liu.seSearch for publications in DiVA
Change search
Link to record
Permanent link

Direct link
BETA
Böttcher (Fagerås), Malin
Alternative names
Publications (10 of 42) Show all publications
Furuhjelm, C., Warstedt, K., Fagerås Böttcher, M., Fälth-Magnusson, K., Larsson, J., Fredriksson, M. & Duchén, K. (2011). Allergic disease in infants up to 2 yr of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation inpregnancy and lactation. Pediatric Allergy and Immunology, 22(5), 505-514
Open this publication in new window or tab >>Allergic disease in infants up to 2 yr of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation inpregnancy and lactation
Show others...
2011 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 22, no 5, p. 505-514Article in journal (Refereed) Published
Abstract [en]

We have previously reported a protective effect of maternal omega-3 long-chain polyunsaturated fatty acids (x-3 LCPUFA) supplementation in pregnancy and lactation on IgE-associated eczema and food allergy in the infant during the first year of life. Here we investigate whether the effects of the LCPUFA supplementation on IgE-associated diseases last up to 2 yr of age and assess the relationship between plasma proportions of x-3 PUFAs and the frequency and severity of infant allergic disease. 145 pregnant women, at risk of having an allergic infant, were randomized to daily supplementation with 1.6 g eicosapentaenoic acid (EPA) and 1.1 g docosahexaenoic acid (DHA) or placebo starting in the 25th gestational week and continuing through 3.5 months of breastfeeding. Clinical examinations, skin prick tests and analysis of maternal and infant plasma phospholipid fatty acids and infant specific IgE were performed. No difference in the prevalence of allergic symptoms was found between the intervention groups. Thecumulative incidence of IgE-associated disease was lower in the x-3-supplemented group (6/54, 13%) compared with the placebo group (19/62, 30%, p = 0.01). Higher maternal and infant proportions of DHA and EPA were associated with lower prevalence of IgE associated disease (p = 0.01–0.05) in a dose-dependent manner. Higher maternal and infant proportions of DHA and EPA were found if the infants presented none, when compared with multiple allergic symptoms, (p < 0.05) regardless of sensitization. In summary, the x-3 supplementation offered no obvious preventive effect on the prevalence of clinical symptoms of allergic disease, but the decrease in cumulative incidence of IgE-associated disease seen during the first year still remained until 2 yr of age. Furthermore, high proportions of DHA and EPA in maternal and infant plasma phospholipids were associated with less IgE-associated disease and a reduced severity of the allergic phenotype.

Place, publisher, year, edition, pages
John Wiley & Sons A/S, 2011
Keywords
allergy; eczema; fatty acids; pregnancy; lactation; dietary supplements; infant
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-61945 (URN)10.1111/j.1399-3038.2010.01096.x (DOI)000292931300009 ()
Note
Original Publication: Catrin Furuhjelm, Kristina Warstedt, Malin Fagerås Böttcher, Karin Fälth-Magnusson, Johanna Larsson, Mats Fredriksson and Karel Duchén, Allergic disease in infants up to 2 yr of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation inpregnancy and lactation, 2011, Pediatric Allergy and Immunology, (22), 5, 505-514. http://dx.doi.org/10.1111/j.1399-3038.2010.01096.x Copyright: John Wiley and Sons http://www.wiley.com/ Available from: 2010-11-18 Created: 2010-11-18 Last updated: 2017-12-12
Sandin, A., Bjorksten, B., Fagerås Böttcher, M., Englund, E., Jenmalm, M. & Braback, L. (2011). High salivary secretory IgA antibody levels are associated with less late-onset wheezing in IgE-sensitized infants. Pediatric Allergy and Immunology, 22(5), 477-481
Open this publication in new window or tab >>High salivary secretory IgA antibody levels are associated with less late-onset wheezing in IgE-sensitized infants
Show others...
2011 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 22, no 5, p. 477-481Article in journal (Refereed) Published
Abstract [en]

Low levels of secretory IgA (SIgA) and transient IgA deficiency have been associated with an increased risk for allergy, but data are conflicting. The aim was to assess the relationship between salivary SIgA antibody levels at 1 yr and wheezing at age four in a birth cohort, in particular the possible protective role of salivary SIgA in sensitized children. Saliva samples were obtained from all children (n = 67) with a positive skin prick test (SPT) at 1 yr and 212 children with a negative SPT. In all, 200 of these children responded to questionnaires at 4 yrs and 183 were skin prick tested at that age. The levels of salivary SIgA and salivary IgA antibodies to the most common food allergen egg and inhalant allergen cat were analyzed by ELISA. Serum was analyzed for IgE antibodies to egg and cat. Development of late-onset wheezing was associated with low SIgA levels in children with positive SPT to at least one allergen both at 1 and 4 yrs of age (p = 0.04), as well as in children with circulating IgE antibodies to egg or cat at 1 yr (p = 0.02). None of nine persistently sensitized children with SIgA levels in the upper quartile developed wheezing, when compared to 10/20 children with lower levels (p = 0.01). Older siblings, more than three infections during infancy, at least one smoking parent, and male gender, were all associated with SIgA in the upper quartile. In conclusion, high levels of SIgA antibodies in sensitized infants were associated with significantly less late-onset wheezing, supporting a protective role against development of asthmatic symptoms. Recurrent infections and other factors supporting an increased microbial pressure during infancy were associated with high levels of salivary SIgA.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd, 2011
Keywords
secretory IgA; saliva; sensitization; late-onset wheezing; children
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-69771 (URN)10.1111/j.1399-3038.2010.01106.x (DOI)000292931300004 ()
Note
This is the authors’ version of: Anna Sandin, Bengt Bjorksten, Malin Fagerås Böttcher, Erling Englund, Maria Jenmalm and Lennart Braback, High salivary secretory IgA antibody levels are associated with less late-onset wheezing in IgE-sensitized infants, 2011, Pediatric Allergy and Immunology, (22), 5, 477-481. http://dx.doi.org/10.1111/j.1399-3038.2010.01106.x Copyright: John Wiley and Sons http://www.wiley.com/ Available from: 2011-08-10 Created: 2011-08-08 Last updated: 2017-12-08
Fagerås Böttcher, M., Tomicic, S., Voor, T., Björkstén, B. & Jenmalm, M. (2011). Slow salivary secretory IgA maturation may relate to low microbial pressure and allergic symptoms in sensitized children. Pediatric Research, 70(6), 572-577
Open this publication in new window or tab >>Slow salivary secretory IgA maturation may relate to low microbial pressure and allergic symptoms in sensitized children
Show others...
2011 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 70, no 6, p. 572-577Article in journal (Refereed) Published
Abstract [en]

It is unknown why allergic symptoms do not develop in all sensitized children. We analyzed prospectively the postnatal secretory IgA (SIgA) development and whether high SIgA levels would protect sensitized infants from developing allergic symptoms. Salivary total IgA and SIgA levels were determined by ELISA, and allergy development was investigated at 3, 6, and 12 mo and at 2 and 5 y in two birth cohorts in Estonia (n = 110) and Sweden (n = 91), two geographically adjacent countries with different living conditions and allergy incidence. Total and SIgA levels increased with age, reaching adult levels at the age of 5. Virtually, all salivary IgA in Estonian children was in the secretory form, while a major part of IgA in Swedish saliva lacked the secretory component up to 2 y of age. In Sweden, high levels of salivary IgA without secretory component correlated inversely with house dust endotoxin levels. High SIgA levels were associated with less development of allergic symptoms in sensitized Swedish children. In conclusion, postnatal maturation of the salivary SIgA system proceeds markedly slower in Swedish than Estonian children, possibly as a consequence of low microbial pressure. SIgA may limit allergy-mediated tissue damage at mucosal surfaces in sensitized individuals.

Place, publisher, year, edition, pages
Nature Publishing Group, 2011
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-73314 (URN)10.1203/PDR.0b013e318232169e (DOI)297433900005 ()21857384 (PubMedID)
Note

When submitted this article was titled "Slower maturation of the secretory IgA system in Swedish than Estonian children: possibly caused by low microbial pressure and related to expression of allergy in sensitised individuals".

Available from: 2012-01-03 Created: 2012-01-02 Last updated: 2017-12-08Bibliographically approved
Tomicic, S., Johansson, G., Voor, T., Björksten, B., Fagerås-Böttcher, M. & Jenmalm, M. (2010). Breast milk cytokine and IgA composition differ in Estonian and Swedish mothers-relationship to microbial pressure and infant allergy. Pediatric Research, 68(4), 330-334
Open this publication in new window or tab >>Breast milk cytokine and IgA composition differ in Estonian and Swedish mothers-relationship to microbial pressure and infant allergy
Show others...
2010 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 68, no 4, p. 330-334Article in journal (Refereed) Published
Abstract [en]

The immune system of the neonate is influenced by maternal immunity during pregnancy and lactation. An altered microbial exposure, possibly underlying the increase of allergic diseases in affluent societies, may affect maternal breast milk immune composition. Secretory IgA (SIgA), IL-4, IL-10, IL-13, IFN-γ, TGF-β1, and TGF-β2 were analyzed with ELISA in colostrum and 1-mo mature milk from mothers from Estonia (n = 39) and Sweden (n = 60), the two geographically adjacent countries with different living conditions and allergy incidence. The IL-10 and IFN-γ levels were higher in colostrum from Estonian than Swedish mothers, whereas the opposite was true for TGF-β2. In mature milk, higher SIgA and IFN-γ levels but lower TGF-β1 and TGF-β2 levels were observed in Estonian than Swedish mothers. Interestingly, in Sweden but not Estonia, the TGF-β1 and TGF-β2 levels correlated inversely with environmental endotoxin concentrations, whereas positive correlations to microbial load were observed for IL-4, IL-10, and IFN-γ. High colostral IL-13 levels were associated with allergic sensitization during infancy in Sweden. In conclusion, Estonian mothers have lower breast milk levels of TGF-β, particularly TGF-β2, but higher levels of SIgA, IL-10, and IFN-γ than Swedish mothers, possibly because of differences in microbial load.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-64314 (URN)10.1203/PDR.0b013e3181ee049d (DOI)20581738 (PubMedID)
Available from: 2011-01-19 Created: 2011-01-19 Last updated: 2017-12-11
Tomičić, S., Fälth-Magnusson, K. & Fagerås Böttcher, M. (2010). Dysregulated Th1 and Th2 responses in food-allergic children: Does elimination diet contribute to the dysregulation?. Pediatric Allergy and Immunology, 21(4), 649-655
Open this publication in new window or tab >>Dysregulated Th1 and Th2 responses in food-allergic children: Does elimination diet contribute to the dysregulation?
2010 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, E-ISSN 1399-3038, Vol. 21, no 4, p. 649-655Article in journal (Refereed) Published
Abstract [en]

Infants with eczema and sensitization to foods are recommended skin care and, if food allergy is proven, an elimination diet. Although most of these children tolerate foods before 3 yr of age, some children experience prolonged food allergy. To our knowledge, no prospective study has investigated the cytokine profile in food-sensitized eczematous children with prolonged food intolerance. The aim of the study was to prospectively investigate the development of cytokine production induced by food allergen in food-sensitized eczematous children who, at 41/2 yr of age, were allergic or tolerant to egg or milk. Twenty-one eczematous infants, [age 5 (3-10) months; median and range], sensitized to egg and/or milk were included, put on elimination diet and followed prospectively. At 41/2 yr of age, the children were defined as tolerant or allergic to egg and/or milk based on open or double-blind placebo-controlled food challenges. Peripheral blood mononuclear cells (PBMC) were isolated from the children on inclusion, after 6 wk of elimination diet, and at 3 and 41/2 yr of age. Ovalbumin, beta-lactoglobulin and tetanus toxoid-induced IL-4, -5, -10, -13 and IFN-gamma production from PBMC were analyzed with enzyme-linked immunosorbent assay. The IFN-gamma and IL-5 secretion induced by food allergen at 41/2 yr was higher in cell cultures from children who were allergic to egg or milk than in tolerant children. In food-allergic children, the levels of IFN-gamma and IL-5 were higher at 41/2 yr compared with inclusion levels, but this increase was generally not observed in the tolerant children who consumed milk and egg. In conclusion, immune cells from food-allergic children on an elimination diet respond with up-regulated T helper 1 and T helper 2 cytokine secretion induced by food allergen. We hypothesize that allergen elimination may influence the regulatory mechanisms maintaining balanced immune responses to innocuous food antigens.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd, 2010
Keywords
children; cytokines; elimination diet; food allergy; tolerance
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13207 (URN)10.1111/j.1399-3038.2009.00937.x (DOI)000278526100011 ()
Available from: 2008-04-17 Created: 2008-04-17 Last updated: 2017-12-13
Sjögren, Y. M., Jenmalm, M., Böttcher, M., Björkstén, B. & Sverremark-Ekström , E. (2009). Altered early infant gut microbiota in children developing allergy up to 5 years of age. CLINICAL AND EXPERIMENTAL ALLERGY, 39(4), 518-526
Open this publication in new window or tab >>Altered early infant gut microbiota in children developing allergy up to 5 years of age
Show others...
2009 (English)In: CLINICAL AND EXPERIMENTAL ALLERGY, ISSN 0954-7894 , Vol. 39, no 4, p. 518-526Article in journal (Refereed) Published
Abstract [en]

Early colonization with bifidobacteria and lactobacilli is postulated to protect children from allergy, while Clostridium (C.) difficile colonization might be associated with allergic disease. Previous studies of infant gut microbiota in relation to subsequent allergy development have mostly employed culture-dependent techniques, studied genera of bacteria and the follow-up period was limited to 2 years.

To relate gut microbiota in early infancy, notably bifidobacteria and lactobacilli at species level, to allergy development during the first 5 years of life and study if environmental factors influence the early infant gut microbiota.

Fecal samples were collected at 1 week, 1 month and 2 months after birth from 47 Swedish infants, followed prospectively to 5 years of age. Bacterial DNA was analysed with real-time PCR and related to allergy development, family size as well as endotoxin and Fel d 1 levels in house dust samples. Primers binding to C. difficile, four species of bifidobacteria, two lactobacilli groups and Bacteroides fragilis were used. Children regarded as allergic manifested allergic symptoms and were skin prick test positive during their first 5 years while non-allergic children were neither.

Children who developed allergy were significantly less often colonized with lactobacilli group I (Lactobacillus (L.) rhamnosus, L. casei, L. paracasei), Bifidobacterium adolescentis and C. difficile during their first 2 months. Infants colonized with several Bifidobacterium species had been exposed to higher amounts of endotoxin and grew up in larger families than infants harbouring few species.

A more diverse gut microbiota early in life might prevent allergy development and may be related to the previously suggested inverse relationship between allergy, family size and endotoxin exposure.

Keywords
allergy, bifidobacteria, Clostridium difficile, endotoxin, Fel d 1, gut microbiota, infant, lactobacilli, siblings
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-17517 (URN)10.1111/j.1365-2222.2008.03156.x (DOI)
Note
The definitive version is available at www.blackwell-synergy.com:Ylva Sjögren, Maria Jenmalm, Malin Böttcher, Bengt Björkstén and E Sverremar-Ekström, Altered early infant gut microbiota in children developing allergy up to 5 years of age, 2009, CLINICAL AND EXPERIMENTAL ALLERGY, (39), 4, 518-526.http://dx.doi.org/10.1111/j.1365-2222.2008.03156.xCopyright: Blackwell Publishing Ltdhttp://www.blackwellpublishing.com/Available from: 2009-04-09 Created: 2009-03-27 Last updated: 2009-04-09Bibliographically approved
Furuhjelm, C., Warstedt, K., Larsson, J., Fredriksson, M., Böttcher, M., Fälth-Magnusson, K. & Duchén, K. (2009). Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatrica, 98(9), 1461-1467
Open this publication in new window or tab >>Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy
Show others...
2009 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 98, no 9, p. 1461-1467Article in journal (Refereed) Published
Abstract [en]

Maternal intake of omega-3 (-3) polyunsaturated fatty acids (PUFAs) during pregnancy has decreased, possibly contributing to a current increased risk of childhood allergy. Aim: To describe the effects of maternal -3 long-chain PUFA supplementation during pregnancy and lactation on the incidence of allergic disease in infancy. Methods: One hundred and forty-five pregnant women, affected by allergy themselves or having a husband or previous child with allergies, were included in a randomized placebo-controlled trial. Daily maternal supplementation with either 1.6 g eicosapentaenoic acid and 1.1 g docosahexaenoic acid or placebo was given from the 25(th) gestational week to average 3-4 months of breastfeeding. Skin prick tests, detection of circulating specific immunoglobulin E (IgE) antibodies and clinical examinations of the infants were performed. Results: The period prevalence of food allergy was lower in the -3 group (1/52, 2%) compared to the placebo group (10/65, 15%, p andlt; 0.05) as well as the incidence of IgE-associated eczema (-3 group: 4/52, 8%; placebo group: 15/63, 24%, p andlt; 0.05). Conclusion: Maternal -3 fatty acid supplementation may decrease the risk of food allergy and IgE-associated eczema during the first year of life in infants with a family history of allergic disease.

Keywords
Allergy, Eczema, Lactation, Polyunsaturated fatty acids, Pregnancy
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-19806 (URN)10.1111/j.1651-2227.2009.01355.x (DOI)
Available from: 2009-08-11 Created: 2009-08-10 Last updated: 2017-12-13
Tomičić, S., Norrman, G., Fälth-Magnusson, K., Jenmalm, M. C., Devenney, I. & Fagerås Böttcher, M. (2009). High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life. Pediatric Allergy and Immunology, 5(1), 35-41
Open this publication in new window or tab >>High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life
Show others...
2009 (English)In: Pediatric Allergy and Immunology, ISSN 0905-6157, Vol. 5, no 1, p. 35-41Article in journal (Refereed) Published
Abstract [en]

Children with eczema and sensitization to foods are recommended skin care and, if food allergy is proven by challenge, an elimination diet. For most children the diet period is transient, but the process behind tolerance development and the influence of decreased allergen exposure is not fully known. The aim of the study was to investigate the effect of elimination diet on serum and salivary antibodies and to identify immunological parameters related to the ability to tolerate foods. Eighty-nine children, below 2 yr of age, with eczema and suspected food allergy were included. Recommended treatment was skin care to all children, and 60 children had a period of elimination diet. At 4½ yr of age, the children were divided into two groups, based on if they had been able to introduce the eliminated foods, or not. Serum and salivary antibodies were analyzed with enzyme-linked immunosorbent assay and UniCAP® before and after a 6-wk treatment period and at 4½ yr of age. Children sensitized to egg and/or milk that could eat and drink the offending foods at 4½ yr of age, had higher levels of Immunoglobulin G4 antibodies to ovalbumin and β-lactoglobulin and also higher IgG4/Immunoglobulin E ratios on inclusion in the study, than those who had to eliminate egg and/or milk from their diet, beyond 4½ yr of age. The highest IgG4/IgE ratios were found in children with circulating IgE antibodies to egg and/or milk but negative skin prick test on inclusion. The 6-wk treatment period did not significantly affect the levels of serum and salivary antibodies. In conclusion, eczematous, food sensitized infants with high levels of IgG4 and high ratios of IgG4/IgE antibodies to food allergens are more likely to consume these foods at 4½ yr than infants with low levels and ratios.

Keywords
food allergy, elimination diet, tolerance, immunoglobulin G4, eczema, children, immunoglobulin E
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13205 (URN)10.1111/j.1399-3038.2008.00738.x (DOI)
Note
The fulltext of this work is available at Blackwell-Syergy: Sara Tomičić, Gunilla Norrman, Karin Fälth-Magnusson, Maria C. Jenmalm, Irene Devenney and Malin Fagerås Böttcher, High levels of IgG4 antibodies to foods during infancy are associated with tolerance to corresponding foods later in life, 2008, Pediatric Allergy and Immunology, (5), 1, 35-41. http://dx.doi.org/10.1111/j.1399-3038.2008.00738.x Copyright: Blackwell-Synergy http://www.blackwellpublishing.com/ Available from: 2009-02-26 Created: 2009-02-26 Last updated: 2010-02-06Bibliographically approved
Sjögren, Y. M., Tomicic, S., Lundberg, A., Fagerås-Böttcher, M., Björkstén, B., Sverremark-Ekström, E. & Jenmalm, M. (2009). Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses. Clinical and Experimental Allergy, 39(12), 1842-1851
Open this publication in new window or tab >>Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses
Show others...
2009 (English)In: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 39, no 12, p. 1842-1851Article in journal (Refereed) Published
Abstract [en]

Introduction Among sensitized infants, those with high, as compared with low levels, of salivary secretory IgA (SIgA) are less likely to develop allergic symptoms. Also, early colonization with certain gut microbiota, e.g. Lactobacilli and Bifidobacterium species, might be associated with less allergy development. Although animal and in vitro studies emphasize the role of the commensal gut microbiota in the development of the immune system, the influence of the gut microbiota on immune development in infants is unclear.

Objective To assess whether early colonization with certain gut microbiota species associates with mucosal and systemic immune responses i.e. salivary SIgA and the spontaneous Toll-like receptor (TLR) 2 and TLR4 mRNA expression and lipopolysaccharide (LPS)-induced cytokine/chemokine responses in peripheral blood mononuclear cells (PBMCs).

Methods Fecal samples were collected at 1 week, 1 month and 2 months after birth from 64 Swedish infants, followed prospectively up to 5 years of age. Bacterial DNA was analysed with real-time PCR using primers binding to Clostridium difficile, four species of bifidobacteria, two lactobacilli groups and Bacteroides fragilis. Saliva was collected at age 6 and 12 months and at 2 and 5 years and SIgA was measured with ELISA. The PBMCs, collected 12 months after birth, were analysed for TLR2 and TLR4 mRNA expression with real-time PCR. Further, the PBMCs were stimulated with LPS, and cytokine/chemokine responses were measured with Luminex.

Results The number of Bifidobacterium species in the early fecal samples correlated significantly with the total levels of salivary SIgA at 6 months. Early colonization with Bifidobacterium species, lactobacilli groups or C. difficile did not influence TLR2 and TLR4 expression in PBMCs. However, PBMCs from infants colonized early with high amounts of Bacteroides fragilis expressed lower levels of TLR4 mRNA spontaneously. Furthermore, LPS-induced production of inflammatory cytokines and chemokines, e.g. IL-6 and CCL4 (MIP-1β), was inversely correlated to the relative amounts of Bacteroides fragilis in the early fecal samples.

Conclusion Bifidobacterial diversity may enhance the maturation of the mucosal SIgA system and early intense colonization with Bacteroides fragilis might down-regulate LPS responsiveness in infancy.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-52701 (URN)10.1111/j.1365-2222.2009.03326.x (DOI)000271774300009 ()19735274 (PubMedID)
Available from: 2010-01-09 Created: 2010-01-09 Last updated: 2017-12-12
Warstedt, K., Furuhjelm, C., Duchén, K., Fälth-Magnusson, K. & Fagerås Böttcher, M. (2009). The Effects of Omega-3 Fatty Acid Supplementation in Pregnancy on Maternal Eicosanoid, Cytokine, and Chemokine Secretion. Pediatric Research, 66(2), 212-217
Open this publication in new window or tab >>The Effects of Omega-3 Fatty Acid Supplementation in Pregnancy on Maternal Eicosanoid, Cytokine, and Chemokine Secretion
Show others...
2009 (English)In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 66, no 2, p. 212-217Article in journal (Refereed) Published
Abstract [en]

The incidence of allergic diseases has increased, and,I relation between allergy and dietary fatty acids has been proposed. Modulation of the maternal immune function during pregnancy may have an impact on future clinical outcomes in the child. The aim of this Study was to determine the effects of omega (omega)-3 long-chain polyunsaturated fatty acids (LCPUFA) Supplementation during pregnancy on the plasma fatty acid composition in relation to the maternal immune function. Pregnant women with allergic disease in their immediate family were supplemented daily with 2.7 g omega-3 LCPUFA (n = 70) or 2.8 g soybean oil as placebo (n = 75) from the 25th gestational week. The proportions of eicosapentaenoic acid and docosahexaenoic acid in plasma/serum phospholipids increased in the omega-3-supplemented group, whereas arachidonic acid decreased during intervention. Lipopolysaccharide-induced prostaglandin E, secretion from whole blood culture supernatants (it = 59) decreased in a majority of the omega-3-supplemented mothers (18 of 28, p = 0.002). The decreased prostaglandin E-2, production was more pronounced among nonatopic than atopic mothers. The lipopolysaccharide-induced cytokine and chemokine secretion was not affected. Out results indicate that omega-3 LCPUFA supplementation during the last trimester may dampen certain immune responses involved in allergic inflammation.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-20127 (URN)10.1203/PDR.0b013e3181aabd1c (DOI)
Available from: 2009-08-31 Created: 2009-08-31 Last updated: 2017-12-13
Organisations

Search in DiVA

Show all publications