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Wahlström, Ola
Publications (10 of 28) Show all publications
Risto, O., Hammar, E., Hammar, K., Fredrikson, M., Hammar, M. & Wahlström, O. (2012). Elderly men with a history of distal radius fracture have significantly lower calcaneal bone density and free androgen index than age-matched controls. The Aging Male, 15(1), 59-62
Open this publication in new window or tab >>Elderly men with a history of distal radius fracture have significantly lower calcaneal bone density and free androgen index than age-matched controls
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2012 (English)In: The Aging Male, ISSN 1368-5538, E-ISSN 1473-0790, Vol. 15, no 1, p. 59-62Article in journal (Refereed) Published
Abstract [en]

Background: Age related bone loss is widely accepted as related to decreased serum levels of circulating sex hormones. Epidemiological data also show distal radius fractures in men to be a sensitive marker of bone fragility. The aim of this study was to assess if men with a history of distal radius fracture have lower bone mass density (BMD), lower free androgen index (FAI), lower total testosterone (T) and lower bio-available testosterone (Bio-T) than healthy age-matched controls. Patients and methods: A case-control study is based on consecutive cases treated for low energy distal radius fracture at our department and age-matched controls. Thirty-nine men treated between 1997-2004 and 45 age-matched controls underwent calcaneal bone density measurements (t-score) and analyses of T, Bio-T and serum hormone binding globulin (SHBG). Results: The fracture group had lower BMD (p andlt; 0.01) and lower FAI (p = 0.01). Linear regression analysis showed a correlation between Bio-T and t-scores (p = 0.03). Using analysis of covariance, a significant difference with lower Bio-T in the fracture group was shown. Conclusion: Bio-T seems to correlate with BMD in elderly men and may serve as a marker for increased fracture risk in this patient group.

Place, publisher, year, edition, pages
Informa Healthcare, 2012
Keywords
Bone mineral density, male, fractures, osteoporosis, testosterone
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-75464 (URN)10.3109/13685538.2011.593659 (DOI)000299840800010 ()
Note
Funding Agencies|County Council of Ostergotland||Available from: 2012-03-02 Created: 2012-03-02 Last updated: 2017-12-07
Wahlström, O., Risto, O., Kalén, A., Linder, C., Ansell, A., Söderström, M. & Magnusson, P. (2011). Acidic preparations of lysed platelets up-regulate proliferative and vascular genes, and the TGFBR pathway in osteoblast-like cells in BONE, vol 48, issue , pp S118-S118. In: BONE (pp. S118-S118). Elsevier Science B.V., Amsterdam., 48
Open this publication in new window or tab >>Acidic preparations of lysed platelets up-regulate proliferative and vascular genes, and the TGFBR pathway in osteoblast-like cells in BONE, vol 48, issue , pp S118-S118
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2011 (English)In: BONE, Elsevier Science B.V., Amsterdam. , 2011, Vol. 48, p. S118-S118Conference paper, Published paper (Refereed)
Abstract [en]

n/a

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam., 2011
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-68230 (URN)10.1016/j.bone.2011.03.215 (DOI)000289879800194 ()
Available from: 2011-05-13 Created: 2011-05-13 Last updated: 2013-10-23
Wahlström, O., Linder, C., Ansell, A., Kalén, A., Söderström, M. & Magnusson, P. (2011). Acidic preparations of lysed platelets upregulate proliferative pathways in osteoblast-like cells as demonstrated by genome-wide microarray analysis. Platelets, 22(6), 452-460
Open this publication in new window or tab >>Acidic preparations of lysed platelets upregulate proliferative pathways in osteoblast-like cells as demonstrated by genome-wide microarray analysis
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2011 (English)In: Platelets, ISSN 0953-7104, E-ISSN 1369-1635, Vol. 22, no 6, p. 452-460Article in journal (Refereed) Published
Abstract [en]

latelets contain numerous growth factors essential for wound and fracture healing. We investigated the gene expression in human osteoblast-like cells stimulated with lysed platelets prepared in acidic, neutral, or alkaline buffers. Lysed platelets prepared in buffers at pH 5.4, 7.4, and 7.9, were added after neutralization to hFOB 1.19 cells. Genome-wide microarray analysis was performed using the Affymetrix GeneChip 7G Scanner. Biometric, cluster, and pathway analyses were performed with GeneSpring GX. Biometric analyses demonstrated that 53 genes were differentially regulated (p andlt;= 0.005, andgt;= 2-fold increase). Pathway analysis revealed 10 significant pathways of which eight are common ones regulating bone formation and cancer growth. Eleven genes were selected for quantitative real-time polymerase chain reaction (PCR) based on the microarray analysis of the lysed platelets prepared in the pH 5.4 experiments. In conclusion, acidic preparations of lysed platelet concentrates release factors essential for cell proliferation and particularly cell metabolism under hypoxic conditions. The genetic response from these factors was dominated by genes associated with the same pathways observed in bone formation and cancer growth. Activation of TGF-beta in the acidic preparation could be a stimulatory key factor of cell proliferation. These results support the hypothesis that acidification of platelets modifies the stimulatory response of mesenchymal cells in vitro, which is analogous with the observed milieu of a low pH present in wound and fracture sites, as well as in growing tumors.

Place, publisher, year, edition, pages
Informa Healthcare, 2011
Keywords
Cell proliferation, gene expression, hypoxia, platelets, TGFBR pathway
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-70115 (URN)10.3109/09537104.2011.565432 (DOI)000293600300008 ()
Note

Original Publication: Ola Wahlström, Cecilia Linder, Anna Ansell, Anders Kalén, Mats Söderström and Per Magnusson, Acidic preparations of lysed platelets upregulate proliferative pathways in osteoblast-like cells as demonstrated by genome-wide microarray analysis, 2011, Platelets, (22), 6, 452-460. http://dx.doi.org/10.3109/09537104.2011.565432 Copyright: Informa Healthcare http://informahealthcare.com/

Available from: 2011-08-19 Created: 2011-08-19 Last updated: 2017-12-08
Wahlström, O. (2011). Commentaries:  in International Journal of Therapy and Rehabilitation, vol 18, issue 12, pp. International Journal of Therapy and Rehabilitation, 18(12), 680
Open this publication in new window or tab >>Commentaries:  in International Journal of Therapy and Rehabilitation, vol 18, issue 12, pp
2011 (English)In: International Journal of Therapy and Rehabilitation, ISSN 1741-1645, E-ISSN 1759-779X, Vol. 18, no 12, p. 680-Article in journal, Editorial material (Other academic) Published
Abstract [en]

[No abstract available]

Place, publisher, year, edition, pages
Mark Allen Healthcare, 2011
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-100712 (URN)10.12968/ijtr.2011.18.12.680 (DOI)
Available from: 2013-11-12 Created: 2013-11-11 Last updated: 2017-12-06
Pelling, S., Kalén, A., Hammar, M. & Wahlström, O. (2011). Preparation for becoming members of health care teams: findings from a 5-year evaluation of a student interprofessional training ward. Journal of Interprofessional Care, 25(5), 328-332
Open this publication in new window or tab >>Preparation for becoming members of health care teams: findings from a 5-year evaluation of a student interprofessional training ward
2011 (English)In: Journal of Interprofessional Care, ISSN 1356-1820, E-ISSN 1469-9567, Vol. 25, no 5, p. 328-332Article in journal (Refereed) Published
Abstract [en]

Setting. An orthopaedic interprofessional training ward manned by students at a University Hospital. less thanbrgreater than less thanbrgreater thanObjective. To assess to what extent students from different undergraduate programmes evaluated the effects of a 2-week rotation at the ward on their professional roles and the value of teamwork within health care. less thanbrgreater than less thanbrgreater thanMethod. A questionnaire was filled in by 841 students by the end of a 2-week rotation at the ward over 5 years. Questions concerned students estimate of how the rotation had strengthened their insight into their own future professional role, into other students professional roles and into the value of teamwork within health care. Differences between the different student categories and possible associations between the different estimates were statistically analysed. less thanbrgreater than less thanbrgreater thanResults. Students from all programmes reported that the rotation at the student ward had dramatically strengthened their insight about their own future professional role as well as the roles of the other professions and the value of teamwork within health care. less thanbrgreater than less thanbrgreater thanConclusion. Health care is a complicated system based on cooperation and professionalism. We suggest that interprofessional training of students from all professions within health care should be a part of their education as a worthwhile preparation for their future professional work and to ensure high-quality health care.

Place, publisher, year, edition, pages
Informa Healthcare, 2011
Keywords
Collaborative competence, collaborative outcomes, interprofessional education, integration, interdisciplinary, patient-centred practice, team-based care, undergraduate, interprofessional training ward
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-70216 (URN)10.3109/13561820.2011.578222 (DOI)000293636300004 ()
Note
Original Publication: Staffan Pelling, Anders Kalén, Mats Hammar and Ola Wahlström, Preparation for becoming members of health care teams: findings from a 5-year evaluation of a student interprofessional training ward, 2011, Journal of Interprofessional Care, (25), 5, 328-332. http://dx.doi.org/10.3109/13561820.2011.578222 Copyright: Informa Healthcare http://informahealthcare.com/ Available from: 2011-08-26 Created: 2011-08-26 Last updated: 2017-12-08
Wahlström, O., Linder, C., Kalén, A. & Magnusson, P. (2008). Acidic preparations of platelet concentrates release bone morphogenetic protein-2.. Acta orthopaedica, 79(3), 433-437
Open this publication in new window or tab >>Acidic preparations of platelet concentrates release bone morphogenetic protein-2.
2008 (English)In: Acta orthopaedica, ISSN 1745-3682, Vol. 79, no 3, p. 433-437Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: Growth factors released from platelets have potent effects on fracture and wound healing. The acidic tide of wound healing, i.e. the pH within wounds and fractures, changes from acidic pH to neutral and alkaline pH as the healing process progresses. We investigated the influence of pH on lysed platelet concentrates regarding the release of growth factors. MATERIAL AND METHODS: Platelet concentrates free of leukocyte components were lysed and incubated in buffers with pH between 4.3 and 8.6. Bone morphogenetic protein-2 (BMP-2), platelet-derived growth factor (PDGF), transforming growth factor-beta(TGF-beta), and vascular endothelial growth factor (VEGF) were measured by quantitative enzyme-linked immunosorbent assays. RESULTS: PDGF, TGF-beta, and VEGF were present in all platelet preparations but the levels varied in a pH-dependent fashion. BMP-2 was only detected in the most acidic preparation (pH 4.3), which is interesting since BMP-2 has been reported to be an endogenous mediator of fracture repair and to be responsible for the initiation of fracture healing. INTERPRETATION: Our findings indicate that platelets release substantial amounts of BMP-2 only under conditions of low pH, the milieu associated with the critical initial stage of fracture healing.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-29162 (URN)10.1080/17453670710015364 (DOI)18626808 (PubMedID)
Note
This is an electronic version of an article published in: Ola Wahlström, Cecilia Linder, Anders Kalén and Per Magnusson, Acidic preparations of platelet concentrates release bone morphogenetic protein-2., 2008, Acta orthopaedica, (79), 3, 433-437. http://dx.doi.org/10.1080/17453670710015364 Copyright: Taylor & Francis http://www.tandf.co.uk/journals/default.asp Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2009-10-09
Engstrom, K., Bergh, P., Gustafson, P., Hultborn, R., Johansson, H., Lofvenberg, R., . . . Bauer, H. C. F. (2008). Liposarcoma - Outcome based on the Scandinavian Sarcoma Group Register. Cancer, 113(7), 1649-1656
Open this publication in new window or tab >>Liposarcoma - Outcome based on the Scandinavian Sarcoma Group Register
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2008 (English)In: Cancer, ISSN 0008-543X, E-ISSN 1097-0142, Vol. 113, no 7, p. 1649-1656Article in journal (Refereed) Published
Abstract [en]

BACKGROUND. The aim was to study the clinicopathological characteristics, treatment, and outcome of liposarcoma in an unselected, population-based patient sample, and to establish whether treatment was according to the Scandinavian Sarcoma Group (SSG) treatment guidelines. METHODS. The SSG Pathology Board reviewed 319 liposarcoma cases reported between 1986 and 1998. After the review, 237 patients without metastasis were analyzed for local recurrence rate in relation to surgical margins, radiotherapy, occurrence of metastasis, and survival. RESULTS. Seventy-eight percent of the patients were primarily operated oil at a sarcoma center, 45% with wide margins. All patients operated on outside the center had nonwide margins. Low-grade lesions constituted 67% of cases. Despite nonwide surgery, only 58% of high-grade lesions were treated with postoperative radiotherapy. The risk of local recurrence after nonwide surgery, without irradiation, was 47% for high-grade lesions. The estimated 10-year, local recurrence-free and metastasis-free survival in the low-grade group was 87% and 95%, respectively. In the high-grade group, it was 75% and 61%, respectively. Independent adverse prognostic factors for local recurrence were surgery outside a sarcoma center and histological type dedifferentiated liposarcoma. For metastases, they were old age, large tumor size, high grade, and histological type myxoid liposarcoma with a round cell component. Radiotherapy showed significant effect oil local recurrence rate for the same grade and margin. CONCLUSIONS. Patients with liposarcoma should be treated at specialized centers. Postoperative radiotherapy decreases the local recurrence rate. To maintain quality and provide support for further trials, reporting to quality registers is crucial.

Keywords
liposarcoma, Scandinavian Sarcoma Group, radiotherapy, local recurrence, metastasis
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-45849 (URN)10.1002/cncr.23784 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13
Pettersson, J., Palmerius, K., Knutsson, H., Wahlström, O., Tillander, B. & Borga, M. (2008). Simulation of Patient Specific Cervical Hip Fracture Surgery With a Volume Haptic Interface. IEEE Transactions on Biomedical Engineering, 55(4), 1255-1265
Open this publication in new window or tab >>Simulation of Patient Specific Cervical Hip Fracture Surgery With a Volume Haptic Interface
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2008 (English)In: IEEE Transactions on Biomedical Engineering, ISSN 0018-9294, E-ISSN 1558-2531, Vol. 55, no 4, p. 1255-1265Article in journal (Refereed) Published
Abstract [en]

The interest for surgery simulator systems with anatomical models generated from authentic patient data is growing as these systems evolve.With access to volumetric patient data, e.g., from a computer tomography scan, haptic and visual feedback can be created directly from this dataset. This opens the door for patient specific simulations. Hip fracture surgery is one area where simulator systems is useful to train new surgeons and plan operations. To simulate the drilling procedure in this type of surgery, a repositioning of the fractured bone into correct position is first needed. This requires a segmentation process in which the bone segments are identified and the position of the dislocated part is determined. The segmentation must be automatic to cope with the large amount of data from the computer tomography scan. This work presents the first steps in the development of a hip fracture surgery simulation with patient specific models. Visual and haptic feedback is generated from the computer tomography data by simulating fluoroscopic images and the drilling process. We also present an automatic segmentation method to identify the fractured bone and determine the dislocation. This segmentation method is based on nonrigid registration with the Morphon method.

Place, publisher, year, edition, pages
IEEE, 2008
Keywords
Automatic segmentation, patient specific data, registration, surgery simulation, volume haptics.
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-19648 (URN)10.1109/TBME.2007.908099 (DOI)000254219900001 ()
Available from: 2009-07-09 Created: 2009-07-09 Last updated: 2017-12-13
Kalén, A., Wahlström, O., Linder, C. & Magnusson, P. (2008). The content of bone morphogenetic proteins in platelets varies greatly between different platelet donors. Biochemical and Biophysical Research Communications - BBRC, 375(2), 261-264
Open this publication in new window or tab >>The content of bone morphogenetic proteins in platelets varies greatly between different platelet donors
2008 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 375, no 2, p. 261-264Article in journal (Refereed) Published
Abstract [en]

Platelet derivates and platelet rich plasma have been used to stimulate bone formation and wound healing because of the rich content of potent growth factors. However, not all reports have been conclusive since some have not been able to demonstrate a positive effect. We investigated the interindividual variation of bone morphogenetic proteins (BMPs) in platelets from healthy donors, and the pH-dependent effect on the release of BMPs in preparations of lysed platelets in buffer (LPB). Platelet concentrates from 31 healthy donors were prepared in pH 4.3 and pH 7.4 buffers and investigated with respect to BMP-2, -4, -6, and -7. BMP-2 and BMP-4 were significantly more common in acidic LPBs in comparison with neutral preparations. We also observed a considerable variation among platelet donors with respect to the release of BMPs at pH 4.3 and 7.4. In conclusion, a considerable variation was found among platelet donors, which may be of importance considering the ambiguous results previously reported on osteoblast proliferation and differentiation. © 2008 Elsevier Inc. All rights reserved.

Keywords
Adolescent Adult Aged *Blood Donors Blood Platelets/*metabolism Bone Morphogenetic Proteins/*metabolism Cell Differentiation Cell Proliferation Female Humans Hydrogen-Ion Concentration Male Middle Aged Osteoblasts/cytology
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-43366 (URN)10.1016/j.bbrc.2008.08.014 (DOI)73650 (Local ID)73650 (Archive number)73650 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Nilsdotter-Augustinsson, Å., Briheim, G., Herder, A., Ljunghusen, O., Wahlström, O. & Öhman, L. (2007). Inflammatory response in 85 patients with loosened hip prostheses: A prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening. Acta Orthopaedica, 78(5), 629-639
Open this publication in new window or tab >>Inflammatory response in 85 patients with loosened hip prostheses: A prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening
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2007 (English)In: Acta Orthopaedica, ISSN 1745-3674, E-ISSN 1745-3682, Vol. 78, no 5, p. 629-639Article in journal (Refereed) Published
Abstract [en]

Over the past decades, prosthetic hip joints have improved the quality oflife for many patients. The most common complications are aseptic biornechanical failures and prosthetic joint infections. For prosthetic hip joints, delayed low-grade infections are seen most often and they are also most difficult to distinguish from aseptic mechanical failures. A prospective study was conducted to campare inilammatory markers in patients diagnosed with aseptic or septic prosthetic loosenffig. The diagnostic criteria were based on the decisions of experienced orthoperlic surgeons and microbiological analys is of periprosthetic tissue samplestaken perioperatively. Coagulase-negative staphylococci were the most common pathogens in the infected patients. Pre- or perioperative results for C-reactive protein and erytlu-ocyte sedimentation rate were valuable tools for diagnosing most, hut not all, low virulence infections. White blood cell count in synavial fluid was an important marker of infection, which was not the case for lactate. Levels of the cytokines turnor necrosis factor-α, interleukin-1 ß. and interleukin-6 in synavial fluid were significantly higher in the infected group. Patterus of inilammatory cell infiltration in periprosthetic tissue differed significantly between the groups, and infiltration of polymorphonuclear cells proved to be the best marker of distinguish between septic and aseptic loosenffig. Treatment and outcome are described for the infected patients.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-81959 (URN)10.1080/17453670710014329 (DOI)
Available from: 2012-09-26 Created: 2012-09-26 Last updated: 2017-12-07Bibliographically approved
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