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Eriksson, Olle
Publications (10 of 28) Show all publications
Timpka, T., Spreco, A., Gursky, E., Eriksson, O., Dahlström, Ö., Strömgren, M., . . . Holm, E. (2014). Intentions to perform non-pharmaceutical protective behaviors during influenza outbreaks in Sweden: a cross-sectional study following a mass vaccination campaign. PLoS ONE, 9(3), e91060
Open this publication in new window or tab >>Intentions to perform non-pharmaceutical protective behaviors during influenza outbreaks in Sweden: a cross-sectional study following a mass vaccination campaign
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2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 3, p. e91060-Article in journal (Refereed) Published
Abstract [en]

Failure to incorporate the beliefs and attitudes of the public into theoretical models of preparedness has been identified as a weakness in strategies to mitigate infectious disease outbreaks. We administered a cross-sectional telephone survey to a representative sample (n = 443) of the Swedish adult population to examine whether self-reported intentions to improve personal hygiene and increase social distancing during influenza outbreaks could be explained by trust in official information, self-reported health (SF-8), sociodemographic factors, and determinants postulated in protection motivation theory, namely threat appraisal and coping appraisal. The interviewees were asked to make their appraisals for two scenarios: a) an influenza with low case fatality and mild lifestyle impact; b) severe influenza with high case fatality and serious disturbances of societal functions. Every second respondent (50.0%) reported high trust in official information about influenza. The proportion that reported intentions to take deliberate actions to improve personal hygiene during outbreaks ranged between 45–85%, while less than 25% said that they intended to increase social distancing. Multiple logistic regression models with coping appraisal as the explanatory factor most frequently contributing to the explanation of the variance in intentions showed strong discriminatory performance for staying home while not ill (mild outbreaks: Area under the curve [AUC] 0.85 (95% confidence interval 0.82;0.89), severe outbreaks AUC 0.82 (95% CI 0.77;0.85)) and acceptable performance with regard to avoiding public transportation (AUC 0.78 (0.74;0.82), AUC 0.77 (0.72;0.82)), using handwash products (AUC 0.70 (0.65;0.75), AUC 0.76 (0.71;0.80)), and frequently washing hands (AUC 0.71 (0.66;0.76), AUC 0.75 (0.71;0.80)). We conclude that coping appraisal was the explanatory factor most frequently included in statistical models explaining self-reported intentions to carry out non-pharmaceutical health actions in the Swedish outlined context, and that variations in threat appraisal played a smaller role in these models despite scientific uncertainties surrounding a recent mass vaccination campaign.

Place, publisher, year, edition, pages
Public Library of Science, 2014
National Category
Health Sciences
Identifiers
urn:nbn:se:liu:diva-105029 (URN)10.1371/journal.pone.0091060 (DOI)000332485800091 ()
Available from: 2014-03-06 Created: 2014-03-06 Last updated: 2018-04-07Bibliographically approved
Timpka, T., Spreco, A., Dahlström, Ö., Eriksson, O., Gursky, E., Ekberg, J., . . . Holm, E. (2014). Performance of eHealth data sources in local influenza surveillance: a 5-year open cohort study. Journal of Medical Internet Research, 16(4), e116
Open this publication in new window or tab >>Performance of eHealth data sources in local influenza surveillance: a 5-year open cohort study
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2014 (English)In: Journal of Medical Internet Research, ISSN 1438-8871, E-ISSN 1438-8871, Vol. 16, no 4, p. e116-Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: There is abundant global interest in using syndromic data from population-wide health information systems--referred to as eHealth resources--to improve infectious disease surveillance. Recently, the necessity for these systems to achieve two potentially conflicting requirements has been emphasized. First, they must be evidence-based; second, they must be adjusted for the diversity of populations, lifestyles, and environments.

OBJECTIVE: The primary objective was to examine correlations between data from Google Flu Trends (GFT), computer-supported telenursing centers, health service websites, and influenza case rates during seasonal and pandemic influenza outbreaks. The secondary objective was to investigate associations between eHealth data, media coverage, and the interaction between circulating influenza strain(s) and the age-related population immunity.

METHODS: An open cohort design was used for a five-year study in a Swedish county (population 427,000). Syndromic eHealth data were collected from GFT, telenursing call centers, and local health service website visits at page level. Data on mass media coverage of influenza was collected from the major regional newspaper. The performance of eHealth data in surveillance was measured by correlation effect size and time lag to clinically diagnosed influenza cases.

RESULTS: Local media coverage data and influenza case rates showed correlations with large effect sizes only for the influenza A (A) pH1N1 outbreak in 2009 (r=.74, 95% CI .42-.90; P<.001) and the severe seasonal A H3N2 outbreak in 2011-2012 (r=.79, 95% CI .42-.93; P=.001), with media coverage preceding case rates with one week. Correlations between GFT and influenza case data showed large effect sizes for all outbreaks, the largest being the seasonal A H3N2 outbreak in 2008-2009 (r=.96, 95% CI .88-.99; P<.001). The preceding time lag decreased from two weeks during the first outbreaks to one week from the 2009 A pH1N1 pandemic. Telenursing data and influenza case data showed correlations with large effect sizes for all outbreaks after the seasonal B and A H1 outbreak in 2007-2008, with a time lag decreasing from two weeks for the seasonal A H3N2 outbreak in 2008-2009 (r=.95, 95% CI .82-.98; P<.001) to none for the A p H1N1 outbreak in 2009 (r=.84, 95% CI .62-.94; P<.001). Large effect sizes were also observed between website visits and influenza case data.

CONCLUSIONS: Correlations between the eHealth data and influenza case rates in a Swedish county showed large effect sizes throughout a five-year period, while the time lag between signals in eHealth data and influenza rates changed. Further research is needed on analytic methods for adjusting eHealth surveillance systems to shifts in media coverage and to variations in age-group related immunity between virus strains. The results can be used to inform the development of alert-generating eHealth surveillance systems that can be subject for prospective evaluations in routine public health practice.

Place, publisher, year, edition, pages
Journal of Medical Internet Research, 2014
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-106758 (URN)10.2196/jmir.3099 (DOI)000336501600017 ()24776527 (PubMedID)
Available from: 2014-05-21 Created: 2014-05-21 Last updated: 2018-04-07Bibliographically approved
Timpka, T., Spreco, A., Eriksson, O., Dahlström, Ö., Gursky, E. A., Stromgren, M., . . . Eriksson, H. (2014). Predictive performance of telenursing complaints in influenza surveillance: a prospective cohort study in Sweden. Eurosurveillance, 19(46), 24-32
Open this publication in new window or tab >>Predictive performance of telenursing complaints in influenza surveillance: a prospective cohort study in Sweden
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2014 (English)In: Eurosurveillance, ISSN 1025-496X, E-ISSN 1560-7917, Vol. 19, no 46, p. 24-32Article in journal (Refereed) Published
Abstract [en]

Syndromic data sources have been sought to improve the timely detection of increased influenza transmission. This study set out to examine the prospective performance of telenursing chief complaints in predicting influenza activity. Data from two influenza seasons (2007/08 and 2008/09) were collected in a Swedish county (population 427,000) to retrospectively determine which grouping of telenursing chief complaints had the largest correlation with influenza case rates. This grouping was prospectively evaluated in the three subsequent seasons. The best performing telenursing complaint grouping in the retrospective algorithm calibration was fever (child, adult) and syncope (r=0.66; pless than0.001). In the prospective evaluation, the performance of 14-day predictions was acceptable for the part of the evaluation period including the 2009 influenza pandemic (area under the curve (AUC)=0.84; positive predictive value (PPV)=0.58), while it was strong (AUC=0.89; PPV=0.93) for the remaining evaluation period including only influenza winter seasons. We recommend the use of telenursing complaints for predicting winter influenza seasons. The method requires adjustments when used during pandemics.

Place, publisher, year, edition, pages
EUR CENTRE DIS PREVENTION and CONTROL, 2014
National Category
Basic Medicine Mathematics Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-113057 (URN)000345424100004 ()
Note

Funding Agencies|Swedish Civil Contingencies Agency [2010-2788]; Swedish Science Council [2008-5252]; Swedish Governmental Agency for Innovations (VINNOVA) [2011-03231]

Available from: 2015-01-09 Created: 2015-01-08 Last updated: 2018-04-07
Timpka, T., Spreco, A., Dahlström, Ö., Eriksson, O., Gursky, E., Ekberg, J., . . . Holm, E. (2013). Intentions to perform non-pharmaceutical protective behaviors during influenza outbreaks: a cross-sectional study of a representative sample of the Swedish adult population. In: : . Paper presented at Eight Conference of Options for the Control of Influenza, Cape Town, South Africa, September 5-10, 2013.
Open this publication in new window or tab >>Intentions to perform non-pharmaceutical protective behaviors during influenza outbreaks: a cross-sectional study of a representative sample of the Swedish adult population
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2013 (English)Conference paper, Oral presentation with published abstract (Other academic)
National Category
Health Sciences
Identifiers
urn:nbn:se:liu:diva-105045 (URN)
Conference
Eight Conference of Options for the Control of Influenza, Cape Town, South Africa, September 5-10, 2013
Available from: 2014-03-06 Created: 2014-03-06 Last updated: 2018-04-07
Timpka, T., Gursky, E. A., Spreco, A., Eriksson, O., Dahlström, Ö., Strömgren, M., . . . Eriksson, H. (2013). Predictive value of telenursing complaints in influenza surveillance: a prospective cohort study in Sweden. Paper presented at 18th World Congress on Disaster and Emergency Medicine (WCDEM), 28-31 May 2013, Manchester, UK.
Open this publication in new window or tab >>Predictive value of telenursing complaints in influenza surveillance: a prospective cohort study in Sweden
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2013 (English)Conference paper, Oral presentation with published abstract (Other academic)
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-91382 (URN)
Conference
18th World Congress on Disaster and Emergency Medicine (WCDEM), 28-31 May 2013, Manchester, UK
Available from: 2013-04-23 Created: 2013-04-23 Last updated: 2018-04-07
Timpka, T., Spreco, A., Dahlström, Ö., Eriksson, O., Gursky, E., Ekberg, J., . . . Holm, E. (2013). Predictive value of telenursing complaints in influenza surveillance: a prospective cohort study in Sweden. In: : . Paper presented at Eight Conference of Options for the Control of Influenza, Cape Town, South Africa, September 5-10, 2013.
Open this publication in new window or tab >>Predictive value of telenursing complaints in influenza surveillance: a prospective cohort study in Sweden
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2013 (English)Conference paper, Oral presentation with published abstract (Other academic)
National Category
Health Sciences
Identifiers
urn:nbn:se:liu:diva-105053 (URN)
Conference
Eight Conference of Options for the Control of Influenza, Cape Town, South Africa, September 5-10, 2013
Available from: 2014-03-06 Created: 2014-03-06 Last updated: 2018-04-07
Timpka, T., Eriksson, O., Spreco, A., Gursky, E. A., Strömgren, M., Holm, E., . . . Eriksson, H. (2012). Age as a determinant for dissemination of seasonal and pandemic influenza: an open cohort study of influenza outbreaks in Östergötland County, Sweden. PLoS ONE, 7(2), e31746
Open this publication in new window or tab >>Age as a determinant for dissemination of seasonal and pandemic influenza: an open cohort study of influenza outbreaks in Östergötland County, Sweden
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2012 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 7, no 2, p. e31746-Article in journal (Refereed) Published
Abstract [en]

An understanding of the occurrence and comparative timing of influenza infections in different age groups is important for developing community response and disease control measures. This study uses data from a Scandinavian county (population 427.000) to investigate whether age was a determinant for being diagnosed with influenza 2005-2010 and to examine if age was associated with case timing during outbreaks. Aggregated demographic data were collected from Statistics Sweden, while influenza case data were collected from a county-wide electronic health record system. A logistic regression analysis was used to explore whether case risk was associated with age and outbreak. An analysis of variance was used to explore whether day for diagnosis was also associated to age and outbreak. The clinical case data were validated against case data from microbiological laboratories during one control year. The proportion of cases from the age groups 10-19 (p<0.001) and 20-29 years old (p<0.01) were found to be larger during the A pH1N1 outbreak in 2009 than during the seasonal outbreaks. An interaction between age and outbreak was observed (p<0.001) indicating a difference in age effects between circulating virus types; this interaction persisted for seasonal outbreaks only (p<0.001). The outbreaks also differed regarding when the age groups received their diagnosis (p<0.001). A post-hoc analysis showed a tendency for the young age groups, in particular the group 10-19 year olds, led outbreaks with influenza type A H1 circulating, while A H3N2 outbreaks displayed little variations in timing. The validation analysis showed a strong correlation (r = 0.625;p<0.001) between the recorded numbers of clinically and microbiologically defined influenza cases. Our findings demonstrate the complexity of age effects underlying the emergence of local influenza outbreaks. Disentangling these effects on the causal pathways will require an integrated information infrastructure for data collection and repeated studies of well-defined communities.

National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-76991 (URN)10.1371/journal.pone.0031746 (DOI)000302916100033 ()22384066 (PubMedID)
Available from: 2012-04-27 Created: 2012-04-27 Last updated: 2018-04-07
Samuelsson, A., Isaksson, B., Chabok, A., Jonasson, J., Nilsson, L. E., Eriksson, O. & Hanberger, H. (2012). Changes in the aerobic faecal flora of patients treated with antibiotics for acute intra-abdominal infection. Scandinavian Journal of Infectious Diseases, 44(11), 820-827
Open this publication in new window or tab >>Changes in the aerobic faecal flora of patients treated with antibiotics for acute intra-abdominal infection
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2012 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 44, no 11, p. 820-827Article in journal (Refereed) Published
Abstract [en]

Background: An open observational study was performed to investigate changes in the rectal flora and antibiotic susceptibility among faecal bacteria in patients treated with antibiotics for acute intra-abdominal infection. Methods: One hundred and forty patients with acute intra-abdominal infection requiring antibiotic treatment and hospitalization were included. Eight surgical units from the southern part of Sweden participated, between January 2006 and November 2007. Antibiotic treatments were according to local guidelines. Rectal swabs were obtained on admission (sample 1) and 2-14 days after the end of antibiotic treatment (sample 2). Aerobic bacteria and yeasts were analysed. The material was divided into 2 groups: 1 group with Enterobacteriaceae and 1 group with non-fermentative Gram-negative bacteria. The susceptibility to antibiotics in each group was compared between samples 1 and 2. Results: The main finding of this study on patients with severe intra-abdominal infections was a shift in the aerobic faecal flora following antibiotic treatment, from Escherichia coli to other more resistant Enterobacteriaceae, Enterococcus faecium, and yeasts. The susceptibility to cephalosporins and piperacillin-tazobactam decreased in Enterobacteriaceae. Conclusions: Following antibiotic treatment, a shift in the aerobic rectal flora to species with intrinsic antibiotic resistance was observed. This indicates that the emergence of resistance is not due to new mutations, but rather to selection of more resistant species. This should be taken into account when designing treatments for secondary intra-abdominal infections.

Place, publisher, year, edition, pages
Informa Healthcare, 2012
Keywords
Antibiotic resistance; faecal flora; intra-abdominal infection
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-86555 (URN)10.3109/00365548.2012.695455 (DOI)000310008900003 ()
Available from: 2012-12-19 Created: 2012-12-19 Last updated: 2017-12-06
Stening, K., Berg, G., Hammar, M., Voster, H., Eriksson, O., Amandusson, Å. & Blomqvist, A. (2012). Influence of estrogen levels on thermal perception, pain thresholds and pain tolerance: Studies on women undergoing in vitro fertilization. Journal of Pain, 13(5), 459-466
Open this publication in new window or tab >>Influence of estrogen levels on thermal perception, pain thresholds and pain tolerance: Studies on women undergoing in vitro fertilization
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2012 (English)In: Journal of Pain, ISSN 1526-5900, E-ISSN 1528-8447, Vol. 13, no 5, p. 459-466Article in journal (Refereed) Published
Abstract [en]

We examined the relationship between estrogen and pain in women undergoing in vitro fertilization (IVF). Quantitative sensory tests (QST) were performed twice during the IVF-regimen: once during hormonal down-regulation and once during hormonal upregulation. A group of healthy men and a group of women using monophasic contraceptives were also examined, to control for session-to-session effects. Among the women undergoing IVF, serum 17β-estradiol levels differed strongly between treatments as expected, and increased from 65.7 (SD = 26) pmol/l during the downregulation phase, to 5188 (SD = 2524) pmol/l during the up-regulation phase. Significant outcomes in the QST were only seen for temperature perception thresholds (1.7°C vs. 2.2°C; P = 0.003) and cold pain threshold (11.5°C vs. 14.5°C; P = 0.04). A similar change in cold pain threshold was also seen in the two control groups, however, and statistical analysis suggested that this change was due to a session-to-session effect rather than being the result of hormonal modulation. Heat pain thresholds, heat tolerance, pressure pain thresholds, and the cold pressor test showed no significant differences between sessions. These data demonstrate that pain perception and pain thresholds in healthy women show little, if any, changes even with major variations in serum estradiol levels.

Keywords
Estrogen, pain, hormonal levels, quantitative sensory testing
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-71869 (URN)10.1016/j.jpain.2012.01.446 (DOI)000304228700005 ()
Note

funding agencies|Swedish Research Council| 7879 |Konung Gustav V:s 80-arsfond||Health Research Council in the South-East of Sweden||Linneus University, Kalmar, Sweden||

Available from: 2011-11-08 Created: 2011-11-08 Last updated: 2017-12-08Bibliographically approved
Stening, K., Eriksson, O., Henriksson, K.-G., Brynhildsen, J., Lindh-Åstrand, L., Berg, G., . . . Blomqvist, A. (2011). Hormonal replacement therapy does not affect self-estimated pain or experimental pain responses in post-menopausal women suffering from fibromyalgia: a double-blind, randomized, placebo-controlled trial. RHEUMATOLOGY, 50(3), 544-551
Open this publication in new window or tab >>Hormonal replacement therapy does not affect self-estimated pain or experimental pain responses in post-menopausal women suffering from fibromyalgia: a double-blind, randomized, placebo-controlled trial
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2011 (English)In: RHEUMATOLOGY, ISSN 1462-0324, Vol. 50, no 3, p. 544-551Article in journal (Refereed) Published
Abstract [en]

Methods. Twenty-nine post-menopausal women were randomized to either 8 weeks of treatment with transdermal 17 beta-oestradiol (50 mu g/day) or placebo according to a double-blind protocol. A self-estimation of pain, a set of quantitative sensory tests measuring thresholds to temperature, thermal pain, cold pain and pressure pain, and a cold pressor test were performed on three occasions: before treatment, after 8 weeks of treatment and 20 weeks after cessation of treatment. Results. Hormonal replacement treatment significantly increased serum oestradiol levels as expected (P andlt; 0.01). However, no differences in self-estimated pain were seen between treatment and placebo groups, nor were there any differences between the two groups regarding the results of the quantitative sensory tests or the cold pressor test at any of the examined time points. Conclusion. Eight weeks of transdermal oestradiol treatment does not influence perceived pain, pain thresholds or pain tolerance as compared with placebo treatment in post-menopausal women suffering from FM.

Place, publisher, year, edition, pages
Oxford University Press, 2011
Keywords
Oestrogen, Substitution, Pain, Hormonal levels, Quantitative sensory testing, Cold pressor test
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-66851 (URN)10.1093/rheumatology/keq348 (DOI)000287745600016 ()
Available from: 2011-03-22 Created: 2011-03-21 Last updated: 2011-11-08
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