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Suska, Anke
Publications (10 of 22) Show all publications
Comina, G., Suska, A. & Filippini, D. (2016). Towards autonomous lab-on-a-chip devices for cell phone biosensing. Biosensors & bioelectronics, 77, 1153-1167
Open this publication in new window or tab >>Towards autonomous lab-on-a-chip devices for cell phone biosensing
2016 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 77, p. 1153-1167Article in journal (Refereed) Published
Abstract [en]

Modern cell phones are a ubiquitous resource with a residual capacity to accommodate chemical sensing and biosensing capabilities. From the different approaches explored to capitalize on such resource, the use of autonomous disposable lab-on-a-chip (LOC) devices conceived as only accessories to complement cell phones underscores the possibility to entirely retain cell phones ubiquity for distributed biosensing. The technology and principles exploited for autonomous LOC devices are here selected and reviewed focusing on their potential to serve cell phone readout configurations. Together with this requirement, the central aspects of cell phones resources that determine their potential for analytical detection are examined. The conversion of these LOC concepts into universal architectures that are readable on unaccessorized phones is discussed within this context. (C) 2015 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2016
Keywords
Autonomous lab-on-a-chip; Cell phone biosensing; Point-of-care
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-124074 (URN)10.1016/j.bios.2015.10.092 (DOI)000366766900161 ()26569446 (PubMedID)
Note

Funding Agencies|Swedish Research Council (VR) [C0453801]; Carl Tryggers Foundation [CTS14140]

Available from: 2016-01-25 Created: 2016-01-19 Last updated: 2017-11-30Bibliographically approved
Comina, G., Suska, A. & Filippini, D. (2015). 3D Printed Unibody Lab-on-a-Chip: Features Survey and Check-Valves Integration dagger. Micromachines, 6(4), 437-451
Open this publication in new window or tab >>3D Printed Unibody Lab-on-a-Chip: Features Survey and Check-Valves Integration dagger
2015 (English)In: Micromachines, ISSN 2072-666X, E-ISSN 2072-666X, Vol. 6, no 4, p. 437-451Article in journal (Refereed) Published
Abstract [en]

The unibody lab-on-a-chip (ULOC) concept entails a fast and affordable micro-prototyping system built around a single monolithic 3D printed element (unibody). A consumer-grade stereo lithography (SL) 3D printer can configure ULOCs with different forms of sample delivery, transport, handling and readout, while minimizing material costs and fabrication time. ULOC centralizes all complex fabrication procedures and replaces the need for clean room resources, delivering prototypes for less than 1 US$, which can be printed in 10 min and ready for testing in less than 30 min. Recent examples of ULOC integration of transport, chemical sensing for optical readout and flow mixing capabilities are discussed, as well as the integration of the first check-valves for ULOC devices. ULOC valves are strictly unidirectional up to 100 psi, show an exponential forward flow behavior up to 70 psi and can be entirely fabricated with the ULOC approach.

Place, publisher, year, edition, pages
MDPI, 2015
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-118257 (URN)10.3390/mi6040437 (DOI)000353777200003 ()
Note

Funding Agencies|Swedish Research Council (Vetenskapsradet); Carl Tryggers Foundation

Available from: 2015-05-22 Created: 2015-05-22 Last updated: 2017-12-04
Comina, G., Suska, A. & Filippini, D. (2015). Autonomous Chemical Sensing Interface for Universal Cell Phone Readout. Angewandte Chemie International Edition, 54(30), 8708-8712
Open this publication in new window or tab >>Autonomous Chemical Sensing Interface for Universal Cell Phone Readout
2015 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 54, no 30, p. 8708-8712Article in journal (Refereed) Published
Abstract [en]

Exploiting the ubiquity of cell phones for quantitative chemical sensing imposes strong demands on interfacing devices. They should be autonomous, disposable, and integrate all necessary calibration and actuation elements. In addition, a single design should couple universally to a variety of cell phones, and operate in their default configuration. Here, we demonstrate such a concept and its implementation as a quantitative glucose meter that integrates finger pumps, unidirectional valves, calibration references, and focusing optics on a disposable device configured for universal video acquisition.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2015
Keywords
3D printed fluidics; analytical methods; autonomous lab-on-a-chip; cell phone readout; sensors
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-120447 (URN)10.1002/anie.201503727 (DOI)000358051600022 ()26095136 (PubMedID)
Note

Funding Agencies|Swedish Research Council (VR); Carl Tryggers Foundation

Available from: 2015-08-12 Created: 2015-08-11 Last updated: 2017-12-04Bibliographically approved
Preechaburana, P., Suska, A. & Filippini, D. (2014). Biosensing with cell phones. Trends in Biotechnology, 32(7), 351-355
Open this publication in new window or tab >>Biosensing with cell phones
2014 (English)In: Trends in Biotechnology, ISSN 0167-7799, E-ISSN 1879-3096, Vol. 32, no 7, p. 351-355Article, review/survey (Refereed) Published
Abstract [en]

Continued progress in cell-phone devices has made them powerful mobile computers, equipped with sophisticated, permanent physical sensors embedded as the default configuration. By contrast, the incorporation of permanent biosensors in cell-phone units has been prevented by the multivocal nature of the stimuli and the reactions involved in biosensing and chemical sensing. Biosensing with cell phones entails the complementation of biosensing devices with the physical sensors and communication and processing capabilities of modern cell phones. Biosensing, chemical-sensing, environmental-sensing, and diagnostic capabilities would thus be supported and run on the residual capacity of existing cell-phone infrastructure. The technologies necessary to materialize such a scenario have emerged in different fields and applications. This article addresses the progress on cell-phone biosensing, the specific compromises, and the blend of technologies required to craft biosensing on cell phones.

Place, publisher, year, edition, pages
Elsevier, 2014
Keywords
cell phones; biosensing; optical sensing; lab-on-a-chip; point-of-care; diagnostics
National Category
Medical Biotechnology
Identifiers
urn:nbn:se:liu:diva-109255 (URN)10.1016/j.tibtech.2014.03.007 (DOI)000338411300003 ()24702730 (PubMedID)
Available from: 2014-08-12 Created: 2014-08-11 Last updated: 2017-12-05Bibliographically approved
Comina, G., Suska, A. & Filippini, D. (2014). Low cost lab-on-a-chip prototyping with a consumer grade 3D printer. Lab on a Chip, 14(16), 2978-2982
Open this publication in new window or tab >>Low cost lab-on-a-chip prototyping with a consumer grade 3D printer
2014 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 14, no 16, p. 2978-2982Article in journal (Refereed) Published
Abstract [en]

Versatile prototyping of 3D printed lab-on-a-chip devices, supporting different forms of sample delivery, transport, functionalization and readout, is demonstrated with a consumer grade printer, which centralizes all critical fabrication tasks. Devices cost 0.57US$ and are demonstrated in chemical sensing and micromixing examples, which exploit established principles from reference technologies.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2014
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-109578 (URN)10.1039/c4lc00394b (DOI)000339470400012 ()24931176 (PubMedID)
Available from: 2014-08-21 Created: 2014-08-21 Last updated: 2017-12-05Bibliographically approved
Comina, G., Suska, A. & Filippini, D. (2014). PDMS lab-on-a-chip fabrication using 3D printed templates. Lab on a Chip, 14(2), 424-430
Open this publication in new window or tab >>PDMS lab-on-a-chip fabrication using 3D printed templates
2014 (English)In: Lab on a Chip, ISSN 1473-0197, E-ISSN 1473-0189, Vol. 14, no 2, p. 424-430Article in journal (Refereed) Published
Abstract [en]

The fabrication of conventional PDMS on glass lab-on-a-chip (LOC) devices, using templates printed with a commercial (2299 US$) micro-stereo lithography 3D printer, is demonstrated. Printed templates replace clean room and photolithographic fabrication resources and deliver resolutions of 50 mu m, and up to 10 mu m in localized hindrances, whereas the templates are smooth enough to allow direct transfer and proper sealing to glass substrates. 3D printed templates accommodate multiple thicknesses, from 50 mu m up to several mm within the same template, with no additional processing cost or effort. This capability is exploited to integrate silicone tubing easily, to improve micromixer performance and to produce multilevel fluidics with simple access to independent functional surfaces, which is illustrated by time-resolved glucose detection. The templates are reusable, can be fabricated in under 20 min, with an average cost of 0.48 US$, which promotes broader access to established LOC configurations with minimal fabrication requirements, relieves LOC fabrication from design skills and provides a versatile LOC development platform.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2014
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-103283 (URN)10.1039/c3lc50956g (DOI)000328910700019 ()
Available from: 2014-01-17 Created: 2014-01-16 Last updated: 2017-12-06Bibliographically approved
Preechaburana, P., Suska, A. & Filippini, D. (2012). Embedded Adaptive Optics for Ubiquitous Lab-on-a-Chip Readout on Intact Cell Phones. Sensors, 12(7), 8586-8600
Open this publication in new window or tab >>Embedded Adaptive Optics for Ubiquitous Lab-on-a-Chip Readout on Intact Cell Phones
2012 (English)In: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 12, no 7, p. 8586-8600Article in journal (Refereed) Published
Abstract [en]

The evaluation of disposable lab-on-a-chip (LOC) devices on cell phones is an attractive alternative to migrate the analytical strength of LOC solutions to decentralized sensing applications. Imaging the micrometric detection areas of LOCs in contact with intact phone cameras is central to provide such capability. This work demonstrates a disposable and morphing liquid lens concept that can be integrated in LOC devices and refocuses micrometric features in the range necessary for LOC evaluation using diverse cell phone cameras. During natural evaporation, the lens focus varies adapting to different type of cameras. Standard software in the phone commands a time-lapse acquisition for best focal selection that is sufficient to capture and resolve, under ambient illumination, 50 mu m features in regions larger than 500 x 500 mu m(2). In this way, the present concept introduces a generic solution compatible with the use of diverse and unmodified cell phone cameras to evaluate disposable LOC devices.

Place, publisher, year, edition, pages
MDPI, 2012
Keywords
adaptive optics, lab-on-a-chip readout, optical chemical sensing, ubiquitous sensing, cell phones
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-81222 (URN)10.3390/s120708586 (DOI)000306796500010 ()
Note

Funding Agencies|Linkoping Centre for Life Science Technologies (LIST), Sweden||Thammasat University of Thailand for Pakorn Preechaburana||

Available from: 2012-09-10 Created: 2012-09-10 Last updated: 2017-12-07
Suska, A., Alehagen, U., Lundström, I. & Dahlström, U. (2012). Salivary Alpha-Amylase Activity, a New Biomarker in Heart Failure?. Journal of Clinical and Experimental Cardiology, S2
Open this publication in new window or tab >>Salivary Alpha-Amylase Activity, a New Biomarker in Heart Failure?
2012 (English)In: Journal of Clinical and Experimental Cardiology, ISSN 2155-9880, Vol. S2Article in journal (Refereed) Published
Abstract [en]

Salivary α-amylase activity is an increasingly investigated biomarker for the activation of the autonomic nervous system. Autonomic imbalance is associated to several diseases, one of which is heart failure, and the aim of the present study was to test if salivary α-amylase activity might be a new biomarker in patients with chronic heart failure.

Methods: In this pilot study, 48 elderly men (range 59-89 years), 24 patients with established chronic heart failure in NYHA class I to III, and 24 controls were included. In all participants, saliva was collected for three consecutive days at three time points (at awakening, 30 minutes later and in the late afternoon), and blood was sampled for analysis of NT-proBNP.

Results: Within the whole group of participants, a statistically significant positive correlation between morning salivary α-amylase activity levels and serum NT-proBNP could be found, which was strongest for the measurement taken 30 minutes after awakening, as well as a significant negative correlation of awakening α-amylase activity levels with arterial blood pressure.

Within the control group separately, higher daily salivary α-amylase activity output correlated with increasing levels of NT-proBNP, while within the patients, the strongest association of α-amylase activity measures were found to be a negative correlation with blood pressure.

Conclusions: Our data supports the idea that sAA activity has the potential as a non-invasive index of adrenergic activity in specific pathological conditions, though for heart failure in particular the results were merely modest, which was likely due to the specific intake of beta-receptor blocking drugs by all patients. Due to the large variability of sAA activity levels, we expect a greater potential for monitoring its changes over time, which could prove a valuable surrogate biomarker for cardiovascular diseases, including heart failure.

Keywords
Saliva; Salivary !-amylase; Alpha-amylase; Heart failure;
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-87295 (URN)10.4172/2155-9880.S2-005 (DOI)
Available from: 2013-01-16 Created: 2013-01-16 Last updated: 2013-09-26
Preechaburana, P., Gonzalez, M., Suska, A. & Filippini, D. (2012). Surface Plasmon Resonance Chemical Sensing on Cell Phones. Angewandte Chemie International Edition, 51(46), 11585-11588
Open this publication in new window or tab >>Surface Plasmon Resonance Chemical Sensing on Cell Phones
2012 (English)In: Angewandte Chemie International Edition, ISSN 1433-7851, E-ISSN 1521-3773, Vol. 51, no 46, p. 11585-11588Article in journal (Refereed) Published
Abstract [en]

Chemosensing based on angle-resolved surface plasmon resonance is demonstrated on intact cell phones using a disposable optical coupler and software to configure illumination and acquisition. This coupler operates on different cell phones and is applied for classical affinity assays with commercial chips and custom-made tests with embedded calibration. Measured performance (2.14x10−6 refractive index units) is comparable with compact SPR systems.

Place, publisher, year, edition, pages
Wiley Online Library, 2012
Keywords
Analytical methods; cell phone; sensors; surface plasmon resonanced
National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-86179 (URN)10.1002/anie.201206804 (DOI)000310875700032 ()
Available from: 2012-12-10 Created: 2012-12-10 Last updated: 2017-12-07Bibliographically approved
Preechaburana, P., Macken, S., Suska, A. & Filippini, D. (2011). HDR imaging evaluation of a NT-proBNP test with a mobile phone.. Biosensors & bioelectronics, 26(5), 2107-2113
Open this publication in new window or tab >>HDR imaging evaluation of a NT-proBNP test with a mobile phone.
2011 (English)In: Biosensors & bioelectronics, ISSN 0956-5663, E-ISSN 1873-4235, Vol. 26, no 5, p. 2107-2113Article in journal (Refereed) Published
Abstract [en]

The determination of NT-proBNP levels is key for the monitoring of patients with diagnosed heart failure and it is a routine measurement typically performed at health care centers, which would benefit from decentralized alternatives. Here we investigate the quantitative evaluation of a well-established NT-proBNP test using a standard mobile phone (Nokia 6720) as measuring platform rather than a dedicated instrument. A Java ME software developed for this application controls the illumination and imaging of the proBNP test under defined time intervals, which enables the composition of multi-exposure sets that are processed as high dynamic range (HDR) images for contrast enhancement. The results show that HDR processing significantly increases the sensitivity and resolution of the technique achieving a performance within the diagnostics range. These results demonstrate the feasibility to exploit a ubiquitous device to decentralize the evaluation of a routine test and identify key processing alternatives to bring the performance of such systems within the diagnostics range.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-63708 (URN)10.1016/j.bios.2010.09.015 (DOI)000286904400051 ()20926279 (PubMedID)
Available from: 2010-12-30 Created: 2010-12-30 Last updated: 2017-12-11Bibliographically approved
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