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Leanderson, Per
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Publications (10 of 36) Show all publications
Chung, R., Leanderson, P., Gustafsson, N. & Jonasson, L. (2019). Liberation of lutein from spinach: Effects of heating time, microwavereheating and liquefaction. Food Chemistry, 277, 573-578
Open this publication in new window or tab >>Liberation of lutein from spinach: Effects of heating time, microwavereheating and liquefaction
2019 (English)In: Food Chemistry, ISSN 0308-8146, E-ISSN 1873-7072, Vol. 277, p. 573-578Article in journal (Refereed) Published
Abstract [en]

Lutein, abundant in dark leafy vegetables, has been associated with several health promoting effects. Still, to what extent different preparation conditions and practices affect the liberation of lutein from food is not fully understood. Here, we compared a range of domestic methods under realistic conditions to prepare spinach, the most common lutein-rich vegetable. After preparations, samples were processed by in vitro digestion and lutein was quantified by HPLC. Data indicate that short-term and medium-term heating of spinach, independent of heating method, substantially reduced liberated lutein and reduction was most pronounced after long boiling times. Interestingly, the loss of lutein in heated samples was partly compensated when samples were reheated in the microwave. However, the highest yield of liberated lutein was obtained from liquefied spinach. Additional dairy enhanced the liquefaction effect. Thus, for optimal liberation of lutein, liquefaction of raw spinach appears to be the method of choice.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Lutein; Liberation; Spinach; Microwave; Heat; Juice; Smoothie
National Category
Food Science
Identifiers
urn:nbn:se:liu:diva-153490 (URN)10.1016/j.foodchem.2018.11.023 (DOI)000451430800070 ()30502187 (PubMedID)2-s2.0-85056223775 (Scopus ID)
Note

Funding Agencies|Heart Lung Foundation, Sweden [20150648]; Swedish Research Council, Sweden [2014-2479]

Available from: 2019-01-02 Created: 2019-01-02 Last updated: 2019-01-30Bibliographically approved
Nosratabadi, A. R., Graff, P., Karlsson, H., Ljungman, A. & Leanderson, P. (2019). Use of TEOM monitors for continuous long-term sampling of ambient particles for analysis of constituents and biological effects. Air quality, atmosphere and health, 12(2), 161-171
Open this publication in new window or tab >>Use of TEOM monitors for continuous long-term sampling of ambient particles for analysis of constituents and biological effects
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2019 (English)In: Air quality, atmosphere and health, ISSN 1873-9318, E-ISSN 1873-9326, Vol. 12, no 2, p. 161-171Article in journal (Refereed) Published
Abstract [en]

Many countries have implemented exposure limits for the concentration of ambient particular matter and do therefore have to monitor their concentration. This could be performed with TEOM monitors (Tapered Element Oscillating Microbalance-monitors) that contain a filter on which particles are collected. These filters are regularly exchanged for new ones. The aim of this study was to test the feasibility of collecting used filters from monitors at different locations and establishing a method to extract particles and then study them with respect to their ability to generate oxidants, their endotoxin content, and ability to activate inflammatory cells. Filters from nine geographically spread locations in Sweden were collected during a 21-month period by local technicians who then sent them to the laboratory where they were extracted and analyzed. The procedure to let local technicians perform the filter exchange and send used TEOM filters to the laboratory worked well. A method was established in which pyrogen-free water was used to extract particles that then were aliquoted and stored for later analysis. Particulate matter (PM10) from different locations showed both a considerable seasonal and spatial-dependent difference with respect to oxidative potential (oxidize glutathione), endotoxin content, and ability to activate blood monocytes to release interleukin-1β. This study shows that, instead of discarding TEOM filters, they can be collected and extracted so that particles that have been sampled in a standardized way could be analyzed with respect to variables that reflect their toxicity. This could be done at a low cost. In combination with information about the ambient particle concentration, such information could be helpful in the evaluation of differences in the risk of breathing air at various locations.

Place, publisher, year, edition, pages
Springer Netherlands, 2019
Keywords
Air pollution, TEOM monitor, Ambient particles, Surface reactivity, Endotoxin, Seasonal variation
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:liu:diva-154602 (URN)10.1007/s11869-018-0638-5 (DOI)000458121600004 ()2-s2.0-85056389584 (Scopus ID)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-03-15Bibliographically approved
Fridell, S., Ström, E., Agebratt, C., Leanderson, P., Guldbrand, H. & Nyström, F. H. (2018). A randomised study in young subjects of the effects of eating extra fruit or nuts on periodontal inflammation. BDJ open, 3, Article ID 17022.
Open this publication in new window or tab >>A randomised study in young subjects of the effects of eating extra fruit or nuts on periodontal inflammation
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2018 (English)In: BDJ open, ISSN 2056-807X, Vol. 3, article id 17022Article in journal (Refereed) Published
Abstract [en]

Objectives/Aims:

Fruit is often advocated as a healthy source of nutrients and vitamins. However, the high contents of sugars in many fruits could potentially counteract positive effects on the teeth.

Materials and methods:

We recruited 30 healthy non-obese participants who were randomised to either supplement their diet with extra fruits or nuts, each at +7 kcal/kg body weight/day, for 2 months.

Results:

Fructose intake increased from 9.1±6.0 to 25.6±9.6 g/day, P<0.0001, in the fruit group and was reduced from 12.4±5.7 to 6.5±5.3 g/day, P=0.007, in the nut group. Serum-vitamin C increased in both groups (fruit: P=0.017; nuts: P=0.009). α-Tocopherol/cholesterol ratio increased in the fruit group (P=0.0033) while β-carotene/cholesterol decreased in the nut group (P<0.0001). The amount of subjects with probing pocket depths ⩾4 mm in the fruit group was reduced (P=0.045) according to blinded examinations, and the difference in the changes in probing pockets ⩾4 mm was also statistically significant between the food groups (P=0.010).

Conclusion:

A large increase of fruit intake, compared with nuts, had a favourable effect on periodontal status in some respects, despite the high sugar contents. To search for potential protective micronutrients in fruit that protect the teeth could be an aim for further research.

Place, publisher, year, edition, pages
Nature Publishing Group, 2018
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:liu:diva-152523 (URN)10.1038/bdjopen.2017.22 (DOI)29607092 (PubMedID)
Available from: 2019-03-28 Created: 2019-03-28 Last updated: 2019-04-02Bibliographically approved
Kentson, M., Leanderson, P., Jacobson, P. & Persson, H. L. (2018). Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT. European Clinical Respiratory Journal, 5(1)
Open this publication in new window or tab >>Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT
2018 (English)In: European Clinical Respiratory Journal, ISSN 2001-8525, Vol. 5, no 1Article in journal (Refereed) Published
Abstract [en]

Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species. Oxidative reactions are prevented by antioxidants such as carotenoids. Objective: To study the differences in Fe status, carotenoid levels, healthy eating habits, and markers of inflammation and oxidative damage on proteins in subjects with severe COPD ± long-term oxygen therapy (LTOT) and lung-healthy control subjects. Methods: Sixty-six Caucasians with advanced COPD (28 with LTOT) and 47 control subjects were included. Questionnaires about general health, lifestyle, and dietary habits were answered. Lung function tests and blood sampling were performed. Results: COPD subjects (±LTOT) did not demonstrate increased oxidative damage, assessed by protein carbonylation (PC), while levels of soluble transferrin receptors (sTfRs) were slightly elevated. Soluble TfRs, which is inversely related to Fe status, was negatively associated with PC. Levels of carotenoids, total and ß-cryptoxanthin, a- and ß-carotenes, were significantly lower in COPD subjects, and their diet contained significantly less fruits and vegetables. Lutein correlated inversely with IL-6, lycopene correlated inversely with SAT, while ß-carotene was positively associated with a Mediterranean-like diet. Conclusions: Fe could favor oxidative stress in COPD patients, suggesting a cautious use of Fe prescription to these patients. COPD subjects ate a less healthy diet than control subjects did and would, therefore, benefit by dietary counseling. COPD patients with hypoxemia are probably in particular need of a lycopene-enriched diet.

Place, publisher, year, edition, pages
Taylor & Francis, 2018
Keywords
Antioxidants; free radicals; hypoxemia; inflammation; long-term oxygen therapy
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-152520 (URN)10.1080/20018525.2018.1447221 (DOI)29696082 (PubMedID)
Available from: 2019-03-08 Created: 2019-03-08 Last updated: 2019-04-30
Flodin, U., Paues, J., Åkerlind, B., Leanderson, P. & Sjögren, B. (2017). Svetsare – en riskgrupp för septisk pneumoni [Welders - a risk group for septic pneumonia]: Vaccination mot pneumokocker kan vara motiverat för yrkesgruppen. Läkartidningen, 114(6)
Open this publication in new window or tab >>Svetsare – en riskgrupp för septisk pneumoni [Welders - a risk group for septic pneumonia]: Vaccination mot pneumokocker kan vara motiverat för yrkesgruppen
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2017 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 114, no 6Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Sveriges Läkarförbund, 2017
National Category
Infectious Medicine
Identifiers
urn:nbn:se:liu:diva-145292 (URN)28195626 (PubMedID)
Available from: 2018-03-06 Created: 2018-03-06 Last updated: 2018-03-26Bibliographically approved
Agebratt, C., Ström, E., Romu, T., Dahlqvist Leinhard, O., Borga, M., Leandersson, P. & Nyström, F. H. (2016). A Randomized Study of the Effects of Additional Fruit and Nuts Consumption on Hepatic Fat Content, Cardiovascular Risk Factors and Basal Metabolic Rate. PLoS ONE, 11(1), e0147149
Open this publication in new window or tab >>A Randomized Study of the Effects of Additional Fruit and Nuts Consumption on Hepatic Fat Content, Cardiovascular Risk Factors and Basal Metabolic Rate
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2016 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 1, p. e0147149-Article in journal (Refereed) Published
Abstract [en]

Background

Fruit has since long been advocated as a healthy source of many nutrients, however, the high content of sugars in fruit might be a concern.

Objectives

To study effects of an increased fruit intake compared with similar amount of extra calories from nuts in humans.

Methods

Thirty healthy non-obese participants were randomized to either supplement the diet with fruits or nuts, each at +7 kcal/kg bodyweight/day for two months. Major endpoints were change of hepatic fat content (HFC, by magnetic resonance imaging, MRI), basal metabolic rate (BMR, with indirect calorimetry) and cardiovascular risk markers.

Results

Weight gain was numerically similar in both groups although only statistically significant in the group randomized to nuts (fruit: from 22.15±1.61 kg/m2 to 22.30±1.7 kg/m2, p = 0.24 nuts: from 22.54±2.26 kg/m2 to 22.73±2.28 kg/m2, p = 0.045). On the other hand BMR increased in the nut group only (p = 0.028). Only the nut group reported a net increase of calories (from 2519±721 kcal/day to 2763±595 kcal/day, p = 0.035) according to 3-day food registrations. Despite an almost three-fold reported increased fructose-intake in the fruit group (from 9.1±6.0 gram/day to 25.6±9.6 gram/day, p<0.0001, nuts: from 12.4±5.7 gram/day to 6.5±5.3 gram/day, p = 0.007) there was no change of HFC. The numerical increase in fasting insulin was statistical significant only in the fruit group (from 7.73±3.1 pmol/l to 8.81±2.9 pmol/l, p = 0.018, nuts: from 7.29±2.9 pmol/l to 8.62±3.0 pmol/l, p = 0.14). Levels of vitamin C increased in both groups while α-tocopherol/cholesterol-ratio increased only in the fruit group.

Conclusions

Although BMR increased in the nut-group only this was not linked with differences in weight gain between groups which potentially could be explained by the lack of reported net caloric increase in the fruit group. In healthy non-obese individuals an increased fruit intake seems safe from cardiovascular risk perspective, including measurement of HFC by MRI.

Keywords
Fruits Basal metabolic rate measurement Fats Vitamin C Fructoses Diet Fatty liver Magnetic resonance imaging
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:liu:diva-124605 (URN)10.1371/journal.pone.0147149 (DOI)000368529100062 ()26788923 (PubMedID)
Note

Funding agencies: County Council of Ostergotland; Linkoping University, Department of Medical and Health Sciences

Available from: 2016-02-05 Created: 2016-02-05 Last updated: 2019-06-14
Fornander, L., Graff, P., Wåhlén, K., Ydreborg, K., Flodin, U., Leanderson, P., . . . Ghafouri, B. (2013). Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids. PLoS ONE, 8(12), e83089
Open this publication in new window or tab >>Airway symptoms and biological markers in nasal lavage fluid in subjects exposed to metalworking fluids
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2013 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 12, p. e83089-Article in journal (Refereed) Published
Abstract [en]

BACKGROUNDS: Occurrence of airway irritation among industrial metal workers was investigated. The aims were to study the association between exposures from water-based metal working fluids (MWF) and the health outcome among the personnel, to assess potential effects on the proteome in nasal mucous membranes, and evaluate preventive actions.

METHODS: The prevalence of airway symptoms related to work were examined among 271 metalworkers exposed to MWF and 24 metal workers not exposed to MWF at the same factory. At the same time, air levels of potentially harmful substances (oil mist, morpholine, monoethanolamine, formaldehyde) generated from MWF was measured. Nasal lavage fluid was collected from 13 workers and 15 controls and protein profiles were determined by a proteomic approach.

RESULTS: Airway symptoms were reported in 39% of the workers exposed to MWF although the measured levels of MWF substances in the work place air were low. Highest prevalence was found among workers handling the MWF machines but also those working in the same hall were affected. Improvement of the ventilation to reduce MWF exposure lowered the prevalence of airway problems. Protein profiling showed significantly higher levels of S100-A9 and lower levels of SPLUNC1, cystatin SN, Ig J and β2-microglobulin among workers with airway symptoms.

CONCLUSIONS: This study confirms that upper airway symptoms among metal workers are a common problem and despite low levels of MWF-generated substances, effects on airway immune proteins are found. Further studies to clarify the role of specific MWF components in connection to airway inflammation and the identified biological markers are warranted.

Place, publisher, year, edition, pages
Public Library of Science, 2013
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-103739 (URN)10.1371/journal.pone.0083089 (DOI)000329325200035 ()24391738 (PubMedID)
Available from: 2014-01-24 Created: 2014-01-24 Last updated: 2019-02-11Bibliographically approved
Rydén, M., Garvin, P., Kristenson, M., Leanderson, P., Ernerudh, J. & Jonasson, L. (2012). Provitamin A carotenoids are independently associated with matrix metalloproteinase-9 in plasma samples from a general population. Journal of Internal Medicine, 272(4), 371-384
Open this publication in new window or tab >>Provitamin A carotenoids are independently associated with matrix metalloproteinase-9 in plasma samples from a general population
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2012 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 272, no 4, p. 371-384Article in journal (Refereed) Published
Abstract [en]

Background and aim:  Carotenoids in plasma are inversely associated with cardiovascular risk. Low levels can be explained by low dietary intake but also by a number of other factors including inflammatory activity. Given that matrix metalloproteinase (MMP)-9 has an important role in inflammation and cardiovascular disease, we hypothesized that circulating MMP-9 levels would be inversely related to total or single carotenoids in a general population cohort. Methods:  A well-characterized population-based cohort of 285 Swedish men and women (45-69 years) was used for the present study. The intake of carotenoid-rich fruits and vegetables was estimated from a food frequency questionnaire. Levels of MMP-9, C-reactive protein (CRP), interleukin (IL)-6 and six major carotenoids [β-cryptoxanthine, α-carotene, β-carotene, lutein (+ zeaxanthin) and lycopene] were determined in plasma. Results:  Lower plasma levels of total and single carotenoids were associated with lower dietary intake of carotenoids, older age, male sex, lower physical activity, higher alcohol consumption, higher body mass index (BMI), higher systolic and diastolic blood pressures, lower levels of total cholesterol and HDL cholesterol and higher levels of CRP, IL-6 and MMP-9. After multivariate adjustments, plasma levels of total carotenoids and provitamin A carotenoids (β-cryptoxanthine, α-carotene and β-carotene) remained independently associated with sex, dietary intake of carotenoids, BMI, HDL cholesterol and MMP-9, while associations with CRP and IL-6 were not maintained. Neither dietary intake of carotenoid-rich fruits and vegetables, nor vitamin supplement use was associated with MMP-9, CRP or IL-6 levels. Conclusion:  Plasma carotenoids were associated with a variety of factors including age, sex, dietary intake and metabolic variables. A new finding was the independent relationship in plasma between low provitamin A carotenoids and high MMP-9, suggesting a link between these carotenoids, matrix turnover and arterial remodelling. © 2012 The Association for the Publication of the Journal of Internal Medicine.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012
Keywords
CMOS, photon counting, spectral computed tomography, x-ray detection
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-75982 (URN)10.1111/j.1365-2796.2012.2534x.x (DOI)000308877500005 ()22372952 (PubMedID)
Note

funding agencies|Swedish Heart-Lung Foundation||Swedish Research Council||Linkoping University||

Available from: 2012-03-21 Created: 2012-03-21 Last updated: 2017-12-07
Rydén, M., Leanderson, P., Garvin, P., Kristenson, M. & Jonasson, L. (2011). Carotenoid levels in plasma: can dietary intake and inflammation explain variability?. In: : . Paper presented at The ESC Congress 2011, Paris, France, August 27-31. Oxford: Oxford University Press, 31(Suppl. 675), Article ID P4149.
Open this publication in new window or tab >>Carotenoid levels in plasma: can dietary intake and inflammation explain variability?
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2011 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Purpose: Low plasma levels of carotenoids and low dietary intake of carotenoids are both linked to increased cardiovascular risk. The supply of carotenoids depends on dietary sources. However, it has also been shown that inflammation may have major influence on plasma carotenoids. The aim of this study was to examine the association of plasma carotenoids with dietary intake of carotenoids and a panel of inflammatory markers including matrix metalloproteinase (MMP)-9.

Methods: A population-based cohort consisting of 285 Swedish men and women (45-69 years) was studied. Fruit and vegetable consumption was estimated from a validated 92-item semi-quantitative food-frequency questionnaire. Plasma levels of C-reactive protein, interleukin (IL)-6, IL-8, myeloperoxidase and MMP-9 were determined as were plasma concentrations of 5 major carotenoids: lutein, β-crypthoxanthine, lycopen, α-carotene and β-carotene.

Result: Lower plasma levels of lipid-adjusted carotenoids (low vs top tertile) were significantly associated with higher age, male sex, higher body mass index (BMI), higher systolic and diastolic blood pressure, higher IL-6 and MMP-9 levels and lower intake of carotenoid-rich food. Low dietary intake of carotenoids was related to male sex, smoking and low plasma carotenoids. After adjustment for age, sex, BMI, blood pressure, physical activity, smoking, dietary intake, IL-6 and MMP-9, plasma carotenoids remained associated with age (Beta= -0.17, p<0.01), sex (Beta=0.19, p<0.01), BMI (Beta= -0.19, p<0.01), dietary intake (Beta=0.21, p<0.01) and MMP-9 (Beta= -0.13, p<0.05). However, these associations differed among individual carotenoids, e.g. the correlation to MMP-9 was restricted to α-carotene (Beta= -0.13, p<0.05) and the correlation to sex was restricted to α-carotene (Beta=0.23, p<0.001) and β-carotene (Beta=0.18, p<0.01).

Conclusion: In this population-based study, plasma carotenoids reflected dietary intake of carotenoids but to a minor extent. Also, levels of inflammatory markers explained very little of the variability in plasma carotenoids. Instead, age, sex and BMI independently influenced the levels of carotenoids. In cardiovascular risk management, we need to better understand the potential determinants of carotenoid levels in plasma.

Place, publisher, year, edition, pages
Oxford: Oxford University Press, 2011
Series
European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-71331 (URN)000208702705321 ()
Conference
The ESC Congress 2011, Paris, France, August 27-31
Available from: 2011-10-12 Created: 2011-10-12 Last updated: 2017-02-09Bibliographically approved
Wieslander, G., Fabjan, N., Vogrincic, M., Kreft, I., Janson, C., Spetz-Nystrom, U., . . . Norback, D. (2011). Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs. Tohoku journal of experimental medicine, 225(2), 123-130
Open this publication in new window or tab >>Eating Buckwheat Cookies Is Associated with the Reduction in Serum Levels of Myeloperoxidase and Cholesterol: A Double Blind Crossover Study in Day-Care Centre Staffs
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2011 (English)In: Tohoku journal of experimental medicine, ISSN 0040-8727, E-ISSN 1349-3329, Vol. 225, no 2, p. 123-130Article in journal (Refereed) Published
Abstract [en]

Buckwheat food is a good source of antioxidants, e.g. rutin, and other beneficial substances. Here we investigated the effects of the intake of common buckwheat (low rutin content) and tartary buckwheat cookies (high rutin content) on selected clinical markers. A double blind crossover study was performed among female day-care centre staffs (N = 62) from five day-care centres. Participants were randomly divided into two groups. The first group initially consumed four common buckwheat cookies per day (16.5 mg rutin equivalents/day) for two weeks, while the second group consumed four tartary buckwheat cookies per day (359.7 mg rutin equivalents/day). Then the groups switched their type of cookies and consumed them for another two weeks. We monitored selected clinical markers related to cardiovascular disease and lower airway inflammation, lung function, and subjective breathing difficulties in the staffs. Intake of tartary buckwheat cookies reduced the serum level of myeloperoxidase (MPO) by a factor 0.84 (p = 0.02). When grouping the two types of buckwheat cookies together, there was a reduction of total serum cholesterol (p andlt; 0.001) and HDL-cholesterol (p andlt; 0.001) during the study period, with improved lung vital capacity (p andlt; 0.001). The degree of reduction in total and HDL cholesterol levels was similar in staffs with low and high body mass index (cut off 25). In conclusion, intake of tartary buckwheat cookies with high level of the antioxidant rutin may reduce levels of MPO, an indicator of inflammation. Moreover, intake of both types of buckwheat cookies may lower cholesterol levels.

Place, publisher, year, edition, pages
Tohoku University Medical Press, 2011
Keywords
antioxidant experiment, buckwheat, cholesterol, inflammation, lung function
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-71794 (URN)10.1620/tjem.225.123 (DOI)000295498500009 ()
Available from: 2011-11-04 Created: 2011-11-04 Last updated: 2017-12-08
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