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Hannestad, Ulf
Publications (10 of 12) Show all publications
Nord, M., Kullman, A., Hannestad, U. & Dizdar Segrell, N. (2017). Is Levodopa Pharmacokinetics in Patients with Parkinson’s Disease Depending on Gastric Emptying?. Advances in Parkinsons Disease, 06(01)
Open this publication in new window or tab >>Is Levodopa Pharmacokinetics in Patients with Parkinson’s Disease Depending on Gastric Emptying?
2017 (English)In: Advances in Parkinsons Disease, ISSN 2169-9712, Vol. 06, no 01Article in journal (Refereed) Published
Abstract [en]

Levodopa uptake from the gastrointestinal tract in patients with Parkinson’s disease (PD) can be affected by delayed gastric emptying (GE). This might lead to fluctuating levodopa levels resulting in increased motor fluctuations. Continuous dopaminergic stimulation (CDS) improves motor fluctuations and could be a result of smoothening in levodopa uptake. In this study we wanted to study the levodopa pharmacokinetics peripherally in PD patients with motor fluctuations and investigate the relation between levodopa uptake and GE and the effect of CDS. PD patients with wearing off (group 1) and on-off syndrome (group 2) were included. Breath tests were performed to evaluate the half time (T1/2) of GE. Concomitantly 1 tablet of Madopark® was given and the levodopa concentrations in blood and subcutaneous (SC) tissue were analyzed for both groups. Group 2 was then given a 10-d continuous intravenous levodopa treatment and the tests were repeated. Higher levels of levodopa in group 1 compared to group 2 in blood (p = 0.014) were seen. The GE was delayed in both group 1 (p < 0.001) and group 2 (p < 0.05) compared to a reference group with healthy volunteers with T1/2 median values 105 and 78 min vs. 72 min. There was no difference in GE between the two PD groups (p = 0.220) or in group 2 before and after infusion period (p = 0.861). CDS resulted in lower levodopa levels in blood (p < 0.001) and SC tissue (p < 0.01). In conclusion, PD patients in early complication phase have a more favourable levodopa uptake than patients later in disease. We found delayed GE in PD patients with motor fluctuations but no obvious relation between GE and levodopa uptake or GE and PD stage. The effect of CDS indicates no effect of CDS on the mechanisms of GE but on the mechanisms of levodopa uptake.

Place, publisher, year, edition, pages
Scientific Research Publishing, 2017
National Category
Neurology Gastroenterology and Hepatology Anesthesiology and Intensive Care Surgery Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-136685 (URN)10.4236/apd.2017.61001 (DOI)
Available from: 2017-04-20 Created: 2017-04-20 Last updated: 2018-01-12
Eriksson, B., Henriksson, H., Löf, M., Hannestad, U. & Forsum, E. (2012). Body-composition development during early childhood and energy expenditure in response to physical activity in 1.5-y-old children. American Journal of Clinical Nutrition, 96(3), 567-573
Open this publication in new window or tab >>Body-composition development during early childhood and energy expenditure in response to physical activity in 1.5-y-old children
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2012 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 96, no 3, p. 567-573Article in journal (Refereed) Published
Abstract [en]

Background: The prevalence of childhood overweight and obesity has increased recently, but the mechanisms involved are incompletely known. Previous research has shown a correlation between the percentage of total body fat (TBF) and physical activity level (PAL). However, the PAL values used may involve a risk of spurious correlations because they are often based on predicted rather than measured estimates of resting energy metabolism. less thanbrgreater than less thanbrgreater thanObjectives: We studied the development of body composition during early childhood and the relation between the percentage of TBF and PAL on the basis of the measured resting energy metabolism. less thanbrgreater than less thanbrgreater thanDesign: Body composition was previously measured in 108 children when they were 1 and 12 wk old. When 44 of these children (21 girls and 23 boys) were 1.5 y old, their total energy expenditure and TBF were assessed by using the doubly labeled water method. Resting energy metabolism, which was assessed by using indirect calorimetry, was used to calculate PAL. less thanbrgreater than less thanbrgreater thanResults: Significant correlations were shown for TBF (r = 0.32, P = 0.035) and fat-free mass (r = 0.34, P = 0.025) between values (kg) assessed at 12 wk and 1.5 y of age. For TBF (kg) a significant interaction (P = 0.035) indicated a possible sex difference. PAL at 1.5 y was negatively correlated with the percentage of TBF (r = -0.40, P = 0.0076) and the increase in the percentage of TBF between 12 wk and 1.5 y (r = 0.38, P = 0.0105). less thanbrgreater than less thanbrgreater thanConclusions: The results indicate that body fatness and physical activity interact during early childhood and thereby influence obesity risk. Our results are based on a small sample, but nevertheless, they motivate additional studies in boys compared with girls regarding the development of body composition during early life.

Place, publisher, year, edition, pages
American Society for Nutrition, 2012
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-84341 (URN)10.3945/ajcn.111.022020 (DOI)000307863800016 ()
Note

Funding Agencies|Swedish Research Council|15402|AFA Insurance||Medical Faculty, Linkoping University||County Council of Ostergotland||Crown Princess Lovisa Foundation||

Available from: 2012-10-05 Created: 2012-10-05 Last updated: 2019-06-28
Eriksson, B., Löf, M., Hannestad, U. & Forsum, E. (2011). Fat-free mass hydration in newborns: assessment and implications for body composition studies. Acta Paediatrica, 100(5), 680-686
Open this publication in new window or tab >>Fat-free mass hydration in newborns: assessment and implications for body composition studies
2011 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 100, no 5, p. 680-686Article in journal (Refereed) Published
Abstract [en]

Equipment (Pea Pod) for assessing infant body density accurately and conveniently has recently become available. This density can be converted to body composition using the “Fomon” or the “Butte” model. These models differ regarding the water content in fat-free mass (hydration factor, HF). We assessed HF and its biological variability in newborns and compared results calculated using the two models at one and 12 weeks. Body volume and body weight were measured in 12 infants less than 10 days old using Pea Pod. Their total body water was assessed using isotope dilution. Their HF was found to be 80.9% with low biological variability (0.81% of average HF). Further, Pea Pod was used to assess body density of 108 infants at one and 12 weeks of age. Values for body fat (%) calculated using the “Butte” model were significantly lower than when using the “Fomon” model at one week (p<0.05) and 12 weeks (p<0.01). The difference between the two models was particularly large at one week, probably due to their different HF-values. Our HF-value is in agreement with that in the “Fomon” model and our results support the conclusion that this model is preferable when calculating body composition in infants.

Place, publisher, year, edition, pages
Wiley, 2011
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-54970 (URN)10.1111/j.1651-2227.2011.02147.x (DOI)000289250200013 ()
Available from: 2010-04-26 Created: 2010-04-26 Last updated: 2019-06-28
Lee, W., Chung, H.-J., Hannestad, U., Kim, S., Chun, S., Park, J.-Y., . . . Min, W.-K. (2011). Letter: Trueness assessment of Korean nation-wide glucose proficiency testing [Letter to the editor]. Clinical Chemistry and Laboratory Medicine, 49(6), 1061-1064
Open this publication in new window or tab >>Letter: Trueness assessment of Korean nation-wide glucose proficiency testing
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2011 (English)In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 49, no 6, p. 1061-1064Article in journal, Letter (Other academic) Published
Abstract [en]

n/a

Place, publisher, year, edition, pages
Walter de Gruyter, 2011
Keywords
glucose; proficiency testing; reference measurement procedure; trueness
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-69895 (URN)10.1515/CCLM.2011.169 (DOI)000291429500020 ()
Available from: 2011-08-09 Created: 2011-08-08 Last updated: 2017-12-08
Osman, A. & Hannestad, U. (2008). A possible ethanol-catalyzed rearrangement of vitamin K-1 detected by gas chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry, 22(23), 3861-3866
Open this publication in new window or tab >>A possible ethanol-catalyzed rearrangement of vitamin K-1 detected by gas chromatography/mass spectrometry
2008 (English)In: Rapid Communications in Mass Spectrometry, ISSN 0951-4198, E-ISSN 1097-0231, Vol. 22, no 23, p. 3861-3866Article in journal (Refereed) Published
Abstract [en]

We studied vitamin K-1(20), vitamin K-1(25), and vitamin K, epoxide in n-hexane and ethanol solutions by gas chromatography/mass spectrometry (GC/MS) utilizing a DB-5 MS fused-silica capillary column. In ethanol solutions of K-1, we observed an extra peak eluting from the GC column with somewhat longer retention time than K-1(20). A similar peak following K-1(25) was also found. These peaks were not found in n-hexane solutions of K-1. A close examination of the mass spectra of these peaks indicated that they were vitamin K-1 variants containing a base peak at m/z 225 characteristic of the methylnaphthoquinone ring with a four-carbon side chain. In addition, they contained the molecular ions of K-1(20) and K-1(25), respectively. We conclude that K-1(20) and K-1(25), but not K-1 epoxide, might undergo rearrangements in ethanol involving an intramolecular proton transfer and a shift of the beta,gamma-double bond on the phytyl side chain toward the ring. The conjugation of the phytyl double bond with the quinone ring is probably the driving force of the rearrangement. We emphasize, however, that our conclusion is based only on mass spectral analysis and would require further investigation by other spectroscopic methods.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-16210 (URN)10.1002/rcm.3807 (DOI)
Available from: 2009-01-12 Created: 2009-01-09 Last updated: 2017-12-14
Hannestad, U., Theodorsson, E. & Evengard, B. (2007). ß-Alanine and ?-aminobutyric acid in chronic fatigue syndrome. Clinica Chimica Acta, 376(1-2), 23-29
Open this publication in new window or tab >>ß-Alanine and ?-aminobutyric acid in chronic fatigue syndrome
2007 (English)In: Clinica Chimica Acta, ISSN 0009-8981, E-ISSN 1873-3492, Vol. 376, no 1-2, p. 23-29Article in journal (Refereed) Published
Abstract [en]

Background: Due to the occurrence of sleep disturbances and fatigue in chronic fatigue syndrome (CFS), an investigation was performed to examine if there is an abnormal excretion of ?-aminobutyric acid (GABA) and/or its structural analogue ß-alanine in the urine from CFS patients. Both GABA and ß-alanine are inhibitory neurotransmitters in the mammalian central nervous system. Methods: The 24 h urine excretion of GABA and ß-alanine was determined by isotope dilution gas chromatography mass spectrometry in 33 CFS patients and 43 healthy controls. The degree of symptoms in both patients and controls was measured by grading of three typical CFS symptoms using a Visual Analogue Scale. Results: Men had a significantly higher excretion of both ß-alanine and GABA than women. Comparing CFS patients with healthy controls showed no significant difference in excretion of neither ß-alanine nor GABA. No correlation was found between the excretion of ß-alanine or GABA and any of the three characteristic CFS symptoms measured. However, two female and two male CFS patients excreted considerably higher amounts of ß-alanine in their 24 h urine samples than control subjects. Conclusions: Increased excretion of ß-alanine was found in a subgroup of CFS patients, indicating that there may be a link between CFS and ß-alanine in some CFS patients. © 2006 Elsevier B.V. All rights reserved.

Keywords
ß-Alanine, ?-Aminobutyric acid, Chronic fatigue syndrome, Immunosuppression, Ornithine decarboxylase, Polyamines
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-50013 (URN)10.1016/j.cca.2006.07.004 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Sjöstedt, C., Hannestad, U., Franzén, L., Söderholm, J. D. & Borch, K. (2005). Atrophic gastritis is associated with increased sucrose permeability related to chronic inflammation. Digestion, 72(4), 201-206
Open this publication in new window or tab >>Atrophic gastritis is associated with increased sucrose permeability related to chronic inflammation
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2005 (English)In: Digestion, ISSN 0012-2823, E-ISSN 1421-9867, Vol. 72, no 4, p. 201-206Article in journal (Refereed) Published
Abstract [en]

Background: Different theories have been presented to explain how atrophic gastritis may lead to gastric cancer development. One contributing factor could be impaired function of the gastric mucosal barrier. The aim of this study was to investigate if there are changes in gastric mucosal permeability to sucrose in atrophic gastritis. Methods: The study comprised 22 patients with atrophic gastritis and 21 normal controls. Gastritis was classified according to the Sydney system from endoscopic biopsies of the gastric corpus and antrum. All subjects were exposed to oral sucrose load (100 g), and the fraction of sucrose excreted in urine was measured by gas chromatography-mass spectrometry. Results: The fraction of sucrose excreted in urine after oral load was significantly increased in atrophic gastritis compared with controls (median 0.08 vs. 0.04%, p = 0.003). Sucrose excretion was positively related to the degree of chronic inflammation (median fraction excreted: mild inflammation 0.06%, moderate inflammation 0.08%, severe inflammation 0.18%, p = 0.04) rather than to the degree of atrophy in the gastric mucosa. Occurrence of intestinal metaplasia was also associated with significantly higher sucrose excretion. However, in multivariate analysis, including intestinal metaplasia, only the degree of inflammation was positively related to sucrose excretion. Conclusion: Atrophic gastritis is associated with increased sucrose permeability, suggesting paracellular leakage of the gastric mucosa. This leakage seems to be related to the degree of inflammation rather than the degree of atrophy. The findings may have implications for the diseases and complications associated with atrophic gastritis. Copyright © 2005 S. Karger AG.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-31495 (URN)10.1159/000089145 (DOI)17290 (Local ID)17290 (Archive number)17290 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
Löf, M., Hannestad, U. & Forsum, E. (2003). Comparison of commonly used procedures, including the doubly-labelled water technique, in the estimation of total energy expenditure of women with special reference to the significance of body fatness. British Journal of Nutrition, 90(5), 961-968
Open this publication in new window or tab >>Comparison of commonly used procedures, including the doubly-labelled water technique, in the estimation of total energy expenditure of women with special reference to the significance of body fatness
2003 (English)In: British Journal of Nutrition, ISSN 0007-1145, E-ISSN 1475-2662, Vol. 90, no 5, p. 961-968Article in journal (Refereed) Published
Abstract [en]

According to the report of the World Health Organization (1985), total energy expenditure (TEE) in human subjects can be calculated as BMR × physical activity level (PAL). However, other reports have pointed out limitations in the suggested procedure related to the % body fat of the subjects. The purpose of the present study was to evaluate the World Health Organization (1985) procedure in thirty-four healthy women with BMI 18-39 kg/m2. BMR and TEE were measured using indirect calorimetry (BMRmeas) and the doubly-labelled water method (TEEref) respectively. When assessed using the doubly-labelled water and skinfold-thickness methods, the women had 34 (SD 8) and 33 (SD 6) % body fat respectively. On the basis of guidelines provided by the World Health Organization (1985), 1.64 was selected to represent the average PAL of the women. Furthermore, PAL was also assessed by means of an accelerometer (PALacc), heart-rate recordings (PALHR) and a questionnaire (PALq). These estimates were: PALacc 1.71 (SD 0.17), PALHR 1.76 (SD 0.24), PALq 1.86 (SD 0.27). These values were lower than TEEref/BMRref, which was 1.98 (SD 0.21). BMR assessed using equations recommended by the World Health Organization (1985) (BMRpredicted) overestimated BMR by 594 (SD 431) kj/24 h. However, when TEE was calculated as BMRpredicted × PALacc, BMRpredicted × PALHR and BMRpredicted × PALq respectively, average results were in agreement with TEEref. Furthermore, TEE values based on BMRpredicted and PALacc, PALHR, PALq as well as on PAL = 1.64, minus TEEref, were significantly correlated with body fatness. When the same PAL value (1.64) was used for all subjects, this correlation was particularly strong. Thus, the World Health Organization (1985) procedure may give TEE results that are biased with respect to the body fatness of subjects.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-25016 (URN)10.1079/BJN2003975 (DOI)9437 (Local ID)9437 (Archive number)9437 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2019-06-28
Löf, M., Hannestad, U. & Forsum, E. (2002). Assessing physical activity of women of childbearing age. Ongoing work to develop and evaluate simple methods. Food and Nutrition Bulletin, 23(3 SUPP), 30-33
Open this publication in new window or tab >>Assessing physical activity of women of childbearing age. Ongoing work to develop and evaluate simple methods
2002 (English)In: Food and Nutrition Bulletin, ISSN 0379-5721, E-ISSN 1564-8265, Vol. 23, no 3 SUPP, p. 30-33Article in journal (Refereed) Published
Abstract [en]

Simple methods were developed and evaluated to assess total energy expenditure in 24 healthy, Swedish women planning pregnancy. Total energy expenditure was measured by the doubly-labeled water method (reference method) and three simple methods: heart rate recording, movement registration by an accelerometer, and a questionnaire. Mean total energy expenditure obtained by the four methods varied between 2,530 kcal per 24 hours (10,570 kJ/24 hours) and 2,730 kcal per 24 hours (11,420 kJ/24 hours). No significant difference between the results obtained by the different methods was found. The mean difference between the simple method and the reference method was for the questionnaire 204 +/- 508 kcal per 24 hours (853 +/- 2,124 kJ/24 hours), for the heart rate recorder 58 +/- 338 kcal per 24 hours (241 +/- 1,416 kJ/24 hours) and for the accelerometer 6 +/- 325 kcal per 24 hours (25 +/- 1,360 kJ/24 hours). The heart rate recorder and the questionnaire overestimated high and underestimated low energy expenditures. The accelerometer and the heart rate recorder were able to assess mean total energy expenditure of groups. No systematic bias was found when the accelerometer was used.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-25014 (URN)9435 (Local ID)9435 (Archive number)9435 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2019-06-28
Söderholm, J. D., Olaison, G., Lindberg, E., Hannestad, U., Vindels, A., Tysk, C., . . . Sjödahl, R. (1999). Different intestinal permeability patterns in relative and spouses of patients with Crohn's disease: an inherited defect in mucosal defence?. Gut, 44, 96-100
Open this publication in new window or tab >>Different intestinal permeability patterns in relative and spouses of patients with Crohn's disease: an inherited defect in mucosal defence?
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1999 (English)In: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 44, p. 96-100Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-25060 (URN)9489 (Local ID)9489 (Archive number)9489 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
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