liu.seSearch for publications in DiVA
Change search
Link to record
Permanent link

Direct link
Lindgren, Per-Eric
Alternative names
Publications (10 of 80) Show all publications
Carlströmer Berthén, N., Tompa, E., Olausson, S., Nyberg, C., Nyman, D., Ringbom, M., . . . Nordberg, M. (2023). The AxBioTick Study: Borrelia Species and Tick-Borne Encephalitis Virus in Ticks, and Clinical Responses in Tick-Bitten Individuals on the Aland Islands, Finland. Microorganisms, 11(5), Article ID 1100.
Open this publication in new window or tab >>The AxBioTick Study: Borrelia Species and Tick-Borne Encephalitis Virus in Ticks, and Clinical Responses in Tick-Bitten Individuals on the Aland Islands, Finland
Show others...
2023 (English)In: Microorganisms, E-ISSN 2076-2607, Vol. 11, no 5, article id 1100Article in journal (Refereed) Published
Abstract [en]

The AxBioTick Study: Borrelia Species and Tick-Borne Encephalitis Virus in Ticks, and Clinical Responses in Tick-Bitten Individuals on the Aland Islands, Finlandby  Nellie Carlströmer Berthén 1,2,*,† , Eszter Tompa 3,† , Susanne Olausson 1,2, Clara Nyberg 1, Dag Nyman 1,2, Malin Ringbom 1,4, Linda Perander 1,4, Joel Svärd 3, Per-Eric Lindgren 3,5, Pia Forsberg 3, Peter Wilhelmsson 3,5,‡, Johanna Sjöwall 3,6,‡  and Marika Nordberg 1,4,‡  1Borrelia Research Group of the Aland Islands, 22100 Mariehamn, The Aland Islands, Finland2Bimelix AB, 22100 Mariehamn, The Aland Islands, Finland3Department of Biomedical and Clinical Sciences, Division of Inflammation and Infection, Linkoping University, 581 83 Linkoping, Sweden4The Aland Islands Healthcare Services, 22100 Mariehamn, The Aland Islands, Finland5Clinical Microbiology, Laboratory Medicine, County Hospital Ryhov, 551 85 Jonkoping, Sweden6Department of Infectious Diseases, Vrinnevi Hospital, 603 79 Norrkoping, Sweden*Author to whom correspondence should be addressed.†These authors contributed equally to the study.‡These authors contributed equally to the study.Microorganisms 2023, 11(5), 1100; https://doi.org/10.3390/microorganisms11051100Received: 30 March 2023 / Revised: 17 April 2023 / Accepted: 19 April 2023 / Published: 22 April 2023(This article belongs to the Special Issue Research on Ticks and Tick-Borne Pathogens)

Download Browse Figures Versions NotesArticle Views585 

AbstractThe AxBioTick study was initiated to investigate the prevalence of ticks and tick-borne pathogens and their impact on antibody and clinical responses in tick-bitten individuals on the Aland Islands. This geographical area is hyperendemic for both Lyme borreliosis (LB) and Tick-borne encephalitis (TBE). Blood samples and ticks were collected from 100 tick-bitten volunteers. A total of 425 ticks was collected, all determined to Ixodes ricinus using molecular tools. Of them 20% contained Borrelia species, of which B. garinii and B. afzelii were most common. None contained the TBE virus (TBEV). Blood samples were drawn in conjunction with the tick bite, and eight weeks later. Sera were analyzed for Borrelia- and TBEV-specific antibodies using an ELISA and a semiquantitative antibody assay. In total 14% seroconverted in Borrelia C6IgG1, 3% in TBEV IgG, and 2% in TBEV IgM. Five participants developed clinical manifestations of LB. The high seroprevalence of both Borrelia (57%) and TBEV (52%) antibodies are likely attributed to the endemic status of the corresponding infections as well as the TBE vaccination program. Despite the similar prevalence of Borrelia spp. detected in ticks in other parts of Europe, the infection rate in this population is high. The AxBioTick study is continuing to investigate more participants and ticks for co-infections, and to characterize the dermal immune response following a tick bite.

Place, publisher, year, edition, pages
MDPI, 2023
Keywords
Borrelia; tick-borne encephalitis virus; Ixodes ricinus; tick bite; clinical; prospective study; ELISA; antibody responses; clinical responses
National Category
Infectious Medicine
Identifiers
urn:nbn:se:liu:diva-194108 (URN)10.3390/microorganisms11051100 (DOI)000997517600001 ()37317075 (PubMedID)
Note

Funding agencies: The Wilhelm and Else Stockmann foundation, The foundation for medical research of the Åland cultural foundation, The Jubilee foundation from the provincial government of the Aland Island (Borrelia Research Group of the Aland Islands), Region Östergötland (ALF Grant, RÖ968220) (J.S. (Johanna Sjöwall)), the Medical Research Council of Southeast Sweden (FORSS, 931010) (P.W.), the Division of Laboratory Medicine, Region Jönköping County, and the European Union through the European Regional Development Fund and the Interreg North Sea Region Program 2014–2020 as part of the NorthTick project (reference number J-No.: 38-2-7-19) (P.-E.L.).

Available from: 2023-05-26 Created: 2023-05-26 Last updated: 2023-06-19
Wass, L., Quarsten, H., Lindgren, P.-E., Forsberg, P., Skoog, E., Nilsson, K., . . . Wennerås, C. (2022). Cytokine responses of immunosuppressed and immunocompetent patients with Neoehrlichia mikurensis infection. Medical Microbiology and Immmunology, 211, 133-141
Open this publication in new window or tab >>Cytokine responses of immunosuppressed and immunocompetent patients with Neoehrlichia mikurensis infection
Show others...
2022 (English)In: Medical Microbiology and Immmunology, ISSN 0300-8584, E-ISSN 1432-1831, Vol. 211, p. 133-141Article in journal (Refereed) Published
Abstract [en]

Purpose

The tick-borne bacterium Neoehrlichia mikurensis causes the infectious disease neoehrlichiosis in humans. Vascular endothelium is one of the target cells of the infection. Neoehrlichiosis patients with compromised B cell immunity present with more severe inflammation than immunocompetent patients. The aim of this study was to compare the cytokine profiles of immunocompetent and immunosuppressed patients with neoehrlichiosis.

Methods

Blood samples from Swedish and Norwegian immunosuppressed (N = 30) and immunocompetent (N = 16) patients with neoehrlichiosis were analyzed for the levels of 30 cytokines, using a multiplex cytokine assay and ELISA. A gender-matched healthy control group (N = 14) was analyzed in parallel. Data were analyzed using the multivariate method OPLS-DA.

Results

The multiplex cytokine analyses generated more cytokine results than did the uniplex ELISA analyses. Multivariate analysis of the multiplex cytokine results established that increased levels of FGF2, GM-CSF, CXCL10, and IFNγ were associated with immunosuppressed patients, whereas increased levels of IL-15 and VEGF were associated with immunocompetent neoehrlichiosis patients. When multivariate analysis findings were confirmed with uniplex ELISA, it was found that both groups of patients had similarly elevated levels of VEGF, FGF2 and IFNγ. In contrast, the immunosuppressed patients had clearly elevated levels of CXCL10, CXCL13 and BAFF, whereas the immunocompetent patients had the same levels as healthy controls.

Conclusion

Pro-angiogenic and type 1 cytokines were produced as part of the host response of neoehrlichiosis independent of immune status, whereas immunosuppressed neoehrlichiosis patients produced cytokines required for B cell-mediated defense.

Place, publisher, year, edition, pages
Springer, 2022
Keywords
Neoehrlichia mikurensis; Neoehrlichiosis; Tick-borne disease; Immunosuppression; B cell; Cytokines
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:liu:diva-184687 (URN)10.1007/s00430-022-00737-6 (DOI)000783035900001 ()35430702 (PubMedID)2-s2.0-85128229755 (Scopus ID)
Note

Funding Agencies: University of Gothenburg; European Union through the European Regional Development Fund, European Commission; Interreg North Sea Region Programme [J-No.: 38-2-7-19]; Swedish government; county councils; ALF-agreement ALF Research Fund [ALFGBG-827291]; Cancer and Allergy Foundation [2020-10154]; Swedish Research Council, European Commission [K200858X-14631-06-3, 2020-01287]

Available from: 2022-05-06 Created: 2022-05-06 Last updated: 2023-03-07Bibliographically approved
Hoffman, T., Wilhelmsson, P., Barboutis, C., Fransson, T., Jaenson, T. G., Lindgren, P.-E., . . . Salaneck, E. (2020). A divergent Anaplasma phagocytophilum variant in an Ixodes tick from a migratory bird; Mediterranean basin. Infection Ecology & Epidemiology, 10(1), Article ID 1729653.
Open this publication in new window or tab >>A divergent Anaplasma phagocytophilum variant in an Ixodes tick from a migratory bird; Mediterranean basin
Show others...
2020 (English)In: Infection Ecology & Epidemiology, ISSN 2000-8686, E-ISSN 2000-8686, Vol. 10, no 1, article id 1729653Article in journal (Refereed) Published
Abstract [en]

Anaplasma phagocytophilum (AP) has vast geographical and host ranges and causes disease in humans and domesticated animals. We investigated the role of northward migratory birds in the dispersal of tick-borne AP in the African-Western Palearctic. Ticks were collected from northward migratory birds trapped during spring migration of 2010 at two localities in the central Mediterranean Sea. AP DNA was detected by PCR (gltA and 16S rRNA) and variant determination was performed using ankA sequences. In total, 358 ticks were collected. One of 19 ticks determined as Ixodes was confirmed positive for AP DNA. The tick was collected from a woodchat shrike (Lanius senator senator) trapped in Greece, and molecularly determined to belong to the I. ricinus complex and sharing highest (95%) 16S RNA sequence identity to I. gibbosus. The ankA AP sequence exhibited highest similarity to sequences from rodents and shrews (82%) and ruminants (80%). Phylogenetic analyses placed it convincingly outside other clades, suggesting that it represents a novel AP variant. The divergent Ixodes species harboring a novel AP variant could either indicate an enzootic cycle involving co-evolution with birds, or dissemination from other regions by avian migration. None of the 331 Hyalomma marginatum sensu lato ticks, all immature stages, were positive for AP DNA, lending no evidence for the involvement of Hyalomma ticks transported by birds in the ecology of AP.

Place, publisher, year, edition, pages
Taylor & Francis, 2020
Keywords
16s rRNA; African-Western Palearctic region; Anaplasma phagocytophilum; Bird migration; Hyalomma marginatum s.l.; Ixodes; ankA
National Category
Microbiology
Identifiers
urn:nbn:se:liu:diva-174232 (URN)10.1080/20008686.2020.1729653 (DOI)32284823 (PubMedID)
Available from: 2021-03-17 Created: 2021-03-17 Last updated: 2021-03-17
Wilhelmsson, P., Fryland, L., Lindblom, P., Sjöwall, J., Ahlm, C., Berglund, J., . . . Lindgren, P.-E. (2016). A prospective study on the incidence of Borrelia infection after a tick bite in Sweden and on the Åland Islands, Finland (2008-2009). Ticks and Tick-borne Diseases, 7(1), 71-79
Open this publication in new window or tab >>A prospective study on the incidence of Borrelia infection after a tick bite in Sweden and on the Åland Islands, Finland (2008-2009)
Show others...
2016 (English)In: Ticks and Tick-borne Diseases, ISSN 1877-959X, E-ISSN 1877-9603, Vol. 7, no 1, p. 71-79Article in journal (Refereed) Published
Abstract [en]

Lyme borreliosis (LB) is a common and increasing tick-borne disease in Europe. The risk of acquiring a Borrelia infection after a tick bite is not fully known. Therefore, we investigated the incidence of Borrelia infection after a tick bite and if the Borrelia load and/or the duration of tick-feeding influenced the risk of infection. During 2008-2009, ticks and blood samples were collected from 1546 tick-bitten persons from Sweden and the Åland Islands, Finland. Follow-up blood samples were taken three months after the tick bite. The duration of tick feeding was microscopically estimated and Borrelia was detected and quantified in ticks by real-time PCR. Anti-Borrelia antibodies were detected in sera using ELISA assays and immunoblot.

Even though 28 % of the participants were bitten by a Borrelia-positive tick, only 7.5% (32/428) of them developed a Borrelia infection, half of them LB. All who seroconverted removed “their” ticks significantly later than those who did not. The Borrelia load in the ticks did not explain the risk of seroconversion. Regional as well as gender differences in the Borrelia seroprevalence were found. The risk of developing a Borrelia infection after a bite by a Borrelia-infected tick is small but increases with the duration of tick feeding.

Place, publisher, year, edition, pages
Elsevier, 2016
Keywords
Borrelia burgdorferi sensu lato; tick bite; incidence of infection; Lyme borreliosis; asymptomatic infection; bacterial load; tick-feeding.
National Category
Infectious Medicine
Identifiers
urn:nbn:se:liu:diva-105475 (URN)10.1016/j.ttbdis.2015.08.009 (DOI)000366953400012 ()
Note

Funding agencies: Swedish Research Council Branch of Medicine [K2008-58X-14631-06-3]; Medical Research Council of South-East Sweden [FORSS-8967, FORSS-12573, FORSS-29021, FORSS-86911]; EU Interreg IV A project ScandTick [167226]; County Council of Ostergotland [LIO-56191];

Available from: 2014-03-25 Created: 2014-03-25 Last updated: 2021-12-29Bibliographically approved
Wilhelmsson, P. & Lindgren, P. E. (2016). Detection of a novel Lyme borreliosis pathogen.. The Lancet - Infectious diseases, 16(5), 511-512
Open this publication in new window or tab >>Detection of a novel Lyme borreliosis pathogen.
2016 (English)In: The Lancet - Infectious diseases, ISSN 1473-3099, E-ISSN 1474-4457, Vol. 16, no 5, p. 511-512Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
Elsevier, 2016
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-126677 (URN)10.1016/S1473-3099(15)00483-1 (DOI)000374272900006 ()26856776 (PubMedID)
Available from: 2016-04-01 Created: 2016-04-01 Last updated: 2024-01-17
Andersson, M. O., Bergvall, U. A., Chirico, J., Christensson, M., Lindgren, P.-E., Nordstrom, J. & Kjellander, P. (2016). Molecular detection of Babesia capreoli and Babesia venatorum in wild Swedish roe deer, Capreolus capreolus. Parasites & Vectors, 9(221)
Open this publication in new window or tab >>Molecular detection of Babesia capreoli and Babesia venatorum in wild Swedish roe deer, Capreolus capreolus
Show others...
2016 (English)In: Parasites & Vectors, E-ISSN 1756-3305, Vol. 9, no 221Article in journal (Refereed) Published
Abstract [en]

Background: The epidemiology of the zoonotic tick-transmitted parasite Babesia spp. and its occurrence in wild reservoir hosts in Sweden is unclear. In European deer, several parasite species, including Babesia capreoli and the zoonotic B. venatorum and B. divergens has been reported previously. The European roe deer, Capreolus capreolus, is an important and common part of the indigenous fauna in Europe, as well as an important host for Ixodes ricinus ticks, the vector of several Babesia spp. in Europe. Here, we aimed to investigate the occurrence of Babesia spp. in roe deer in Sweden. Findings: Roe deer (n = 77) were caught and sampled for blood. Babesia spp. was detected with a PCR assay targeting the 18S rRNA gene. The prevalence of Babesia spp. was 52 %, and two species were detected; B. capreoli and B. venatorum in 44 and 7.8 % of the individuals, respectively. Infection occurred both in summer and winter. Conclusions: We showed that roe deer in Sweden, close to the edge of their northern inland distributional range, are infected with Babesia spp. The occurrence of B. venatorum in roe deer imply that it is established in Sweden and the zoonotic implication of this finding should be regarded to a greater extent in future.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD, 2016
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-128748 (URN)10.1186/s13071-016-1503-8 (DOI)000375038700001 ()27094215 (PubMedID)
Note

Funding Agencies|Lawski foundation (Sven och Lilly Lawskis fond for naturvetenskaplig forskning); Royal Physiographic Society in Lund; Royal Swedish Academy of Agriculture and Forestry [H14-0069-ALF]; Swedish Environmental Protection Agency project; Swedish hunters organization; foundation Marie-Clair Cronstedts stiftelse: RaFast; EU Interreg - ScandTick Innovation

Available from: 2016-05-31 Created: 2016-05-30 Last updated: 2024-01-17
Mernelius, S., Carlsson, E., Henricson, J., Löfgren, S., Lindgren, P.-E., Ehricht, R., . . . Anderson, C. (2016). Staphylococcus aureus colonization related to severity of hand eczema. European Journal of Clinical Microbiology and Infectious Diseases, 35(8), 1355-1361
Open this publication in new window or tab >>Staphylococcus aureus colonization related to severity of hand eczema
Show others...
2016 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 35, no 8, p. 1355-1361Article in journal (Refereed) Published
Abstract [en]

Knowledge on Staphylococcus aureus colonization rates and epidemiology in hand eczema is limited. The aim of this study was to clarify some of these issues. Samples were collected by the "glove juice" method from the hands of 59 patients with chronic hand eczema and 24 healthy individuals. Swab samples were taken from anterior nares and throat from 43 of the 59 patients and all healthy individuals. S. aureus were spa typed and analysed by DNA-microarray-based genotyping. The extent of the eczema was evaluated by the hand eczema extent score (HEES). The colonization rate was higher on the hands of hand eczema patients (69 %) compared to healthy individuals (21 %, p amp;lt; 0.001). This was also seen for bacterial density (p = 0.002). Patients with severe hand eczema (HEES a parts per thousand yen 13) had a significantly higher S. aureus density on their hands compared to those with milder eczema (HEES = 1 to 12, p = 0.004). There was no difference between patients and healthy individuals regarding colonization rates in anterior nares or throat. spa typing and DNA-microarray-based genotyping indicated certain types more prone to colonize eczematous skin. Simultaneous colonization, in one individual, with S. aureus of different types, was identified in 60-85 % of the study subjects. The colonization rate and density indicate a need for effective treatment of eczema and may have an impact on infection control in healthcare.

Place, publisher, year, edition, pages
Springer, 2016
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-130833 (URN)10.1007/s10096-016-2672-2 (DOI)000380089800017 ()27193891 (PubMedID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden; Futurum - the Academy of Healthcare, County Council, Jonkoping; Medeca Pharma AB, Uppsala

Available from: 2016-08-26 Created: 2016-08-26 Last updated: 2017-11-21Bibliographically approved
Aase, A., Hajdusek, O., Oines, O., Quarsten, H., Wilhelmsson, P., Herstad, T. K., . . . Aaberge, I. S. (2016). Validate or falsify: Lessons learned from a microscopy method claimed to be useful for detecting Borrelia and Babesia organisms in human blood. INFECTIOUS DISEASES, 48(6), 411-419
Open this publication in new window or tab >>Validate or falsify: Lessons learned from a microscopy method claimed to be useful for detecting Borrelia and Babesia organisms in human blood
Show others...
2016 (English)In: INFECTIOUS DISEASES, ISSN 2374-4235, Vol. 48, no 6, p. 411-419Article in journal (Refereed) Published
Abstract [en]

Background A modified microscopy protocol (the LM-method) was used to demonstrate what was interpreted as Borrelia spirochetes and later also Babesia sp., in peripheral blood from patients. The method gained much publicity, but was not validated prior to publication, which became the purpose of this study using appropriate scientific methodology, including a control group. Methods Blood from 21 patients previously interpreted as positive for Borrelia and/or Babesia infection by the LM-method and 41 healthy controls without known history of tick bite were collected, blinded and analysed for these pathogens by microscopy in two laboratories by the LM-method and conventional method, respectively, by PCR methods in five laboratories and by serology in one laboratory. Results Microscopy by the LM-method identified structures claimed to be Borrelia- and/or Babesia in 66% of the blood samples of the patient group and in 85% in the healthy control group. Microscopy by the conventional method for Babesia only did not identify Babesia in any samples. PCR analysis detected Borrelia DNA in one sample of the patient group and in eight samples of the control group; whereas Babesia DNA was not detected in any of the blood samples using molecular methods. Conclusions The structures interpreted as Borrelia and Babesia by the LM-method could not be verified by PCR. The method was, thus, falsified. This study underlines the importance of doing proper test validation before new or modified assays are introduced.

Place, publisher, year, edition, pages
TAYLOR & FRANCIS LTD, 2016
Keywords
Lyme disease; Borrelia burgdorferi sensu lato; babesiosis; Babesia spp.; Lyme borreliosis; PCR; microscopy
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-127739 (URN)10.3109/23744235.2016.1144931 (DOI)000373810800001 ()27030913 (PubMedID)
Note

Funding Agencies|Grant Agency of the Czech Republic [13-27630P, 13-12816P]; EU FP7 project MODBIOLIN [316304]; Interreg IV A project ScandTick

Available from: 2016-05-12 Created: 2016-05-12 Last updated: 2016-05-12
Labbe Sandelin, L., Tolf, C., Larsson, S., Wilhelmsson, P., Salaneck, E., Jaenson, T. G. T., . . . Waldenstrom, J. (2015). Candidatus Neoehrlichia mikurensis in Ticks from Migrating Birds in Sweden. PLOS ONE, 10(7), e0133250
Open this publication in new window or tab >>Candidatus Neoehrlichia mikurensis in Ticks from Migrating Birds in Sweden
Show others...
2015 (English)In: PLOS ONE, E-ISSN 1932-6203, Vol. 10, no 7, p. e0133250-Article in journal (Refereed) Published
Abstract [en]

Candidatus Neoehrlichia mikurensis (CNM; family Anaplasmataceae) was recently recognized as a potential tick-borne human pathogen. The presence of CNM in mammals, in host-seeking Ixodes ticks and in ticks attached to mammals and birds has been reported recently. We investigated the presence of CNM in ornithophagous ticks from migrating birds. A total of 1,150 ticks (582 nymphs, 548 larvae, 18 undetermined ticks and two adult females) collected from 5,365 birds captured in south-eastern Sweden was screened for CNM by molecular methods. The birds represented 65 different species, of which 35 species were infested with one or more ticks. Based on a combination of morphological and molecular species identification, the majority of the ticks were identified as Ixodes ricinus. Samples were initially screened by real-time PCR targeting the CNM 16S rRNA gene, and confirmed by a second real-time PCR targeting the groEL gene. For positive samples, a 1260 base pair fragment of the 16S rRNA gene was sequenced. Based upon bacterial gene sequence identification, 2.1% (24/1150) of the analysed samples were CNM-positive. Twenty-two out of 24 CNM-positive ticks were molecularly identified as I. ricinus nymphs, and the remaining two were identified as I. ricinus based on morphology. The overall CNM prevalence in I. ricinus nymphs was 4.2%. None of the 548 tested larvae was positive. CNM-positive ticks were collected from 10 different bird species. The highest CNM-prevalences were recorded in nymphs collected from common redpoll (Carduelis flammea, 3/7), thrush nightingale (Luscinia luscinia, 2/29) and dunnock (Prunella modularis, 1/17). The 16S rRNA sequences obtained in this study were all identical to each other and to three previously reported European strains, two of which were obtained from humans. It is concluded that ornithophagous ticks may be infected with CNM and that birds most likely can disperse CNM-infected ticks over large geographical areas.

Place, publisher, year, edition, pages
Public Library of Science, 2015
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-120741 (URN)10.1371/journal.pone.0133250 (DOI)000358622000071 ()26207834 (PubMedID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden [FORSS-307591, FORSS-387231]; Carl Tryggers Foundation for Scientific Research; Langmanska kulturfonden; Magnus Bergvalls Foundation for Scientific Research; Helge Ax:son Johnsons Foundation; EU Interreg IVA project ScandTick

Available from: 2015-08-24 Created: 2015-08-24 Last updated: 2021-06-14
Grankvist, A., Labbe Sandelin, L., Andersson, J., Fryland, L., Wilhelmsson, P., Lindgren, P.-E., . . . Wenneras, C. (2015). Infections with Candidatus Neoehrlichia mikurensis and Cytokine Responses in 2 Persons Bitten by Ticks, Sweden. Emerging Infectious Diseases, 21(8), 1462-1465
Open this publication in new window or tab >>Infections with Candidatus Neoehrlichia mikurensis and Cytokine Responses in 2 Persons Bitten by Ticks, Sweden
Show others...
2015 (English)In: Emerging Infectious Diseases, ISSN 1080-6040, E-ISSN 1080-6059, Vol. 21, no 8, p. 1462-1465Article in journal (Refereed) Published
Abstract [en]

The prevalence of Candidatus Neoehrlichia mikurensis infection was determined in 102 persons bitten by ticks in Sweden. Two infected women had erythematous rashes; 1 was co-infected with a Borrelia sp., and the other showed seroconversion for Anaplasma phagocytophilum. Both patients had increased levels of Neoehrlichia DNA and serum cytokines for several months.

Place, publisher, year, edition, pages
Centers for Disease Control and Prevention, 2015
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-120731 (URN)10.3201/eid2108.150060 (DOI)000358458300031 ()26197035 (PubMedID)
Note

Funding Agencies|ALF-Goteborg [71580]; Cancer and Allergy Foundation [149781]; Vastra Gotaland Region Research and Development [94510]; Laboratory Medicine at Sahlgrenska University Hospital [6333]; Medical Research Council of South-East Sweden [FORSS-297311, FORSS-307591, FORSS-87231]; Swedish Research Council/Medicine [2011-345]; ALF-Ostergotland

Available from: 2015-08-24 Created: 2015-08-24 Last updated: 2017-12-04
Organisations

Search in DiVA

Show all publications