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Jiang, Chonghe
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Publications (10 of 26) Show all publications
Zeng, J., Xie, K., Jiang, C., Mo, J. & Lindström, S. (2012). Bladder mechanoreceptor changes after artificial bladder outlet obstruction in the anesthetized rat. Neurourology and Urodynamics, 31(1), 178-184
Open this publication in new window or tab >>Bladder mechanoreceptor changes after artificial bladder outlet obstruction in the anesthetized rat
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2012 (English)In: Neurourology and Urodynamics, ISSN 0733-2467, E-ISSN 1520-6777, Vol. 31, no 1, p. 178-184Article in journal (Refereed) Published
Abstract [en]

Aims Experimental animal models of bladder outlet obstruction (BOO) have reproduced several features of BOO in man, i.e., detrusor hypertrophy, instability, frequency, and residual urine. This study was focused on the mechanisms underlying the development of residual urine in patient with benign prostatic hyperplasia (BPH) by examining changes in tension sensitivity of bladder mechanoreceptors in rat model. Methods: Female adult Sprague-Dawley rats including 12 BOO and 17 sham operated rats were used in this study. Cystometrograms together with the bladder afferent activity were recorded. Tension sensitivity of the afferents was determined by plotting the normalized afferent response against the contraction evoked bladder pressure at different volumes. Degree of obstruction was assessed by the wet weight of the bladder at the end of the experiment. Results: The bladder weight, maximal bladder capacity, micturition threshold volume, peak contraction force, and volume at peak contraction force were all significantly increased in obstructed animals. The threshold volume for afferent activation was increased ( mean 0.60 ml compared to 0.15 ml in controls; P andlt; 0.001), positively correlated with the bladder weight ( r 0.74). The tension sensitivity of the bladder mechanoreceptors and the slope of their normalized pressure-response functions were significantly lower at the comparable volumes in the obstructed animals. Conclusions: Rats with BOO had bladder mechanoreceptors with higher threshold volumes and lower tension sensitivity. Such changes would result in a weaker afferent drive of the micturition reflex. Similar changes may contribute to the development of residual urine and retention in patients with BOO. Neurourol. Urodynam. 31: 178-184, 2012. (C) 2011 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2012
Keywords
afferent, cystometry, obstruction, rat, receptor, reflex, residual urine
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-75119 (URN)10.1002/nau.21219 (DOI)000299372300032 ()
Note
Funding Agencies|Swedish Medical Research Council|04767|Qingyuan City Peoples Hospital of Jinan University, China||Available from: 2012-02-21 Created: 2012-02-17 Last updated: 2017-12-07
Zeng, J., Pan, C., Jiang, C. & Lindström, S. (2012). Cause of Residual Urine in Bladder Outlet Obstruction: An Experimental Study in the Rat. Journal of Urology, 188(3), 1027-1032
Open this publication in new window or tab >>Cause of Residual Urine in Bladder Outlet Obstruction: An Experimental Study in the Rat
2012 (English)In: Journal of Urology, ISSN 0022-5347, E-ISSN 1527-3792, Vol. 188, no 3, p. 1027-1032Article in journal (Refereed) Published
Abstract [en]

Purpose: We explored the role of bladder mechanoreceptors in post-void residual urine in rats with bladder outlet obstruction. less thanbrgreater than less thanbrgreater thanMaterials and Methods: Partial bladder outlet obstruction was induced by a urethral ligature in 11 adult female Sprague-Dawley (R) rats. Nine sham operated rats served as controls. The outcome was evaluated in acute experiments using alpha-chloralose anesthesia 6 weeks later. Bladders were catheterized for infusion, pressure recording and intravesical electrical stimulation. Bladder efferent activity was recorded from a thin pelvic nerve branch close to the bladder. Micturition contractions were triggered at different bladder volumes by a brief train of electrical stimulation of bladder afferents while monitoring post-stimulus efferent activity and reflex bladder contractions. The degree of obstruction was assessed by bladder wet weight at the end of the experiment. less thanbrgreater than less thanbrgreater thanResults: Bladder weight, micturition threshold volume, anatomical bladder capacity and peak contraction force were significantly increased in obstructed rats. In sham operated controls a triggered micturition reflex was sustained by afferent feedback from the bladder until the bladder was empty. In contrast, reflex discharges failed with substantial volume remaining in the bladder in obstructed rats. The minimal micturition reflex volume correlated positively with bladder weight, micturition threshold volume and maximal bladder capacity (r andgt;= 0.74). less thanbrgreater than less thanbrgreater thanConclusions: In rats with partial bladder outlet obstruction the micturition reflex failed before the bladder was empty due to a decreased afferent drive from bladder mechanoreceptors. Similar changes may contribute to post-void residual urine in humans with bladder outlet obstruction.

Place, publisher, year, edition, pages
Elsevier, 2012
Keywords
urinary bladder, urinary bladder neck obstruction, reflex, mechanoreceptors, rats, Sprague-Dawley
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-84898 (URN)10.1016/j.juro.2012.04.101 (DOI)000307551200114 ()
Available from: 2012-10-26 Created: 2012-10-26 Last updated: 2017-12-07
He, L., Wang, Y., Long, Z. & Jiang, C. (2010). Clinical Significance of IL-2, IL-10, and TNF-alpha in Prostatic Secretion of Patients With Chronic Prostatitis. Urology, 75(3), 654-657
Open this publication in new window or tab >>Clinical Significance of IL-2, IL-10, and TNF-alpha in Prostatic Secretion of Patients With Chronic Prostatitis
2010 (English)In: Urology, ISSN 0090-4295, E-ISSN 1527-9995, Vol. 75, no 3, p. 654-657Article in journal (Refereed) Published
Abstract [en]

Objectives

To explore the clinical significance of interleukin-2 (IL-2), interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-α) in expressed prostatic secretions (EPS) of patients with different types of chronic prostatitis (CP).

Methods

Fifty-seven CP patients and 12 healthy males (controls) were investigated. The CP patients were evaluated through routine examination of urine, EPS, 2 glasses urine culture, and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score and classified by the NIH prostatitis diagnostic criteria. The levels of cytokines TNF-α, IL-10, and IL-2 in the EPS were measured by two-antibody enzyme-linked immunosorbent assay.

Results

CP patients fell into 3 groups: type II (n = 10), type IIIa (n = 26), and type IIIb (n = 21). EPS TNF-α and IL-10 levels were significantly higher in type II and type IIIa than in type IIIb and control groups. The levels of IL-2 were lower than control in all CP groups, but only type II was statistically different from the controls. In the CP patients, the level of TNF-α was positively related to the white blood cell counts (r = .77; P <.01), and the level of IL-10 was positively related to the NIH-CPSI scores (r = .55; P <.01).

Conclusions

Determination of variety expression of TNF-α, IL-10, and IL-2 in the EPS of CP patients may provide a potential indicator for clinical diagnosis classification and an indicator to evaluate the effect of treatment of CP.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-53159 (URN)10.1016/j.urology.2009.09.061 (DOI)000275814500051 ()
Available from: 2010-01-16 Created: 2010-01-16 Last updated: 2017-12-12
Lin, X., Qu, S., Hu, M. & Jiang, C. (2010). Protective Effect of Erythropoietin on Renal Injury Induced by Acute Exhaustive Exercise in the Rat. INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 31(12), 847-853
Open this publication in new window or tab >>Protective Effect of Erythropoietin on Renal Injury Induced by Acute Exhaustive Exercise in the Rat
2010 (English)In: INTERNATIONAL JOURNAL OF SPORTS MEDICINE, ISSN 0172-4622, Vol. 31, no 12, p. 847-853Article in journal (Refereed) Published
Abstract [en]

We investigated the protective effect of Erythropoietin (EPO) analogue rHuEPO on renal injury induced by acute exhaustive exercise in the rat. Rats were randomly allocated to one of 3 groups: normal control (C), exhaustive exercise test (ET) and EPO pre-treatment (rHuEPO 2 000 U/kg) plus ET (EPO + ET). Compared with controls, animals in the ET group had increased serum urea nitrogen, serum creatinine, urine protein, and renal tissue malondialdehyde (MDA) and decreased renal tissue nitric oxide (NO), nitric oxide synthase (NOS) and superoxide dismutase (SOD) activities. There was severe damage in renal tubular epithelial cells with a lot of cell apoptosis, and TUNEL assay revealed a remarkably high apoptotic index (p andlt; 0.01). Changes in renal function and kidney tissue were much less in the EPO + ET group (p andlt; 0.05) and the apoptotic index was much lower than in the ET group (18.45 +/- 0.32 vs. 27.55 +/- 0.49, p andlt; 0.05). EPO pretreatment thus significantly prevented renal cell apoptosis, and counteracted high MDA and low NO and NOS renal contents induced by exhaustive exercise. The data point to a potential value of EPO in preventing the acute renal injury after exhaustive exercise.

Place, publisher, year, edition, pages
Georg Thieme Verlag, 2010
Keywords
erythropoietin, exhaustive exercise, apoptosis, kidney, rat
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-64577 (URN)10.1055/s-0030-1265205 (DOI)000285407300003 ()
Note
Original Publication: X Lin, S Qu, M Hu and Chonghe Jiang, Protective Effect of Erythropoietin on Renal Injury Induced by Acute Exhaustive Exercise in the Rat, 2010, INTERNATIONAL JOURNAL OF SPORTS MEDICINE, (31), 12, 847-853. http://dx.doi.org/10.1055/s-0030-1265205 Copyright: Georg Thieme Verlag http://www.thieme.de/ Available from: 2011-01-28 Created: 2011-01-28 Last updated: 2011-02-16
Jiang, C., Mazieres, L. & Lindström, S. (2009). Gating of the Micturition Reflex by Tonic Activation of Bladder Cold Receptors in the Cat. NEUROUROLOGY AND URODYNAMICS, 28(6), 555-560
Open this publication in new window or tab >>Gating of the Micturition Reflex by Tonic Activation of Bladder Cold Receptors in the Cat
2009 (English)In: NEUROUROLOGY AND URODYNAMICS, ISSN 0733-2467, Vol. 28, no 6, p. 555-560Article in journal (Refereed) Published
Abstract [en]

Aims: To determine whether C afferents can modify the gating of the A delta micturition reflex in order to identify the neuronal site of interaction of the two afferent systems. Methods: Adult female cats, anaesthetized with a.-chloralose, had their bladder and urethra catherized through a slit in the proximal urethra. Micturition threshold volume was assessed by cystometry and bladder efferent activity recorded simultaneously. The bladder was filled at a slow rate (1.2-3.5 ml/min) with either body-warm saline (control) or menthol solution (0.06 mM) or by cold saline (4 degrees C). Results: Of 14 trial sessions in 5 animals, the threshold volume of the A delta micturition reflex was consistently reduced by menthol infusions from a control median (md) value of 16.8 to 10.2 ml (P andlt; 0.01). The threshold pressure was also somewhat decreased from and 0.7 to 0.5 kPa (P andlt; 0.05), while the peak pressure or pressure slope did no differ in two situations. Similar results were obtained with slow cold infusions into the bladder (nine sessions in three animals). The threshold volume decreased from and 19.8 to 17.4 ml (P andlt; 0.05). The bladder reflex response to slow menthol or cold infusions had the typical features of an A delta micturition reflex in that the efferent activity was largely abolished by the bladder A delta mechanoreceptor unloading. Conclusions: Gradual tonic activation of bladder cold receptors lowers the threshold volume of the ordinary A delta micturition, pointing to a segmental spinal mechanism for the gating of the micturition reflex. Neurourol. Urodyrzam. 28:555-560, 2009.

Keywords
C afferents, cold receptors, gating, micturition reflex, urinary bladder
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-19794 (URN)10.1002/nau.20690 (DOI)
Available from: 2009-08-10 Created: 2009-08-10 Last updated: 2009-08-10
Song, B., Jiang, C., Wang, Y., Lu, Y. & Li, L. (2009). Newly found prostate-bladder neural reflex in rats--possible mechanism for      voiding dysfunction associated with prostatitis/pelvic pain. Urology, 74(6), 1365-1369
Open this publication in new window or tab >>Newly found prostate-bladder neural reflex in rats--possible mechanism for      voiding dysfunction associated with prostatitis/pelvic pain
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2009 (English)In: Urology, ISSN 0090-4295, E-ISSN 1527-9995, Vol. 74, no 6, p. 1365-1369Article in journal (Refereed) Published
Abstract [en]
Objectives

To demonstrate the existence of a prostate-bladder neural reflex that might help clarify a neurologic mechanism for voiding dysfunction associated with chronic prostatitis/chronic pelvic pain syndrome.

Methods

Experiments were performed on anesthetized adult male Wistar rats. Repeated cystometry was used to study the changes in urinary bladder behavior induced by injecting formalin into the prostate. The pathway of a prostate-bladder reflex was identified by recording the electromyographic (EMG) response of the detrusor to electrical stimulation of the prostate, after saline or lidocaine injections into the prostate, and transection of the prostate nerves.

Results

Intraprostatic formalin injection induced significant changes in the parameters of cystometry. Electrical stimulation of the prostate consistently evoked a bladder EMG response. Intraprostatic lidocaine injection increased the delay and reduced the amplitude of this EMG response. The bladder EMG response was not affected by transection of the cervical spinal cord nor by just cutting the sympathetic chain; however, it was suppressed by resection of the sympathetic chain and by transection of the ipsilateral L6-S3 nerve roots.

Conclusions

A prostate-bladder reflex is proposed, and the lumbosacral spinal cord is assumed to be the primary center of the reflex. These findings might help determine the therapeutic approach to voiding dysfunction in patients with chronic prostatitis/chronic pelvic pain syndrome.

Identifiers
urn:nbn:se:liu:diva-53158 (URN)10.1016/j.urology.2009.02.063 (DOI)
Available from: 2010-01-16 Created: 2010-01-16 Last updated: 2017-12-12
Li, L., Jiang, C., Song, B., Yan, J. & Pan, J. (2008). Altered expression of calcium-activated K and Cl channels in detrusor overactivity of rats with partial bladder outflow obstruction. BJU International, 101(12), 1588-1594
Open this publication in new window or tab >>Altered expression of calcium-activated K and Cl channels in detrusor overactivity of rats with partial bladder outflow obstruction
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2008 (English)In: BJU International, ISSN 1464-4096, E-ISSN 1464-410X, ISSN 1464-4096, Vol. 101, no 12, p. 1588-1594Article in journal (Refereed) Published
Abstract [en]

To evaluate the activity of large- and small-conductance calcium-activated potassium channels (BKCa, SKCa) and calcium-activated chloride channels (ClCa) in detrusor overactivity (DO) cells after partial bladder outlet obstruction (PBOO) in rats.

MATERIALS AND METHODS

Thirteen female Wistar rats with DO caused by PBOO were studied simultaneously with eight sham-operated rats. The expression of KCa and ClCa channels was assessed by reverse transcription-polymerase chain reaction, and the function of the two groups compared.

RESULTS

In the DO cells the expression of BKCa, SKCa2 and SKCa3 was lower, and that of ClCa channels higher, than in the control group cells. Using confocal laser scanning microscopic analysis, the function of BKCa and SKCa channels was suppressed, and that of ClCa channels was enhanced in DO group cells. KCa and ClCa effectors altered the cell membrane potentials more significantly in the DO cells than in the control cells, indicating a decrease in KCa and an increase in ClCa in DO group in either iso- or hypo-osmolar medium. Moreover, the change in BKCa, SKCa and ClCa channel activators in DO cells showed a more excitable state in hypo-osmolar medium than in iso-osmolar medium.

CONCLUSION

In DO myocytes after PBOO, the expression and function of KCa channels were decreased, and those of ClCa channels increased. These changes all provoke greater cell excitability, and could partly account for the DO.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-53151 (URN)10.1111/j.1464-410X.2008.07522.x (DOI)
Available from: 2010-01-15 Created: 2010-01-15 Last updated: 2017-12-12
Jiang, C., Yang, H., Fu, X., Qu, S. & Lindström, S. (2008). Bladder cooling reflex and external urethral sphincter activity in the anesthetized and awake guinea pig. Pflügers Archiv: European Journal of Physiology, 457(1), 61-66
Open this publication in new window or tab >>Bladder cooling reflex and external urethral sphincter activity in the anesthetized and awake guinea pig
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2008 (English)In: Pflügers Archiv: European Journal of Physiology, ISSN 0031-6768, E-ISSN 1432-2013, Vol. 457, no 1, p. 61-66Article in journal (Refereed) Published
Abstract [en]

A spinal bladder cooling reflex, triggered by cold receptors of transient receptor potential melastatin type in the bladder wall, has been identified in several mammals, including man. This reflex and its influence on the external urethral sphincter were further characterized in the urethane anesthetized and awake guinea pigs. A total of 214 bladder infusions were performed in the 12 animals. Compared to controls, cold fluid induced a significant decrease in the threshold volume for reflex bladder contractions (median 82%, p<0.01). Menthol induced a further decrease (median 50%), signifying a bladder cooling reflex. Detrusor-sphincter activities were dyssynergic during voidings triggered by cold or menthol infusions but were coordinated during control infusions. The bladder cooling reflex was suppressed and the sphincter activity synergic following cold infusions in the awake state. Thus, the bladder cooling reflex is under the active descending inhibitory control in intact, awake animals. © 2008 Springer-Verlag.

Keywords
Cooling reflex, EMG, Guinea pig, Urinary bladder, Wakefulness
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-50020 (URN)10.1007/s00424-008-0502-9 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Hu, M., Li, Y.-L., Jiang, C., Liu, Z.-Q., Qu, S. & Huang, Y. (2008). Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a      high-fat diet in rabbits. Nutrition Journal, 24(10), 1030-1038
Open this publication in new window or tab >>Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a      high-fat diet in rabbits
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2008 (English)In: Nutrition Journal, ISSN 1475-2891, E-ISSN 1475-2891, Vol. 24, no 10, p. 1030-1038Article in journal (Refereed) Published
Abstract [en]
Objective

We evaluated the antiatherogenic effect of lycopene in rabbits fed a high-fat diet.

Methods

Forty adult male rabbits were divided into five groups that were fed a standard diet, a high-fat diet, a high-fat diet plus 4 mg/kg of lycopene, a high-fat diet plus 12 mg/kg of lycopene, and a high-fat diet plus 10 mg/kg of fluvastatin, respectively. Lycopene and fluvastatin were administered intragastrically. The level of serum total cholesterol, total triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total antioxidant capacity, and malondialdehyde were measured before and after 4 and 8 wk of experimental treatment. In addition, plasma levels of lycopene, oxidized low-density lipoprotein, serum nitric oxide, and interleukin-1 were measured after the experiment. The area of atherosclerotic plaque and pathologic changes of the aorta were evaluated.

Results

Compared with the control, levels of total cholesterol, total triacylglycerol, low-density lipoprotein cholesterol, malonaldehyde, oxidized low-density lipoprotein, and interleukin-1 were increased and total antioxidant capacity and nitric oxide were decreased in the animals with a high-fat diet (P < 0.05). Intragastric administration of lycopene counteracted the change in these parameters (P < 0.05). In this case, the data showed that lycopene in the used dose was better than the fluvastatin intervention. Morphologic analysis revealed that lycopene and fluvastatin markedly reduced the formation of atherosclerotic plaques in the aorta compared with the situation in rabbits on a high-fat diet alone.

Conclusion

Lycopene, like fluvastatin, significantly attenuated atherogenesis in rabbits fed a high-fat diet.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-53156 (URN)10.1016/j.nut.2008.05.006 (DOI)
Available from: 2010-01-16 Created: 2010-01-16 Last updated: 2017-12-12
Li, l., Jiang, C., Song, C., Zhou, Z., Song, B. & Li, W. (2008). Transurethral endoscopy technique with a ureteroscope for diagnosis and      management of seminal tracts disorders: a new approach. Journal of endourology, 22(4), 719-724
Open this publication in new window or tab >>Transurethral endoscopy technique with a ureteroscope for diagnosis and      management of seminal tracts disorders: a new approach
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2008 (English)In: Journal of endourology, ISSN 0892-7790, E-ISSN 1557-900X, Vol. 22, no 4, p. 719-724Article in journal (Refereed) Published
Abstract [en]

Purpose: To apply a transurethral endoscopic technique for examining and managing suspicious distal seminal tracts disorders with a ureteroscope.

Patients and Methods: Sixteen patients with distal seminal tracts disorders underwent transurethral endoscopy through the distal seminal tracts using a semirigid ureteroscope. Of the 16 patients, 6 had suspected hemospermia, 4 spermatocele, and 6 male infertility.

Results: The ejaculatory duct, seminal vesicle, and ampulla of the vas deferens were observed under direct vision with the ureteroscope. The vas deferens was investigated by cannulation with a guidewire or an epidural anesthesia catheter. Four patients received a diagnosis of spermatocele, four seminal vesiculitis, and three vas deferens obstruction. All patients received appropriate treatment. The remaining five patients had no anatomic disorders. All patients received careful postoperative observation and treatment, and were monitored for at least 3 months. Three patients had postoperative discomfort in the perineal region. There were no further complications.

Conclusions: This new technique with the ureteroscope enables diagnosis and management of distal seminal tracts disorders through the normal anatomic tract. This endoscopic technique can be performed easily with minimal complications.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-53153 (URN)10.1089/end.2007.0130 (DOI)
Available from: 2010-01-16 Created: 2010-01-16 Last updated: 2017-12-12
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