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Wyon, Yvonne
Publications (10 of 21) Show all publications
Zaborowska, E., Brynhildsen, J., Damberg, S., Fredriksson, M., Lindh-Åstrand, L., Nedstrand, E., . . . Hammar, M. (2007). Effects of acupuncture, applied relaxation, estrogens and placebo on hot flushes in postmenopausal women – an analysis of two prospective, parallel, randomised studies. Climacteric, 10(1), 38-45
Open this publication in new window or tab >>Effects of acupuncture, applied relaxation, estrogens and placebo on hot flushes in postmenopausal women – an analysis of two prospective, parallel, randomised studies
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2007 (English)In: Climacteric, ISSN 1369-7137, E-ISSN 1473-0804, Vol. 10, no 1, p. 38-45Article in journal (Refereed) Published
Abstract [en]

Objective: To assess if transdermal or oral estrogens, acupuncture and applied relaxation decrease the number of menopausal hot flushes/24 h and improve climacteric symptoms, as assessed by the Kupperman index, more than transdermal placebo treatment.

Setting: An outpatient clinic at a Swedish university hospital.

Methods: A total of 102 postmenopausal women were recruited to two studies performed in parallel. In Study I, the women were randomized between transdermal placebo or estrogen treatment and, in Study II, between oral estrogens, acupuncture or applied relaxation for 12 weeks. Climacteric symptoms were measured with daily logbooks on hot flushes. Women completed the assessment questionnaire for the Kupperman index at baseline and after 12 weeks.

Results: The number of flushes/24 h decreased significantly after 4 and 12 weeks in all groups except the placebo group. Both at 4 and 12 weeks, acupuncture decreased the number of flushes more (p < 0.05; p < 0.01, respectively) than placebo. At 12 weeks, applied relaxation decreased the number of flushes more (p < 0.05) than placebo. The Kupperman index score decreased in all groups except the placebo group. The decrease in score was significantly greater in all treatment groups than in the placebo group (p < 0.01).

Conclusion: Acupuncture and applied relaxation both reduced the number of hot flushes significantly better than placebo and should be further evaluated as alternatives to hormone therapy in women with menopausal vasomotor complaints.

Place, publisher, year, edition, pages
Climacteric, 2007
Keywords
VASOMOTOR SYMPTOMS, HOT FLUSHES, ACUPUNCTURE, APPLIED RELAXATION, PLACEBO
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-11718 (URN)10.1080/13697130601165059 (DOI)
Note
Original publication: Ewa Zaborowska, Jan Brynhildsen, Sara Damberg, Mats Fredriksson, Lotta Lindh-Åstrand, Elisabeth Nedstrand, Yvonne Wyon and Mats Hammar, Effects of acupuncture, applied relaxation, estrogens and placebo on hot flushes in postmenopausal women – an analysis of two prospective, parallel, randomised studies, 2007, Climacteric, (10), 1, 38-45. http://dx.doi.org/10.1080/13697130601165059. Copyright © Taylor & Francis Group, an informa businessAvailable from: 2008-05-02 Created: 2008-05-02 Last updated: 2017-12-13
Wyon, Y., Synnerstad, I., Fredrikson, M. & Rosdahl, I. (2007). Spectrophotometric analysis of melanocytic naevi during pregnancy. Acta Dermato-Venereologica, 87(3), 231-237
Open this publication in new window or tab >>Spectrophotometric analysis of melanocytic naevi during pregnancy
2007 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 87, no 3, p. 231-237Article in journal (Refereed) Published
Abstract [en]

Malignant melanoma is the most common cancer during pregnancy, but it is unknown whether melanocytic naevi in general are activated. A total of 381 melanocytic naevi in 34 Caucasian primigravidae were examined using spectrophotometric intracutaneous analysis (SIAscopy) technology in early pregnancy and prior to delivery. The Siagraphs of each naevus were then compared in order to evaluate changes over time. A total of 163 melanocytic naevi in 21 nulliparous women served as an additional control group. At the first visit none of the Siagraphs examined for the case or control groups aroused suspicion of dysplastic naevus or melanoma and no significant structural changes were noted during the observation period. However, 2.1% of the melanocytic naevi in the pregnant group increased and 1.3% decreased in size. Corresponding figures in the non-pregnant group were 1.8% and 0%, respectively. Only one naevus in a pregnant woman increased slightly in epidermal pigmentation, and a decrease in pigmentation was noted in 3.7% of the melanocytic naevi in the cases and 1.8% in the controls. None of the differences within or between the groups was statistically significant. We conclude that pregnancy does not influence the appearance of pigmented naevi. A changing naevus during pregnancy should be examined carefully and considered for excision and histopathology. © 2007 Acta Dermato-Venereologica.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-39204 (URN)47231 (Local ID)47231 (Archive number)47231 (OAI)
Note

DOI does not work: 10.2340/00015555-0227

Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2018-03-13
Nedstrand, E., Wyon, Y., Hammar, M. & Wijma, K. (2006). Psychological well-being improves in women with breast cancer after treatment with applied relaxation or electro-acupuncture for vasomotor symptom. Journal of Psychosomatic Obstetrics and Gynaecology, 27(4), 193-199
Open this publication in new window or tab >>Psychological well-being improves in women with breast cancer after treatment with applied relaxation or electro-acupuncture for vasomotor symptom
2006 (English)In: Journal of Psychosomatic Obstetrics and Gynaecology, ISSN 0167-482X, E-ISSN 1743-8942, Vol. 27, no 4, p. 193-199Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to evaluate the effect of applied relaxation and electro-acupuncture (EA) on psychological well-being in breast cancer-treated women with vasomotor symptoms. Thirty-eight breast cancer-treated postmenopausal women with vasomotor symptoms were included in the study. They were randomized to either treatment with electro-acupuncture (EA) (N = 19, three of them with tamoxifen) or applied relaxation (AR) (n = 19, five of them with tamoxifen) over a 12-week study period with six months follow-up. Vasomotor symptoms were registered daily. A visual analog scale was used to assess climacteric symptom, estimation of general well-being was made using the Symptom Checklist, and mood using the Mood Scale. These were applied during treatment and at follow-up. In total 31 women completed 12 weeks of treatment and six months of follow-up. Hot flushes were reduced by more than 50%. Climacteric symptoms significantly decreased during treatment and remained so six months after treatment in both groups. Psychological well-being significantly improved during therapy and at follow-up visits in both groups. Mood improved significantly in the electro-acupuncture treated group. In conclusion psychological well-being improved in women with breast cancer randomized to treatment with either AR or EA for vasomotor symptoms and we therefore suggest that further studies should be performed in order to evaluate and develop these alternative therapies. © 2006 Informa UK Ltd.

Keywords
Acupuncture, Applied relaxation, Breast cancer, Menopause, Vasomotor symptoms, Well-being
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-50058 (URN)10.1080/01674820600724797 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Nedstrand, E., Wijma, K., Wyon, Y. & Hammar, M. (2005). Applied relaxation and oral estradiol treatment of vasomotor symptoms in postmenopausal women. Maturitas, 51(2), 154-162
Open this publication in new window or tab >>Applied relaxation and oral estradiol treatment of vasomotor symptoms in postmenopausal women
2005 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 51, no 2, p. 154-162Article in journal (Refereed) Published
Abstract [en]

Objective: The aim was to evaluate and compare the effects of applied relaxation and oral estradiol treatment on hot flushes, mood and psychological wellbeing in postmenopausal women.

Patients and methods: In a prospective study, 30 postmenopausal women with vasomotor symptoms were randomized to applied relaxation or oral estradiol treatment during 12 weeks with 6 months follow-up. Number and severity of flushes were registered daily and Kupperman’s Index and a general estimate of climacteric symptoms, Mood Scale and Symptom Check List were completed at baseline, 4, 8 and 12 weeks of treatment, and 3 and 6 months after therapy.

Results: After 12 weeks of treatment, the number of flushes/24 h decreased significantly over time in both treatment groups. In the group receiving applied relaxation, the mean number of flushes/24 h decreased from 6.0 (95% CI 4.5–7.6) to 3.0 (95% CI 2.1–3.9) after 12 weeks of treatment. The mean number of flushes/24 h was 1.7 (95% CI 0.7–2.5) at 6 months follow-up; i.e. a 72% decrease. In the estrogen group, the mean number of flushes/24 h decreased from 8.4 to 0.8; i.e a 90% decrease in the number of flushes after 12 weeks of treatment. The significant change in flushes reached after 12 weeks of treatment and remained to 6 months after end of treatment in both groups. Estrogen therapy reduced flushes significantly faster than applied relaxation. General climacteric symptoms according to the Visual Analogue Scale and the Kupperman’s Index decreased significantly over time in both groups. General mood (Mood Scale) increased significantly in the estrogen group, but not in the group receiving applied relaxation. Psychological wellbeing according to Symptom Checklist, increased significantly from baseline to 12 weeks in both groups.

Conclusions: We suggest that applied relaxation may be used as an alternative treatment of vasomotor symptoms for postmenopausal women but should be further evaluated.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-29369 (URN)10.1016/j.maturitas.2004.05.017 (DOI)14701 (Local ID)14701 (Archive number)14701 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13Bibliographically approved
Wyon, Y., Nedstrand, E. & Hammar, M. (2005). Klimakteriebesvär: Mer forskning behövs om olika behandlingsformer - inklusive akupunktur.. Läkartidningen, 1664-1665
Open this publication in new window or tab >>Klimakteriebesvär: Mer forskning behövs om olika behandlingsformer - inklusive akupunktur.
2005 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, p. 1664-1665Article in journal (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-28865 (URN)14058 (Local ID)14058 (Archive number)14058 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
Nedstrand, E., Wijma, K., Wyon, Y. & Hammar, M. (2005). Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study. Climacteric, 8(3), 243-250
Open this publication in new window or tab >>Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study
2005 (English)In: Climacteric, ISSN 1369-7137, E-ISSN 1473-0804, Vol. 8, no 3, p. 243-250Article in journal (Refereed) Published
Abstract [en]

Objective: To evaluate the effect of applied  relaxation and electro-acupuncture on vasomotor symptoms in women treated for breast cancer.

Methods: Thirty-eight postmenopausal women with  breast cancer and vasomotor symptoms were randomized to treatment with electro-acupuncture (n = 19) or applied relaxation (n = 19) during 12 weeks. The number of hot flushes was registered daily in a logbook before and during treatment and after 3 and 6 months of follow-up.

Results: Thirty-one women completed 12 weeks of treatment and 6  months of follow-up. After 12 weeks of applied relaxation, the number of flushes/24 h had decreased from 9.2 (95% confidence interval (CI) 6.6-11.9) at baseline to 4.5 (95% CI 3.2-5.8) and to 3.9 (95% CI 1.8-6.0) at 6 months follow-up (n = 14). The flushes/24 h were reduced from 8.4 (95% CI 6.6-10.2) to 4.1 (95% CI 3.0-5.2) after 12 weeks of treatment with electro-acupuncture and to 3.5 (95% CI 1.7-5.3) after 6 months follow-up (n = 17). In both groups, the mean Kupperman Index score was significantly reduced after treatment and remained unchanged 6 months after end of treatment.

Conclusion: We suggest that applied relaxation and  electro-acupuncture should be further evaluated as possible treatments for vasomotor symptoms in postmenopausal women with breast cancer.

Place, publisher, year, edition, pages
Institutionen för klinisk och experimentell medicin, 2005
Keywords
Vasomotor symptoms; Menopause; Breast cancer; Applied relaxation; Acupuncture
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-11901 (URN)10.1080/13697130500118050 (DOI)
Note
Original publication: E. Nedstrand, K. Wijma, Y. Wyon, M. Hammar, Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study, 2005, Climacteric, (8), 3, 243-250. http://dx.doi.org/10.1080/13697130500118050. Copyright © Taylor & Francis Group, an informa businessAvailable from: 2008-05-23 Created: 2008-05-23 Last updated: 2017-12-13
Wyon, Y., Wijma, K., Nedstrand, E. & Hammar, M. (2004). A comparison of acupuncture and oral estradiol treatment of vasomotor symptoms in postmenopausal women. Climacteric, 7(2), 153-164
Open this publication in new window or tab >>A comparison of acupuncture and oral estradiol treatment of vasomotor symptoms in postmenopausal women
2004 (English)In: Climacteric, ISSN 1369-7137, E-ISSN 1473-0804, Vol. 7, no 2, p. 153-164Article in journal (Refereed) Published
Abstract [en]

Objective To compare the effects of electro-acupuncture with oral estradiol and superficial needle insertion on hot flushes in postmenopausal women.

Material and methods  Forty-five postmenopausal women with vasomotor symptoms were randomized to electro-acupuncture, superficial needle insertion or oral estradiol treatment during 12 weeks, with 6 months' follow-up. The number and severity of flushes were registered daily and the Kupperman index and a general estimate of climacteric symptoms were completed before, during and after therapy.

Results In the electro-acupuncture group, the mean number of flushes/24 h decreased from 7.3 to 3.5 (ANOVA, p  < 0.001). Eleven of the 15 women had at least a 50% decrease in number of flushes (with a mean decrease of 82%). Superficial needle insertion decreased the number of flushes/24 h from 8.1 to 3.8 (p  < 0.001). In seven out of 13 women, the number of flushes decreased by at least 50% (mean decrease 83%). In the estrogen group, the number of flushes decreased from 8.4 to 0.8 (p < 0.001). The decrease in number of flushes persisted during the 24-week follow-up period in all treatment groups. The Kupperman index and the general climacteric symptom score decreased, and remained unchanged 24 weeks after treatment in all groups (p < 0.001). Electro-acupuncture decreased the number of flushes/24 h significantly over time, but not to the same extent as the estrogen treatment. No significant difference in effect was found between electro-acupuncture and the superficial needle insertion.

Conclusion We suggest that acupuncture is a viable alternative treatment of vasomotor symptoms in postmenopausal women and cannot recommend superficial needle insertion as an inactive control treatment.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-22013 (URN)10.1080/13697130410001713814 (DOI)1041 (Local ID)1041 (Archive number)1041 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13Bibliographically approved
Hammar, M., Nedstrand, E. & Wyon, Y. (2004). Få alternativ till östrogenbehandling vid vegetativa besvär efter menopaus.. Läkartidningen, 101(18), 1612-1615
Open this publication in new window or tab >>Få alternativ till östrogenbehandling vid vegetativa besvär efter menopaus.
2004 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 101, no 18, p. 1612-1615Article in journal (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-22040 (URN)1092 (Local ID)1092 (Archive number)1092 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Lindh-Åstrand, L., Nedstrand, E., Wyon, Y. & Hammar, M. (2004). Vasomotor symptoms and quality of life in previously sedentary postmenopausal women randomised to physical activity or estrogen therapy. Maturitas, 48(2), 97-105
Open this publication in new window or tab >>Vasomotor symptoms and quality of life in previously sedentary postmenopausal women randomised to physical activity or estrogen therapy
2004 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 48, no 2, p. 97-105Article in journal (Refereed) Published
Abstract [en]

Objective: To assess if regular physical exercise or oral oestradiol therapy decreased vasomotor symptoms and increased quality of life in previously sedentary postmenopausal women. Setting: A prospective, randomised trial at a University Hospital. Methods: 75 postmenopausal, sedentary women with vasomotor symptoms were randomised to: exercise three-times weekly over 12 weeks (15 women), oral oestradiol therapy for 12 weeks (15 women) and 45 women to three other treatment arms. Results from the exercise and oestradiol groups are presented here. The effects on vasomotor symptoms and wellbeing were assessed with logbooks and validated questionnaires. Results: Ten women fulfilled 12 weeks of exercise. The number of flushes was rather unchanged in five women and decreased to 28% (range 18-42%) of baseline in the other five women. Five of the ten women continued to exercise another 24 weeks, thus in all 36 weeks. The mean number of flushes decreased by about 50% in these five women (from 6.2/24 to 3.2 flushes/24 h at 36 weeks). In the same group a score made as the product of reduction in number and severity of flushes decreased by 92% at 12 weeks, 75% at 24 weeks and 72% at 36 weeks compared with baseline. In the estrogen group flushes decreased from 8.4 to 0.8 (P<0.001) after 12 weeks of therapy and remained at this level after 36 weeks. Well-being according to different measurements improved significantly in both groups, albeit more markedly in the estrogen group. Conclusions: Apart from many other health benefits regular physical exercise may decrease vasomotor symptoms and increase quality of life in postmenopausal women, but this has to be further evaluated scientifically. Exercise should be introduced gradually to ensure compliance.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-22015 (URN)10.1016/S0378-5122(03)00187-7 (DOI)1043 (Local ID)1043 (Archive number)1043 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Sandberg, M., Wijma, K., Wyon, Y., Nedstrand, E. & Hammar, M. (2002). Effects of electro-acupuncture on psychological distress in postmenopausal women. Complementary Therapies in Medicine, 10(3), 161-169
Open this publication in new window or tab >>Effects of electro-acupuncture on psychological distress in postmenopausal women
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2002 (English)In: Complementary Therapies in Medicine, ISSN 0965-2299, Vol. 10, no 3, p. 161-169Article in journal (Refereed) Published
Abstract [en]

Objectives: To evaluate effects of electro–acupuncture (EA) on general psychological distress and relate to experience of climacteric symptoms in 30 postmenopausal women.

Design: A randomised single-blind controlled design was used to evaluate effects of EA and extremely superficial needle insertion, with the latter serving as a near-placebo control.

Settings: The Linköping University Hospital in Sweden. Interventions: Fourteen treatments during 12 weeks with follow-ups at 3 and 6 months.

Outcome measures: General psychological well-being, mood and experience of climacteric symptoms. Results: Mood Scale improved only in EA group and not until 12 weeks compared to baseline, from 110 to 129 (P=0.01), and to 120 at 3-month follow-up (P=0.04). Mood was significantly better than control at 8 (P=0.05) and 12 weeks (P=0.01). Visual analogue scale estimation of climacteric symptoms was decreased at 4 weeks in both groups, and lasted throughout the study period, in EA group from 5 to 2 (P=0.04) and in control group from 5 to 3 (P=0.02) at 6-month follow-up. Well-being was ameliorated from 4 weeks in EA and from 8 weeks in control group until end of study (P=0.01, P=0.03). No significant differences on climacteric symptoms or well-being existed between the groups.

Conclusions: This study does not show that EA is better than superficial needle insertion for the amelioration of general psychological distress and experience of climacteric symptoms in women with vasomotor symptoms after menopause. However, the more pronounced effect on mood suggests that EA might have additional effects compared with superficial needle insertion.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-12842 (URN)10.1016/S0965229902000547 (DOI)
Available from: 2008-01-09 Created: 2008-01-09 Last updated: 2009-08-20
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