liu.seSearch for publications in DiVA
Change search
Link to record
Permanent link

Direct link
Persson, Anders, ProfessorORCID iD iconorcid.org/0000-0002-9446-6981
Alternative names
Publications (10 of 150) Show all publications
Persson, A. (2022). Bilddiagnostik: då, nu och i framtiden (2ed.). In: Lennart Blomqvist, Sophia Zackrisson (Ed.), Radiologi: (pp. 19-27). Lund: Studentlitteratur AB, Sidorna 19-27
Open this publication in new window or tab >>Bilddiagnostik: då, nu och i framtiden
2022 (Swedish)In: Radiologi / [ed] Lennart Blomqvist, Sophia Zackrisson, Lund: Studentlitteratur AB, 2022, 2, Vol. Sidorna 19-27, p. 19-27Chapter in book (Other academic)
Abstract [sv]

Detta kapitel handlar om radiologins framväxt i Sverige från år 1895, då den första röntgenbilden på en hand framställdes med hjälp av röntgenstrålning, till nutidens två- och fyrdimensionella digitala röntgenundersökningar. Avslutningsvis avslöjas hur framtidens radiologi, med hjälp av artificiell intelligens, kommer att möjliggöra undersökningar som förutom att avbilda olika organ och kommer att avbilda skeenden på cellulär nivå, molekulär nivå och nanonivå. Radiologen kommer med hjälp av ny teknik att få en betydande central samordnade roll inom morgondagens hälso- och sjukvård.

Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2022 Edition: 2
Keywords
Bilddiagnostik, Radiologi
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-202396 (URN)9789144129013 (ISBN)
Available from: 2024-04-09 Created: 2024-04-09 Last updated: 2024-04-09Bibliographically approved
Skoog, S., Henriksson, L., Gustafsson, H., Sandstedt, M., Elvelind, S. & Persson, A. (2022). Comparison of the Agatston score acquired with photon-counting detector CT and energy-integrating detector CT: ex vivo study of cadaveric hearts. The International Journal of Cardiovascular Imaging, 38(5), 1145-1155
Open this publication in new window or tab >>Comparison of the Agatston score acquired with photon-counting detector CT and energy-integrating detector CT: ex vivo study of cadaveric hearts
Show others...
2022 (English)In: The International Journal of Cardiovascular Imaging, ISSN 1569-5794, E-ISSN 1875-8312, Vol. 38, no 5, p. 1145-1155Article in journal (Refereed) Published
Abstract [en]

The purpose of this study was to compare the correlation and agreement between AS derived from either an energy-integrating detector CT (EID-CT) or a photon-counting detector CT (PCD-CT). Reproducibility was also compared. In total, 26 calcified coronary lesions (from five cadaveric hearts) were identified for inclusion. The hearts were positioned in a chest phantom and scanned in both an EID-CT and a prototype PCD-CT. The EID-CT and PCD-CT acquisition and reconstruction parameters were matched. To evaluate the reproducibility, the phantom was manually repositioned, and an additional scan was performed using both methods. The EID-CT reconstructions were performed using the dedicated calcium score kernel Sa36. The PCD-CT reconstructions were performed with a vendor-recommended kernel (Qr36). Several monoenergetic energy levels (50-150 keV) were evaluated to find the closest match with the EID-CT scans. A semi-automatic evaluation of calcium score was performed on a post-processing multimodality workplace. The best match with Sa36 was PCD-CT Qr36 images, at a monoenergetic level of 72 keV. Statistical analyses showed excellent correlation and agreement. The correlation and agreement with regards to the Agatston score (AS) between the two methods, for each position as well as between the two positions for each method, were assessed with the Spearman s rank correlation. The correlation coefficient, rho, was 0.98 and 0.97 respectively 0.99 and 0.98. The corresponding agreements were investigated by means of Bland-Altman plots. High correlation and agreement was observed between the AS derived from the EID-CT and a PCD-CT. Both methods also demonstrated excellent reproducibility.

Place, publisher, year, edition, pages
Springer, 2022
Keywords
Photon counting detector CT; CT-angiography; Heart; Arteriosclerosis; Calcium; Coronary vessels
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-182359 (URN)10.1007/s10554-021-02494-8 (DOI)000739258200001 ()34988781 (PubMedID)2-s2.0-85122403893 (Scopus ID)
Note

Funding Agencies|Linkoping University; ALF Grants, Region Ostergotland [LIO 899441]

Available from: 2022-01-19 Created: 2022-01-19 Last updated: 2024-11-08
Kataria, B., Nilsson Althén, J., Smedby, Ö., Persson, A., Sökjer, H. & Sandborg, M. (2021). Image Quality and Potential Dose Reduction Using Advanced Modeled Iterative Reconstruction (Admire) in Abdominal Ct: A Review. Radiation Protection Dosimetry, 195(3-4), 177-187, Article ID ncab-020.
Open this publication in new window or tab >>Image Quality and Potential Dose Reduction Using Advanced Modeled Iterative Reconstruction (Admire) in Abdominal Ct: A Review
Show others...
2021 (English)In: Radiation Protection Dosimetry, ISSN 0144-8420, E-ISSN 1742-3406, Vol. 195, no 3-4, p. 177-187, article id ncab-020Article, review/survey (Refereed) Published
Abstract [en]

Traditional filtered back projection (FBP) reconstruction methods have served the computed tomography (CT) community wellfor over 40 years. With the increased use of CT during the last decades, efforts to minimise patient exposure, while maintainingsufficient or improved image quality, have led to the development of model-based iterative reconstruction (MBIR) algorithms fromseveral vendors. The usefulness of the advanced modeled iterative reconstruction (ADMIRE) (Siemens Healthineers) MBIR inabdominal CT is reviewed and its noise suppression and/or dose reduction possibilities explored. Quantitative and qualitativemethods with phantom and human subjects were used. Assessment of the quality of phantom images will not always correlatepositively with those of patient images, particularly at the higher strength of the ADMIRE algorithm. With few exceptions,ADMIRE Strength 3 typically allows for substantial noise reduction compared to FBP and hence to significant (≈30%) patientdose reductions. The size of the dose reductions depends on the diagnostic task.

Place, publisher, year, edition, pages
Oxford University Press, 2021
Keywords
Iterative rekonstruktion, bildkvalité
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-174704 (URN)10.1093/rpd/ncab020 (DOI)000711245400009 ()33778892 (PubMedID)
Funder
Region Östergötland
Note

Funding: ALF-grant from Region Ostergotland [LiO-602731, LIO-697941]; FoU-grant from Region Ostergotland [LIO-724631, LIO-620341]; RFoU-grant from Region Ostergotland; Medical Faculty at Linkoping University

Available from: 2021-03-30 Created: 2021-03-30 Last updated: 2024-03-25Bibliographically approved
Ynnerman, A., Ljung, P., Persson, A. & Jönsson, D. (2021). Multi-Touch Surfaces and Patient-Specific Data (1ed.). In: Jean-François Uhl, Joaquim Jorge, Daniel Simões Lopes, Pedro F. Campos (Ed.), Digital Anatomy: Applications of Virtual, Mixed and Augmented Reality (pp. 223-242). Springer
Open this publication in new window or tab >>Multi-Touch Surfaces and Patient-Specific Data
2021 (English)In: Digital Anatomy: Applications of Virtual, Mixed and Augmented Reality / [ed] Jean-François Uhl, Joaquim Jorge, Daniel Simões Lopes, Pedro F. Campos, Springer, 2021, 1, p. 223-242Chapter in book (Refereed)
Abstract [en]

While the usefulness of 3D visualizations has been shown for a range of clinical applications such as treatment planning it still had difficulties in being adopted in widespread clinical practice. This chapter describes how multi-touch surfaces with patient-specific data have contributed to breaking this barrier, paving the way for adoption into clinical practice and, at the same time, also found widespread use in educational settings and in communication of science to the general public. The key element identified for this adoption is the string of steps found in the full imaging chain, which will be described as an introduction to the topic in this chapter. Emphasis in the chapter is, however, visualization aspects, e.g., intuitive interaction with patient-specific data captured with the latest high speed and high-quality imaging modalities. A necessary starting point for this discussion is the foundations of and state-of-the-art in volumetric rendering, which form the basis for the underlying theory part of the chapter. The chapter presents two use cases. One case is focusing on the use of multi-touch in medical education and the other is focusing on the use of touch surfaces at public venues, such as science centers and museums. 

Place, publisher, year, edition, pages
Springer, 2021 Edition: 1
National Category
Other Basic Medicine
Identifiers
urn:nbn:se:liu:diva-183951 (URN)10.1007/978-3-030-61905-3_12 (DOI)9783030619046 (ISBN)
Available from: 2022-03-28 Created: 2022-03-28 Last updated: 2024-11-25Bibliographically approved
Henriksson, L., Woisetschläger, M., Alfredsson, J., Janzon, M., Ebbers, T., Engvall, J. & Persson, A. (2021). The transluminal attenuation gradient does not add diagnostic accuracy to coronary computed tomography. Acta Radiologica, 867-874
Open this publication in new window or tab >>The transluminal attenuation gradient does not add diagnostic accuracy to coronary computed tomography
Show others...
2021 (English)In: Acta Radiologica, ISSN 0284-1851, E-ISSN 1600-0455, p. 867-874Article in journal (Refereed) Published
Abstract [en]

Background A method for improving the accuracy of coronary computed tomography angiography (CCTA) is highly sought after as it would help to avoid unnecessary invasive coronary angiographies. Measurement of the transluminal attenuation gradient (TAG) has been proposed as an alternative to other existing methods, i.e. CT perfusion and CT fractional flow reserve (FFR). Purpose To evaluate the incremental value of three types of TAG in high-pitch spiral CCTA with invasive FFR measurements as reference. Material and Methods TAG was measured using two semi-automatic methods and one manual method. A receiver operating characteristic (ROC) analysis was made to determine the usefulness of TAG alone as well as TAG combined with CCTA for detection of significant coronary artery stenoses defined by an invasive FFR value <= 0.80. Results A total of 51 coronary vessels in 37 patients were included in this retrospective study. Hemodynamically significant stenoses were found in 13 vessels according to FFR. The ROC analysis TAG alone resulted in areas under the curve (AUCs) of 0.530 and 0.520 for the semi-automatic TAG and 0.557 for the manual TAG. TAG and CCTA combined resulted in AUCs of 0.567, 0.562 for semi-automatic TAG, and 0.569 for the manual TAG. Conclusion The results from our study showed no incremental value of TAG measured in single heartbeat CCTA in determining the severity of coronary artery stenosis degrees.

Place, publisher, year, edition, pages
Sage Publications, 2021
Keywords
Computed tomography angiography; coronary arteries; transluminal attenuation gradient; stenosis evaluation
National Category
Medical Imaging
Identifiers
urn:nbn:se:liu:diva-168541 (URN)10.1177/0284185120943042 (DOI)000554076900001 ()32722968 (PubMedID)2-s2.0-85088824098 (Scopus ID)
Available from: 2020-08-26 Created: 2020-08-26 Last updated: 2025-02-09Bibliographically approved
Kataria, B., Nilsson Althen, J., Smedby, O., Persson, A., Sökjer-Petersen, H. & Sandborg, M. (2020). Assessment of image quality in abdominal computed tomography: Effect of model-based iterative reconstruction, multi-planar reconstruction and slice thickness on potential dose reduction. European Journal of Radiology, 122, Article ID 108703.
Open this publication in new window or tab >>Assessment of image quality in abdominal computed tomography: Effect of model-based iterative reconstruction, multi-planar reconstruction and slice thickness on potential dose reduction
Show others...
2020 (English)In: European Journal of Radiology, ISSN 0720-048X, E-ISSN 1872-7727, Vol. 122, article id 108703Article in journal (Refereed) Published
Abstract [en]

Purpose: To determine the effect of tube load, model-based iterative reconstruction (MBIR) strength and slice thickness in abdominal CT using visual comparison of multi-planar reconstruction images. Method: Five image criteria were assessed independently by four radiologists on two data sets at 42- and 98-mAs tube loads for 25 patients examined on a 192-slice dual-source CT scanner. Effect of tube load, MBIR strength, slice thickness and potential dose reduction was estimated with Visual Grading Regression (VGR). Objective image quality was determined by measuring noise (SD), contrast-to-noise (CNR) ratio and noise-power spectra (NPS). Results: Comparing 42- and 98-mAs tube loads, improved image quality was observed as a strong effect of log tube load regardless of MBIR strength (p amp;lt; 0.001). Comparing strength 5 to 3, better image quality was obtained for two criteria (p amp;lt; 0.01), but inferior for liver parenchyma and overall image quality. Image quality was significantly better for slice thicknesses of 2mm and 3mm compared to 1mm, with potential dose reductions between 24%-41%. As expected, with decrease in slice thickness and algorithm strength, the noise power and SD (HU-values) increased, while the CNR decreased. Conclusion: Increasing slice thickness from 1 mm to 2 mm or 3 mm allows for a possible dose reduction. MBIR strength 5 shows improved image quality for three out of five criteria for 1 mm slice thickness. Increasing MBIR strength from 3 to 5 has diverse effects on image quality. Our findings do not support a general recommendation to replace strength 3 by strength 5 in clinical abdominal CT protocols. However, strength 5 may be used in task-based protocols.

Place, publisher, year, edition, pages
ELSEVIER IRELAND LTD, 2020
Keywords
Computed tomography; Abdomen; Iterative reconstruction; Dose; Slice thickness; Multi-planar reconstruction (MPR)
National Category
Medical Imaging
Identifiers
urn:nbn:se:liu:diva-163101 (URN)10.1016/j.ejrad.2019.108703 (DOI)000505150900002 ()31810641 (PubMedID)
Note

Funding Agencies|ALF-and LFoU-grants from Region Ostergotland; Medical Faculty at Linkoping University

Available from: 2020-01-13 Created: 2020-01-13 Last updated: 2025-02-09
Tesche, C., Otani, K., De Cecco, C. N., Coenen, A., De Geer, J., Kruk, M., . . . Schoepf, U. J. (2020). Influence of Coronary Calcium on Diagnostic Performance of Machine Learning CT-FFR Results From MACHINE Registry. JACC Cardiovascular Imaging, 13(3), 760-770
Open this publication in new window or tab >>Influence of Coronary Calcium on Diagnostic Performance of Machine Learning CT-FFR Results From MACHINE Registry
Show others...
2020 (English)In: JACC Cardiovascular Imaging, ISSN 1936-878X, E-ISSN 1876-7591, Vol. 13, no 3, p. 760-770Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES

This study was conducted to investigate the influence of coronary artery calcium (CAC) score on the diagnostic performance of machine-learning-based coronary computed tomography (CT) angiography (cCTA)-derived fractional flow reserve (CT-FFR).

BACKGROUND

CT-FFR is used reliably to detect lesion-specific ischemia. Novel CT-FFR algorithms using machine-learning artificial intelligence techniques perform fast and require less complex computational fluid dynamics. Yet, influence of CAC score on diagnostic performance of the machine-learning approach has not been investigated.

METHODS

A total of 482 vessels from 314 patients (age 62.3 +/- 9.3 years, 77% male) who underwent cCTA followed by invasive FFR were investigated from the MACHINE (Machine Learning based CT Angiography derived FFR: a Multi-center Registry) registry data. CAC scores were quantified using the Agatston convention. The diagnostic performance of CT-FFR to detect lesion-specific ischemia was assessed across all Agatston score categories (CAC 0, >0 to <100, 100 to <400, and >=$400) on a per-vessel level with invasive FFR as the reference standard.

RESULTS

The diagnostic accuracy of CT-FFR versus invasive FFR was superior to cCTA alone on a per-vessel level (78% vs. 60%) and per patient level (83% vs. 73%) across all Agatston score categories. No statistically significant differences in the diagnostic accuracy, sensitivity, or specificity of CT-FFR were observed across the categories. CT-FFR showed good discriminatory power in vessels with high Agatston scores (CAC >= 400) and high performance in low-to-intermediate Agatston scores (CAC >0 to <400) with a statistically significant difference in the area under the receiver-operating characteristic curve (AUC) (AUC: 0.71 [95% confidence interval (CI): 0.57 to 0.85] vs. 0.85 [95% CI: 0.82 to 0.89], p = 0.04). CT-FFR showed superior diagnostic value over cCTA in vessels with high Agatston scores (CAC >= 400: AUC 0.71 vs. 0.55, p = 0.04) and low-to-intermediate Agatston scores (CAC >0 to <400: AUC 0.86 vs. 0.63, p < 0.001).

CONCLUSIONS

Machine-learning-based CT-FFR showed superior diagnostic performance over cCTA alone in CAC with a significant difference in the performance of CT-FFR as calcium burden/Agatston calcium score increased. (Machine Learning Based CT Angiography Derived FFR: a Multicenter, Registry [MACHINE] NCT02805621). (C) 2020 by the American College of Cardiology Foundation.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 2020
Keywords
coronary artery disease, coronary computed tomography angiography, computational fractional flow reserve, invasive coronary angiography
National Category
Medical Engineering
Identifiers
urn:nbn:se:liu:diva-167489 (URN)10.1016/j.jcmg.2019.06.027 (DOI)000518475000017 ()31422141 (PubMedID)2-s2.0-85079363468 (Scopus ID)
Available from: 2020-07-10 Created: 2020-07-10 Last updated: 2024-01-24Bibliographically approved
Hagstrom, E., Bergstrom, G., Rosengren, A., Brolin, E. B., Brandberg, J., Cederlund, K., . . . Lind, L. (2019). IMPACT OF BODY WEIGHT AT AGE 20 AND WEIGHT GAIN DURING ADULTHOOD ON MIDLIFE CORONARY ARTERY CALCIUM IN 15,000 MEN AND WOMEN: AN INTERIM ANALYSIS OF THE SWEDISH CARDIOPULMONARY BIOIMAGE STUDY. Paper presented at 68th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), MAR 16-18, 2019, New Orleans, LA. Journal of the American College of Cardiology, 73(9), 1692-1692
Open this publication in new window or tab >>IMPACT OF BODY WEIGHT AT AGE 20 AND WEIGHT GAIN DURING ADULTHOOD ON MIDLIFE CORONARY ARTERY CALCIUM IN 15,000 MEN AND WOMEN: AN INTERIM ANALYSIS OF THE SWEDISH CARDIOPULMONARY BIOIMAGE STUDY
Show others...
2019 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 73, no 9, p. 1692-1692Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background

Elevated body weight in adolescence is strongly associated with early cardiovascular disease, but whether this association is traceable to weight in early adulthood, or to weight gain with subsequent high adult weight is not known. Using data from the Swedish CArdioPulmonary bioImage Study (SCAPIS), we investigated the association between weight at age 20, weight gain to midlife and coronary artery calcium score (CACS) at midlife.

Methods

In the first 15,810 participants in SCAPIS (mean age 58 years, 52% women), data on CACS at midlife, self-reported body weight at age 20 and weight at examination in SCAPIS were recorded.

Results

CACS in midlife was significantly higher with increasing weight at age 20 (p<0.001 for both sexes), and then increased with weight gain until midlife at all levels of body weight at age 20 after adjusting for age, height, smoking, alcohol intake, education level, exercise levels and LDL cholesterol. However, the association with weight gain was only significant in men (p = 0.047), not in women (p=0.474). No significant interaction was seen between weight at age 20 and midlife weight with CACS. The effect of weight at age 20 on CACS was significantly more marked in men than in women, as was the effect of weight gain (p<0.001 for both interactions).

Conclusion

Weight at age 20 and weight gain to midlife were both related to CACS, but much more markedly so in men than in women, indicating a generally larger effect of both early adult weight and further weight gain until midlife on CACS in men, compared to women.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 2019
National Category
Cardiology and Cardiovascular Disease
Identifiers
urn:nbn:se:liu:diva-177947 (URN)10.1016/S0735-1097(19)32298-3 (DOI)000460565901704 ()
Conference
68th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), MAR 16-18, 2019, New Orleans, LA
Available from: 2021-07-08 Created: 2021-07-08 Last updated: 2025-02-10
Lantz, J., Gupta, V., Henriksson, L., Karlsson, M., Persson, A., Carlhäll, C.-J. & Ebbers, T. (2019). Impact of Pulmonary Venous Inflow on Cardiac Flow Simulations: Comparison with In Vivo 4D Flow MRI. Annals of Biomedical Engineering, 47(2), 413-424
Open this publication in new window or tab >>Impact of Pulmonary Venous Inflow on Cardiac Flow Simulations: Comparison with In Vivo 4D Flow MRI
Show others...
2019 (English)In: Annals of Biomedical Engineering, ISSN 0090-6964, E-ISSN 1573-9686, Vol. 47, no 2, p. 413-424Article in journal (Refereed) Published
Abstract [en]

Blood flow simulations are making their way into the clinic, and much attention is given to estimation of fractional flow reserve in coronary arteries. Intracardiac blood flow simulations also show promising results, and here the flow field is expected to depend on the pulmonary venous (PV) flow rates. In the absence of in vivo measurements, the distribution of the flow from the individual PVs is often unknown and typically assumed. Here, we performed intracardiac blood flow simulations based on time-resolved computed tomography on three patients, and investigated the effect of the distribution of PV flow rate on the flow field in the left atrium and ventricle. A design-of-experiment approach was used, where PV flow rates were varied in a systematic manner. In total 20 different simulations were performed per patient, and compared to in vivo 4D flow MRI measurements. Results were quantified by kinetic energy, mitral valve velocity profiles and root-mean-square errors of velocity. While large differences in atrial flow were found for varying PV inflow distributions, the effect on ventricular flow was negligible, due to a regularizing effect by mitral valve. Equal flow rate through all PVs most closely resembled in vivo measurements and is recommended in the absence of a priori knowledge.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2019
Keywords
Sensitivity analysis, Design-of-experiments, Computational fluid dynamics, In vivo measurements
National Category
Medical Imaging Fluid Mechanics
Identifiers
urn:nbn:se:liu:diva-153252 (URN)10.1007/s10439-018-02153-5 (DOI)000456383600007 ()30362080 (PubMedID)2-s2.0-85055724908 (Scopus ID)
Funder
Knut and Alice Wallenberg Foundation
Available from: 2018-12-06 Created: 2018-12-06 Last updated: 2025-02-09Bibliographically approved
Persson, A. (2019). Staying on course The EU and the Palestinian-Israeli conflict. Osteuropa: Zeitschrift für Gegenwartsfragen des Ostens, 69(9-11), 429-+
Open this publication in new window or tab >>Staying on course The EU and the Palestinian-Israeli conflict
2019 (English)In: Osteuropa: Zeitschrift für Gegenwartsfragen des Ostens, ISSN 0030-6428, Vol. 69, no 9-11, p. 429-+Article in journal (Refereed) Published
Abstract [en]

Despite very rapid changes in the Palestinian-Israeli conflict and throughout the Middle East, the EU continues to support a two-state solution. During the 1970s, the member states of the European Community jointly developed this approach as a pioneering concept for a just peace in the Middle East. Today, the EUs Middle East policy is on the verge of becoming irrelevant. Furthermore, the member states are finding it increasingly difficult to agree on a common position. However, those that criticise the continued adherence to the two-state solution offer no alternative concepts for peace in the Middle East. The EU would therefore be wise, with its new concept of resilience, not throw what is regarded as being the right approach overboard.

Place, publisher, year, edition, pages
BWV-BERLINER WISSENSCHAFTS-VERLAG GMBH, 2019
National Category
Other Geographic Studies
Identifiers
urn:nbn:se:liu:diva-164413 (URN)000517347500026 ()
Available from: 2020-03-19 Created: 2020-03-19 Last updated: 2025-05-08
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-9446-6981

Search in DiVA

Show all publications