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Lundström, Ingemar
Publications (10 of 319) Show all publications
Silverå Ejneby, M., Wu, X., Ottosson, N., Münger, E. P., Lundström, I., Konradsson, P. & Elinder, F. (2018). Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid. The Journal of General Physiology, 150(5), 731-750
Open this publication in new window or tab >>Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid
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2018 (English)In: The Journal of General Physiology, ISSN 0022-1295, E-ISSN 1540-7748, Vol. 150, no 5, p. 731-750Article in journal (Refereed) Published
Abstract [en]

Dehydroabietic acid (DHAA) is a naturally occurring component of pine resin that was recently shown to open voltage-gated potassium (KV) channels. The hydrophobic part of DHAA anchors the compound near the channel’s positively charged voltage sensor in a pocket between the channel and the lipid membrane. The negatively charged carboxyl group exerts an electrostatic effect on the channel’s voltage sensor, leading to the channel opening. In this study, we show that the channel-opening effect increases as the length of the carboxyl-group stalk is extended until a critical length of three atoms is reached. Longer stalks render the compounds noneffective. This critical distance is consistent with a simple electrostatic model in which the charge location depends on the stalk length. By combining an effective anchor with the optimal stalk length, we create a compound that opens the human KV7.2/7.3 (M type) potassium channel at a concentration of 1 µM. These results suggest that a stalk between the anchor and the effector group is a powerful way of increasing the potency of a channel-opening drug.

Place, publisher, year, edition, pages
New York, United States: Rockefeller Institute for Medical Research, 2018
National Category
Physiology
Identifiers
urn:nbn:se:liu:diva-147837 (URN)10.1085/jgp.201711965 (DOI)000434417800008 ()2-s2.0-85046705149 (Scopus ID)
Note

Funding agencies: Swedish Research Council [2016-02615]; Swedish Heart-Lung Foundation [20150672]; Swedish Brain Foundation [2016-0326]

Available from: 2018-05-15 Created: 2018-05-15 Last updated: 2018-06-28Bibliographically approved
Karlsson, J. O., Ignarro, L. J., Lundström, I., Jynge, P. & Almén, T. (2015). Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties. Drug Discovery Today, 20(4), 411-421
Open this publication in new window or tab >>Calmangafodipir [Ca4Mn(DPDP)5], mangafodipir (MnDPDP) and MnPLED with special reference to their SOD mimetic and therapeutic properties
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2015 (English)In: Drug Discovery Today, ISSN 1359-6446, E-ISSN 1878-5832, Vol. 20, no 4, p. 411-421Article, review/survey (Refereed) Published
Abstract [en]

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) participate in pathological tissue damage. Mitochondrial manganese superoxide dismutase (MnSOD) normally keeps ROS and RNS in check. During development of mangafodipir (MnDPDP) as a magnetic resonance imaging (MRI) contrast agent, it was discovered that MnDPDP and its metabolite manganese pyridoxyl ethyldiamine (MnPLED) possessed SOD mimetic activity. MnDPDP has been tested as a chemotherapy adjunct in cancer patients and as an adjunct to percutaneous coronary intervention in patients with myocardial infarctions, with promising results. Whereas MRI contrast depends on release of Mn2+, the SOD mimetic activity depends on Mn2+ that remains bound to DPDP or PLED. Calmangafodipir [Ca4Mn(DPDP)5] is stabilized with respect to Mn2+ and has superior therapeutic activity. Ca4Mn(DPDP)5 is presently being explored as a chemotherapy adjunct in a clinical multicenter Phase II study in patients with metastatic colorectal cancer.

Place, publisher, year, edition, pages
Elsevier, 2015
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:liu:diva-118607 (URN)10.1016/j.drudis.2014.11.008 (DOI)000354581300005 ()25463039 (PubMedID)
Available from: 2015-06-04 Created: 2015-06-02 Last updated: 2017-12-04Bibliographically approved
Dini, F., Magna, G., Martinelli, E., Pomarico, G., Di Natale, C., Paolesse, R. & Lundström, I. (2015). Combining porphyrins and pH indicators for analyte detection. Analytical and Bioanalytical Chemistry, 407(14), 3975-3984
Open this publication in new window or tab >>Combining porphyrins and pH indicators for analyte detection
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2015 (English)In: Analytical and Bioanalytical Chemistry, ISSN 1618-2642, E-ISSN 1618-2650, Vol. 407, no 14, p. 3975-3984Article in journal (Refereed) Published
Abstract [en]

High sensitivity and cross-selectivity are mandatory properties for sensor arrays. Although metalloporphyrins and pH indicators are among the most common and appropriate choices for the preparation of optical sensor arrays, the sensitivity spectrum of these dyes is limited to those analytes able to induce an optical response. To extend the receptive field of optical sensors, we explore the design of composite materials, where the molecular interaction among the subunits enriches their sensing working mechanisms. We demonstrate that blends of single metalloporphyrins and pH indicators, tested with a transduction apparatus based on ubiquitous and easily available hardware, can be endowed with sensing properties wider than those of single constituents, enabling the recognition of a broad range of volatiles.

Place, publisher, year, edition, pages
Springer, 2015
National Category
Atom and Molecular Physics and Optics
Identifiers
urn:nbn:se:liu:diva-118620 (URN)10.1007/s00216-014-8445-9 (DOI)000354190300008 ()25614242 (PubMedID)
Available from: 2015-06-04 Created: 2015-06-02 Last updated: 2017-12-04Bibliographically approved
Vagin, M. Y., Sekretareva, A., Lindgren, P., Håkansson, A., Eriksson, M., Lundström, I., . . . Yakimova, R. (2015). Direct bioelectrocatalysis on anodized epitaxial graphene. In: Program of the XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society14-18 June, 2015Malmö, Sweden: . Paper presented at Program of the XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society 14-18 June, 2015 Malmö, Sweden (pp. 170-170). Lausanne: Bioelectrochemical Society
Open this publication in new window or tab >>Direct bioelectrocatalysis on anodized epitaxial graphene
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2015 (English)In: Program of the XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society14-18 June, 2015Malmö, Sweden, Lausanne: Bioelectrochemical Society , 2015, p. 170-170Conference paper, Published paper (Other academic)
Abstract [en]

Graphene as a nanomaterial consisting of a single layer sheets of atoms of carbon in hexagonal arrangement is making a significant impact in variety of technologies such as energy storage and chemical analysis. The significant attention paid to this thinnest nanomaterial resulted in thousands of patent applications is due to its staggering properties. Due to the planar conjugation of the sp2bonds in graphene, two-dimensional electrical conduction is highly efficient. On the contrary, the efficiency of electron exchange at the out-of-plane of the graphene sheet is small. The significant difference of the densities of electronic states at in-plane and out-of-plane of graphene sheet determines two distinct structural contributions (basal and edge plane respectively) to the behavior of all graphitic materials yielding the chemical and electrochemical anisotropy. Being the simplest building block of graphitic materials, graphene offers the possibility to study the behavior on the simplest level of structural organization. However, the major effort of the recent electrochemical studies of graphene were done using a bulk materials based on graphene flakes possessing the domination of edges of high reactivity. The planar orientation of graphene sheets with controllable exposure of basal plane is achievable via the growth by chemical vapor deposition or by epitaxial flash annealing on crystalline structures of silicon carbide. The slow growth of graphene onto crystalline support during annealing in the inert atmosphere results in a development of a high quality graphene monolayer attached to the solid insulating support. The creation of sp3-type reactive defects on the basal plane of graphite can be achieved by anodization at high anodic potentials.

We developed the procedure for the real-time monitoring of epitaxial graphene anodization. The changes of electrochemical properties of graphene monolayer with anodization have been comparatively investigated by electrochemical methods. The estimation of specific capacitance in pure electrolyte and in conditions of Faradaic process has been carried out. Finally, the direct electrocatalysis of laccase (Trametes versicolor) has been used as an electrode reaction to probe the reactivities of anodized epitaxial graphene and conventional carbon materials.

Place, publisher, year, edition, pages
Lausanne: Bioelectrochemical Society, 2015
National Category
Condensed Matter Physics
Identifiers
urn:nbn:se:liu:diva-122686 (URN)
Conference
Program of the XXIII International Symposium on Bioelectrochemistry and Bioenergetics of the Bioelectrochemical Society 14-18 June, 2015 Malmö, Sweden
Available from: 2015-11-16 Created: 2015-11-16 Last updated: 2017-11-03Bibliographically approved
Lvova, L., Pudi, R., Galloni, P., Lippolis, V., Di Natale, C., Lundström, I. & Paolesse, R. (2015). Multi-transduction sensing films for Electronic Tongue applications. Sensors and actuators. B, Chemical, 207, 1076-1086
Open this publication in new window or tab >>Multi-transduction sensing films for Electronic Tongue applications
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2015 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 207, p. 1076-1086Article in journal (Refereed) Published
Abstract [en]

In this paper the use of multi-transduction principle for sensing materials development is reviewed. In particular, the application of porphyrin-based films to a multi-transduction Electronic Tongue system for different analytical tasks is presented. The optical response of sensing films was registered by means of Computer Screen Photoassisted Technology (CSPT) that applies familiar devices, such as computer monitor screen and web-camera, as illumination light source and signal detectors. Simultaneously the electrochemical amperometric or potentiometric response of the same sensing material was measured. Data analysis combining both signals significantly improves the performance of the Electronic Tongue, thus opening new frontiers in application of such a system.

Place, publisher, year, edition, pages
Elsevier, 2015
Keywords
Multi-transduction principle; Electronic Tongue; Optical and electrochemical sensing; Porphyrin films
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-113150 (URN)10.1016/j.snb.2014.10.086 (DOI)000345895400026 ()
Available from: 2015-01-14 Created: 2015-01-12 Last updated: 2017-12-05
Vagin, M., Sekretareva, A., Sanchez, R., Lundström, I., Winquist, F. & Eriksson, M. (2014). Arrays of Screen-Printed Graphite Microband Electrodes as a Versatile Electroanalysis Platform. ChemElectroChem, 1(4), 755-762
Open this publication in new window or tab >>Arrays of Screen-Printed Graphite Microband Electrodes as a Versatile Electroanalysis Platform
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2014 (English)In: ChemElectroChem, ISSN 2196-0216, Vol. 1, no 4, p. 755-762Article in journal (Refereed) Published
Abstract [en]

Arrays of microband electrodes were developed by screen printing followed by cutting, which enabled the realization of microband arrays at the cut edge. The microband arrays of different designs were characterized by physical and electro-chemical methods. In both cases, the methods showed that the microband width was around 5 mm. Semi-steady-state cyclic voltammetry responses were observed for redox probes, and chronocoulometric measurements showed the establishment of convergent diffusion regimes characterized by current densities similar to those of a single microelectrode. The analytical performance of the electrode system and its versatility were illustrated with two electrochemical assays: detection of ascorbic acid through direct oxidation and a mediated glucose biosensor fabricated by dip coating. Due to convergent mass transport, both systems showed an enhancement in their analytical characteristics. The developed approach can be adapted to automated electrode recovery.

Place, publisher, year, edition, pages
Wiley, 2014
Keywords
graphite screen printing; microarrays; microband; sensors; voltammetry
National Category
Physical Sciences Chemical Sciences
Identifiers
urn:nbn:se:liu:diva-109289 (URN)10.1002/celc.201300204 (DOI)000338296100010 ()
Available from: 2014-08-11 Created: 2014-08-11 Last updated: 2017-11-03Bibliographically approved
Vagin, M. Y., Lundström, I., Turner, A., Beni, V. & Eriksson, M. (2014). Boron-doped diamond microelectrode arrays for electrochemical monitoring of antibiotics contamination in water. In: 15th International Conference on Electroanalysis (ESEAC): . Paper presented at 15th International Conference on Electroanalysis (ESEAC), 11-15 June 2014, Malmö, Sweden.
Open this publication in new window or tab >>Boron-doped diamond microelectrode arrays for electrochemical monitoring of antibiotics contamination in water
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2014 (English)In: 15th International Conference on Electroanalysis (ESEAC), 2014Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

The improvement of water management and increasing the access to safe drinking water can develop the quality of life for millions of people world-wide and reduce child mortality due to water-borne diseases [1]. Sweden was recently affected by the lack of appropriate water management which resulted in microbial contamination and tens of thousands of people falling ill [2]. Pollution with chemical compounds is also a waterworks concern. The appearance of pharmaceuticals such as antibiotics in raw water affects the cleaning processes at waterworks [3]. Substances which are not, or are only partly, eliminated in the sewage treatment plant will reach the surface water where they may affect organisms of different trophic levels and cause, for example, the of antibiotics resistance [4]. The inhibition of bacteria of waste water plants by antibiotics may seriously affect organic matter degradation. The efficiency of nitrification as an important step in waste water purification, can be decreased by antibiotics inhibition [5]. Boron-doped diamond (BDD) is an advanced electrode material that possesses the combination of good electrical conductivity achieved via film doping and the extreme chemical inertness of diamond, which gives rise to a number of highly desirable properties of BDD as electrode material: a wide potential window in aqueous media allows electrochemical measurements at both extreme anodic and cathodic potentials, very low capacitive currents leads to a sensitivity increase and extreme chemical and structural inertness prevents electrode fouling [6]. Usage of a microelectrode array as the working electrode offers a variety of benefits for electroanalysis: an improvement of the analytical performance in comparison with macroelectrodes under planar diffusion, higher signal-to-noise ratios due to low capacitive currents at the small surface area, shorter response times and less sensitivity to variations in the water flow rate. The BDD arrays of this work contain 2900 microelectrodes (10 mm diameter each) and have been used for the detection of antibiotics (ofloxacine and canamycin A) in water with high amplitude pulse voltammetry processed by multivariate data analysis. The detection limits observed in monitoring mode were comparable with the characteristics of standard protocols of antibiotics detection, which opens the possibility for continuous monitoring of water.

[1] The United Nations, World Water Development Report 4, 2012; [2] Lindberg, A. et al.,

FOI-R--3376--SE, 2011; Dryselius, R.; National Food Agency, Sweden, 2012; [3] Kummerer

K. Chemosphere, 2009, 75, 417; [4] Kummerer K. Chemosphere, 2009, 75, 435; [5]

Dokianakis, S.N. et al., Water Sci. Technol. 50, 341; [6] Goeting, C. et al.,

NewDiam.Front.C.Tech. 1999, 9, 207; Compton, R. et al., Electroanal. 2003, 15, 1349.

 

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-108450 (URN)
Conference
15th International Conference on Electroanalysis (ESEAC), 11-15 June 2014, Malmö, Sweden
Funder
Formas
Available from: 2014-06-27 Created: 2014-06-27 Last updated: 2017-11-03
Lundström, I. (2014). From a Laboratory Exercise for Students to a Pioneering Biosensing Technology. PLASMONICS, 9(4), 741-751
Open this publication in new window or tab >>From a Laboratory Exercise for Students to a Pioneering Biosensing Technology
2014 (English)In: PLASMONICS, ISSN 1557-1955, Vol. 9, no 4, p. 741-751Article in journal (Refereed) Published
Abstract [en]

Surface plasmon resonance (SPR) for biosensing was demonstrated 30 years ago. In the present contribution, its general background is described together with the necessary developments both in instrumentation and surface chemistry, leading to the final so-called BIAcore technology. The description is naturally colored by my personal opinion of the developments. SPR for the elucidation of organic mono- and multilayers introduced at the end of the 1970s formed the basis for the first biosensing demonstration of SPR in the beginning of the 1980s. It is pointed out how the need of an up-to-date laboratory exercise for the undergraduate students and the multidisciplinary environment at the Laboratory of Applied Physics at Linkoping University led to this demonstration. The initial experiments are touched upon and the further developments at Pharmacia, which led to the BIAcore technology, are described in some details. Some of the present activities in Linkoping related to optical biosensing with ubiquitous instrumentation are also described, including SPR detection with a computer screen and a web camera and most recently with a cellular phone.

Place, publisher, year, edition, pages
Springer Verlag (Germany), 2014
Keywords
Surface plasmon resonance; Historical overview; BIAcore; Computer screen photo-assisted techniques
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-111290 (URN)10.1007/s11468-013-9654-3 (DOI)000341423800004 ()25177230 (PubMedID)
Available from: 2014-10-14 Created: 2014-10-14 Last updated: 2014-10-16
Holub, D., Gifford, R., Lundström, I. & Turner, A. (2014). PoC Amylase Biosensor. In: 24th Anniversary World Congress on Biosensors – Biosensors 2014: . Paper presented at 24th Anniversary World Congress on Biosensors – Biosensors 2014, 27-30 May 2014, Melbourne, Australia. Elsevier
Open this publication in new window or tab >>PoC Amylase Biosensor
2014 (English)In: 24th Anniversary World Congress on Biosensors – Biosensors 2014, Elsevier, 2014Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

A rapid, inexpensive and quantitative biosensor to measure alpha-amylase activity within the relevant clinical range has been developed.  This device is suited for point-of-care (PoC) applications because it is easy to use and disposable.  Salivary α-amylase activity is correlated to stress levels and, therefore, it is a potential monitoring candidate for neurological conditions (e.g. Multiple Sclerosis) for which there are no objective diagnostics available.  The enzyme is also utilized in many industrial processes like fermentation and textile production, where real-time, on-site monitoring can be advantageous for accurate process control.  In contrast to other α-amylase quantitative methods, this biosensor is rapid (results within 10 minutes), it does not require bench-top or specialized equipment (i.e. it is portable and does not need to be sent to a laboratory for results), and the general public can perform the analysis (no specialized training needed).  An electro-active moiety, which is sensitive to α-amylase activity, is incorporated into the biosensor design and generates a signal that is proportional to the alpha-amylase activity in the sample (Figure 1, below).  This new device will allow researchers to better diagnose and monitor neurological conditions and follow treatment effectiveness without relying solely on subjective assessments.  In addition, using this novel biosensor to monitor industrial processes that utilize α-amylase could reduce production costs and waste generation for these industries.

Place, publisher, year, edition, pages
Elsevier, 2014
National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-108423 (URN)
Conference
24th Anniversary World Congress on Biosensors – Biosensors 2014, 27-30 May 2014, Melbourne, Australia
Available from: 2014-06-27 Created: 2014-06-27 Last updated: 2014-08-26
Cao, Z., Lvova, L., Paolesse, R., Di Natale, C., D' Amico, A. & Lundström, I. (2014). Porphyrin electropolymers as opto-electrochemical probe for the detection of red-ox analytes. In: Sensors: Proceedings of the First National Conference on Sensors, Rome 15-17 February, 2012: . Paper presented at 1st National Conference on Sensors, 15-17 February, 2012 (pp. 49-55). Springer Science Business Media, 162 LNEE
Open this publication in new window or tab >>Porphyrin electropolymers as opto-electrochemical probe for the detection of red-ox analytes
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2014 (English)In: Sensors: Proceedings of the First National Conference on Sensors, Rome 15-17 February, 2012, Springer Science Business Media , 2014, Vol. 162 LNEE, p. 49-55Conference paper, Published paper (Refereed)
Abstract [en]

The application of pyrrole-substituted porphyrin electropolymers for simultaneous optical and electrochemical analysis of red-ox active analytes, namely diazo-conjugated dyes of Sudan family, is presented. Sudan colorants are widely used in many fields, but accurate screening of their consumption is required due to their high toxicity. The inherent electrochemical activity of Sudan dyes, as far as their intense coloration, makes possible to find the appropriate conditions of hybrid optical and electrochemical porphyrin electropolymer based sensor array system application. This approach allowed a significant increase in the chemical information, improving the analytical system performance in terms of selectivity and sensitivity, and permitted the fast and simple monitoring of Sudan dye analytes.

Place, publisher, year, edition, pages
Springer Science Business Media, 2014
Series
Lecture Notes in Electrical Engineering, ISSN 1876-1100 ; Vol 162
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-110536 (URN)10.1007/978-1-4614-3860-1_8 (DOI)2-s2.0-84883229832 (Scopus ID)9781461438595 (ISBN)
Conference
1st National Conference on Sensors, 15-17 February, 2012
Available from: 2014-09-18 Created: 2014-09-12 Last updated: 2014-09-18
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