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Selbing, Anders
Publications (10 of 19) Show all publications
Hildebrand, E., Selbing, A. & Blomberg, M. (2010). Comparison of first and second trimester ultrasound screening for fetal anomalies in the southeast region of Sweden. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 89(11), 1412-1419
Open this publication in new window or tab >>Comparison of first and second trimester ultrasound screening for fetal anomalies in the southeast region of Sweden
2010 (English)In: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, ISSN 0001-6349, Vol. 89, no 11, p. 1412-1419Article in journal (Refereed) Published
Abstract [en]

Objective. To assess and compare the sensitivity for detecting fetal anomalies and chromosomal aberrations by routine ultrasound examination performed in the second trimester with results from an examination performed at 11-14 weeks gestation. Design. Observational study. Setting. Five centers in the southeast region of Sweden. Population. A total of 21,189 unselected pregnant women. Methods. The scan was performed at one center in the first trimester and at the remaining four centers in the second trimester. Outcome measures resulting from first trimester scanning were compared with those from the second trimester scanning. Main outcome measures. Detection rates of fetal structural anomalies and chromosomal aberrations. Results. At the first trimester scan 13% of all anomalies were detected, and at the second trimester scan 29% were detected. Lethal anomalies were detected at a high level at both times: 88% in the first, 92% in the second. The percentage of chromosomal aberrations discovered at the early scan was 71%, in the later 42%. The percentage of heart malformations detected was surprisingly low. Conclusion. The results showed the advantages of the later scan in discovering anomalies of the heart, urinary tract and CNS, and of the early scan in discovering chromosomal aberrations. Lethal malformations were detected at a high level in both groups, but detection of heart malformations needs improvement.

Place, publisher, year, edition, pages
Informa Healthcare, 2010
Keywords
Fetal structural anomalies, ultrasound, detection rate
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-61211 (URN)10.3109/00016349.2010.517307 (DOI)000283130700006 ()
Available from: 2010-11-05 Created: 2010-11-05 Last updated: 2014-06-04
Bergh, C., Soderstrom-Anttila, V., Selbing, A., Aittomaki, K., Hazekamp, J., Loft, A., . . . Wennerholm, U. (2007). Attitudes towards and management of single embryo transfer among Nordic IVF doctors. Acta Obstetricia et Gynecologica Scandinavica, 86(10), 1222-1230
Open this publication in new window or tab >>Attitudes towards and management of single embryo transfer among Nordic IVF doctors
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2007 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 86, no 10, p. 1222-1230Article in journal (Refereed) Published
Abstract [en]

Background. The objective of this study was to investigate the attitudes towards and management of single embryo transfer (SET) among Nordic in vitro fertilisation (IVF) doctors, and to present the rate of SET and multiple pregnancies in the different countries. Methods. A questionnaire was sent to all IVF doctors in the Nordic countries (n=198, 78.5% responded). Pregnancy rates, SET and multiple births rates were extracted from registries. Main outcome measure was attitudes and management of SET. Results. Almost all doctors thought that a twin pregnancy compared unfavourably to a singleton. A twin rate >10% was acceptable for 5% of Swedish doctors. Corresponding figures for Finnish, Danish and Norwegian doctors were 21, 35 and 35%, respectively. For a woman <36 years, performing her first cycle and with two good quality embryos, almost all doctors would recommend SET. For a woman =36 years in a similar situation, SET would be recommended only in Sweden and Finland. The pregnancy rate per embryo transfer (ET), the SET rate 2003, the multiple birth rate, and the estimated SET rate 2004 were 33.3, 21.5, 22.7 and 25% (Denmark), 31.3, 43.4, 14 and 51% (Finland), 40.5, 10.5, 26.5 and 16% (Iceland), 30.6, 18, 25.2 and 26% (Norway), and 35.3, 55.1, 11.8 and 71% (Sweden). Conclusions. The SET and multiple birth rates reflect the attitudes of Nordic IVF doctors to SET and multiple births well. When introducing SET, the attitude of the IVF doctor seems to be important. © 2007 Taylor & Francis.

Keywords
Attitudes, Doctor, IVF, Single embryo transfer, Twins
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-48588 (URN)10.1080/00016340701622393 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Selbing, A., Anghagen, O., Bylund, B., Nelson, N., Nylander, E. & Engvall, J. (2007). Velocity vector imaging to assess fetal myocardial function. In: Ultrasound Obstet Gynecol.,2007.
Open this publication in new window or tab >>Velocity vector imaging to assess fetal myocardial function
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2007 (English)In: Ultrasound Obstet Gynecol.,2007, 2007Conference paper, Published paper (Other academic)
Abstract [en]

     

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-40408 (URN)53214 (Local ID)53214 (Archive number)53214 (OAI)
Available from: 2009-10-10 Created: 2009-10-10
Palfi, M., Hildén, J.-O., Matthiesen, L., Selbing, A. & Berlin, G. (2006). A case of severe Rh (D) alloimmunization treated by intensive plasma exchange and high-dose intravenous immunoglobulin. Transfusion and apheresis science, 35(2), 131-136
Open this publication in new window or tab >>A case of severe Rh (D) alloimmunization treated by intensive plasma exchange and high-dose intravenous immunoglobulin
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2006 (English)In: Transfusion and apheresis science, ISSN 1473-0502, E-ISSN 1878-1683, Vol. 35, no 2, p. 131-136Article in journal (Refereed) Published
Abstract [en]

Background: In extremely severe Rh (D) alloimmunization, during pregnancy, early diagnosis and treatment is essential to avoid hydrops fetalis. Intrauterine transfusion (IUT) is of utmost importance in the prevention of fetal anemia but it is usually feasible only after 20 weeks of pregnancy. Therefore, additional treatment options in early pregnancy are needed. Study design and methods: A 27-year-old severely D + C immunized woman was admitted at 8 weeks of gestation in her fifth pregnancy with an extremely high concentration of anti-D. Her first pregnancy was uneventful but resulted in D + C alloimmunization. The next two pregnancies were unsuccessful, because of hydrops fetalis resulting in fetal death in pregnancy week 20 and 24, respectively, despite treatment with high-dose intravenous immunoglobulin (IVIG) and IUT treatment. A fourth pregnancy was terminated with legal abortion. The patient was eager and persistent to accomplish a successful pregnancy. Therefore, a combination of treatments consisting of plasma exchange (PE) three times/week and IVIG 100 g/week was started in pregnancy week 12. PE was performed 53 times and totally 159 L of plasma was exchanged. Results: The anti-D concentration was 12 μg/mL (IAT titer 2000) before start of treatment by PE and IVIG in pregnancy week 12. The concentration of anti-D was gradually reduced to approximately 3 μg/mL after only two weeks of treatment and was maintained at that level until pregnancy week 22. In pregnancy week 26 and 27, signs of hydrops were detected by ultrasonography and IUT were performed at each occasion. Sectio was inevitable at pregnancy week 28 + 1 and a male baby was born: Hb 58 g/L (cord sample) and 68 g/L (venous sample), weight 1385 g, Apgar score = 4-5-7, Bilirubin 56-150 mmol/L (4 h). Exchange transfusion was performed on day two and day five. Phototherapy was also implemented for eight days. The newborn's recovery thereafter was uneventful and complete. Conclusion: A combination of PE and IVIG may be an efficient treatment possible to start in early pregnancy in patients with extremely severe Rh (D) alloimmunization, with a history of hydrops fetalis in previous pregnancies. © 2006 Elsevier Ltd. All rights reserved.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-37218 (URN)10.1016/j.transci.2006.07.002 (DOI)33938 (Local ID)33938 (Archive number)33938 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Cedergren, M. & Selbing, A. (2006). Detection of fetal structural abnormalities by an 11-14-week ultrasound dating scan in an unselected Swedish population. Acta Obstetricia et Gynecologica Scandinavica, 85(8), 912-915
Open this publication in new window or tab >>Detection of fetal structural abnormalities by an 11-14-week ultrasound dating scan in an unselected Swedish population
2006 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 85, no 8, p. 912-915Article in journal (Refereed) Published
Abstract [en]

Background. To determine the detection rate of fetal structural abnormalities by a routine 11-14-week ultrasound scan for dating in an unselected pregnant population. Methods. A prospective observational cohort study of 2,708 unselected pregnant women attending an abdominal ultrasound examination at 11-14 weeks gestation. The number of major fetal structural abnormalities diagnosed after birth was obtained from a computerized database at the same unit. Results. Out of 2,708 pregnant women, 89 (3.3%) were found to have a missed abortion at the time of the ultrasound scan and 33 (1.2%) were diagnosed as twins. Thirteen major structural abnormalities were detected, three cases of anencephaly (one case also had a spina bifida), one case with hydranencephaly, one fetus with Dandy-Walker syndrome, two cases with gastroschisis, one case with a bilateral hydronephrosis, one case with a generalized hydrops, one fetus with multiple malformations, and three cystic hygromas. An additional 19 major structural defects were detected at birth. Four cases of neural tube defects and nine fetuses with congenital heart defects were diagnosed. The antenatal ultrasound detection rate was 40.6% (13/32). Nine patients had a nuchal translucency greater than 3.0 mm (excluding cystic hygromas), two of them had chromosomal abnormalities (trisomy 21 and trisomy 18). Conclusions. Fetal structural abnormalities were detected in 41% (95%CI = 24-59) of the cases in an unselected pregnant population at a routine 11-14-week ultrasound scan for dating purpose. Two out of nine fetuses with a nuchal translucency greater than 3.0 mm had a chromosomal abnormality. © 2006 Taylor & Francis.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-35130 (URN)10.1080/00016340500448438 (DOI)24947 (Local ID)24947 (Archive number)24947 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Aittomaki, K., Bergh, C., Hazekamp, J., Nygren, K.-G., Selbing, A., Soderstrom-Anttila, V. & Wennerholm, U.-B. (2005). Genetics and assisted reproduction technology. Acta Obstetricia et Gynecologica Scandinavica, 84(5), 463-473
Open this publication in new window or tab >>Genetics and assisted reproduction technology
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2005 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 84, no 5, p. 463-473Article, review/survey (Refereed) Published
Abstract [en]

In the past 20 years, a significant improvement has been shown in the treatment for infertility in both women and men through the development of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Only donated sperm could be previously used for treatment, now oocytes can also be donated. Furthermore, the combination of IVF and ICSI with advanced genetic methods has made preimplantation genetic diagnosis possible for many genetic conditions. These methods enable genetic testing of the early human embryo by using only a single cell, one blastomere biopsied from the embryo, as the sample from which the diagnosis of many chromosome rearrangements and other inherited diseases can be made. It has also been established that a considerable proportion of infertility is caused by genetic defects, which have several implications for infertility treatment. The purpose of this review is to give a concise introduction on how genetics is involved in assisted reproduction technology to specialists who may not be working in this particular field of gynecology, but who would need some knowledge of this for proper care of their patients. © Acta Obstet Gynecol Scand (2005).

Keywords
Genetics, ICSI, Infertility, IVF, PGD
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-45454 (URN)10.1111/j.0001-6349.2005.00777.x (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13
Aittomäki, K., Wennerholm, U.-B., Bergh, C., Selbing, A., Hazekamp, J. & Nygren, K.-G. (2004). Safety issues in assisted reproduction technology. Should ICSI patients have genetic testing before treatment? A practical proposition to help patient information. Human Reproduction, 19(3), 472-476
Open this publication in new window or tab >>Safety issues in assisted reproduction technology. Should ICSI patients have genetic testing before treatment? A practical proposition to help patient information
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2004 (English)In: Human Reproduction, ISSN 0268-1161, E-ISSN 1460-2350, Vol. 19, no 3, p. 472-476Article in journal (Refereed) Published
Abstract [en]

ICSI is a highly efficient treatment of male factor infertility and therefore increasingly used to treat infertile men successfully. However, when used to treat patients with a genetic cause for their infertility, there may be an increased risk for the offspring. Chromosome aberrations, Y chromosome microdeletions and CFTR (cystic fibrosis transmembrane conductance regulator) mutations alone may explain up to 25% of azoospermia and severe oligozoospermia. These genetic defects could be identified before treatment, in which case informed decisions could be made by the couple to be treated concerning the treatment, prenatal testing or preimplantation genetic diagnosis. Therefore, we propose that men with very low sperm counts (<5 × 106/ml) considering ICSI should always be informed of the possibility of genetic testing. The information should include a precise statement of the implications of the results for the patient, his family and his offspring, and reassurance that a decision to test or not to test, or the subsequent test results will not be used as a reason for withholding treatment. Testing should always remain voluntary, and the couples themselves should decide whether or not they choose to be tested. If an abnormality is identified, patients should be referred to specialist genetic counselling.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24694 (URN)10.1093/humrep/deh100 (DOI)6931 (Local ID)6931 (Archive number)6931 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Cedergren, M., Selbing, A., Löfman, O. & Källen, B. A. J. (2002). Chlorination Byproducts and Nitrate in Drinking Water and Risk for Congenital Cardiac Defects. Environmental Research, 89(2), 124-130
Open this publication in new window or tab >>Chlorination Byproducts and Nitrate in Drinking Water and Risk for Congenital Cardiac Defects
2002 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 89, no 2, p. 124-130Article in journal (Refereed) Published
Abstract [en]

Drinking water disinfection byproducts have been associated with an increased risk for congenital defects including cardiac defects. Using Swedish health registers linked to information on municipal drinking water composition, individual data on drinking water characteristics were obtained for 58,669 women. Among the infants born, 753 had a cardiac defect. The risk for a cardiac defect was determined for ground water versus surface water, for different chlorination procedures, and for trihalomethane and nitrate concentrations. Ground water was associated with an increased risk for cardiac defect when crude rates were analyzed but after suitable adjustments this excess rate was found to be determined by chlorination procedures including chlorine dioxide. Chlorine dioxide appears itself as an independent risk factor for cardiac defects (adjusted odds ratio 1.61 (95%CI 1.00–2.59)). The risk for cardiac defects increased with increasing trihalomethane concentrations (P=0.0005). There was an indicated but statistically nonsignificant excess risk associated with nitrate concentration. The individual risk for congenital cardiac defect caused by chlorine dioxide and trihalomethanes is small but as a large population is exposed to public drinking water, the attributable risk for cardiac defects may not be negligible.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26406 (URN)10.1006/enrs.2001.4362 (DOI)10946 (Local ID)10946 (Archive number)10946 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Immerstrand, C., Holmgren Peterson, K., Magnusson, K.-E., Jager, E., Krogh, M., Skoglund, M., . . . Inganäs, O. (2002). Conjugated-polymer micro- and milliactuators for biological applications. MRS bulletin, 27(6), 461-464
Open this publication in new window or tab >>Conjugated-polymer micro- and milliactuators for biological applications
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2002 (English)In: MRS bulletin, ISSN 0883-7694, E-ISSN 1938-1425, Vol. 27, no 6, p. 461-464Article in journal (Refereed) Published
Abstract [en]

The development of new conjugated-polymer tools for the study of the biological realm, and for use in a clinical setting, is reviewed in this article. Conjugated-polymer actuators, based on the changes of volume of the active conjugated polymer during redox transformation, can be used in electrolytes employed in cell-culture media and in biological fluids such as blood, plasma, and urine. Actuators ranging in size from 10 μm to 100 μm suitable for building structures to manipulate single cells are produced with photolithographic techniques. Larger actuators may be used for the manipulation of blood vessels and biological tissue.

National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-17565 (URN)10.1557/mrs2002.146 (DOI)
Note

Original Publication:Charlotte Immerstrand, Kajsa Holmgren Peterson, Karl-Eric Magnusson, Edwin Jager, Magnus Krogh, Mia Skoglund, Anders Selbing and Olle Inganäs, Conjugated-Polymer Micro- and Milliactuators for Biological Applications, 2002, MRS bulletin, (27), 6, 461-464.http://www.mrs.org/s_mrs/sec_subscribe.asp?CID=2959&DID=171856&action=detailCopyright: MRS Materials Research Societyhttp://www.mrs.org/

Available from: 2009-04-01 Created: 2009-04-01 Last updated: 2017-12-13Bibliographically approved
Cedergren, M., Selbing, A. & Källén, B. (2002). Geographic variations in possible risk factors for severe cardiac malformations. Acta Paediatrica, 91(2), 222-228
Open this publication in new window or tab >>Geographic variations in possible risk factors for severe cardiac malformations
2002 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 91, no 2, p. 222-228Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate various putative risk factors in a county in Sweden, described as having a 28% increased prevalence of cardiovascular malformations, and to compare them with the risk factors in two reference counties. Women giving birth in the studied counties differed in age and parity distribution, smoking, and educational level but these differences could not explain the increased risk of cardiovascular malformations in the county, since after stratification for these variables, the risk estimate did not change substantially. A number of potential risk factors were studied in a case/control design: spontaneous abortions, involuntary childlessness, maternal disease, body mass index, medical drug use, alcohol use, parental employment, paternal age, and urban/rural residency. No single factor could be attributed to the increased rate, with the exception of living in a rural district. Nearly all risk factors, however, were stronger in the county studied than those in the reference counties (0.02 > p > 0.01).

Conclusion: The only single putative risk factor that could have contributed to the increased risk for cardiac defects described in the county studied was maternal residency in a rural district. Notably, nearly all potential risk factors studied were stronger in the county studied compared with those in the reference area. A conceivable explanation is that one or more unidentified factors related to rural residency could potentiate prevalent and weak teratogenic risk factors for cardiac defects.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26404 (URN)10.1111/j.1651-2227.2002.tb01699.x (DOI)10944 (Local ID)10944 (Archive number)10944 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
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