Open this publication in new window or tab >>2022 (English)In: Advanced Materials, ISSN 0935-9648, E-ISSN 1521-4095, Vol. 34, no 8, article id 2107345Article in journal (Refereed) Published
Abstract [en]
Inspired by the dynamic process of initial bone development, in which a soft tissue turns into a solid load-bearing structure, the fabrication, optimization, and characterization of bioinduced variable-stiffness actuators that can morph in various shapes and change their properties from soft to rigid are hereby presented. Bilayer devices are prepared by combining the electromechanically active properties of polypyrrole with the compliant behavior of alginate gels that are uniquely functionalized with cell-derived plasma membrane nanofragments (PMNFs), previously shown to mineralize within 2 days, which promotes the mineralization in the gel layer to achieve the soft to stiff change by growing their own bone. The mineralized actuator shows an evident frozen state compared to the movement before mineralization. Next, patterned devices show programmed directional and fixated morphing. These variable-stiffness devices can wrap around and, after the PMNF-induced mineralization in and on the gel layer, adhere and integrate onto bone tissue. The developed biohybrid variable-stiffness actuators can be used in soft (micro-)robotics and as potential tools for bone repair or bone tissue engineering.
Place, publisher, year, edition, pages
Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2022
Keywords
actuators, biohybrids, mineralization, variable stiffness
National Category
Physical Chemistry
Identifiers
urn:nbn:se:liu:diva-182493 (URN)10.1002/adma.202107345 (DOI)000743102000001 ()34877728 (PubMedID)2-s2.0-85122837081 (Scopus ID)
Note
Funding Agencies: Japanese Society of the Promotion of Science (JSPS) Bridge Fellowship program [BR170502]; KAKENHI Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) [JP20H04534]; Swedish Research Council European Commission [VR2014-3079]; Promobilia [F17603]; China Scholarship Council [201808330454]; JSPS Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science [JPJSBP 120 209 923]; STINT, The Swedish Foundation for International Cooperation in Research and Higher Education [MG2019-8171]
2022-01-262022-01-262023-03-16Bibliographically approved