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Fortin, Marc-André
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Publications (4 of 4) Show all publications
Petoral, R. M., Söderlind, F., Klasson, A., Suska, A., Fortin, M.-A., Abrikossova, N., . . . Uvdal, K. (2009). Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals: A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties. The Journal of Physical Chemistry C, 113(17), 6913-6920
Open this publication in new window or tab >>Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals: A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties
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2009 (English)In: The Journal of Physical Chemistry C, ISSN 1932-7447, E-ISSN 1932-7455, Vol. 113, no 17, p. 6913-6920Article in journal (Refereed) Published
Abstract [en]

Ultrasmall gadolinium oxide nanoparticles doped with terbium ions were synthesized by the polyol route and characterized as a potentially bifunctional material with both fluorescent and magnetic contrast agent properties. The structural, optical, and magnetic properties of the organic-acid-capped and PEGylated Gd2O3:Tb3+ nanocrystals were studied by HR-TEM, XPS, EDX, IR, PL, and SQUID. The luminescent/fluorescent property of the particles is attributable to the Tb3+ ion located on the crystal lattice of the Gd2O3 host. The paramagnetic behavior of the particles is discussed. Pilot studies investigating the capability of the nanoparticles for fluorescent labeling of living cells and as a MRI contrast agent were also performed. Cells of two cell lines (THP-1 cells and fibroblasts) were incubated with the particles, and intracellular particle distribution was visualized by confocal microscopy. The MRI relaxivity of the PEGylated nanoparticles in water at low Gd concentration was assessed showing a higher T-1 relaxation rate compared to conventional Gd-DTPA chelates and comparable to that of undoped Gd2O3 nanoparticles.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-12944 (URN)10.1021/jp808708m (DOI)000265529700009 ()
Note

On the day of the defence date the status of this article was Submitted

Available from: 2008-02-21 Created: 2008-02-21 Last updated: 2018-10-29Bibliographically approved
Söderlind, F., Fortin, M. A., Petoral, R. M., Klasson, A., Veres, T., Engström, M., . . . Käll, P.-O. (2008). Colloidal synthesis and characterization of ultrasmall perovskite GdFeO3 nanocrystals. Nanotechnology, 19(8), 085608
Open this publication in new window or tab >>Colloidal synthesis and characterization of ultrasmall perovskite GdFeO3 nanocrystals
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2008 (English)In: Nanotechnology, ISSN 0957-4484, Vol. 19, no 8, p. 085608-Article in journal (Refereed) Published
Abstract [en]

Synthesis of very small (about 4 nm) perovskite structured gadolinium orthoferrite nanoparticles (GdFeO3) was performed by the polyol method. The material shows promising relaxivity properties and potential as a contrast agent in magnetic resonance imaging. The perovskite nanoparticles were characterized by x-ray diffraction, transmission electron microscopy, energy dispersive x-ray spectroscopy, Fourier transform infrared spectroscopy, magnetic resonance, and magnetization measurements. Upon heating in air at 800 °C for 3 h the size of the crystals increased to about 40 nm. The crystalline structure of the heat treated compound is in good agreement with perovskite GdFeO3 as the primary product. Contributions from various secondary phases were also identified, including one hitherto unknown phase with the suggested composition 'Gd3FeO6' and isostructural with Gd3GaO6. The novel 'Gd3FeO6' phase appears to be kinetically stabilized in the nano state.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-13298 (URN)10.1088/0957-4484/19/8/085608 (DOI)000252967400014 ()
Available from: 2008-05-21 Created: 2008-05-21 Last updated: 2015-10-09
Fortin, M.-A., Petoral Jr, R. M., Söderlind, F., Klasson, A., Engström, M., Veres, T., . . . Uvdal, K. (2007). Polyethylene glycol-cover ultra-small Gd2O3 nanoparticles for positive contras at 1.5 T magnetic resonance clinical scanning. Nanotechnology, 18(39), 395501
Open this publication in new window or tab >>Polyethylene glycol-cover ultra-small Gd2O3 nanoparticles for positive contras at 1.5 T magnetic resonance clinical scanning
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2007 (English)In: Nanotechnology, ISSN 0957-4484, Vol. 18, no 39, p. 395501-Article in journal (Refereed) Published
Abstract [en]

The size distribution and magnetic properties of ultra-small gadolinium oxide crystals (US-Gd2O3) were studied, and the impact of polyethylene glycol capping on the relaxivity constants (r1, r2) and signal intensity with this contrast agent was investigated. Size distribution and magnetic properties of US-Gd2O3 nanocrystals were measured with a TEM and PPMS magnetometer. For relaxation studies, diethylene glycol (DEG)-capped US-Gd2O3 nanocrystals were reacted with PEG-silane (MW 5000). Suspensions were adequately dialyzed in water to eliminate traces of Gd3+ and surfactants. The particle hydrodynamic radius was measured with dynamic light scattering (DLS) and the proton relaxation times were measured with a 1.5 T MRI scanner. Parallel studies were performed with DEG–Gd2O3 and PEG-silane–SPGO (Gd2O3,< 40 nm diameter). The small and narrow size distribution of US-Gd2O3 was confirmed with TEM (~3 nm) and DLS. PEG-silane–US-Gd2O3 relaxation parameters were twice as high as for Gd–DTPA and the r2/r1 ratio was 1.4. PEG-silane–SPGO gave low r1 relaxivities and high r2/r1 ratios, less compatible with positive contrast agent requirements. Higher r1 were obtained with PEG-silane in comparison to DEG–Gd2O3. Treatment of DEG–US-Gd2O3 with PEG-silane provides enhanced relaxivity while preventing aggregation of the oxide cores. This study confirms that PEG-covered Gd2O3 nanoparticles can be used for positively contrasted MR applications requiring stability, biocompatible coatings and nanocrystal functionalization.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-13297 (URN)10.1088/0957-4484/18/39/395501 (DOI)000249283300006 ()
Available from: 2008-05-21 Created: 2008-05-21 Last updated: 2015-12-17
Fortin, M.-A., Petoral, R. J., Söderlind, F., Käll, P.-O., Engström, M. & Uvdal, K. (2006). Synthesis of gadolinium oxide nanoparticles as a contrast agent in MRI. In: Trends in Nanotechnology,2006.
Open this publication in new window or tab >>Synthesis of gadolinium oxide nanoparticles as a contrast agent in MRI
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2006 (English)In: Trends in Nanotechnology,2006, 2006Conference paper, Published paper (Other academic)
Abstract [en]

       

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-36903 (URN)32989 (Local ID)32989 (Archive number)32989 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2013-09-04
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