Open this publication in new window or tab >>Show others...
2020 (English)In: Molecular and clinical oncology, ISSN 2049-9450, E-ISSN 2049-9469, Vol. 12, no 5, p. 415-420Article in journal (Refereed) Published
Abstract [en]
Over the last few decades, improved and more individualized treatment has contributed to the increased survival rate of patients with breast cancer. However, certain patients may receive excessive treatment resulting in undesired side effects. In a previous study, it was demonstrated that systemically untreated patients with estrogen receptor (ER)-positive/progesterone receptor (PR)-negative tumors with high Ras-related protein Rab-6C (RAB6C) expression levels (RAB6C(+)) had prolonged distant recurrence-free survival compared with that of patients exhibiting low RAB6C (RAB6C(-))-expressing tumors. The aim of the present study was to investigate whether RAB6C predicts the effectiveness of tamoxifen treatment. The present study used a dataset comprising 486 female patients with ER+ tumors from a randomized study conducted by the Stockholm Breast Cancer Study Group between November 1976 and August 1990. The patients were considered as low-risk if their tumor size was <= 30 mm and their lymph node status was negative. Patients were followed up until distant recurrence, mortality or when 25 years after randomization was achieved, whichever occurred first. For patients with ER+/PR-/RAB6C(+) tumors, prolonged distant recurrence-free survival could not be observed if the patients were treated with tamoxifen [hazard ratio (HR), 1.82; 95% confidence interval (CI), 0.69-4.79; P=0.23], whereas patients with ER+/PR-/RAB6C(-) tumors had 75% reduced distant recurrence risk (HR, 0.25; 95% CI, 0.09-0.70; P=0.008). In the ER+/PR+ subgroup, patients with RAB6C(-) and RAB6C(+) tumors benefited from tamoxifen treatment, though it was most evident in the RAB6C(+) group (HR, 0.27; 95% CI, 0.13-0.58; P=0.001). The results of the present study indicated that, for patients with ER+/PR- tumors, those with low RAB6C expression benefited from tamoxifen treatment, whereas no benefit was observed in patients with high RAB6C levels.
Place, publisher, year, edition, pages
SPANDIDOS PUBL LTD, 2020
Keywords
breast neoplasm; WTH3; RAB6A; endocrine therapy; hormone receptors
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:liu:diva-173992 (URN)10.3892/mco.2020.2014 (DOI)000523727900004 ()32257197 (PubMedID)2-s2.0-85087341543 (Scopus ID)
Note
Funding Agencies|Swedish Cancer SocietySwedish Cancer Society [17-0479]; Cancer Research Foundation of Radiumhemmet [181093]; King Gustav V Jubilee Clinical Research Foundation [181093]; Onkologiska klinikerna i Linkopings forskningsfond [2016-06-21]; ALF grants Region Ostergotland [LIO-795201]; County Council of Ostergotland [LIO-625491]; Cancer Society in Stockholm [181093]
2021-03-162021-03-162021-03-23Bibliographically approved