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Herland, Anna
Publications (10 of 22) Show all publications
Björk, P., Herland, A., Hamedi, M. & Inganäs, O. (2010). Biomolecular nanowires decorated by organic electronic polymers. JOURNAL OF MATERIALS CHEMISTRY, 20(12), 2269-2276
Open this publication in new window or tab >>Biomolecular nanowires decorated by organic electronic polymers
2010 (English)In: JOURNAL OF MATERIALS CHEMISTRY, ISSN 0959-9428, Vol. 20, no 12, p. 2269-2276Article in journal (Refereed) Published
Abstract [en]

We demonstrate the shaping and forming of organic electronic polymers into designer nanostructures using biomacromolecules. In order to create nanowires, nanohelixes and assemblies of these, we coordinate semiconducting or metallic polymers to biomolecular polymers in the form of DNA and misfolded proteins. Optoelectronic and electrochemical devices utilizing these shaped materials are discussed.

National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-54609 (URN)10.1039/b910639a (DOI)000275380000001 ()
Available from: 2010-03-26 Created: 2010-03-26 Last updated: 2010-03-26
Andersson, V., Herland, A., Masich, S. & Inganäs, O. (2009). Imaging of the 3D Nanostructure of a Polymer Solar Cell by Electron Tomography. Nano letters (Print), 9(2), 853-855
Open this publication in new window or tab >>Imaging of the 3D Nanostructure of a Polymer Solar Cell by Electron Tomography
2009 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 9, no 2, p. 853-855Article in journal (Refereed) Published
Abstract [en]

Electron tomography has been used for analyzing the active layer in a polymer solar cell, a bulk heterojunction of an alternating copolymer of fluorene and a derivative of fullerene. The method supplies a three-dimensional representation of the morphology of the film, where domains with different scattering properties may be distinguished. The reconstruction shows good contrast between the two phases included in the film and demonstrates that electron tomography is an adequate tool for investigations of the three-dimensional nanostructure of the amorphous materials used in polymer solar cells.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-16961 (URN)10.1021/nl803676e (DOI)
Available from: 2009-02-28 Created: 2009-02-27 Last updated: 2017-12-13
Karlsson, R., Herland, A., Hamedi, M., Wigenius, J., Åslund, A., Liu, X., . . . Konradsson, P. (2009). Iron-Catalyzed Polymerization of Alkoxysulfonate-Functionalized 3,4-Ethylenedioxythiophene Gives Water-Soluble Poly(3,4-ethylenedioxythiophene) of High Conductivity. Chemistry of Materials, 21(9), 1815-1821
Open this publication in new window or tab >>Iron-Catalyzed Polymerization of Alkoxysulfonate-Functionalized 3,4-Ethylenedioxythiophene Gives Water-Soluble Poly(3,4-ethylenedioxythiophene) of High Conductivity
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2009 (English)In: Chemistry of Materials, ISSN 0897-4756, E-ISSN 1520-5002, Vol. 21, no 9, p. 1815-1821Article in journal (Refereed) Published
Abstract [en]

Chemical polymerization of a 3,4-ethylenedioxythiophene derivative bearing a sulfonate group (EDOTS) is reported. The polymer, PEDOT-S, is fully water-soluble and has been produced by polymerizing EDOT-S in water, using Na2S2O8 and a catalytic amount of FeCl3. Elemental analysis and XPS measurements indicate that PEDOT-S is a material with a substantial degree of self-doping, but also contains free sulfate ions as charge-balancing counterions of the oxidized polymer. Apart from self-doping PEDOT-S, the side chains enable full water solubility of the material; DLS studies show an average cluster size of only 2 nm. Importantly, the solvation properties of the PEDOT-S are reflected in spin-coated films, which show a surface roughness of 1.2 nm and good conductivity (12 S/cm) in ambient conditions. The electro-optical properties of this material are shown with cyclic voltammetry and spectroelectrochemical experiment reveals an electrochromic contrast (similar to 48% at lambda(max) = 606 nm).

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2009
National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-18398 (URN)10.1021/cm801512r (DOI)000265781000012 ()
Available from: 2009-05-25 Created: 2009-05-25 Last updated: 2017-12-13Bibliographically approved
Herland, A., Thomsson, D., Mirzov, O., Scheblykin, I. G. & Inganäs, O. (2008). Decoration of amyloid fibrils with luminescent conjugated polymers. Journal of Materials Chemistry, 18(1), 126-132
Open this publication in new window or tab >>Decoration of amyloid fibrils with luminescent conjugated polymers
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2008 (English)In: Journal of Materials Chemistry, ISSN 0959-9428, E-ISSN 1364-5501, Vol. 18, no 1, p. 126-132Article in journal (Refereed) Published
Abstract [en]

In this work we report the coating of a biological template with a polar, but uncharged, luminescent conjugated polymer, soluble in organic solvents but not in water, to produce a nanowire. Amyloid fibrils from bovine insulin were decorated with an alternating polyfluorene derivative. Decorated fibrils were partially aligned on hydrophobic surfaces as separate and bundled fibrils, by means of molecular combing. The single molecule spectroscopy technique utilizing excitation by rotating linearly polarized light and fluorescence detection through a rotating polarizer showed a high degree of anisotropy of the polymer chains on the individual fibrils. The high degree of polarization indicated highly oriented polymer chains with the preferential orientation of the polymer backbone along the fibrils. The anisotropy ratios are comparable with those of well-oriented polymer chains in films. © The Royal Society of Chemistry.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-14603 (URN)10.1039/b712829k (DOI)000251580400016 ()
Available from: 2007-10-12 Created: 2007-10-12 Last updated: 2017-12-13
Hamedi, M., Herland, A., Karlsson, R. H. & Inganäs, O. (2008). Electrochemical Devices Made from Conducting Nanowire Networks Self-Assembled from Amyloid Fibrils and Alkoxysulfonate PEDOT. Nano letters (Print), 8(6), 1736-1740
Open this publication in new window or tab >>Electrochemical Devices Made from Conducting Nanowire Networks Self-Assembled from Amyloid Fibrils and Alkoxysulfonate PEDOT
2008 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 8, no 6, p. 1736-1740Article in journal (Refereed) Published
Abstract [en]

Proteins offer an almost infinite number of functions and geometries for building nanostructures. Here we have focused on amyloid fibrillar proteins as a nanowire template and shown that these fibrils can be coated with the highly conducting polymer alkoxysulfonate PEDOT through molecular self-assembly in water. Transmission electron microscopy and atomic force microscopy show that the coated fibers have a diameter around 15 nm and a length/thickness aspect ratio >1:1000 . We have further shown that networks of the conducting nanowires are electrically and electrochemically active by constructing fully functional electrochemical transistors with nanowire networks, operating at low voltages between 0 and 0.5 V.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-17660 (URN)10.1021/nl0808233 (DOI)
Available from: 2009-04-08 Created: 2009-04-08 Last updated: 2017-12-13
Tanaka, H., Herland, A., Lindgren, L., Tsutsui, T., Andersson, M. R. & Inganäs, O. (2008). Enhanced current efficiency from Bio-Organic light-emitting diodes using decorated amyloid fibrils with conjugated polymer. Nano letters (Print), 8(9), 2858-2861
Open this publication in new window or tab >>Enhanced current efficiency from Bio-Organic light-emitting diodes using decorated amyloid fibrils with conjugated polymer
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2008 (English)In: Nano letters (Print), ISSN 1530-6984, E-ISSN 1530-6992, Vol. 8, no 9, p. 2858-2861Article in journal (Refereed) Published
Abstract [en]

We demonstrate the use of self-assembled bionanostructures in polymer light-emitting diodes. Amyloid fibrils formed by protein misfolding were decorated with a soluble luminescent conjugated polymer. This conjugated polymer complex with amyloid fibrils was used as the active layer in a light emitting diode, resulting in a 10-fold increase in external quantum efficiency compared with pristine polymer, because of improved carrier injection. © 2008 American Chemical Society.

National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-50420 (URN)10.1021/nl801510z (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Barrau, S., Zhang, F., Herland, A., Mammo, W., Andersson, M. R. & Inganäs, O. (2008). Integration of Amyloid Nanowires in Organic Solar Cells. Applied Physics Letters, 93, 23307
Open this publication in new window or tab >>Integration of Amyloid Nanowires in Organic Solar Cells
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2008 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 93, p. 23307-Article in journal (Refereed) Published
Abstract [en]

  

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-42807 (URN)10.1063/1.2949073 (DOI)68940 (Local ID)68940 (Archive number)68940 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Herland, A., Björk, P., Hania, P. R., Scheblykin, I. G. & Inganäs, O. (2007). Alignment of a conjugated polymer onto amyloid-like protein fibrils. Small, 3(2), 318-325
Open this publication in new window or tab >>Alignment of a conjugated polymer onto amyloid-like protein fibrils
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2007 (English)In: Small, ISSN 1613-6810, Vol. 3, no 2, p. 318-325Article in journal (Refereed) Published
Abstract [en]

The amyloid-like fibril is a biomolecular nanowire template of very high stability. Here we describe the coordination of a conjugated polyelectrolyte, poly(thiophene acetic acid) (PTAA), to bovine insulin fibrils with widths of <10 nm and lengths of up to more than 10 m. Fibrils complexed with PTAA are aligned on surfaces through molecular combing and transfer printing. Single-molecule spectroscopy techniques are applied to chart spectral variation in the emission of these wires. When these results are combined with analysis of the polarization of the emitted light, we can conclude that the polymer chains are preferentially aligned along the fibrillar axis.

Keywords
fibrils, nanowires, polymers, self-assembly, template synthesis
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-14602 (URN)10.1002/smll.200600377 (DOI)
Available from: 2007-10-12 Created: 2007-10-12 Last updated: 2009-04-29
Herland, A. (2007). Conjugated Polymers, Amyloid Detection and Assembly of Biomolecular Nanowires. (Doctoral dissertation). : Institutionen för fysik, kemi och biologi
Open this publication in new window or tab >>Conjugated Polymers, Amyloid Detection and Assembly of Biomolecular Nanowires
2007 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The research field of conjugated polymers has grown due to the optical and electronic properties of the material, useful in applications such as solar cells and printed electronics, but also in biosensors and for interactions with biomolecules. In this thesis conjugated polymers have been used in two related topics; to detect conformational changes in proteins and to assemble the polymers with biomolecules into nanowires.

Within biosensing, conjugated polymers have been used for detection of a wide range of biological events, such as DNA hybridization or enzymatic activity, utilizing both electronic and optical changes in the polymer. Here the focus has been to use the polymers as optical probes to discriminate between native and misfolded protein, as well as to follow the misfolding processes in vitro. The understanding and detection of protein misfolding, for example amyloid fibril formation, is a topic of growing importance. The misfolding process is strongly associated with several devastating diseases such as Alzheimer’s disease, Parkinson’s disease and Bovine Spongiform Encephalopathy (BSE). We have developed detection schemes for discrimination between proteins in the native or amyloid fibril state based on luminescent polythiophene derivatives. Through a synthesis strategy based on polymerization of trimer blocks rather than of monomers, polythiophene derivatives with higher optical signal specificity for amyloid-like fibrils were obtained.

Self-assembly of nanowires containing conjugated polymers is a route to generate structures of unique opto-electrical characteristics without the need for tedious topdown processes. Biomolecules can have nanowire geometries of extraordinary aspect ratio and functionalities. The DNA molecule is the most well known and exploited of these. In this thesis work the more stable amyloid fibril has been used as a template to organize conjugated polymers. Luminescent, semi-conducting, conjugated polymers have been incorporated in and assembled onto amyloid fibrils. Using luminescence quenching we have demonstrated that the conjugated material can retain the electro-activity after the incorporation process. Furthermore, the amyloid fibril/conjugated polymer hybrid structures can be organized on surfaces by the means of molecular combing and soft lithography.

In the process of generating self-assembled biomolecular nanowires functionalized with conjugated polymers, we have shown a new synthesis strategy for a water-soluble highly conducting polythiophene derivative. This material, PEDOT-S, has shown affinity for amyloid fibrils, but can also be very useful in conventional opto-electronic polymer-based devices.

Place, publisher, year, edition, pages
Institutionen för fysik, kemi och biologi, 2007
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1117
Keywords
Conjugated Polymers, Amyloid Fibrils, Nanowires, Self-Assembly, Sensor, Amyloid Detection
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-9577 (URN)978-91-85831-42-5 (ISBN)
Public defence
2007-09-04, Planck, Physics Building, Linköping University, Linköping, 10:15 (English)
Opponent
Supervisors
Available from: 2007-10-12 Created: 2007-10-12 Last updated: 2009-04-29
Herland, A. & Inganäs, O. (2007). Conjugated polymers as optical probes for protein interactions and protein conformations. Macromolecular rapid communications, 28(17), 1703-1713
Open this publication in new window or tab >>Conjugated polymers as optical probes for protein interactions and protein conformations
2007 (English)In: Macromolecular rapid communications, ISSN 1022-1336, E-ISSN 1521-3927, Vol. 28, no 17, p. 1703-1713Article in journal (Refereed) Published
Abstract [en]

There is a need for highly sensitive, multi-parallel protein sensors within diagnostics and proteomic research. Conjugated polymers (CPs) have been demonstrated as highly sensitive optical probes for protein biosensing. Compared to small molecules, the polymeric probe has the possibility of multiple interactions and a collective response, which enhances the sensor signal. The optical output is colorimetric or, more sensitive, fluorescence based, including Förster energy transfer and changes in the emission wavelengths and/or intensity. Using CPs, many interesting protein detection events have been demonstrated, e.g., protein interactions, enzymatic activity, amyloid fibril formation, and detection by aptamers. CPs have also been successfully used to stain bacterial, cellular, and tissue samples. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-39411 (URN)10.1002/marc.200700281 (DOI)48251 (Local ID)48251 (Archive number)48251 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
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