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Uvdal, Kajsa
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Publications (10 of 110) Show all publications
Hu, J., Liu, T., Gao, H.-W., Lu, S., Uvdal, K. & Hu, Z.-J. (2018). Selective detections of Hg2+ and F- by using tailor-made fluorogenic probes. Sensors and actuators. B, Chemical, 269, 368-376
Open this publication in new window or tab >>Selective detections of Hg2+ and F- by using tailor-made fluorogenic probes
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2018 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 269, p. 368-376Article in journal (Refereed) Published
Abstract [en]

By ingeniously using a (imino)coumarin-precursor, three reactive fluorogenic probes of MP, FP, and FMP have been fabricated in a single facile synthetic route. MP and FP are able to respectively act as selective "turn-on" fluorescent probes for detecting Hg2+ and F- in buffer solution via specific analyte-induced reactions. Linear ranges for the detection of Hg2+ and F- are 0-10 mu M and 0-100 mu M with the limits of detection (LODs) of 4.0 x 10(-8) M and 1.14 x 10(-6) M (3 delta/slope), respectively. FMP is able to work as a molecular "AND" logic gate-based fluorogenic probe for monitoring the coexistence of Hg2+ and F- via a multistep reaction cascade. The analytes-induced sensing mechanisms have been determined by using high-performance liquid chromatography analysis (HPLC). In addition, three probes show negligible toxicity under the experimental conditions, and are successfully used for monitoring Hg2+ and F- in living cells with good cell permeability. The success of the work demonstrates that ingenious utility of specific analyte-induced reactions and conventional concepts on the appropriate molecular scaffold can definitely deliver tailor-made probes for various intended sensing purposes. (C) 2018 Published by Elsevier B.V.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Coumarin; Chemosensor; Mercury; Fluoride; "AND" logic gate
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:liu:diva-149331 (URN)10.1016/j.snb.2018.04.164 (DOI)000433211100044 ()
Note

Funding Agencies|Natural Science Foundation of Shanghai [17ZR1410500]; National Natural Science Foundation of China [21577098, 21477073]; Swedish Research Council (VR) [621-2013-5357]; Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM) (VR) [5.1-2015-5959]

Available from: 2018-07-02 Created: 2018-07-02 Last updated: 2018-08-10
Hu, J., Hu, Z.-J., Chen, Z., Gao, H.-W. & Uvdal, K. (2016). A logic gate-based fluorogenic probe for Hg2+ detection and its applications in cellular imaging. Analytica Chimica Acta, 919, 85-93
Open this publication in new window or tab >>A logic gate-based fluorogenic probe for Hg2+ detection and its applications in cellular imaging
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2016 (English)In: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 919, p. 85-93Article in journal (Refereed) Published
Abstract [en]

A new colorimetric and fluorogenic probe (RN3) based on rhodamine-B has been successfully designed and synthesized. It displays a selective response to Hg2+ in the aqueous buffer solution over the other competing metals. Upon addition of Hg2+, the solution of RN3 exhibits a naked eye observable color change from colorless to red and an intensive fluorescence with about 105-fold enhancement. The changes in the color and fluorescence are ascribed to the ring-opening of spirolactam in rhodamine fluorophore, which is induced by a binding of the constructed receptor to Hg2+ with the association and dissociation constants of 0.22 x 10(5) M-1 and 25.2 mM, respectively. The Jobs plot experiment determines a 1: 1 binding stoichiometry between RN3 and Hg2+. The resultant "turn-on" fluorescence in buffer solution, allows the application of a method to determine Hg2+ levels in the range of 4.0-15.0 mu M, with the limit of detection (LOD) calculated at 60.7 nM (3 sigma/slope). In addition, the fluorescence turn-off and color fading-out happen to the mixture of RN3-Hg2+ by further addition of I- or S2-. The reversible switching cycles of fluorescence intensity upon alternate additions of Hg2+ and S2- demonstrate that RN3 can perform as an INHIBIT logic gate. Furthermore, the potential of RN3 as a fluorescent probe has been demonstrated for cellular imaging. (C) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2016
Keywords
Mercury; Rhodamine; Fluorogenic probe; Fluorescent imaging; Logical gate
National Category
Analytical Chemistry
Identifiers
urn:nbn:se:liu:diva-128135 (URN)10.1016/j.aca.2016.03.017 (DOI)000374642400011 ()27086103 (PubMedID)
Note

Funding Agencies|National Natural Science Foundation of China [21577098]; Knut and Alice Wallenberg Foundation (KAW) [2012.0083]; Swedish Government Strategic Faculty Grant in Material Science 11 (SFO, MATLIU) in Advanced Functional Materials (AFM) (VR) [5.1-2015-5959]; Centre in Nano Science and Nanotechnology (CeNano) Grant in LiTH

Available from: 2016-05-19 Created: 2016-05-19 Last updated: 2018-03-21
Hu, J., Hu, Z.-J., Liu, S., Zhang, Q., Gao, H.-W. & Uvdal, K. (2016). A new ratiometric fluorescent chemodosimeter based on an ICT modulation for the detection of Hg2+. Sensors and actuators. B, Chemical, 230, 639-644
Open this publication in new window or tab >>A new ratiometric fluorescent chemodosimeter based on an ICT modulation for the detection of Hg2+
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2016 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 230, p. 639-644Article in journal (Refereed) Published
Abstract [en]

We design and synthesize a new ratiometric fluorescent chemodosimeter (S1) for the selective and sensitive detection of Hg2+. Upon addition of Hg2+, the emission of the S1 exhibits a large bathochromic shift from 393 to 515 nm (up to 122 nm) which is ascribed to an intramolecular charge transfer process in the resultant. The Hg2+-induced dethioacetalization for sensing mechanism has been demonstrated by using high-performance liquid chromatography analysis of the sensing process. The interference experiments further demonstrate that S1 exhibits very high selectivity towards Hg2+ over other coexisting cations/anions. Subsequently, a good linearity of the concentrations of Hg2+ (0-15 mu M) vs the ratiometric signals (I-515/I-393) allows a fluorogenic method for the quantitative detection of Hg2+, with the limitation of detection determined to be 5.22 x 10(-7) M. (C) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE SA, 2016
Keywords
Chemodosimeter; Ratiometric fluorescence; Mercury detection; Intramolecular charge transfer; Phenanthroimidazole
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-128714 (URN)10.1016/j.snb.2016.02.125 (DOI)000374329300081 ()
Note

Funding Agencies|National Natural Science Foundation of China [21577098]; Foundation of State Key Laboratory of Pollution Control and Resource Reuse, China [PCRRK13024]; Knut and Alice Wallenberg Foundation (KAW) [2012.0083]; Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM) (VR) [5.1-2015-5959]; International Exchange Program for Graduate Students of Tongji University [201502013]

Available from: 2016-06-07 Created: 2016-05-30 Last updated: 2018-03-20
Zhang, Q., Luo, L., Xu, H., Hu, Z.-J., Brommesson, C., Wu, J., . . . Uvdal, K. (2016). Design, synthesis, linear and nonlinear photophysical properties of novel pyrimidine-based imidazole derivatives. New Journal of Chemistry, 40(4), 3456-3463
Open this publication in new window or tab >>Design, synthesis, linear and nonlinear photophysical properties of novel pyrimidine-based imidazole derivatives
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2016 (English)In: New Journal of Chemistry, ISSN 1144-0546, E-ISSN 1369-9261, Vol. 40, no 4, p. 3456-3463Article in journal (Refereed) Published
Abstract [en]

Novel donor-pi-acceptor (D-pi-A) and donor-pi-acceptor-pi-donor (D-pi-A-pi-D) type pyrimidine imidazole derivatives with flexible ether chains (L1 and L2) have been efficiently synthesized through improved Knoevenagel condensation and Ullmann reactions with high yields. Based on systematic photophysical investigations and theoretical calculations, the structure-property relationships can be described as follows: (1) the linear and nonlinear optical properties of the target chromophores change regularly with increasing the number of branches and the polarity of the solvents. (2) The single-substituted chromophore L2 exhibited a remarkable negative solvato-kinetic effect, while the double-substituted chromophore L1 showed a positive solvato-kinetic effect. Significant bathochromic shifting of the emission spectra and larger Stokes shifts were observed in polar solvents. (3) The two-photon absorption (TPA) cross-section results further demonstrated that their TPA cross section values (delta) increase notably with increasing branch number, and the presence of high pi-delocalization could induce large size-scalable TPA enhancements. (4) By comprehensively considering the optical performance, cytotoxicity and solubility, L1 was identified as the better candidate for living cell (HepG2) imaging.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY, 2016
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-127760 (URN)10.1039/c5nj02874d (DOI)000373993600060 ()
Note

Funding Agencies|National Natural Science Foundation of China [21501001, 21271004, 51372003, 51432001, 21271003, 51072001, 81503009, 51272001]; National Key Basic Research Program 973 [2013CB632705]; Ministry of Education; Program for New Century Excellent Talents in University (China); Doctoral Program Foundation of Ministry of Education of China [20113401110004]; China Postdoctoral Science Foundation [2015M571912]; Swedish Research Council (VR) [621-2013-5357]; Swedish Government (SFO, MATLIU) in Advanced Functional Materials (AFM); Wenner-Gren Foundation

Available from: 2016-05-12 Created: 2016-05-12 Last updated: 2017-11-30
Eriksson, J., Puglisi, D., Strandqvist, C., Gunnarsson, R., Ekeroth, S., Ivanov, I. G., . . . Lloyd Spetz, A. (2016). Modified Epitaxial Graphene on SiC for Extremely Sensitive andSelective Gas Sensors. Paper presented at ICSCRM 2015, The International Conference on Silicon Carbide and Related Materials, 4-9 October 2015, Giardini Naxos, Italy. Materials Science Forum, 858, 1145-1148
Open this publication in new window or tab >>Modified Epitaxial Graphene on SiC for Extremely Sensitive andSelective Gas Sensors
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2016 (English)In: Materials Science Forum, ISSN 0255-5476, E-ISSN 1662-9752, Vol. 858, p. 1145-1148Article in journal (Refereed) Published
Abstract [en]

Two-dimensional materials offer a unique platform for sensing where extremely high sensitivity is a priority, since even minimal chemical interaction causes noticeable changes inelectrical conductivity, which can be used for the sensor readout. However, the sensitivity has to becomplemented with selectivity, and, for many applications, improved response- and recovery times are needed. This has been addressed, for example, by combining graphene (for sensitivity) with metal/oxides (for selectivity) nanoparticles (NP). On the other hand, functionalization or modification of the graphene often results in poor reproducibility. In this study, we investigate thegas sensing performance of epitaxial graphene on SiC (EG/SiC) decorated with nanostructured metallic layers as well as metal-oxide nanoparticles deposited using scalable thin-film depositiontechniques, like hollow-cathode pulsed plasma sputtering. Under the right modification conditions the electronic properties of the surface remain those of graphene, while the surface chemistry can betuned to improve sensitivity, selectivity and speed of response to several gases relevant for airquality monitoring and control, such as nitrogen dioxide, benzene, and formaldehyde.

Place, publisher, year, edition, pages
Trans Tech Publications Inc., 2016
Keywords
Epitaxial graphene, graphene hybrid materials, gas sensor
National Category
Condensed Matter Physics
Identifiers
urn:nbn:se:liu:diva-128078 (URN)10.4028/www.scientific.net/MSF.858.1145 (DOI)
Conference
ICSCRM 2015, The International Conference on Silicon Carbide and Related Materials, 4-9 October 2015, Giardini Naxos, Italy
Available from: 2016-05-16 Created: 2016-05-16 Last updated: 2018-03-26
Zhang, Q., Tian, X., Wang, H., Hu, Z.-J., Wu, J., Zhou, H., . . . Uvdal, K. (2016). NIR-region two-photon fluorescent probes for Fe3+/Cu2+ ions based on pyrimidine derivatives with different flexible chain. Sensors and actuators. B, Chemical, 222, 574-578
Open this publication in new window or tab >>NIR-region two-photon fluorescent probes for Fe3+/Cu2+ ions based on pyrimidine derivatives with different flexible chain
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2016 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 222, p. 574-578Article in journal (Refereed) Published
Abstract [en]

Two novel NIR-region two-photon fluorescent probes CCP and COP, show strong fluorescence quenching and good ratiometric responses toward Fe3+ and Cu2+, respectively; and their two-photon fluorescence are reversible by the subsequent addition of EDTA. CCP and COP are valuable candidates for two-photon imaging in the biological transparency window. (C) 2015 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE SA, 2016
Keywords
Two-photon absorption; Pyrimidine; Multi-functional sensor; Metal ions
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-122779 (URN)10.1016/j.snb.2015.08.079 (DOI)000363815800074 ()
Note

Funding Agencies|National Natural Science Foundation of China [21271004, 51372003, 51432001, 21271003, 21501001, 51072001, 51272001]; National Key Basic Research Program [2013CB632705]; Program for New Century Excellent Talents in University (China); CETV; China Postdoctoral Science Foundation [2015M571912]; Swedish Research Council (VR) [621-2013-5357]; Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM)

Available from: 2015-11-23 Created: 2015-11-23 Last updated: 2017-12-01
Zhang, Q., Tian, X., Hu, Z.-J., Brommesson, C., Wu, J., Zhou, H., . . . Uvdal, K. (2016). Nonlinear optical response and two-photon biological applications of a new family of imidazole-pyrimidine derivatives. Dyes and pigments, 126, 286-295
Open this publication in new window or tab >>Nonlinear optical response and two-photon biological applications of a new family of imidazole-pyrimidine derivatives
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2016 (English)In: Dyes and pigments, ISSN 0143-7208, E-ISSN 1873-3743, Vol. 126, p. 286-295Article in journal (Refereed) Published
Abstract [en]

A series of novel D-pi-A type two-photon absorption (2PA) imidazole-pyrimidine derivatives (EX-1 similar to EX-4) have been synthesized and characterized, with EX-1 was crystallography confirmed. Based on systematic photophysical investigations, the structure property relationships can be drawn as follows: (1) Both theoretical and experimental studies indicated that the different donor groups have large influences on the optical properties. (2) The 2PA cross-section values (sigma) were obtained both by Z-Scan and two photon excited fluorescence (2PEF) measurements. 2PA cross sections show an increasing trend with increasing electron-donating strength and the number of branches. (3) Comprehensively considered the optical performance, molecular volume, cytotoxicity and solubility, EX-1 and EX-2 were identified to be the best candidates for living cells (HepG2) imaging. Moreover, the 2PA excitable features of EX-1 and EX-2 are capable of imaging in fresh mouses liver tissues with a depth of ca. 70 mu m. (C) 2015 Elsevier Ltd. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD, 2016
Keywords
Two-photon absorption; Triphenylamine; Imidazole; Pyrimidine; Two-photon fluorescent microscopy; Z-Scan
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-125797 (URN)10.1016/j.dyepig.2015.11.026 (DOI)000370090600035 ()
Note

Funding Agencies|National Natural Science Foundation of China [21501001, 21271004, 51372003, 51432001, 21271003, 51472003, 51272001]; National Key Basic Research Program 973 [2013CB632705]; Program for New Century Excellent Talents in University (China); Doctoral Program Foundation of Ministry of Education of China [20113401110004]; China Postdoctoral Science Foundation [2015M571912]; Swedish Research Council (VR) [621-2013-5357]; Swedish Government strategic faculty grant in material science (SFO, MATLIU) in Advanced Functional Materials (AFM); Wenner-Gren Foundations

Available from: 2016-03-08 Created: 2016-03-04 Last updated: 2018-03-20
Zhang, Q., Tian, X., Hu, Z.-J., Brommesson, C., Wu, J., Zhou, H., . . . Uvdal, K. (2015). A series of Zn(II) terpyridine complexes with enhanced two-photon-excited fluorescence for in vitro and in vivo bioimaging. Journal of materials chemistry. B, 3(36), 7213-7221
Open this publication in new window or tab >>A series of Zn(II) terpyridine complexes with enhanced two-photon-excited fluorescence for in vitro and in vivo bioimaging
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2015 (English)In: Journal of materials chemistry. B, ISSN 2050-750X, E-ISSN 2050-7518, Vol. 3, no 36, p. 7213-7221Article in journal (Refereed) Published
Abstract [en]

It is still a challenge to obtain two-photon excited fluorescent bioimaging probes with intense emission, high photo-stability and low cytotoxicity. In the present work, four Zn(II)-coordinated complexes (1-4) constructed from two novel D-A and D-p-A ligands (L-1 and L-2) are investigated both experimentally and theoretically, aiming to explore efficient two-photon probes for bioimaging. Molecular geometry optimization used for theoretical calculations is achieved using the crystallographic data. Notably, the results indicate that complexes 1 and 2 display enhanced two-photon absorption (2PA) cross sections compared to their corresponding D-A ligand (L1). Furthermore, it was found that complex 1 has the advantages of moderate 2PA cross section in the near-infrared region, longer fluorescence lifetime, higher quantum yield, good biocompatibility and enhanced two-photon excited fluorescence. Therefore, complex 1 is evaluated as a bioimaging probe for in vitro imaging of HepG2 cells, in which it is observed under a two-photon scanning microscope that complex 1 exhibits effective co-staining with endoplasmic reticulum (ER) and nuclear membrane; as well as for in vivo imaging of zebrafish larva, in which it is observed that complex 1 exhibits specificity in the intestinal system.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY, 2015
National Category
Physical Chemistry
Identifiers
urn:nbn:se:liu:diva-122077 (URN)10.1039/c5tb01185j (DOI)000360658000007 ()
Note

Funding Agencies|National Natural Science Foundation of China [51372003, 21271004, 51272001, 51472003, 51432001, 21271003]; Ministry of Education Funded Projects Focus on returned overseas scholar; Program for New Century Excellent Talents in University (China); Doctoral Program Foundation of Ministry of Education of China [20113401110004]; China Postdoctoral Science Foundation [2015M571912]; Swedish Research Council (VR) [621-2013-5357]; Swedish Government strategic faculty grant in materials science (SFO, MATLIU) in Advanced Functional Materials (AFM)

Available from: 2015-10-20 Created: 2015-10-19 Last updated: 2017-12-01
Zhang, X., Wang, W., Hu, Z., Wang, G. & Uvdal, K. (2015). Coordination polymers for energy transfer: Preparations, properties, sensing applications, and perspectives. Coordination chemistry reviews, 284, 206-235
Open this publication in new window or tab >>Coordination polymers for energy transfer: Preparations, properties, sensing applications, and perspectives
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2015 (English)In: Coordination chemistry reviews, ISSN 0010-8545, E-ISSN 1873-3840, Vol. 284, p. 206-235Article, review/survey (Refereed) Published
Abstract [en]

This review highlights the recent progress of bulk and nanoscale coordination polymer (CP) materials forenergy transfer. Artificial light-harvesting materials with efficient energy transfer are practically usefulfor a variety of applications including photovoltaic, white emitting devices, and sensors. In the pastdecades CP (aka Metal-organic framework, MOF) has experienced rapid development due to a multitude of applications, including catalyst, gas storage and separations, non-linear optics, luminescence, and soon. Recent research has shown that CP is a very promising light-harvesting platform because the energytransfers can occur between different ligands, from ligand to metal centers, or from MOF skeleton to guestspecies. This review comprehensively surveyed synthetic approaches to light-harvesting CPs, and postfunctionalization. Sensing applications and achievements in energy-transfer CP nanoparticles and thinfilms were also discussed.

Place, publisher, year, edition, pages
Elsevier, 2015
Keywords
Coordination polymers, Energy transfer, luminescence, sensing, nanoparticles, thin film
National Category
Chemical Sciences Inorganic Chemistry Materials Chemistry
Identifiers
urn:nbn:se:liu:diva-114189 (URN)10.1016/j.ccr.2014.10.006 (DOI)000348016700007 ()
Funder
Linköpings universitet, SFO-Mat-Liu #2009-00971
Available from: 2015-02-12 Created: 2015-02-12 Last updated: 2017-12-04
Larsson, E., Dullin, C., Abrikossova, N., Mikac, U., Brommesson, C., Accardo, A., . . . Serša, I. (2015). Dual-modal CT and MRI functional and anatomical imaging using barium sulphate and gadolinium nanoparticle loaded macrophages in a preclinical asthma mouse model.
Open this publication in new window or tab >>Dual-modal CT and MRI functional and anatomical imaging using barium sulphate and gadolinium nanoparticle loaded macrophages in a preclinical asthma mouse model
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2015 (English)Manuscript (preprint) (Other academic)
Abstract [en]

Objectives In this study we investigated the potentials of dual-modal CT-MRI macrophage tracking, by a intratracheal instillation of a mixture of either gadolinium nanoparticles or barium sulphate loaded alveolar macrophages into mice of an allergic airway inflammation (asthma) model and their respective healthy control, imaged with Synchrotron X-rays microtomography (SR μCT) and Micro Magnetic Resonance Imaging (μMRI).

Materials and Methods The mice were scanned ex vivo using SRμCT at 22 keV and with a 9.4 Tesla μMRI scanner. The CT and MRI data sets were registered and fused together, followed by quantitative and statistical analysis.

Results The asthmatic sample injected with contrast agent loaded macrophages showed high absorbing spots inside the soft-tissue regions of the lung for the CT data set, as well as higher contrast for the soft-tissue in the MRI data set. Furthermore, the correlation analysis showed a perfect negative correlation between the soft tissue mean grey value in CT and the soft tissue mean grey value in MRI.

Conclusion The dual-modal CT-MRI cell tracking of intratracheally administered macrophages (loaded with contrast agent) in an asthmatic mouse helps to extract synergistic information about the migration  behaviour of macrophages, where clusters of cells were detected in CT, while as a general increase of the soft-tissue contrast could be observed in MRI, due to a homogeneous cell distribution.

Keywords
Gadolinium oxide (Gd2O3); alveolar macrophages; asthma; magnetic resonance imaging; Synchrotron X-Ray Computed Microtomography
National Category
Physical Sciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-122603 (URN)
Available from: 2015-11-11 Created: 2015-11-11 Last updated: 2015-11-11Bibliographically approved
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