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Abdiu, Avni
Publications (10 of 15) Show all publications
Ohannessian, P., Berggren, A. & Abdiu, A. (2011). The cleft lip evaluation profile (CLEP): A new approach for postoperative nasolabial assessment in patients with unilateral cleft lip and palate. SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, 45(1), 8-13
Open this publication in new window or tab >>The cleft lip evaluation profile (CLEP): A new approach for postoperative nasolabial assessment in patients with unilateral cleft lip and palate
2011 (English)In: SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, ISSN 0284-4311, Vol. 45, no 1, p. 8-13Article in journal (Refereed) Published
Abstract [en]

To assess the postoperative results after primary or secondary operation on unilateral cleft lip and nose, various methods have been published, in which qualitative methods are often based on the opinions of an expert panel and the quantitative methods are based on measurements of different landmarks of the lip and nose. Common problems with the present methods are the associated costs, based on the need for advanced techniques and expertise. Our cleft team now present a simplified, inexpensive, and reproducible protocol to evaluate the cosmetic and functional outcome after operations on the cleft lip and nose, together with the patients. Our protocol has been developed as a guideline to evaluate and score six variables of the lip and seven variables of the nose, including scars, projections of the lips and nose, volumes of the lip, and the alae and septum. The protocol contains series of three photographs of each of the variables that present a good postoperative result, an acceptable result, and finally a result with a clearly visible disfigurement. We also tested the reproducibility and validity of the protocol. Plastic surgeons with no knowledge of the index were approached twice and asked to assess a version with photographs in random order. The evaluation protocol is a simple and cost-effective tool for evaluation of the lip or nose, or both, among patients with repaired unilateral complete cleft lip.

Place, publisher, year, edition, pages
Informa Healthcare, 2011
Keywords
Cleft lip, surgery, evaluation protocol
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-67005 (URN)10.3109/2000656X.2010.541754 (DOI)000288167000003 ()
Available from: 2011-03-25 Created: 2011-03-25 Last updated: 2011-03-25
Djerf, E., Trinks, C., Green, H., Abdiu, A., Hallbeck, A.-L., Stål, O. & Walz, T. (2011). The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo. Biochemical and Biophysical Research Communications - BBRC, 414(3), 563-568
Open this publication in new window or tab >>The pan-ErbB receptor tyrosine kinase inhibitor canertinib promotes apoptosis of malignant melanoma in vitro and displays anti-tumor activity in vivo
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2011 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 414, no 3, p. 563-568Article in journal (Refereed) Published
Abstract [en]

The ErbB receptor family has been suggested to constitute a therapeutic target for tumor-specific treatment of malignant melanoma. Here we investigate the effect of the pan-ErbB tyrosine kinase inhibitor canertinib on cell growth and survival in human melanoma cells in vitro and in vivo. Canertinib significantly inhibited growth of cultured melanoma cells, RaH3 and RaH5, in a dose-dependent manner as determined by cell counting. Half-maximum growth inhibitory dose (IC(50)) was approximately 0.8 mu M and by 5 mu M both cell lines were completely growth-arrested within 72 h of treatment. Incubation of exponentially growing RaH3 and RaH5 with 1 mu M canertinib accumulated the cells in the G(1)-phase of the cell cycle within 24 h of treatment without induction of apoptosis as determined by flow cytometry. Immunoblot analysis showed that 1 mu M canertinib inhibited ErbB1-3 receptor phosphorylation with a concomitant decrease of Akt-, Erk1/2- and Stat3 activity in both cell lines. In contrast to the cytostatic effect observed at doses less than= 5 mu M canertinib, higher concentrations induced apoptosis as demonstrated by the Annexin V method and Western blot analysis of PARP cleavage. Furthermore, canertinib significantly inhibited growth of RaH3 and RaH5 melanoma xenografts in nude mice. Pharmacological targeting of the ErbB receptors may prove successful in the treatment of patients with metastatic melanoma.

Place, publisher, year, edition, pages
Elsevier, 2011
Keywords
Malignant melanoma; Tyrosine kinase inhibitor; Canertinib; ErbB-receptor; Apoptosis
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-73740 (URN)10.1016/j.bbrc.2011.09.118 (DOI)000298519500021 ()
Note

On the day of the defence date the status of this article was Manuscript and the title "The pan-ErbB receptor tyrosine kinase inhibitor Canertinib (CI-1033)promotes cell cycle arrest and apoptosis of human malignantmelanoma in vitro".

Available from: 2012-01-12 Created: 2012-01-12 Last updated: 2017-12-08
Abdiu, A., Ohannessian, P. & Berggren, A. (2009). The nasal alar elevator: A new device that may reduce the need for primary operation of the nose in patients with cleft lip. SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, 43(2), 71-74
Open this publication in new window or tab >>The nasal alar elevator: A new device that may reduce the need for primary operation of the nose in patients with cleft lip
2009 (English)In: SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY, ISSN 0284-4311, Vol. 43, no 2, p. 71-74Article in journal (Refereed) Published
Abstract [en]

To improve the shape of the cleft lip nose preoperatively, we have developed the nasal alar elevator. This has been used routinely since 1996 on all our cleft lip patients who have an asymmetrical nose, from the first week after birth until the date of primary lip surgery. We present our 11-year-long experience of using the device on patients born with complete, unilateral cleft lip. In this study 56 children, born between 1996 and 2006 inclusive, with complete unilateral cleft lip, had preoperative treatment with the elevator. During this 11-year period, continuous evaluation during the preoperative period, and its effects on the cleft lip nose, were evaluated, both preoperatively and postoperatively. Our results show that the preoperative use of the device has led to less need for primary nasal surgery. Instead of having to have a primary rhinoplasty (McComb) together with a lip plasty, as a routine, now only about 30% of the patients need primary surgical correction of the nose. If nasal correction is needed, a rather limited undermining of skin over the ala on the cleft side will often be sufficient. The use of a nasal elevator reduces both the length and the extent of the primary intervention, without compromising the final result.

Keywords
Cleft lip, presurgical, rhinoplasty
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-17696 (URN)10.1080/02844310802514520 (DOI)
Available from: 2009-04-16 Created: 2009-04-14 Last updated: 2010-04-08
Larsson, B., Rosendal, L., Kristiansen, J., Sjogaard, G., Sogaard, K., Ghafouri, B., . . . Gerdle, B. (2008). Responses of algesic and metabolic substances to 8 h of repetitive manual work in myalgic human trapezius muscle. Pain, 140(3), 479-490
Open this publication in new window or tab >>Responses of algesic and metabolic substances to 8 h of repetitive manual work in myalgic human trapezius muscle
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2008 (English)In: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 140, no 3, p. 479-490Article in journal (Refereed) Published
Abstract [en]

The trapezius muscle often develops pain as the result of repetitive and stressful work tasks although it is unclear to what extent this pain is due to alterations in muscle concentrations of algesic/nociceptive substances. Twenty women with chronic neck- and shoulder pain (TM) whose work required highly repetitive work tasks and 20 pain-free female colleagues (CON) were studied during and after a full 8-hour workday. We collected microdialysates from their dominant/most painful trapezius muscle; concentrations of serotonin, glutamate, lactate, pyruvate, potassium, bradykinin, and cytokines and blood flow were determined. In addition, we measured surface electromyogram, task exposure level, pain intensity, perceived mental stress, and urine-cortisol. In connection to the clinical neck and Shoulder examination, we determined pressure pain thresholds (PPTs) over the trapezius and tibialis muscles. TM had higher concentrations Of glutamate (71 +/- 42 vs. 36 +/- 15 mu mol l(-1)) and pyruvate (187 +/- 89 vs. 125 +/- 63 mu mol l(-1)) than CON. Interstitial serotonin was higher ill TM (before work: 10.6 +/- 10.8 vs. 2.2 +/- 1.2 nM; after work: 9.2 +/- 8.3 vs. 1.5 +/- 2.9 nM). The trapezius blood flow during the working day was higher in TM than in CON. TM had lower PPT and higher pain intensity throughout the working day. No differences in EMG, task exposure level, Mental Stress, Or Urine-cortisol in the groups were found. These findings Support the idea that peripheral nociceptive processes are activated ill Occupationally active Subjects, who are diagnosed with trapezius myalgia. In contrast, no sign of low blood flow or increased stress or muscle activity markers were found in TM.

Keywords
Blood flow, Pyruvate, Serotonin, Glutamate, Muscle pain, Nociception, Work
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-16346 (URN)10.1016/j.pain.2008.10.001 (DOI)
Available from: 2009-01-16 Created: 2009-01-16 Last updated: 2017-12-14
Mattsson, J., Bergkvist, L., Abdiu, A., Aili Iow, J. F., Naredi, P., Ullberg, K., . . . Ingvar, C. (2008). Sentinel node biopsy in malignant melanoma: Swedish experiences 1997–2005. Acta Oncologica, 47(8), 1519-1525
Open this publication in new window or tab >>Sentinel node biopsy in malignant melanoma: Swedish experiences 1997–2005
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2008 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 47, no 8, p. 1519-1525Article in journal (Refereed) Published
Abstract [en]

The sentinel node biopsy (SNB) procedure is a multidisciplinary technique, invented to gain prognostic information in different malignant tumors. The aim of the present study was to study the cohort of patients with malignant melanoma, operated with SNB, from the introduction of the technique in Sweden, concerning the prognostic information retrieved and the outcome of the procedures. In Sweden all patients with malignant melanoma are registered at regional Oncological Centers. From these databases ten centers were identified, treating malignant melanoma and performing sentinel node biopsy. Consecutive data concerning tumor characteristics, outcome of the procedure and disease related events during the follow-up time were collected from these ten centers. All cases from the very first in each centre were included. The SNB procedure was performed in 422 patients with a sentinel node (SN) detection rate of 97%, the mean Breslow thickness of the primary tumors was 3.2 mm (median 2.4 mm) and the proportion of ulcerated melanomas 38%. Metastasis in the SN was found in 19% of the patients but there was a wide range in the proportion of SN metastases between the different centers (5–52%). After a follow-up of median 12 months of 361 patients, SN negative patients had better disease-free survival than SN positive (p<0.0001). A false negative rate of 14% was found during the follow-up time. In this study the surgical technique seemed acceptable, but the non-centralized pathology work-up sub-optimal. However, SNB was still found to be a significant prognostic indicator, concerning disease free survival.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-48877 (URN)10.1080/02841860701785533 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Samuelsson, A., Abdiu, A., Wackenfors, A. & Sjöberg, F. (2008). Serotonin kinetics in patients with burn injuries: A comparison between the local and systemic responses measured by microdialysis-A pilot study. Burns, 34(5), 617-622
Open this publication in new window or tab >>Serotonin kinetics in patients with burn injuries: A comparison between the local and systemic responses measured by microdialysis-A pilot study
2008 (English)In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 34, no 5, p. 617-622Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate serotonin (5HT) locally in burned and uninjured skin (intracutaneous) by microdialysis, and simultaneously record urinary and blood values in the same subjects. For comparison, serotonin values were also measured in skin of healthy controls. Design and setting: An experimental study in burned patients with of more than 25% TBSA (total burn surface area) % in an 8-bed tertiary burns unit, serving about 3.5 million persons. Patients and methods: Six subjects with a median TBSA% of 59% (range 33.5-90), and five healthy controls were examined by intracutaneous microdialysis of the skin. Results: 5HT was increased in burned patients, compared with controls. This increase was tenfold in skin and was noted both in uninjured and burned skin. The highest values were recorded on day 1 (median 16.1 nmol in uninjured and 9.5 nmol in burned skin) and day 2 (15.6 nmol in uninjured and 13.4 nmol in burned skin). A rapid reduction was noted on day 3 (4.9 nmol in uninjured and 3.8 nmol in burned skin). The corresponding value for control subjects was 1.3 nmol. The 5HT in blood was twice normal on day 2, and gradually reduced on days 3 and 4 (3189, 3035 and 2573 nmol, respectively). Urinary 5HT concentrations were increased only on day 2 at 1755 nmol and thereafter returned to the normal range on days 3 and 4 (1248 and 1344 nmol, respectively). Conclusions: We showed that microdialysis may be used in the critical care of burns, and local skin serotonin concentrations examined continuously for several days. The findings of significantly raised tissue serotonin concentrations, compared to that in blood and urine, suggests that serotonin may be important in local vascular control and formation of oedema. © 2007 Elsevier Ltd and ISBI.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-43419 (URN)10.1016/j.burns.2007.08.003 (DOI)73800 (Local ID)73800 (Archive number)73800 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Nayeri, F., Xu, J., Abdiu, A., Nayeri, T., Aili, D., Liedberg, B. & Carlsson, U. (2006). Autocrine production of biologically active hepatocyte growth factor (HGF) by injured human skin. Journal of dermatological science (Amsterdam), 43(1), 49-56
Open this publication in new window or tab >>Autocrine production of biologically active hepatocyte growth factor (HGF) by injured human skin
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2006 (English)In: Journal of dermatological science (Amsterdam), ISSN 0923-1811, E-ISSN 1873-569X, Vol. 43, no 1, p. 49-56Article in journal (Refereed) Published
Abstract [en]

Background

Hepatocyte growth factor (HGF) is a potent regenerative factor involved in wound healing. Previous studies have shown that mesenchymal cells produce HGF, stimulating epithelial cells in a paracrine fashion.

Objective

To examine whether autocrine HGF production by keratinocytes can occur upon skin injury.

Methods

A 31-year-old male patient sustained a burn affecting 80% of his total body surface area. Biopsies were taken from intact skin near the injured area, and skin keratinocytes were separated and cultured. Conditioned medium from keratinocytes was analyzed for HGF by ELISA, surface plasmon resonance (SPR), and dot blotting. Binding of HGF from conditioned medium to its receptor, c-Met, was compared with recombinant HGF by SPR. Finally, we examined the motogenic effect on mouse transformed skin epithelial cells (CCL-53.1) of HGF from conditioned medium.

Results

HGF was detected in the cultured keratinocyte medium. Similar to recombinant HGF, HGF from conditioned medium had a high affinity for dextran sulfate and albumin, and the same epitopes were engaged by the interaction of HGF with the c-Met receptor. The conditioned medium from keratinocytes obtained from the burn patient, but not medium from keratinocytes obtained from healthy volunteers, accelerated the motogenesis of CCL-53.1 cells. Unexpectedly, anti-HGF antibodies did not prevent this effect. However, anti-c-Met antibodies completely inhibited the motogenic effect.

Conclusion

Upon injury, human skin keratinocytes might produce biologically active HGF in an autocrine fashion. This HGF might have different structural and/or biological properties from HGF produced by mesenchymal cells.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-34983 (URN)10.1016/j.jdermsci.2006.03.004 (DOI)24445 (Local ID)24445 (Archive number)24445 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2018-03-23Bibliographically approved
Berggren, A., Abdiu, A., Marcusson, A. & Paulin, G. (2005). Letter: The nasal alar elevator: An effective tool in the presurgical treatment of infants born with cleft lip [Letter to the editor]. Plastic and reconstructive surgery (1963), 115(6), 1785-1787
Open this publication in new window or tab >>Letter: The nasal alar elevator: An effective tool in the presurgical treatment of infants born with cleft lip
2005 (English)In: Plastic and reconstructive surgery (1963), ISSN 0032-1052, E-ISSN 1529-4242, Vol. 115, no 6, p. 1785-1787Article in journal, Letter (Other academic) Published
Abstract [en]

[No abstract available]

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-30007 (URN)10.1097/01.PRS.0000162110.83406.58 (DOI)15450 (Local ID)15450 (Archive number)15450 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13Bibliographically approved
Rousseau, A., Abdiu, A. & Sjöberg, F. (2004). Hyperoxaemia does not change concentrations of serotonin and beta‐thromboglobulin in blood of healthy humans. Scandinavian Journal of Clinical and Laboratory Investigation, 64(2), 81-85
Open this publication in new window or tab >>Hyperoxaemia does not change concentrations of serotonin and beta‐thromboglobulin in blood of healthy humans
2004 (English)In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 64, no 2, p. 81-85Article in journal (Refereed) Published
Abstract [en]

Background: The mechanisms of oxygen‐induced effects on blood vessels (vasoconstriction in hyperoxaemia and vasodilatation during hypoxaemia) are uncertain. Many investigators have suggested that the vasoconstriction seen during hyperoxia/hyperoxaemia is mediated through the endothelium as a result of either increased release or activity of vasoconstrictors (oxygen radicals, endothelin, norepinephrine, angiotensin II, or serotonin (5‐HT)), or reduced activity of vasodilators (prostaglandin E2 and nitric oxide). Serotonin has been assumed to have a central role.

Methods: Eight healthy volunteers were exposed to FiO2 of 1.0 for 20 min and serum concentrations of serotonin and activated platelets were measured (indicated by concentrations of β‐thromboglobulin (β‐TG)).

Results. During hyperoxaemia in humans, serum concentrations of serotonin and β‐TG remained unchanged.

Conclusion: If serotonin is involved in oxygen‐induced vasoconstriction, the mechanism is more likely to be either a potentiating effect of serotonin on other vasoconstrictors or increased activity of serotonin on its receptor.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24029 (URN)10.1080/00365510410004137 (DOI)3584 (Local ID)3584 (Archive number)3584 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13Bibliographically approved
Håkansson, A., Gustafsson, B., Abdiu, A., Krysander, L. & Håkansson, L. (2003). Bcl-2 expression in metastatic malignant melanoma. Importance for the therapeutic efficacy of biochemotherapy. Cancer Immunology and Immunotherapy, 52(4), 249-254
Open this publication in new window or tab >>Bcl-2 expression in metastatic malignant melanoma. Importance for the therapeutic efficacy of biochemotherapy
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2003 (English)In: Cancer Immunology and Immunotherapy, ISSN 0340-7004, E-ISSN 1432-0851, Vol. 52, no 4, p. 249-254Article in journal (Refereed) Published
Abstract [en]

For the majority of patients with metastatic malignant melanoma the prognosis is poor. Immunotherapy and biochemotherapy have shown promise with a subset of durable responses, but there is still a great need for a better understanding of the mechanisms of action during treatment to optimize future treatment schedules. In the present study Bcl-2 expression was studied in biopsies from ten patients with metastatic malignant melanoma (five with regional disease and five with systemic disease) treated with biochemotherapy, (cisplatinum 30 mg/m2 days 1-3, DTIC 250 mg/m2 days 1-3 i.v. and Interferon-a2b 10 MIU s.c. 3 days a week, on a 28-day cycle). The expression of Bcl-2 by the tumour cells was separately recorded in areas of histopathological regressive changes and in areas of unaffected tumour growth. Comparisons were made with biopsies from 14 untreated patients. In 10 of 10 treated patients a high expression of Bcl-2 by the tumour cells was found in areas of unaffected tumour growth. In contrast, only in 5 of 13 untreated patients was a high expression of Bcl-2 by the tumour cells found in these areas (P = 0.008). A significant difference was also found in the expression of Bcl-2 by the tumour cells between areas of unaffected tumour growth and areas of histopathological regressive changes (P=0.03). The significantly higher expression of Bcl-2 by the tumour cells in areas of unaffected tumour growth in treated patients compared to untreated patients indicates that clones with a high expression of Bcl-2 may be present after therapy, preventing apoptosis and eventually in many patients resulting in progressive disease. Supporting this concept, a difference was also found between the expression of Bcl-2 in areas of unaffected tumour growth, i.e. in areas of treatment failure, and the expression in areas of histopathological regressive changes. Thus immunohistochemical analysis of tumour biopsies shortly after therapy seems to be a good surrogate endpoint that allows a detailed analysis of Bcl-2 expression. The high expression of Bcl-2 shown in unaffected tumour areas after therapy suggests the need for additional treatment, e.g. Bcl-2 antisense therapy.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24822 (URN)10.1007/s00262-003-0373-z (DOI)9219 (Local ID)9219 (Archive number)9219 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
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