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Jonasson, Lena
Publications (10 of 101) Show all publications
Good, E., Åkerman, L., Nyström, S. N., Jonasson, L., Ernerudh, J. & de Muinck, E. (2023). Changes in natural killer and T lymphocyte phenotypes in response to cardiovascular risk management. Scientific Reports, 13(1), Article ID 20810.
Open this publication in new window or tab >>Changes in natural killer and T lymphocyte phenotypes in response to cardiovascular risk management
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2023 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 13, no 1, article id 20810Article in journal (Refereed) Published
Abstract [en]

The pro-inflammatory and regulatory roles of T lymphocytes in atherosclerosis are well established but less is known about natural killer (NK) cells and natural killer T (NKT)-like cells. The effects of cardiovascular risk management on the phenotypes of these cells are unknown. To assess changes in NK cell and lymphocyte phenotypes and circulating inflammatory proteins in response to cardiovascular risk management in patients with carotid atherosclerosis. Fifty patients were included in a prospective clinical study. Measurements were at baseline and after 12 months of cardiovascular risk management. Circulating NK, NKT-like and T lymphocyte subpopulations were phenotyped by multi-colour flow cytometry. Proximity extension assay was performed for 176 plasma proteins associated with inflammation and cardiovascular disease. At 12 months there were significant reductions in LDL (P=0.001) and blood pressure (P=0.028). NK cells responded with a reduction in pro-inflammatory (NKG2C(+)) cells (P=0.0003), an increase in anti-inflammatory (NKG2A(+)) cells (P=0.032), and a reduction in terminally differentiated (CD57(+)) NK cells. NKT-like cells showed a similar decrease in terminally differentiated subpopulations (P=0.000002). Subpopulations of T helper cells exhibited a significant reduction in central memory (P=1.09x10(-8)) and a significant increase in CD4(+) naive- (P=0.0008) and effector memory T cells (P=0.006). The protein analysis indicated that cardiovascular risk management affects proteins involved in the inflammatory NF-kappa B pathway. The consistent decrease in senescent phenotypes of NK, NKT-like and CD4(+) cells with a concomitant increase in more naive, phenotypes suggests a change towards a less pro-inflammatory lymphocyte profile in response to cardiovascular risk management.Trial registry name: CARotid MRI of Atherosclerosis (CARMA). ClinicalTrials.gov identifier NCT04835571 (08/04/2021). https://www.clinicaltrials.gov/study/NCT04835571.

Place, publisher, year, edition, pages
Nature Publishing Group, 2023
National Category
Immunology in the medical area
Identifiers
urn:nbn:se:liu:diva-200751 (URN)10.1038/s41598-023-48111-7 (DOI)001144297500084 ()38012327 (PubMedID)
Note

Funding Agencies|Linkoping University; Region Ostergotland [RO-610581]; Henry och Ella Margareta Stahls Stiftelse (Henry and Ella Margareta Stahl's Foundation) [LIO-748491]; Forskningsradet i Sydostra Sverige [FORSS-756191]

Available from: 2024-02-07 Created: 2024-02-07 Last updated: 2024-02-07
Hammaréus, F., Nilsson, L., Ong, K.-L., Kristenson, M., Festin, K., Lundberg, A. K., . . . Jonasson, L. (2023). Plasma type I collagen α1 chain in relation to coronary artery disease: findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden.. BMJ Open, 13(9), Article ID e073561.
Open this publication in new window or tab >>Plasma type I collagen α1 chain in relation to coronary artery disease: findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden.
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2023 (English)In: BMJ Open, E-ISSN 2044-6055, Vol. 13, no 9, article id e073561Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: To investigate the association between type I collagen α1 chain (COL1α1) levels and coronary artery disease (CAD) by using absolute quantification in plasma. Also, to investigate the correlates of COL1α1 to clinical characteristics and circulating markers of collagen metabolism.

DESIGN: Life conditions, Stress and Health (LSH) study: prospective cohort study, here with a nested case-control design.Assessing Platelet Activity in Coronary Heart Disease (APACHE) study: prospective cohort study.

SETTING: LSH: primary care setting, southeast Sweden.APACHE: cardiology department, university hospital, southeast Sweden.

PARTICIPANTS: LSH: 1007 randomly recruited individuals aged 45-69 (50% women). Exclusion criteria was serious disease. After 13 years of follow-up, 86 cases with primary endpoint were identified and sex-matched/age-matched to 184 controls.

APACHE: 125 patients with myocardial infarction (MI), 73 with ST-elevation MI and 52 with non-ST-elevation MI.

EXCLUSION CRITERIA: Intervention study participation, warfarin treatment and short life expectancy.

PRIMARY AND SECONDARY OUTCOME MEASURES: Primary outcome was the association between baseline COL1α1 and first-time major event of CAD, defined as fatal/non-fatal MI or coronary revascularisation after 13 years. Secondary outcomes were the association between the collagen biomarkers PRO-C1 (N-terminal pro-peptide of type I collagen)/C1M (matrix metalloproteinase-mediated degradation of type I collagen) and CAD; temporal change of COL1α1 after acute MI up to 6 months and lastly, correlates between COL1α1 and patient characteristics along with circulating markers of collagen metabolism.

RESULTS: COL1α1 levels were associated with CAD, both unadjusted (HR=0.69, 95% CI=0.56 to 0.87) and adjusted (HR=0.55, 95% CI=0.41 to 0.75). PRO-C1 was associated with CAD, unadjusted (HR=0.62, 95% CI=0.47 to 0.82) and adjusted (HR=0.61, 95% CI=0.43 to 0.86), while C1M was not. In patients with MI, COL1α1 remained unchanged up to 6 months. COL1α1 was correlated to PRO-C1, but not to C1M.

CONCLUSIONS: Plasma COL1α1 was independently and inversely associated with CAD. Furthermore, COL1α1 appeared to reflect collagen synthesis but not degradation. Future studies are needed to confirm whether COL1α1 is a clinically useful biomarker of CAD.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2023
Keywords
coronary heart disease, ischaemic heart disease, vascular medicine
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-198543 (URN)10.1136/bmjopen-2023-073561 (DOI)001127161700042 ()37714678 (PubMedID)
Funder
Futurum - Academy for Health and Care, Jönköping County Council, SwedenSwedish Heart Lung Foundation
Note

Funding: Swedish Research Council [2004-1881]; Swedish Heart and Lung Foundation [2004053]; ALF Region Ostergotland [LIO 131 471]; County Council of Ostergotland [ROE-910951]; Academy of Health Care, County Council of Jonkoping; Danish Research Foundation; Linkoping University; Innovation Fund Denmark

Available from: 2023-10-16 Created: 2023-10-16 Last updated: 2024-03-18Bibliographically approved
Neelissen, J., Leanderson, P., Jonasson, L. & Chung, R. W. S. (2023). The Effects of Dairy and Plant-Based Liquid Components on Lutein Liberation in Spinach Smoothies. Nutrients, 15(3), Article ID 779.
Open this publication in new window or tab >>The Effects of Dairy and Plant-Based Liquid Components on Lutein Liberation in Spinach Smoothies
2023 (English)In: Nutrients, E-ISSN 2072-6643, Vol. 15, no 3, article id 779Article in journal (Refereed) Published
Abstract [en]

Lutein is a dietary lipophilic compound with anti-inflammatory properties. We havepreviously shown that dairy fat can improve the lutein content in spinach smoothies. It is, however,unclear whether fat concentrations and fermentation status in dairy products affect lutein liberation insmoothies. Moreover, plant-based milks vary in fat, protein, and fiber content which may affect luteindissolution. This study aimed to provide translatable information to consumers by comparing luteinliberation in spinach smoothies made with different dairy or plant-based liquids in domestic settings.The smoothies were digested in vitro, and liberated lutein was measured by high-performance liquidchromatography (HPLC). High-fat and medium-fat cow’s milk, as well as coconut milk with andwithout additives, were found to significantly improve lutein liberation by 36%, 30%, 25%, and 42%,respectively, compared to blending spinach with water alone. Adjustment models suggested thatthe effects of cow’s milk and coconut milk were derived from fat and protein, respectively. On theother hand, soymilk with and without additives showed significantly reduced lutein liberation by40% and 61%, respectively. To summarize, only 4 out of 14 tested liquids increased lutein liberationin spinach smoothies. The results highlight the importance of testing food companions for lipophilicactive ingredients.

Place, publisher, year, edition, pages
MDPI, 2023
Keywords
lutein; spinach; smoothie; cow’s milk; coconut milk; soymilk; liberation
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:liu:diva-191914 (URN)10.3390/nu15030779 (DOI)000929611500001 ()36771485 (PubMedID)
Funder
Swedish Heart Lung Foundation, 20180436Swedish Research Council, 2018-03232
Note

Funding: Heart-Lung Foundation, Sweden [20180436]; Swedish Research Council [2018-03232]

Available from: 2023-02-22 Created: 2023-02-22 Last updated: 2023-08-28
Holm, A., Swahn, E., Sederholm Lawesson, S., Gustafsson, K., Janzon, M., Jonasson, L., . . . Alfredsson, J. (2021). Sex differences in platelet reactivity in patients with myocardial infarction treated with triple antiplatelet therapy-results from assessing platelet activity in coronary heart disease (APACHE). Platelets, 32(1), 524-532
Open this publication in new window or tab >>Sex differences in platelet reactivity in patients with myocardial infarction treated with triple antiplatelet therapy-results from assessing platelet activity in coronary heart disease (APACHE)
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2021 (English)In: Platelets, ISSN 0953-7104, E-ISSN 1369-1635, Vol. 32, no 1, p. 524-532Article in journal (Refereed) Published
Abstract [en]

)Several earlier studies have reported increased risk of bleeding in women with myocardial infarction, (MI) compared to men. The reasons for the observed difference are incompletely understood, but one suggested explanation has been excess dosing of antithrombotic drugs in women. The aim of this prospective observational study was to assess sex differences in platelet activity in patients treated with three different platelet inhibitors. We recruited 125 patients (37 women and 88 men) with MI, scheduled for coronary angiography. All patients received clopidogrel and aspirin. A subgroup of patients received glycoprotein (GP) IIb/IIIa-inhibitor. Platelet aggregation in whole blood was assessed at several time points, using impedance aggregometry. SolubleP-selectin was measured 3 days after admission. There were no significant differences between women and men in baseline features or comorbidities except higher frequency of diabetes, lower hemoglobin value, and lower estimated glomerular filtration rate, in women on admission. We observed significantly more in-hospital bleeding events in women compared to men (18.9% vs. 6.8%,p= .04). There were no differences in platelet aggregation using three different agonists, reflecting treatment effect of GPIIb/IIIa-inhibitors, clopidogrel, and aspirin, 6-8 hours, 3 days, 7-9 days, or 6 months after loading dose. Moreover, there was no significant difference in solubleP-selectin. The main finding of this study was a consistent lack of difference between the sexes in platelet aggregation, using three different agonists at several time-points. Our results do not support excess dosing of anti-platelet drugs as a major explanation for increased bleeding risk in women.

Place, publisher, year, edition, pages
Taylor & Francis, 2021
Keywords
Gender; myocardial infarction; platelet aggregation; sex
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-167751 (URN)10.1080/09537104.2020.1771550 (DOI)000543070400001 ()32493086 (PubMedID)2-s2.0-85088856352 (Scopus ID)
Note

Funding Agencies|Linkoping University; County Council of Ostergotland

Available from: 2020-07-21 Created: 2020-07-21 Last updated: 2022-05-25Bibliographically approved
Holm Nielsen, S., Jonasson, L., Kalogeropoulos, K., Karsdal, M. A., Reese-Petersen, A. L., Keller, U. A., . . . Goncalves, I. (2020). Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome. Journal of Internal Medicine, 287(5), 493-513
Open this publication in new window or tab >>Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome
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2020 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 287, no 5, p. 493-513Article, review/survey (Refereed) Published
Abstract [en]

Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.

Place, publisher, year, edition, pages
WILEY, 2020
Keywords
atherosclerosis; biomarkers; extracellular matrix; outcome; vulnerable plaque
National Category
Cell and Molecular Biology
Identifiers
urn:nbn:se:liu:diva-164873 (URN)10.1111/joim.13034 (DOI)000517773600001 ()32012358 (PubMedID)
Available from: 2020-03-30 Created: 2020-03-30 Last updated: 2021-05-01
Mahmood, Z., Davidsson, A., Olsson, E., Leanderson, P., Lundberg, A. & Jonasson, L. (2020). The effect of acute exercise on interleukin-6 and hypothalamic-pituitary-adrenal axis responses in patients with coronary artery disease. Scientific Reports, 10, Article ID 21390.
Open this publication in new window or tab >>The effect of acute exercise on interleukin-6 and hypothalamic-pituitary-adrenal axis responses in patients with coronary artery disease
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2020 (English)In: Scientific Reports, E-ISSN 2045-2322, Vol. 10, article id 21390Article in journal (Refereed) Published
Abstract [en]

Vulnerability to stress-induced inflammation has been linked to a dysfunctional hypothalamus–pituitary–adrenal (HPA) axis. In the present study, patients with known or suspected coronary artery disease (CAD) were assessed with respect to inflammatory and HPA axis response to acute physical exercise. An exercise stress test was combined with SPECT myocardial perfusion imaging. Plasma and saliva samples were collected before and 30 min after exercise. Interleukin (IL)-6 and adrenocorticotropic hormone (ACTH) were measured in plasma, while cortisol was measured in both plasma and saliva. In total, 124 patients were included of whom 29% had a prior history of CAD and/or a myocardial perfusion deficit. The levels of exercise intensity and duration were comparable in CAD and non-CAD patients. However, in CAD patients, IL-6 increased after exercise (p = 0.019) while no differences were seen in HPA axis variables. Conversely, patients without CAD exhibited increased levels of ACTH (p = 0.003) and cortisol (p = 0.004 in plasma, p = 0.006 in saliva), but no change in IL-6. We conclude that the IL-6 response to acute physical exercise is exaggerated in CAD patients and may be out of balance due to HPA axis hypoactivity. It remains to be further investigated whether this imbalance is a potential diagnostic and therapeutic target in CAD.

Place, publisher, year, edition, pages
Nature Publishing Group, 2020
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-172146 (URN)10.1038/s41598-020-78286-2 (DOI)000609199000013 ()33288784 (PubMedID)2-s2.0-85097298871 (Scopus ID)
Available from: 2020-12-28 Created: 2020-12-28 Last updated: 2022-09-15Bibliographically approved
Ong, K. L., Chung, R., Hui, N., Festin, K., Lundberg, A., Rye, K.-A., . . . Kristenson, M. (2020). Usefulness of Certain Protein Biomarkers for Prediction of Coronary Heart Disease. American Journal of Cardiology, 125(4), 542-548
Open this publication in new window or tab >>Usefulness of Certain Protein Biomarkers for Prediction of Coronary Heart Disease
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2020 (English)In: American Journal of Cardiology, ISSN 0002-9149, E-ISSN 1879-1913, Vol. 125, no 4, p. 542-548Article in journal (Refereed) Published
Abstract [en]

Identification of biomarkers can help monitor and prevent cardiovascular disease (CVD) risk. We performed an exploratory analysis to identify potential biomarkers for coronary heart disease (CHD) in participants from the Life Conditions, Stress, and Health study. A total of 1,007 participants (50% women), randomly selected from the general population, were followed for incident CHD at 8 and 13 years of follow-up. Plasma levels of 184 CVD-related biomarkers were measured in samples collected at baseline in 86 cases with CHD and 184 age- and sex-matched controls by proximity extension assay. Biomarker levels were presented as normalized protein expression values (log 2 scale). After adjusting for confounding factors, 6 biomarkers showed significant association with incident CHD at 13 years. In a sensitivity analysis, this association remained significant at 8 years for 3 biomarkers; collagen alpha-1(I) chain (COL1A1), bone morphogenetic protein-6 (BMP-6), and interleukin-6 receptor alpha chain (IL-6R alpha). When entering these biomarkers in the full adjustment model simultaneously, their association with incident CHD at 13 years remained significant, hazards ratio being 0.671, 0.335, and 2.854, respectively per unit increase in normalized protein expression values. Subjects with low COL1A1, low BMP-6, and high IL-6R alpha levels had a hazards ratio of 5.097 for incident CHD risk (p = 0.019), compared with those without. In conclusion, we identified COL1A1, BMP-6 and IL-6Ra as biomarkers for incident CHD over a long-term follow-up in this exploratory analysis. For COL1A1 and BMP-6 this has not been previously reported. Further studies are needed to confirm our findings and establish their clinical relevance. (C) 2019 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC, 2020
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-164669 (URN)10.1016/j.amjcard.2019.11.016 (DOI)000514249400009 ()31812227 (PubMedID)
Note

Funding Agencies|Swedish Research CouncilSwedish Research Council [2004-1881]; Swedish Heart and Lung FoundationSwedish Heart-Lung Foundation [2004053]; NSW CVRN Research Development Project from the National Heart Foundation of Australia [100715]; Australian National Health and Medical Research CouncilNational Health and Medical Research Council of Australia [1122854]

Available from: 2020-03-29 Created: 2020-03-29 Last updated: 2021-05-01
Jonasson, L. & Kristenson, M. (2019). Hjärtinfarkt. In: Ali Sarkohi, Gerhard Andersson (Ed.), Somatisk sjukdom: biopsykosocialt perspektiv (pp. 65-91). Lund: Studentlitteratur AB, Sidorna 65-91
Open this publication in new window or tab >>Hjärtinfarkt
2019 (Swedish)In: Somatisk sjukdom: biopsykosocialt perspektiv / [ed] Ali Sarkohi, Gerhard Andersson, Lund: Studentlitteratur AB, 2019, Vol. Sidorna 65-91, p. 65-91Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2019
Keywords
Hjärtinfarkt
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-161981 (URN)9789144119601 (ISBN)
Available from: 2019-11-15 Created: 2019-11-15 Last updated: 2019-11-15Bibliographically approved
Lundgren, O., Garvin, P., Kristenson, M., Jonasson, L. & Thylén, I. (2018). A journey through chaos and calmness: experiences of mindfulness training in patients with depressive symptoms after a recent coronary event - a qualitative diary content analysis.. BMC Psychology, 6(1), Article ID 46.
Open this publication in new window or tab >>A journey through chaos and calmness: experiences of mindfulness training in patients with depressive symptoms after a recent coronary event - a qualitative diary content analysis.
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2018 (English)In: BMC Psychology, E-ISSN 2050-7283, Vol. 6, no 1, article id 46Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Psychological distress with symptoms of depression and anxiety is common and unrecognized in patients with coronary artery disease (CAD). Efforts have been made to treat psychological distress in CAD with both conventional methods, such as antidepressant drugs and psychotherapy, and non-conventional methods, such as stress management courses. However, studies focusing on the experiences of mindfulness training in this population are still scarce. Therefore, the aim of this study was to explore immediate experiences of mindfulness practice among CAD patients with depressive symptoms.

METHODS: A qualitative content analysis of diary entries, written immediately after practice sessions and continuously during an 8-week long Mindfulness Based Stress Reduction course (MBSR), was applied.

RESULTS: Twelve respondents participated in the study. The main category: a journey through chaos and calmness captured the participants' concurrent experiences of challenges and rewards over time. This journey appears to reflect a progressive development culminating in the harvesting of the fruits of practice at the end of the mindfulness training. Descriptions of various challenging facets of mindfulness practice - both physical and psychological - commonly occurred during the whole course, although distressing experiences were more predominant during the first half. Furthermore, the diary entries showed a wide variety of ways of dealing with these struggles, including both constructive and less constructive strategies of facing difficult experiences. As the weeks passed, participants more frequently described an enhanced ability to concentrate, relax and deal with distractions. They also developed their capacity to observe the content of their mind and described how the practice began to yield rewards in the form of well-being and a sense of mastery.

CONCLUSIONS: Introducing MBSR in the aftermath of a cardiac event, when depressive symptoms are present, is a complex and delicate challenge in clinical practice. More nuanced information about what to expect as well as the addition of motivational support and skillful guidance during the course should be given in accordance with the participants' experiences and needs.

TRIAL REGISTRATION: The trial was retrospectively registered in clinicaltrials.gov (registration number: NCT03340948 ).

Place, publisher, year, edition, pages
BioMed Central, 2018
Keywords
Depressive symptoms, Mindfulness based stress reduction, Myocardial infarction, Qualitative content analysis, Unstable angina pectoris
National Category
Other Medical Sciences not elsewhere specified
Identifiers
urn:nbn:se:liu:diva-153226 (URN)10.1186/s40359-018-0252-1 (DOI)30213276 (PubMedID)2-s2.0-85053272711 (Scopus ID)
Available from: 2018-12-03 Created: 2018-12-03 Last updated: 2019-05-01Bibliographically approved
Lundgren, O., Garvin, P., Andersson, G., Jonasson, L. & Kristenson, M. (2018). Inverted items and validity: A psychobiological evaluation of two measures of psychological resources and one depression scale. Health psychology open, 5(1), Article ID 2055102918755045.
Open this publication in new window or tab >>Inverted items and validity: A psychobiological evaluation of two measures of psychological resources and one depression scale
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2018 (English)In: Health psychology open, ISSN 2055-1029, Vol. 5, no 1, article id 2055102918755045Article in journal (Refereed) Published
Abstract [en]

Psychological resources and risk factors influence risk of coronary heart disease. We evaluated whether inverted items in the Self-esteem, Mastery, and Center for Epidemiological Studies Depression scales compromise validity in the context of coronary heart disease. In a population-based sample, validity was investigated by calculating correlations with other scales (n = 1004) and interleukin-6 (n = 374), and by analyzing the relationship with 8-year coronary heart disease risk (n = 1000). Negative items did not affect the validity of the resource scales. In contrast, positive items from Center for Epidemiological Studies Depression showed no significant relationships with biological variables. However, they had no major impact on the validity of the original scale.

Place, publisher, year, edition, pages
Sage Publications, 2018
Keywords
coronary heart disease, depressiveness, interleukin-6, mastery, self-esteem, wording effect
National Category
General Practice
Identifiers
urn:nbn:se:liu:diva-146087 (URN)10.1177/2055102918755045 (DOI)29479456 (PubMedID)
Available from: 2018-03-27 Created: 2018-03-27 Last updated: 2019-04-10Bibliographically approved
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