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Maller, Rolf
Publications (10 of 13) Show all publications
Hammar, M., Asp, M., Berlin, G., Dahlström, U., Eintrei, C., Ekdahl, A., . . . Maller, R. (2006). A new program for better clinical supervision of students. A joint project at the Halsouniversitet and county council in Ostergotland. Läkartidningen, 103, 649-654
Open this publication in new window or tab >>A new program for better clinical supervision of students. A joint project at the Halsouniversitet and county council in Ostergotland
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2006 (English)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, p. 649-654Article in journal (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-34878 (URN)23764 (Local ID)23764 (Archive number)23764 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Hammar, M., Asp, M., Berlin, G., Dahlström, U., Eintrei, C., Ekdahl, A., . . . Maller, R. (2006). Ny handlingsplan för bättre klinisk handledning av studenter.. Läkartidningen, 103, 649-654
Open this publication in new window or tab >>Ny handlingsplan för bättre klinisk handledning av studenter.
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2006 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, p. 649-654Article in journal (Other academic) Published
Abstract [sv]

    

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-37177 (URN)33866 (Local ID)33866 (Archive number)33866 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Maller, R. (2004). Infektioner i hud och mjukdelar (3ed.). In: Iwarson-Norrby (Ed.), Infektionsmedicin: epidemiologi, klinik, terapi (pp. 313-323). Säve Förlag
Open this publication in new window or tab >>Infektioner i hud och mjukdelar
2004 (Swedish)In: Infektionsmedicin: epidemiologi, klinik, terapi / [ed] Iwarson-Norrby, Säve Förlag , 2004, 3, p. 313-323Chapter in book (Other academic)
Place, publisher, year, edition, pages
Säve Förlag, 2004 Edition: 3
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-33045 (URN)19008 (Local ID)91-972689-7-6 (ISBN)978-9-19726-897-4 (ISBN)19008 (Archive number)19008 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-10-25Bibliographically approved
Maller, R. (2004). Infektioner i skelett och leder (3ed.). In: Iwarson-Norrby och Iwarson, Sten (Ed.), Infektionmedicin: epidemiologi, klinik, terapi (pp. 324-348). Säve Förlag
Open this publication in new window or tab >>Infektioner i skelett och leder
2004 (Swedish)In: Infektionmedicin: epidemiologi, klinik, terapi / [ed] Iwarson-Norrby och Iwarson, Sten, Säve Förlag , 2004, 3, p. 324-348Chapter in book (Other academic)
Place, publisher, year, edition, pages
Säve Förlag, 2004 Edition: 3
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-33046 (URN)19009 (Local ID)91-972689-7-6 (ISBN)978-9-1972-6897-4 (ISBN)19009 (Archive number)19009 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-10-25Bibliographically approved
Ekdahl, C., Broqvist, M., Franzén, S., Ljunghusen, O., Maller, R. & Sander, B. (2002). IL-8 and tumor necrosis factor alpha in heart valves from patients with infective endocarditis. Scandinavian Journal of Infectious Diseases, 34(10), 759-762
Open this publication in new window or tab >>IL-8 and tumor necrosis factor alpha in heart valves from patients with infective endocarditis
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2002 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, Vol. 34, no 10, p. 759-762Article in journal (Refereed) Published
Abstract [en]

The embedding of bacteria in the vegetation of infective endocarditis impedes the penetration of phagocytic cells. IL-8 has a stimulating effect on the immune system, particularly with respect to chemotaxis and activation of granulocytes. Tumor necrosis factor alpha (TNF-) is 1 of the major proinflammatory cytokines. IL-8 and TNF- were visualized by means of immunohistochemistry in paraffin-embedded heart valve biopsies from 6 patients with infective endocarditis who required cardiac surgery during the active phase of the infection. In 5/6 patients there were signs of inflammation, and in these patients IL-8- and TNF- -containing cells were visualized in the heart valve stromas or vegetations. The largest numbers of IL-8-containing cells, and the greatest amount of inflammation, were seen in patients with short preoperative treatment courses. No such relationships were seen with respect to TNF- -containing cells. These observations may suggest that the occurrence of IL-8-containing cells in infected heart valves could be used as a marker of disease activity.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13332 (URN)10.1080/00365540210147912 (DOI)
Available from: 2008-06-18 Created: 2008-06-18 Last updated: 2009-08-17
Isaksson, B., Maller, R., Nilsson, L. E. & Nilsson, M. (1993). Postantibiotic effect of aminoglycosides on staphylococci.. Journal of Antimicrobial Chemotherapy, 32(2), 215-222
Open this publication in new window or tab >>Postantibiotic effect of aminoglycosides on staphylococci.
1993 (English)In: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, E-ISSN 1460-2091, Vol. 32, no 2, p. 215-222Article in journal (Refereed) Published
Abstract [en]

The postantibiotic effects (PAEs) of amikacin, gentamicin, netilmicin and tobramycin on Staphylococcus aureus and S. epidermidis were determined in vitro by a bioluminescence assay of bacterial ATP. Five strains of S. aureus and two strains of S. epidermidis were exposed for 1 h to varying concentrations of these aminoglycosides. Following removal of the antibiotics by dilution, bacterial regrowth was monitored at hourly intervals. The duration of the PAE increased with increasing aminoglycoside concentration. The mean PAEs for the five S. aureus strains ranged from 5-10 h at clinically achievable aminoglycoside concentrations (16-32 mg/L of amikacin and 4-8 mg/L of gentamicin, netilmicin and tobramycin). The results for one of the strains of S. epidermidis were similar to those observed for the S. aureus strains, while the PAEs on the other less susceptible S. epidermidis strain were shorter (0.5-2.5 h). For comparison, two of the S. aureus strains were exposed for 1 and 2 h to a range of concentrations of dicloxacillin (0.25-32 mg/L); this agent induced a much shorter PAE (0-2.3 h). It may be important to take account of the PAE when designing dosing regimens.

Place, publisher, year, edition, pages
Oxford University Press, 1993
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-112426 (URN)10.1093/jac/32.2.215 (DOI)8226423 (PubMedID)
Available from: 2015-01-08 Created: 2014-11-26 Last updated: 2017-12-05Bibliographically approved
Hanberger, H., Nilsson, L. E., Maller, R. & Isaksson, B. (1991). Pharmacodynamics of daptomycin and vancomycin on Enterococcus faecalis and Staphylococcus aureus demonstrated by studies of initial killing and postantibiotic effect and influence of Ca2+ and albumin on these drugs.. Antimicrobial Agents and Chemotherapy, 35(9), 1710-1716
Open this publication in new window or tab >>Pharmacodynamics of daptomycin and vancomycin on Enterococcus faecalis and Staphylococcus aureus demonstrated by studies of initial killing and postantibiotic effect and influence of Ca2+ and albumin on these drugs.
1991 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 35, no 9, p. 1710-1716Article in journal (Refereed) Published
Abstract [en]

The pharmacodynamics of daptomycin and vancomycin on Enterococcus faecalis ATCC 29212 and Staphylococcus aureus ATCC 25923 were investigated by studying the postantibiotic effect (PAE) and initial killing. The influence of Ca2+ and albumin on these drugs was also evaluated. The PAE was studied by use of bioluminescence assay of bacterial ATP. Daptomycin at clinically achievable concentrations produced a dose-dependent PAE on E. faecalis (0.6 to 6.7 h) and S. aureus (1.0 to 6.3 h). The long PAE of daptomycin was seen simultaneously with a potent dose-dependent initial killing assayed by viable count determination. The initial change in bacterial ATP was not as extensive as the decrease in viability. Vancomycin at corresponding concentrations produced shorter PAEs on E. faecalis (0.5 to 1.0 h) and S. aureus (1.3 to 1.8 h). This coincides with a weak non-dose-dependent initial change in viability and intracellular ATP. The MICs of vancomycin were not influenced by different Ca2+ concentrations or by the addition of albumin to the broth. The MICs of daptomycin for both strains were lowered, and the PAEs were prolonged with increasing concentrations of Ca2+ in the broth. The PAE of daptomycin was Ca2+ dependent to the same extent as the MIC was. In the presence of physiological concentrations of albumin and free Ca2+, the PAEs of daptomycin on both strains were reduced and the MICs were increased in comparison with the results obtained in pure Mueller-Hinton broth with approximately the same free Ca2+ concentration. This decrease in daptomycin activity was considered to be due to the albumin binding of daptomycin. Despite the albumin binding of daptomycin, the PAE produced on E. faecalis and S. aureus in the presence of a physiological free Ca2+ concentration was still over 6 h at clinically achievable concentrations.

Place, publisher, year, edition, pages
American Society for Microbiology, 1991
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-112427 (URN)1659305 (PubMedID)
Available from: 2015-01-08 Created: 2014-11-26 Last updated: 2017-12-05Bibliographically approved
Isaksson, B., Hanberger, H., Maller, R., Nilsson, L. E. & Nilsson, M. (1991). Synergic post-antibiotic effect of amikacin in combination with beta-lactam antibiotics on gram-negative bacteria.. Journal of Antimicrobial Chemotherapy, 28(1), 25-34
Open this publication in new window or tab >>Synergic post-antibiotic effect of amikacin in combination with beta-lactam antibiotics on gram-negative bacteria.
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1991 (English)In: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, E-ISSN 1460-2091, Vol. 28, no 1, p. 25-34Article in journal (Refereed) Published
Abstract [en]

The post-antibiotic effect (PAE) of amikacin alone and in combination with ceftazidime, ceftriaxone and piperacillin was studied for two strains each of Pseudomonas aeruginosa and Serratia marcescens using a bioluminescent assay of bacterial ATP. Two models were used for combining beta-lactam antibiotics and amikacin: in one model the cultures were incubated with 32 mg/L of ceftazidime, 128 mg/L of ceftriaxone or 32 mg/L of piperacillin for 1 h. Different concentrations of amikacin (0.5-64 mg/L) were then added. Incubation of the combinations continued for one more hour. The antibiotics were eliminated by dilution. In the second model tested, one strain of S. marcescens was simultaneously exposed to amikacin and a beta-lactam antibiotic for 2 h. The PAEs produced by the drugs in combination were longer than the sum of the individual effects of the drugs when they were used alone. Results were equally good with both models. A synergic PAE was also found with amikacin concentrations close to the MIC in combination with low concentrations of ceftazidime, ceftriaxone and piperacillin.

Place, publisher, year, edition, pages
Oxford University Press, 1991
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-112428 (URN)10.1093/jac/28.1.25 (DOI)1769941 (PubMedID)
Available from: 2015-01-08 Created: 2014-11-26 Last updated: 2017-12-05Bibliographically approved
Isaksson, B., Hanberger, H., Maller, R., Nilsson, L. E. & Nilsson, M. (1991). Synergistic post-antibiotic effect of amikacin and beta-lactam antibiotics on Enterococcus faecalis.. Journal of Antimicrobial Chemotherapy, 27, 9-14
Open this publication in new window or tab >>Synergistic post-antibiotic effect of amikacin and beta-lactam antibiotics on Enterococcus faecalis.
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1991 (English)In: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, E-ISSN 1460-2091, Vol. 27, p. 9-14Article in journal (Refereed) Published
Abstract [en]

The in-vitro post-antibiotic effect (PAE) of amikacin alone and in combination with ceftazidime, ceftriaxone and piperacillin was studied for two strains of Enterococcus faecalis using a bioluminescent assay of bacterial ATP. The two strains of E. faecalis were resistant to amikacin, ceftazidime and ceftriaxone but sensitive to piperacillin. The bacterial cultures were incubated with the beta-lactam antibiotics for 1 h and concentrations of amikacin between 2-64 mg/l were then added. Thereafter, incubation continued with the combinations for one more hour. After dilution, regrowth was monitored by measuring bacterial ATP every hour. Increasing concentrations of amikacin (2-64 mg/l), ceftazidime (8-32 mg/l) and ceftriaxone (32-128 mg/l) resulted in little or no PAE (0-0.3 h) on these strains. PAEs of 0.5 to 1.6 h resulted from exposure to piperacillin (4-32 mg/l). In combination amikacin and piperacillin increased the PAE to 5.5 h. A synergistic PAE was also seen when the enterococci were exposed to amikacin combined with ceftazidime or ceftriaxone in concentrations close to the MICs of the latter antibiotics.

Place, publisher, year, edition, pages
Oxford University Press, 1991
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-112429 (URN)10.1093/jac/27.suppl_C.9 (DOI)1906865 (PubMedID)
Available from: 2015-01-08 Created: 2014-11-26 Last updated: 2017-12-05Bibliographically approved
Maller, R., Emanuelsson, B.- . M., Isaksson, B. & Nilsson, L. (1990). Amikacin once daily: a new dosing regimen based on drug pharmacokinetics.. Scandinavian Journal of Infectious Diseases, 22(5), 575-579
Open this publication in new window or tab >>Amikacin once daily: a new dosing regimen based on drug pharmacokinetics.
1990 (English)In: Scandinavian Journal of Infectious Diseases, ISSN 0036-5548, E-ISSN 1651-1980, Vol. 22, no 5, p. 575-579Article in journal (Refereed) Published
Abstract [en]

Once-daily dosing of amikacin is a novel therapy regimen which seems pharmacokinetically appropriate for the primary group of patients considered for aminoglycoside therapy. In this study of 29 elderly patients with serious infections, amikacin 11 mg/kg or 15 mg/kg bw was administered as a short-term (30 min) intravenous infusion. The amikacin serum concentration-time profile was best described by a bi-exponential equation with a half-life of about 4.8 h. A triexponential equation was not applicable because the slow terminal elimination phase was not detected during the 24 h dosing interval. In practice, a uni-exponential equation is often used, and this may lead to incorrect conclusions about the elimination rate of amikacin. Amikacin clearance provides more direct information about elimination of amikacin than does serum half-life. Thus, there was a better correlation between the individual amikacin clearances and creatinine clearances (r = 0.89), than between the serum half-lives of amikacin and the creatinine clearances (r = 0.71). For elderly patients a smaller dose of amikacin than the regular daily dose of 15 mg/kg bw, i.e. about 11 mg/kg bw, seems recommendable, when it is given once daily. From the data obtained it is also obvious that once-daily dosing of amikacin does not eliminate the need for checking serum concentrations of the drug.

National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-112431 (URN)10.3109/00365549009027099 (DOI)2259867 (PubMedID)
Available from: 2015-01-08 Created: 2014-11-26 Last updated: 2017-12-05Bibliographically approved
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