images of the solvent-exposed MS patients showed more hypointense areas in the basal ganglia. Hypointensity on T2-weighted images of the basal ganglia in the solvent-exposed MS patients may correspond to neurodegeneration and could be an early event in MS.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26444 (URN)10.1007/s100720300014 (DOI)10987 (Local ID)10987 (Archive number)10987 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
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