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Nosratabadi, Ali Reza
Publications (4 of 4) Show all publications
Nosratabadi, A. R., Graff, P., Karlsson, H., Ljungman, A. & Leanderson, P. (2019). Use of TEOM monitors for continuous long-term sampling of ambient particles for analysis of constituents and biological effects. Air quality, atmosphere and health, 12(2), 161-171
Open this publication in new window or tab >>Use of TEOM monitors for continuous long-term sampling of ambient particles for analysis of constituents and biological effects
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2019 (English)In: Air quality, atmosphere and health, ISSN 1873-9318, E-ISSN 1873-9326, Vol. 12, no 2, p. 161-171Article in journal (Refereed) Published
Abstract [en]

Many countries have implemented exposure limits for the concentration of ambient particular matter and do therefore have to monitor their concentration. This could be performed with TEOM monitors (Tapered Element Oscillating Microbalance-monitors) that contain a filter on which particles are collected. These filters are regularly exchanged for new ones. The aim of this study was to test the feasibility of collecting used filters from monitors at different locations and establishing a method to extract particles and then study them with respect to their ability to generate oxidants, their endotoxin content, and ability to activate inflammatory cells. Filters from nine geographically spread locations in Sweden were collected during a 21-month period by local technicians who then sent them to the laboratory where they were extracted and analyzed. The procedure to let local technicians perform the filter exchange and send used TEOM filters to the laboratory worked well. A method was established in which pyrogen-free water was used to extract particles that then were aliquoted and stored for later analysis. Particulate matter (PM10) from different locations showed both a considerable seasonal and spatial-dependent difference with respect to oxidative potential (oxidize glutathione), endotoxin content, and ability to activate blood monocytes to release interleukin-1β. This study shows that, instead of discarding TEOM filters, they can be collected and extracted so that particles that have been sampled in a standardized way could be analyzed with respect to variables that reflect their toxicity. This could be done at a low cost. In combination with information about the ambient particle concentration, such information could be helpful in the evaluation of differences in the risk of breathing air at various locations.

Place, publisher, year, edition, pages
Springer Netherlands, 2019
Keywords
Air pollution, TEOM monitor, Ambient particles, Surface reactivity, Endotoxin, Seasonal variation
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:liu:diva-154602 (URN)10.1007/s11869-018-0638-5 (DOI)000458121600004 ()2-s2.0-85056389584 (Scopus ID)
Available from: 2019-02-21 Created: 2019-02-21 Last updated: 2019-03-15Bibliographically approved
Nosratabadi, A. R., Ljungman, A., Lindahl, M., Welch, R., Pilon, A. & Tagesson, C. (2003). Clara cell 10-KDA protein inhibits endotoxin-induced airway contraction in isolated perfused rat lungs. Experimental Lung Research, 29(7), 455-473
Open this publication in new window or tab >>Clara cell 10-KDA protein inhibits endotoxin-induced airway contraction in isolated perfused rat lungs
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2003 (English)In: Experimental Lung Research, ISSN 0190-2148, E-ISSN 1521-0499, Vol. 29, no 7, p. 455-473Article in journal (Refereed) Published
Abstract [en]

Clara cell 10-kDa protein (CC10) is a major component of bronchoalveolar lavage fluid and is suggested to be a natural regulator of airway inflammation, possibly through its effects on theproin-flammatory enzyme(s), phospholipase A2. We examined the effect of recombinant human (rh) CC10 on endotoxin-induced airway contraction and cytokine release in isolated perfused rat lungs. We found that rhCC10 added to the lung perfusate abolished the endotoxin-induced airway contraction, and that it inhibited both the release of interleukin-1▀ and interleukin-6 into the lung perfusate and the release of tumor necrosis factors, into the pulmonary lavage fluid. By contrast, the levels of interferon-? were unaffected by CC10 administration. Rutin, a phospholipase A2 inhibitor, and N?-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, also attenuated the contraction induced by endotoxin. These findings demonstrate that rhCC10 inhibits endotoxin-induced airway contraction and the release of proinflammatory cytokines (interleukin-1▀, interleukin-6, and tumor necrosis factor-a) in isolated perfused rat lungs. The results also indicate that phospholipase A2 and nitric oxide are involved in the airway contraction in this model, possibly through their influence on the production of eicosanoids.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26519 (URN)10.1080/01902140303778 (DOI)11077 (Local ID)11077 (Archive number)11077 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Nilsson, A., Nosratabadi, A. R., Lagesson, V., Murgia, N., Leanderson, P. & Tagesson, C. (2002). Novel technique for measuring low molecular weight chemicals in indoor dust. Indoor and Built Environment, 11(3), 153-161
Open this publication in new window or tab >>Novel technique for measuring low molecular weight chemicals in indoor dust
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2002 (English)In: Indoor and Built Environment, ISSN 1420-326X, Vol. 11, no 3, p. 153-161Article in journal (Refereed) Published
Abstract [en]

A new technique is described which can measure low molecular weight compounds adsorbed onto dust particles in a simple yet accurate way. The technique, gas chromatography-ultraviolet spectrometry (GC-UV), comprises a one-stage thermal desorption oven, a gas flow cell with a miniaturised GC column, and a nitrogen-flushed photo diode array (PDA) detector for fast UV spectra recording. The dust sample is thermally desorbed in the oven and the compounds released are flushed onto the GC column by means of a carrier gas stream. The separated compounds are then registered by the PDA detector and identified by their characteristic gas-phase UV spectra. This method enables the analysis of volatile organic as well as inorganic compounds adsorbed onto dust particles, many of which are difficult to analyse together in one single analysis using conventional methods. For example, both nitric oxide and ammonia can be analysed, as well as hydrogen sulphide, pyridine, 2-furaldehyde, 2-methylfuran, and isoprene. It is concluded that GC-UV may be used as an alternative or to complement other methods for measuring chemicals in indoor dusts, thus improving survey and control of the human exposure to particle-bound irritants and other chemicals.

Keywords
Dust, Indoor air, Thermal desorption, Gas chromatography-ultraviolet spectrometry, Nitric oxide
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-13657 (URN)10.1159/000064124 (DOI)
Available from: 2004-10-09 Created: 2004-10-09 Last updated: 2009-08-20
Kristjansson, I., Faresjö, T., Lionis, C., Nosratabadi, A. R., Gudmundsson, K., Halling, A. & Tagesson, C. (2000). Assessment of aluminium in human deciduous teeth. European Journal of Epidemiology, 16(3), 231-233
Open this publication in new window or tab >>Assessment of aluminium in human deciduous teeth
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2000 (English)In: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 16, no 3, p. 231-233Article in journal (Refereed) Published
Abstract [en]

The possible role of environmental aluminium exposure in the pathogenesis of various diseases has highlighted the need for methods by which the long-term exposure to aluminium can be assessed. Therefore, we have further developed a method to determine aluminium in human deciduous teeth and applied this method for studying populations in Sweden, Crete and Iceland.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-25938 (URN)10.1023/A:1007676432537 (DOI)10384 (Local ID)10384 (Archive number)10384 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
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