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Olsson, Eva
Publications (10 of 12) Show all publications
Davidsson, A., Olsson, E., Engvall, J. & Gustafsson, A. (2017). Influence of reconstruction algorithms on image quality in SPECT myocardial perfusion imaging. Clinical Physiology and Functional Imaging, 37(6), 655-662
Open this publication in new window or tab >>Influence of reconstruction algorithms on image quality in SPECT myocardial perfusion imaging
2017 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 37, no 6, p. 655-662Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: We investigated if image- and diagnostic quality in SPECT MPI could be maintained despite a reduced acquisition time adding Depth Dependent Resolution Recovery (DDRR) for image reconstruction. Images were compared with filtered back projection (FBP) and iterative reconstruction using Ordered Subsets Expectation Maximization with (IRAC) and without (IRNC) attenuation correction (AC).

MATERIALS AND METHODS: Stress- and rest imaging for 15 min was performed on 21 subjects with a dual head gamma camera (Infinia Hawkeye; GE Healthcare), ECG-gating with 8 frames/cardiac cycle and a low-dose CT-scan. A 9 min acquisition was generated using five instead of eight gated frames and was reconstructed with DDRR, with (IRACRR) and without AC (IRNCRR) as well as with FBP. Three experienced nuclear medicine specialists visually assessed anonymized images according to eight criteria on a four point scale, three related to image quality and five to diagnostic confidence. Statistical analysis was performed using Visual Grading Regression (VGR).

RESULTS: Observer confidence in statements on image quality was highest for the images that were reconstructed using DDRR (P<0·01 compared to FBP). Iterative reconstruction without DDRR was not superior to FBP. Interobserver variability was significant for statements on image quality (P<0·05) but lower in the diagnostic statements on ischemia and scar. The confidence in assessing ischemia and scar was not different between the reconstruction techniques (P = n.s.).

CONCLUSION: SPECT MPI collected in 9 min, reconstructed with DDRR and AC, produced better image quality than the standard procedure. The observers expressed the highest diagnostic confidence in the DDRR reconstruction.

Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
image quality, MPI SPECT, noise regularization, resolution recovery, Visual Grading Regression
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-129965 (URN)10.1111/cpf.12354 (DOI)000413678400015 ()26991110 (PubMedID)
Note

Funding agencies: Region Ostergotland [285001]; Swedish Heart-Lung foundation [20120449]; Faculty of Health Sciences at Linkoping University [284731]

Available from: 2016-07-02 Created: 2016-07-02 Last updated: 2017-11-13Bibliographically approved
De Geer, J., Gjerde, M., Brudin, L., Olsson, E., Persson, A. & Engvall, J. (2015). Large variation in blood flow between left ventricular segments, as detected by adenosine stress dynamic CT perfusion.. Clinical Physiology and Functional Imaging, 35(4), 291-300
Open this publication in new window or tab >>Large variation in blood flow between left ventricular segments, as detected by adenosine stress dynamic CT perfusion.
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2015 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 35, no 4, p. 291-300Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Dynamic cardiac CT perfusion (CTP) is based on repeated imaging during the first-pass contrast agent inflow. It is a relatively new method that still needs validation.

PURPOSE: To evaluate the variation in adenosine stress dynamic CTP blood flow as compared to (99m) Tc SPECT. Secondarily, to compare manual and automatic segmentation.

METHODS: Seventeen patients with manifest coronary artery disease were included. Nine were excluded from evaluation for various reasons. All patients were examined with dynamic stress CTP and stress/rest SPECT. CTP blood flow was compared with SPECT on a per segment basis. Results for manual and automated AHA segmentation were compared.

RESULTS: CTP showed a positive correlation with SPECT, with correlation coefficients of 0·38 and 0·41 for manual and automatic segmentation, respectively (P<0·0001). There was no significant difference between the correlation coefficients of the manual and automated segmentation procedures (P = 0·75). The average per individual global CTP blood flow value for normal segments varied by a factor of 1·9 (manual and automatic segmentation). For the whole patient group, the CTP blood flow value in normal segments varied by a factor of 2·9/2·7 (manual/automatic segmentation). Within each patient, the average per segment blood flow in normal segments varied by a factor of 1·3-2·0/1·2-2·1 (manual/automatic segmentation).

CONCLUSION: A positive but rather weak correlation was found between CTP and (99m) Tc SPECT. Large variations in CTP blood flow suggest that a cut-off value for stress myocardial blood flow is inadequate to detect ischaemic segments. Dynamic CTP is hampered by a limited coverage.

National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-113400 (URN)10.1111/cpf.12163 (DOI)000356312800007 ()24842265 (PubMedID)
Available from: 2015-01-17 Created: 2015-01-17 Last updated: 2017-12-05
Davidsson, A., Olsson, E., Engvall, J. & Norberg, P. (2015). Myokardscintigrafi med ny hjärtkamera (D-SPECT): Hur mycket kan vi minska strålbelastningen till patienten utan att försämra diagnostisk bildkvalité?. In: : . Paper presented at Nuklearmedicinska Vårmötet I Helsingborg 20-22 maj 2015.
Open this publication in new window or tab >>Myokardscintigrafi med ny hjärtkamera (D-SPECT): Hur mycket kan vi minska strålbelastningen till patienten utan att försämra diagnostisk bildkvalité?
2015 (Swedish)Conference paper, Poster (with or without abstract) (Other academic)
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-124334 (URN)
Conference
Nuklearmedicinska Vårmötet I Helsingborg 20-22 maj 2015
Available from: 2016-01-26 Created: 2016-01-26 Last updated: 2016-02-09Bibliographically approved
Edenbrandt, L., Hoglund, P., Frantz, S., Hasbak, P., Johansen, A., Johansson, L., . . . Tragardh, E. (2014). Area of ischemia assessed by physicians and software packages from myocardial perfusion scintigrams. BMC Medical Imaging, 14(5)
Open this publication in new window or tab >>Area of ischemia assessed by physicians and software packages from myocardial perfusion scintigrams
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2014 (English)In: BMC Medical Imaging, ISSN 1471-2342, E-ISSN 1471-2342, Vol. 14, no 5Article in journal (Refereed) Published
Abstract [en]

Background: The European Society of Cardiology recommends that patients with greater than 10% area of ischemia should receive revascularization. We investigated inter-observer variability for the extent of ischemic defects reported by different physicians and by different software tools, and if inter-observer variability was reduced when the physicians were provided with a computerized suggestion of the defects. Methods: Twenty-five myocardial perfusion single photon emission computed tomography (SPECT) patients who were regarded as ischemic according to the final report were included. Eleven physicians in nuclear medicine delineated the extent of the ischemic defects. After at least two weeks, they delineated the defects again, and were this time provided a suggestion of the defect delineation by EXINI Heart(TM) (EXINI). Summed difference scores and ischemic extent values were obtained from four software programs. Results: The median extent values obtained from the 11 physicians varied between 8% and 34%, and between 9% and 16% for the software programs. For all 25 patients, mean extent obtained from EXINI was 17.0% (+/- standard deviation (SD) 14.6%). Mean extent for physicians was 22.6% (+/- 15.6%) for the first delineation and 19.1% (+/- 14.9%) for the evaluation where they were provided computerized suggestion. Intra-class correlation (ICC) increased from 0.56 (95% confidence interval (CI) 0.41-0.72) to 0.81 (95% CI 0.71-0.90) between the first and the second delineation, and SD between physicians were 7.8 (first) and 5.9 (second delineation). Conclusions: There was large variability in the estimated ischemic defect size obtained both from different physicians and from different software packages. When the physicians were provided with a suggested delineation, the inter-observer variability decreased significantly.

Place, publisher, year, edition, pages
BioMed Central, 2014
Keywords
Ischemic heart disease; Myocardial perfusion imaging; Intra-observer variability; Software tools
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-105418 (URN)10.1186/1471-2342-14-5 (DOI)000332080400001 ()
Available from: 2014-03-21 Created: 2014-03-21 Last updated: 2017-12-05
Davidsson, A., Olsson, E., Engvall, J., Holmberg, B. & Gustafsson, A. (2014). Left ventricle ejection fraction with gated myocardial perfusion SPECT: a comparison between a conventional scintillation detector gamma camera and cadmium-zinc-telluride dectector camera. In: : . Paper presented at European Association of Nuclear Medicine.
Open this publication in new window or tab >>Left ventricle ejection fraction with gated myocardial perfusion SPECT: a comparison between a conventional scintillation detector gamma camera and cadmium-zinc-telluride dectector camera
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2014 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-114006 (URN)
Conference
European Association of Nuclear Medicine
Available from: 2015-02-05 Created: 2015-02-05 Last updated: 2015-03-31
Davidsson, A., Olsson, E., Engvall, J. & Gustafsson, A. (2012). Assessment of image quality for SPECT myocardial perfusion imaging with regard to reconstruction algorithms using visual grading regression.. Paper presented at EANM Milano.
Open this publication in new window or tab >>Assessment of image quality for SPECT myocardial perfusion imaging with regard to reconstruction algorithms using visual grading regression.
2012 (Swedish)Conference paper, Poster (with or without abstract) (Other academic)
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-91091 (URN)
Conference
EANM Milano
Available from: 2013-04-15 Created: 2013-04-15 Last updated: 2013-04-17
Tamás, É., Broqvist, M., Olsson, E., Franzén, S. & Nylander, E. (2009). Exercise radionuclide ventriculography for predicting postoperative left ventricular function in chronic aortic regurgitation. JACC: Cardiovascular Imaging, 2(1), 48-55
Open this publication in new window or tab >>Exercise radionuclide ventriculography for predicting postoperative left ventricular function in chronic aortic regurgitation
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2009 (English)In: JACC: Cardiovascular Imaging, ISSN 1936-878X, Vol. 2, no 1, p. 48-55Article in journal (Refereed) Published
Abstract [en]

Objectives: Ejection fraction (EF) reaction upon exercise by radionuclide ventriculography and standard echocardiographic parameters was evaluated as predictors for post-operative left ventricular (LV) function in chronic aortic regurgitation (AR).

Background: The optimal timing of surgery for chronic AR is when the left ventricle is still compensating for the volume and pressure overload without irreversible dysfunction. For asymptomatic patients when EF is normal and LV diameters are borderline, exercise testing is recommended by present guidelines. However, only a limited number of studies have been performed, and data are scarce on this subject.

Methods: Radionuclide ventriculography with multiple gated acquisition at rest and during exercise was performed in 29 consecutive patients with severe chronic aortic regurgitation pre-operatively and 6 months post-operatively. Patient subgroups were formed based on pre-operative EF exercise response (ΔEF) and were categorized as decreasing (ΔEF <−5%), unaltered (−5% ≤ ΔEF ≤ 5%), and increasing (ΔEF > 5%). A 5% or higher increase was considered normal. The LV diameters and mass were measured by echocardiography.

Results: Pre-operative LV diameters were markedly elevated before surgery and diminished significantly after surgery. Left ventricular diameters, LV mass, EF at rest (EFrest), and EF change from rest to exercise (ΔEF) were independent of New York Heart Association functional class. Pre-operative end-diastolic diameter proved to be a predictor for pre- and post-operative ΔEF (p = 0.003; p = 0.04) but not for the nature of the exercise response post-operatively. Patients with decreasing and unaltered EF pre-operatively presented a significantly higher but still abnormal ΔEF post-operatively. Those with increasing EF pre-operatively had a similar response and a normal ΔEF post-operatively. Pre-operative ΔEF was not only a predictor for post-operative ΔEF (p = 0.02) but also classified patients into post-operative subgroups (EF decreasing, p = 0.03; unaltered, p = 0.02; increasing, p = 0.0008).

Conclusions: An abnormal EF response to exercise may also occur in patients who do not fulfill criteria for surgery based on LV dimensions or EF. A follow-up of exercise LV function and adjusting the timing of surgery according to the nature of exercise response could, therefore, be beneficial.

Place, publisher, year, edition, pages
Elsevier, 2009
Keywords
radionuclide ventriculography, ejection fraction, exercise testing, aortic regurgitation, cardiac surgery
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13338 (URN)10.1016/j.jcmg.2008.09.009 (DOI)000287651900008 ()
Available from: 2008-06-18 Created: 2008-06-18 Last updated: 2011-03-11
Ohlson, M., Grétarsdóttir, J., Olsson, E., Johansson, L. & Gustafsson, A. (2008). Kartläggning av bildkvalitet vid myokardscintifrafi: en nationell studie.
Open this publication in new window or tab >>Kartläggning av bildkvalitet vid myokardscintifrafi: en nationell studie
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2008 (Swedish)Report (Other academic)
Abstract [sv]

 www.ssi.se Statens strålsskyddsinstitut Swedish Radiation Protection Authority.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-42351 (URN)62819 (Local ID)62819 (Archive number)62819 (OAI)
Available from: 2009-10-10 Created: 2009-10-10
Ohlsson, M., Grétarsdóttir, J., Olsson, E., Johansson, L. & Gustafsson, A. (2007). Image quality survey and evaluation of myocardial perfusion SPECT: a national study. Paper presented at European Association in Nuclear Medicine (EANM), 13-17 October 2007, Köpenhamn.
Open this publication in new window or tab >>Image quality survey and evaluation of myocardial perfusion SPECT: a national study
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2007 (English)Conference paper, Oral presentation only (Other academic)
National Category
Medical Image Processing
Identifiers
urn:nbn:se:liu:diva-79387 (URN)
Conference
European Association in Nuclear Medicine (EANM), 13-17 October 2007, Köpenhamn
Available from: 2012-07-16 Created: 2012-07-16 Last updated: 2012-08-14
Ohlsson, M., Grétarsdóttir, J., Olsson, E., Johansson, L. & Gustafsson, A. (2007). Kartläggning och utvärdering av bildkvalitet vid myokard SPECT - En nationell studie. Paper presented at Svenskt Vårmöte i Nuklearmedicin, 23-25 maj 2007, Falun.
Open this publication in new window or tab >>Kartläggning och utvärdering av bildkvalitet vid myokard SPECT - En nationell studie
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2007 (Swedish)Conference paper, Oral presentation only (Other academic)
National Category
Medical Image Processing
Identifiers
urn:nbn:se:liu:diva-79386 (URN)
Conference
Svenskt Vårmöte i Nuklearmedicin, 23-25 maj 2007, Falun
Available from: 2012-07-16 Created: 2012-07-16 Last updated: 2012-08-14
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