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Hamrin, Elisabeth
Alternative names
Publications (10 of 50) Show all publications
Hamrin, E., Ernerudh, J. & Rosén, A. (2018). Immunological and Quality-of-Life Profiles in Women with Breast Cancer: Complementary versus Conventional Care. Complementary Medicine Research, 25, 391-397
Open this publication in new window or tab >>Immunological and Quality-of-Life Profiles in Women with Breast Cancer: Complementary versus Conventional Care
2018 (English)In: Complementary Medicine Research, ISSN 2504-2092, Vol. 25, p. 391-397Article in journal (Refereed) Published
Abstract [en]

Background: Previous studies showed that women with breast cancer treated in anthroposophic clinic versus conventional care had increased quality of life (QoL) parameters, fighting spirit, and anxiety coping. We have now analyzed immune and QoL factors in these 2 groups for possible differences during the first 6 months after admission, prompted by anthroposophic studies, including mistletoe extracts, showing beneficial immune system effects.

Patients and MethodsFourteen immunological variables, including leukocyte count, lymphocyte count, activated T cells (CD4+ and CD8+), NK cells, B cells, IL1β, IL6, IL10, and oxytocin, were longitudinally analyzed in both groups (n = 2 × 26). A panel of QoL parameters were analyzed using 3 different instruments. Statistical evaluation included that each patient was its own control.

Results: Cytotoxic CD8+ T cell frequency (percent of lymphocytes analyzed by flow-cytometry) significantly decreased over time in the anthroposophic group versus the conventional group (repeated measures ANOVA, p = 0.05). No major differences were observed in other immunological parameters, whereas QoL variables, anxiety decreased and physical symptoms increased/improved significantly in the anthroposophic group (p = 0.04 and p = 0.05, respectively).

Conclusion: Overall, women with breast cancer in anthroposophic or conventional therapy did not differ in their immune profiles over time, with exception of decreased cytotoxic T cells in the anthroposophic group. Improvement in physical symptoms along with less anxiety in this group may have influenced the brain-immune axis resulting in lower frequency of CD8+ T cells, a feature associated with less aggressive cancer stages. To evaluate whether this observation is associated with good or bad prognosis, further detailed analyses of memory and naïve CD8+ T cells at tumor site and in blood circulation are essential.

Abstract [de]

Hintergrund: Bisherige Studien haben gezeigt, dass die Behandlung von Brustkrebspatientinnen in anthroposophischen Kliniken gegenüber einer konventionellen Behandlung mit einer verbesserten Lebensqualität (quality of life; QoL), größerem Kampfgeist und einer besseren Angstbewältigung einhergeht. Angespornt durch anthroposophische Studien, solche mit Mistelextrakt eingeschlossen, die eine günstige Wirkung auf das Immunsystem zeigten, haben wir nun Immun- und QoL-Faktoren in diesen beiden Gruppen während der ersten 6 Monate nach Aufnahme untersucht.

Patienten und Methoden: 14 immunologische Variablen, einschließlich Leukozyten- und Lymphozytenzahl, aktivierter T-Zellen (CD4+ und CD8+), NK-Zellen, B-Zellen, IL1β, IL6, IL10 und Oxytocin, wurden in beiden Gruppen longitudinal analysiert (n = 2 × 26). Unter Zuhilfenahme von 3 verschiedenen Instrumenten wurde eine Reihe von QoL-Parametern analysiert. Die statistische Auswertung war so angelegt, dass jeder Patient als seine eigene Kontrolle diente.

Ergebnisse: Die Häufigkeit von zytotoxischen CD8+-T-Zellen (prozentualer Anteil an Lymphozyten analysiert mittels Durchflusszytometrie) nahm in der anthroposophischen gegenüber der konventionell behandelten Gruppe im Zeitverlauf signifikant ab (wiederholte ANOVA-Messungen; p = 0,05). Während für weitere immunologische Parameter keine größeren Unterschiede festgestellt wurden, verbesserten sich die QoL-Variablen; die Angst verringerte sich und die physischen Symptome verbesserten sich signifikant in der anthroposophischen Gruppe (p = 0,04 bzw. p = 0,05).

Schlussfolgerung: Insgesamt zeigte sich, dass es während des untersuchten Zeitraums keinen Unterschied in den Immunprofilen von Brustkrebspatientinnen mit anthroposophischer gegenüber solchen mit ausschließlich konventioneller Therapie gab. Die Verbesserung der physischen Symptome sowie die verringerte Angst in dieser Gruppe könnte die Gehirnimmunachse beeinflusst und zu einer geringeren Häufigkeit der CD8+-T-Zellen, einem Kennzeichen für weniger aggressive Tumorstadien, geführt haben. Um beurteilen zu können, ob diese Beobachtung mit einer guten oder schlechten Prognose assoziiert ist, sind weitere detaillierte Untersuchungen von Gedächtnis- und naiven CD8+-T-Zellen am Tumorort und in der Blutzirkulation unerlässlich.

Place, publisher, year, edition, pages
S. Karger, 2018
Keywords
Breast cancer treatment, Complementary medicine, Anthroposophical care, Immunology, Tumor immunity, Cytotoxic CD8 + T cells, Physical symptoms, Anxiety, Brustkrebstherapie, Komplementärmedizin, Anthroposophische Versorgung, Immunologie, Tumorimmunität, Zytotoxische CD8+-T-Zellen, Physische Symptome, Angst
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:liu:diva-153754 (URN)10.1159/000490049 (DOI)000456452900009 ()30145583 (PubMedID)2-s2.0-85053163476 (Scopus ID)
Funder
Swedish Cancer Society
Available from: 2019-01-08 Created: 2019-01-08 Last updated: 2020-01-16Bibliographically approved
Hamrin, E. (2015). Editorial Material: When Nursing Care became Science. The first decades 1970-2000 in SCANDINAVIAN JOURNAL OF CARING SCIENCES, vol 29, issue 1, pp. Scandinavian Journal of Caring Sciences, 29(1)
Open this publication in new window or tab >>Editorial Material: When Nursing Care became Science. The first decades 1970-2000 in SCANDINAVIAN JOURNAL OF CARING SCIENCES, vol 29, issue 1, pp
2015 (English)In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 29, no 1Article in journal, Editorial material (Other academic) Published
Abstract [en]

n/a

Place, publisher, year, edition, pages
WILEY-BLACKWELL, 2015
National Category
Health Sciences
Identifiers
urn:nbn:se:liu:diva-116831 (URN)10.1111/scs.12214 (DOI)000350285500001 ()25690264 (PubMedID)
Available from: 2015-04-07 Created: 2015-04-07 Last updated: 2017-12-04
Andersson, E., Arlinger, S., Magnusson, L. & Hamrin, E. (2013). Audiometric screening of a population with intellectual disability. International Journal of Audiology, 52(1), 50-56
Open this publication in new window or tab >>Audiometric screening of a population with intellectual disability
2013 (English)In: International Journal of Audiology, ISSN 1499-2027, E-ISSN 1708-8186, Vol. 52, no 1, p. 50-56Article in journal (Refereed) Published
Abstract [en]

Objective: Evaluation of pure-tone audiometry (PTA) in hearing screening of a population with mild to profound intellectual disability (ID).

Design: PTA was performed at six frequencies at the screening level 20 dB HL. Referral criteria were threshold levels ≥ 25 dB HL at two or more frequencies for one ear or both.

Study sample: 1478 participants aged 7–91 years were included.

Results: 1470 (99.5%) people cooperated in screening of which 1325 (90%) could be tested on both ears at all six frequencies. A majority, 987 (66.8%), performed ordinary PTA, 234 (15.8%) conditioned play audiometry, and 249 (16.9%) behavioural observation audiometry. Six hundred and sixty-nine (45%) passed and 809 (55%) failed according to referral criteria. Of those failing, 441 (54.5%) accepted referral to clinical evaluation.

Conclusions: PTA with slight modifications is applicable for screening of a population with mild to profound intellectual disability. The most challenging and time-consuming activity is to introduce the test procedure in a way that reduces anxiety and establishes trust.

Place, publisher, year, edition, pages
London: Informa Healthcare, 2013
Keywords
intellectual disability, screening audiometry, psycho-acoustic method
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-87267 (URN)10.3109/14992027.2012.700773 (DOI)000312223800008 ()
Available from: 2013-04-09 Created: 2013-01-14 Last updated: 2017-12-06Bibliographically approved
Hamrin, E. K., Gustafsson, G. & Jaracz, K. (2012). Quality of life among the elderly with locomotor disabilities in Sweden and Poland in the 1990s. Quality of Life Research, 21(2), 281-289
Open this publication in new window or tab >>Quality of life among the elderly with locomotor disabilities in Sweden and Poland in the 1990s
2012 (English)In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 21, no 2, p. 281-289Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To estimate the proportion of locomotor disabilities in two elderly populations in Sweden and Poland, respectively. To estimate the perceived quality of life (QoL) in the disabled groups in samples from each country using a model developed by Carol Estwing Ferrans.

METHODS: The study comprised three parts: an epidemiological screening test for identification of individuals with a locomotor disability, an analysis of background data of importance and home visits with evaluations of quality of life and functional capacity. Home visits were made using the Quality of Life Index, (QLI) of Ferrans and Powers and a functional scale, the Standardized Practical Equipment (SPE). Data were collected for the period 1991-1996.

RESULTS: In the population part of the study, with 1,380 respondents (78%) comprising elderly Swedish persons, 288 reported a locomotor disability. This can be compared with 425 among 1,045 respondents (52%) in a Polish elderly group. The tests at the home visits (Sweden, n = 89; Poland, n = 84) showed that both men and women in the Swedish group reported significantly higher scores for the total QLI (max. 30.00) with men reporting 26.68 points compared to 19.73 and women reporting 21.39 points compared to 19.40 and for three of the four subscales. Also, the Polish group scored lower for balance and mobility (SPE).

CONCLUSION: The study provides an important view of the life situation measured with the QLI tool and the SPE for elderly persons with locomotor disorders in Sweden and Poland during the mid-1990s. The results are congruent with epidemiological reports on the poor health situation in Poland, particularly during that time. A new investigation among the elderly with locomotor disorders in the two countries today might provide different results.

Place, publisher, year, edition, pages
Springer Science+Business Media B.V., 2012
Keywords
Aged, Disabled persons, Quality of life, Sweden, Poland
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-76097 (URN)10.1007/s11136-011-9949-9 (DOI)000303404500010 ()21769685 (PubMedID)
Note
funding agencies|County Council of Jonkoping||Faculty of Health Sciences at Linkoping University||Poznan University of Medical Sciences||Available from: 2012-03-27 Created: 2012-03-27 Last updated: 2017-12-07
Enskär, K., Hamrin, E., Carlsson, M. & von Essen, L. (2011). Swedish mothers and fathers of children with cancer: perceptions of well-being, social life, and quality care.. Journal of psychosocial oncology, 29(1), 51-66
Open this publication in new window or tab >>Swedish mothers and fathers of children with cancer: perceptions of well-being, social life, and quality care.
2011 (English)In: Journal of psychosocial oncology, ISSN 1540-7586, Vol. 29, no 1, p. 51-66Article in journal (Refereed) Published
Abstract [en]

The overall aim was to describe and compare well-being, social life, and quality care among parents of children with cancer with respect to mothers versus fathers and whether the children were on versus. off treatment. The Life Situation Scale for Parents (LSS-P) was answered by 320 parents, comprising 85 mothers and 71 fathers of children on treatment, and 93 mothers and 71 fathers of children off treatment. The results show that the well-being of parents of children with cancer is affected by their child's situation, and that they experience such things as economic strain and a sense of being dependent on the care provided, especially during the child's treatment phase. Mothers whose children are receiving treatment see their life situation as less satisfying, and report being sadder and having lower self-esteem.

Place, publisher, year, edition, pages
Routledge, 2011
Keywords
care, childhood neoplasm, parents, social life, wellbeing
National Category
Nursing
Identifiers
urn:nbn:se:liu:diva-65694 (URN)10.1080/07347332.2011.534026 (DOI)000286823100004 ()21240725 (PubMedID)
Available from: 2011-02-17 Created: 2011-02-17 Last updated: 2012-03-27
Johansson, I. & Hamrin, E. (2009). Bedömning av akut förvirringstillstånd med hjälp av NEECHAM Confusion Scale. Vård i Norden, 29(2), 42-43
Open this publication in new window or tab >>Bedömning av akut förvirringstillstånd med hjälp av NEECHAM Confusion Scale
2009 (English)In: Vård i Norden, ISSN 0107-4083, E-ISSN 1890-4238, Vol. 29, no 2, p. 42-43Article in journal (Refereed) Published
Abstract [en]

To assess and identify early sign as well as to follow up the progress or regress of acute confusion are important in nursing care. For this purpose different instruments have been developed and tested psychometrically. One of these instruments is the NEECHAM Confusion Scale. The aim of this article is to describe the development and content of the NEECHAM Confusion Scale and its application in a Swedish sample. This scale is a screening instrument for rapid and non-intrusive assessment and contains nine items organized in three domains; cognitive functions; behavioral measures; physiological control and stability. Possible total score ranging from 0 (minimal responsiveness) to 30 (normal function). A score equal to or less than 24 indicated the presence of confusion. The scale has been psychometrically tested among elderly patients with hip fractures in Sweden. The internal consistency (Cronbach´s alpha coefficient) was satisfactory at two test occasions .73 versus .82 and the construct validity with a three-factor solution accounted for 69% and 73% of the variance. Four months after discharge the predictive value showed a correlation between level of confusion, quality of life, and functional capacity. The study and the literature confirmed that the NEECHAM-scale can be helpful both for patients with delirium and those responsible of the care.

Keywords
Acute confusion, hip fracture, nursing assessment psychometric test
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-21474 (URN)
Available from: 2009-10-02 Created: 2009-10-02 Last updated: 2017-12-13
Minhage, M., Wilde Larsson, B., Gustafsson, G. & Hamrin, E. (2008). The Swedish Version of the Philadelphia Geriatric Center Multilevel Assessment Instrument, by age and gender in an old-age swedish population, especially related to locomotor disability. Scandinavian Journal of Caring Sciences, 22(3), 478-484
Open this publication in new window or tab >>The Swedish Version of the Philadelphia Geriatric Center Multilevel Assessment Instrument, by age and gender in an old-age swedish population, especially related to locomotor disability
2008 (English)In: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, Vol. 22, no 3, p. 478-484Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to explore the pattern of the Swedish version of the Philadelphia Geriatric Center Multilevel Assessment Instrument (PGCMAI), in respect of age and gender, in a sample of old people with locomotor disability from a population aged 60 years and older in Sweden and compare it with other studies in the same area for the purpose of further validation. The participants (n = 199) were selected from a population (n = 3469), age ≥60 years, in two counties in Sweden and were visited in their own homes. The measure was carried out with two instruments, the Swedish version of PGCMAI, used as an interview, and the Standardized Practical Equipment test consisting of practical tasks. We found that these two instruments distinguished the functional pattern among old men and women where women had deteriorated most with age. This is in agreement with other studies.

Keywords
gender, locomotor disability, old age, Philadelphia Geriatric Center Multilevel Assessment Instrument
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-14611 (URN)10.1111/j.1471-6712.2007.00544.x (DOI)
Available from: 2007-08-27 Created: 2007-08-27
Hamrin, E. (2007). Further qualitative analyses on six Focus group interviews of young stroke victims in an Action Programme and one group of spouses. In: Nordic Stroke 2007,2007 (pp. 65-65).
Open this publication in new window or tab >>Further qualitative analyses on six Focus group interviews of young stroke victims in an Action Programme and one group of spouses
2007 (English)In: Nordic Stroke 2007,2007, 2007, p. 65-65Conference paper, Published paper (Other academic)
Abstract [en]

    

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-42744 (URN)68524 (Local ID)68524 (Archive number)68524 (OAI)
Available from: 2009-10-10 Created: 2009-10-10
Minhage, M., Wilde Larsson, B., Gustafsson, G. & Hamrin, E. (2007). Psychometric testing of the Swedish version of the Philadelphia Geriatric Center Multilevel Assessment Instrument. International Journal of Nursing Practice, 13(3), 139-150
Open this publication in new window or tab >>Psychometric testing of the Swedish version of the Philadelphia Geriatric Center Multilevel Assessment Instrument
2007 (English)In: International Journal of Nursing Practice, ISSN 1322-7114, Vol. 13, no 3, p. 139-150Article in journal (Refereed) Published
Abstract [en]

We examined whether the Swedish adaptation of the Philadelphia Geriatric Center Multilevel Assessment Instrument (PGCMAI) developed by Lawton meets criteria for reliability and validity in an elderly Swedish population with locomotor disability. Data were collected, using the mid-length version of the instrument, from 199 elderly people with locomotor disability in two Swedish counties. Reliability was determined by Cronbach's alpha and construct validity was tested by means of exploratory factor analysis. Comparison was made with the Standardized Practical Equipment (SPE) test. Factor analysis identified eight factors, which were comparable to the original eight domains. There was a logical correlation between the PGCMAI and the SPE test. Further psychometric testing is recommended on other groups of elderly people.

Keywords
locomotor disability, multidimensional instrument, old age, reliability, validity
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-14610 (URN)10.1111/j.1440-172X.2007.00619.x (DOI)
Available from: 2007-08-27 Created: 2007-08-27 Last updated: 2009-05-08
Hamrin, E. (2007). Studies on functional ability and quality of life of older people in Sweden (English). In: Multidyscyplinarne aspekty opieki geriatryczno-gerontologicznej,2007 (pp. 35-42).
Open this publication in new window or tab >>Studies on functional ability and quality of life of older people in Sweden (English)
2007 (English)In: Multidyscyplinarne aspekty opieki geriatryczno-gerontologicznej,2007, 2007, p. 35-42Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-42745 (URN)68525 (Local ID)68525 (Archive number)68525 (OAI)
Available from: 2009-10-10 Created: 2009-10-10
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