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Jacobsson, Ingela
Publications (9 of 9) Show all publications
Karlsson, S. A., Jacobsson, I., Danell Boman, M., Hakkarainen, K. M., Lövborg, H., Hägg, S. & Jönsson, A. K. (2015). The impact of a changed legislation on reporting of adverse drug reactions in Sweden, with focus on nurses reporting. European Journal of Clinical Pharmacology, 71(5), 631-636
Open this publication in new window or tab >>The impact of a changed legislation on reporting of adverse drug reactions in Sweden, with focus on nurses reporting
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2015 (English)In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 71, no 5, p. 631-636Article in journal (Refereed) Published
Abstract [en]

In March 2007, a legislative amendment was issued in Sweden compelling nurses to report all suspected adverse drug reactions (ADRs) to the national pharmacovigilance system. The aims of this study were to describe the status of ADR reporting, before and after the implementation of the legislative changes, and to describe the general characteristics of suspected ADRs reported by nurses. The Swedish pharmacovigilance system during the study period constituted six regional centres responsible for the handling of all spontaneous ADR reports within their region. In this study, we identified all individual ADR reports from 2005 and 2010, analysed in depth the ADR reports from two regional centres and collated information about the reporter and the nature of the reported ADR. From the two regional centres, a total of 898 and 1074 reports were submitted in 2005 and 2010 respectively. Nurses submitted 31 % (275 reports) of the reports in 2005 and 24 % (260 reports) in 2010. Nurses reporting of serious ADRs was 3 % (seven reports) in 2005 and 7 % (17 reports) in 2010 with reporting of unlabelled ADRs at 4 % (11 reports) in 2005 and 17 % (45 reports) in 2010. Most of the serious and/or unlabelled reactions were related to vaccine administration (14 reports in 2005 and 36 reports in 2010). The overall ADR reporting by nurses did not appear to increase after the change in reporting legislation. The proportion of serious and/or unlabelled ADRs reported by nurses did however appear to increase during the same period. Taken together, our data suggests that further pro-active measures should be considered in order to involve nurses in the reporting of suspected ADRs.

Place, publisher, year, edition, pages
Springer Verlag (Germany), 2015
Keywords
Adverse drug reaction; Spontaneous reporting; Pharmacovigilance; Nurses
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-118037 (URN)10.1007/s00228-015-1839-6 (DOI)000353059900013 ()25845655 (PubMedID)
Available from: 2015-05-21 Created: 2015-05-20 Last updated: 2017-12-04
Jacobsson, I., Jönsson, A. K., Gerdén, B. & Hägg, S. (2009). Spontaneously reported adverse reactions in association with complementary and alternative medicine substances in Sweden.. Pharmacoepidemiology and drug safety
Open this publication in new window or tab >>Spontaneously reported adverse reactions in association with complementary and alternative medicine substances in Sweden.
2009 (English)In: Pharmacoepidemiology and drug safety, ISSN 1099-1557Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Although the safety information is limited, use of complementary and alternative medicine (CAM) products is not without risks. Spontaneous reporting systems may be used in the surveillance of these products. We describe the pattern of spontaneously reported CAM related adverse reactions submitted to the Swedish Medical Products Agency (MPA) and highlight areas of safety concern. METHODS: All adverse reactions spontaneously reported to MPA between 1987 and 2006, where at least one CAM substance was a suspected agent, were scrutinised. From each report information about the patient, adverse reaction/s, drug treatment/s, dosage, time relationship and outcome was retrieved. RESULTS: Among a total of 64 493 reports, 778 reports concerned 967 suspected adverse reactions related to 175 different CAM products. The main distribution of suspected adverse reactions was: urticaria (8.3%), exanthema (7.4%) and contact dermatitis (5.7%). The most reported CAM substances were purple coneflower (Echinacea purpurea) (8.1%), purple coneflower + siberian ginseng (Eleutherococcus senticosus) + malabar nut (Adhatoda vasica) (7.3%) and ginkgo leaf (Ginkgo biloba) (6.7%). In 221 reports, at least one reaction was categorised as serious, the most frequent being pulmonary embolism (1.7%), mixed liver reaction (2.8%), and anaphylactic reaction (2.0%). Eleven of the serious adverse reactions had a fatal outcome. CONCLUSIONS: CAM substances were associated with a variety of adverse reactions. Some of these have previously been unrecognised or poorly documented and suggest further investigations. By stimulating the reporting of adverse reactions of CAM products, the signal detection power of the spontaneous reporting system may increase further.

Keywords
complementary and alternative medicine; herbal drugs; adverse drug reaction; drug interaction; adverse drug reaction reporting systems
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-19974 (URN)10.1002/pds.1818 (DOI)19650152 (PubMedID)
Available from: 2009-08-24 Created: 2009-08-21 Last updated: 2009-09-04
Jönsson, A., Jacobsson, I., Andersson, K., Hägg, S. & Sundström, A. (2008). Factors Predisposing an Abstract To Be Accepted for Oral Presentation. In: Pharmacoepidemiology and drug safety: . Paper presented at 24th International Conference on Pharmacoepidemiology & Terapeutic Risk Management (pp. 190-191). Wiley-Blackwell
Open this publication in new window or tab >>Factors Predisposing an Abstract To Be Accepted for Oral Presentation
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2008 (English)In: Pharmacoepidemiology and drug safety, Wiley-Blackwell , 2008, p. 190-191Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Wiley-Blackwell, 2008
Series
Pharmacoepidemiology and drug safety, ISSN 1053-8569 ; 17 (S1)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-69467 (URN)
Conference
24th International Conference on Pharmacoepidemiology & Terapeutic Risk Management
Note

DOI does not work: 10.1002/pds

Available from: 2011-06-28 Created: 2011-06-28 Last updated: 2018-02-28
Jacobsson, I., Danell Boman, M., Jönsson, A. & Hägg, S. (2008). Who Reports Suspected Adverse Drug Reactions to the Spontaneous Reporting System in Sweden?. Paper presented at 24th International Conference on Pharmacoepidemiology & Therapeutic Risk Management. Wiley-Blackwell
Open this publication in new window or tab >>Who Reports Suspected Adverse Drug Reactions to the Spontaneous Reporting System in Sweden?
2008 (English)Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Wiley-Blackwell, 2008
Series
Pharmacoepidemiology and Drug Safety, ISSN 1053-8569 ; 17 (S1)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-69489 (URN)
Conference
24th International Conference on Pharmacoepidemiology & Therapeutic Risk Management
Available from: 2011-06-29 Created: 2011-06-29 Last updated: 2011-08-08
Jönsson, A. K., Spigset, O., Jacobsson, I. & Hägg, S. (2007). Cerebral haemorrhage induced by warfarin - the influence of drug-drug interactions. Pharmacoepidemiology and Drug Safety, 16(3), 309-315
Open this publication in new window or tab >>Cerebral haemorrhage induced by warfarin - the influence of drug-drug interactions
2007 (English)In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, ISSN 1, Vol. 16, no 3, p. 309-315Article in journal (Refereed) Published
Abstract [en]

Purpose: To evaluate the frequency, severity and preventability of warfarin-induced cerebral haemorrhages due to warfarin and warfarin-drug interactions in patients living in the county of Östergötland, Sweden.

Methods: All patients with a diagnosed cerebral haemorrhage at three hospitals during the period 2000-2002 were identified. Medical records were studied retrospectively to evaluate whether warfarin and warfarin-drug interactions could have caused the cerebral haemorrhage. The proportion of possibly avoidable cases due to drug interactions was estimated.

Results: Among 593 patients with cerebral haemorrhage, 59 (10%) were assessed as related to warfarin treatment. This imply an incidence of 1.7/100 000 treatment years. Of the 59 cases, 26 (44%) had a fatal outcome, compared to 136 (25%) among the non-warfarin patients (p < 0.01). A warfarin-drug interaction could have contributed to the haemorrhage in 24 (41%) of the warfarin patients and in 7 of these (12%) the bleeding complication was considered being possible to avoid.

Conclusions: Warfarin-induced cerebral haemorrhages are a major clinical problem with a high fatality rate. Almost half of the cases was related to a warfarin-drug interaction. A significant proportion of warfarin-related cerebral haemorrhages might have been prevented if greater caution had been taken when prescribing drugs known to interact with warfarin.

Keywords
warfarin, cerebral haemorrhage, drug interactions, prevention
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-12849 (URN)10.1002/pds.1291 (DOI)
Available from: 2007-12-19 Created: 2007-12-19 Last updated: 2017-12-14
Jacobsson, I., Jönsson, A., Gerdén, B., Axling, C. & Hägg, S. (2007). Spontaneously Reported Suspected Adverse Drug Reactions in Association with Complementary and Alternative Medicine Products. In: Pharmacoepidemiology and Drug Safety: . Paper presented at 23rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management (pp. 196-197). Wiley
Open this publication in new window or tab >>Spontaneously Reported Suspected Adverse Drug Reactions in Association with Complementary and Alternative Medicine Products
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2007 (English)In: Pharmacoepidemiology and Drug Safety, Wiley , 2007, p. 196-197Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Wiley, 2007
Series
Pharmacoepidemiology and Drug Safety, ISSN 1053-8569 ; 16 (S2)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-69454 (URN)10.1002/pds.1818 (DOI)
Conference
23rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management
Available from: 2011-06-28 Created: 2011-06-28 Last updated: 2018-03-12
Jönsson, A., Jacobsson, I., Andersson, M. & Hägg, S. (2006). Stor underrapportering av hjärnblödning som läkemedelsbiverkning. Läkartidningen, 103, 3456-3458
Open this publication in new window or tab >>Stor underrapportering av hjärnblödning som läkemedelsbiverkning
2006 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, p. 3456-3458Article in journal (Refereed) Published
Abstract [sv]

     

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-35522 (URN)27425 (Local ID)27425 (Archive number)27425 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Jönsson, A., Andersson, M., Jacobsson, I. & Hägg, S. (2005). Large underreporting of cerebral haemorrhage during warfarin treatment in Sweden. In: 7th Congress of European association for clinical pharmacology,2005.
Open this publication in new window or tab >>Large underreporting of cerebral haemorrhage during warfarin treatment in Sweden
2005 (English)In: 7th Congress of European association for clinical pharmacology,2005, 2005Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-30468 (URN)16039 (Local ID)16039 (Archive number)16039 (OAI)
Available from: 2009-10-09 Created: 2009-10-09
Jönsson, A., Andersson, M., Jacobsson, I. & Hägg, S. (2005). Stor underrapportering av hjärnblödningar under warfarinbehandling. In: Läkarsällskapets Riksstämma,2005.
Open this publication in new window or tab >>Stor underrapportering av hjärnblödningar under warfarinbehandling
2005 (Swedish)In: Läkarsällskapets Riksstämma,2005, 2005Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-30470 (URN)16041 (Local ID)16041 (Archive number)16041 (OAI)
Available from: 2009-10-09 Created: 2009-10-09
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