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Haj-Hosseini, N., Richter, J., Milos, P., Hallbeck, M. & Wårdell, K. (2018). 5-ALA fluorescence and laser Doppler flowmetry for guidance in a stereotactic brain tumor biopsy. Biomedical Optics Express, 9(5), 2284-2296
Open this publication in new window or tab >>5-ALA fluorescence and laser Doppler flowmetry for guidance in a stereotactic brain tumor biopsy
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2018 (English)In: Biomedical Optics Express, E-ISSN 2156-7085, Vol. 9, no 5, p. 2284-2296Article in journal (Refereed) Published
Abstract [en]

A fiber optic probe was developed for guidance during stereotactic brain biopsy procedures to target tumor tissue and reduce the risk of hemorrhage. The probe was connected to a setup for the measurement of 5-aminolevulinic acid (5-ALA) induced fluorescence and microvascular blood flow. Along three stereotactic trajectories, fluorescence (n = 109) and laser Doppler flowmetry (LDF) (n = 144) measurements were done in millimeter increments. The recorded signals were compared to histopathology and radiology images. The median ratio of protoporphyrin IX (PpIX) fluorescence and autofluorescence (AF) in the tumor was considerably higher than the marginal zone (17.3 vs 0.9). The blood flow showed two high spots (3%) in total. The proposed setup allows simultaneous and real-time detection of tumor tissue and microvascular blood flow for tracking the vessels.

Place, publisher, year, edition, pages
Optical Society of America, 2018
National Category
Medical Engineering
Identifiers
urn:nbn:se:liu:diva-147514 (URN)10.1364/BOE.9.002284 (DOI)000431181700022 ()29760987 (PubMedID)
Funder
Swedish Childhood Cancer Foundation, 2013-0043Linköpings universitet, LiU CancerRegion Östergötland, ALF LIO-599651
Note

Funding agencies: Linkoping University Cancer Organization; Swedish Childhood Cancer Organization [MT 2013-0043]; ALF Grants Region Ostergotland [LIO-599651]

Available from: 2018-04-23 Created: 2018-04-23 Last updated: 2019-10-14Bibliographically approved
Bruhn, H., Strandeus, M., Milos, P., Hallbeck, M., Vrethem, M. & Lind, J. (2018). Improved survival of Swedish glioblastoma patients treated according to Stupp. Acta Neurologica Scandinavica, 138(4), 332-337
Open this publication in new window or tab >>Improved survival of Swedish glioblastoma patients treated according to Stupp
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2018 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 138, no 4, p. 332-337Article in journal (Refereed) Published
Abstract [en]

ObjectivesThe median survival in glioblastoma (GBM) patients used to be less than 1year. Surgical removal of the tumor with subsequent concomitant radiation/temozolomide (the Stupp regimen) has been shown to prolong survival. The Stupp protocol was implemented in the county of Jonkoping in 2006. The purpose of this study was to examine if the Stupp treatment has prolonged overall survival, in an unselected patient cohort with histologically verified GBM. Material and MethodThis study includes all patients from the county of Jonkoping, with a diagnosis of GBM from January 2001 to December 2012. Patients were divided into 2 cohorts, 2001-2005 and 2006-2012, that is before and after implementation of the Stupp regimen. By reviewing the medical case notes, the dates of the histological diagnosis and of death were identified. The median and mean overall survival and Kaplan-Meier survival analysis were calculated and compared between the 2 cohorts. ResultsThe mean survival was 110days longer in the cohort treated according to the Stupp regimen. Four patients in the 2006-2012 cohort and 1 patient in the 2001-2005 cohort are still alive. When comparing survival in patients with radical surgery vs biopsy, those that underwent radical surgery survived longer. The significance was slightly greater in the 2001-2005 cohort (mean 163 vs 344days, Pamp;lt;.001) than in the 2006-2012 cohort (mean 220 vs 397days, P=.02). ConclusionSurvival significantly improved after the implementation of the Stupp regimen in the study region of Sweden.

Place, publisher, year, edition, pages
WILEY, 2018
Keywords
glioblastoma; mortality; radiotherapy; Stupp treatment; survival; temozolomide
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-151465 (URN)10.1111/ane.12966 (DOI)000443931400010 ()29882211 (PubMedID)
Note

Funding Agencies|Gustav Lindholms Stiftelse for elakartade hjarntumorer; Futurum

Available from: 2018-09-24 Created: 2018-09-24 Last updated: 2019-10-14
Sardar Sinha, M., Villamil Giraldo, A. M., Öllinger, K., Hallbeck, M. & Civitelli, L. (2018). Lipid vesicles affect the aggregation of 4-hydroxy-2-nonenal-modified alpha-synuclein oligomers. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1864(9), 3060-3068
Open this publication in new window or tab >>Lipid vesicles affect the aggregation of 4-hydroxy-2-nonenal-modified alpha-synuclein oligomers
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2018 (English)In: Biochimica et Biophysica Acta - Molecular Basis of Disease, ISSN 0925-4439, E-ISSN 1879-260X, Vol. 1864, no 9, p. 3060-3068Article in journal (Refereed) Published
Abstract [en]

Parkinsons disease (PD) and other synucleinopathies are characterized by accumulation of misfolded aggregates of alpha-synuclein (alpha-syn). The normal function of alpha-syn is still under investigation, but it has been generally linked to synaptic plasticity, neurotransmitter release and the maintenance of the synaptic pool. alpha-Syn localizes at synaptic terminals where it can bind to synaptic vesicles as well as to other cellular membranes. It has become clear that these interactions have an impact on both alpha-syn functional role and its propensity to aggregate. In this study, we investigated the aggregation process of alpha-syn covalently modified with 4-hydroxy-2-nonenal (HNE). HNE is a product of lipid peroxidation and has been implicated in the pathogenesis of different neurodegenerative diseases by modifying the kinetics of soluble toxic oligomers. Although HNE-modified alpha-syn has been reported to assemble into stable oligomers, we found that slightly acidic conditions promoted further protein aggregation. Lipid vesicles delayed the aggregation process in a concentration-dependent manner, an effect that was observed only when they were added at the beginning of the aggregation process. Co-aggregation of lipid vesicles with HNE-modified alpha-syn also induced cytotoxic effects on differentiated SHSY-SY cells. Under conditions in which the aggregation process was delayed cell viability was reduced. By exploring the behavior and potential cytotoxic effects of HNE-alpha-syn under acidic conditions in relation to protein-lipid interactions our study gives a framework to examine a possible pathway leading from a physiological setting to the pathological outcome of PD.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2018
Keywords
alpha-Synuclein; Parkinsons disease; Lipids; Aggregation kinetics; Toxicity
National Category
Neurosciences
Identifiers
urn:nbn:se:liu:diva-151192 (URN)10.1016/j.bbadis.2018.06.020 (DOI)000442056200028 ()29960040 (PubMedID)
Note

Funding Agencies|Swedish Research Council [MH: 523-2013-2735]; Research Foundation of the Swedish Parkinsons Disease Association; Ostergotland Research Foundation for Parkinsons Disease; Parkinson Research Foundation; Swedish Alzheimer foundation; Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research; Konung Gustaf V och Drottning Victorias Frimurarestiftelse; Swedish Dementia Foundation; Linkoping University Neurobiology Centre; County Council of Ostergotland

Available from: 2018-09-17 Created: 2018-09-17 Last updated: 2019-10-14
Gustafsson, G., Loov, C., Persson, E., Lazaro, D. F., Takeda, S., Bergstrom, J., . . . Ingelsson, M. (2018). Secretion and Uptake of -Synuclein Via Extracellular Vesicles in Cultured Cells. Cellular and molecular neurobiology, 38(8), 1539-1550
Open this publication in new window or tab >>Secretion and Uptake of -Synuclein Via Extracellular Vesicles in Cultured Cells
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2018 (English)In: Cellular and molecular neurobiology, ISSN 0272-4340, E-ISSN 1573-6830, Vol. 38, no 8, p. 1539-1550Article in journal (Refereed) Published
Abstract [en]

In Parkinsons disease and other Lewy body disorders, the propagation of pathology has been accredited to the spreading of extracellular -synuclein (-syn). Although the pathogenic mechanisms are not fully understood, cell-to-cell transfer of -syn via exosomes and other extracellular vesicles (EVs) has been reported. Here, we investigated whether altered molecular properties of -syn can influence the distribution and secretion of -syn in human neuroblastoma cells. Different -syn variants, including -syn:hemi-Venus and disease-causing mutants, were overexpressed and EVs were isolated from the conditioned medium. Of the secreted -syn, 0.1-2% was associated with vesicles. The major part of EV -syn was attached to the outer membrane of vesicles, whereas a smaller fraction was found in their lumen. For -syn expressed with N-terminal hemi-Venus, the relative levels associated with EVs were higher than for WT -syn. Moreover, such EV-associated -syn:hemi-Venus species were internalized in recipient cells to a higher degree than the corresponding free-floating forms. Among the disease-causing mutants, A53T -syn displayed an increased association with EVs. Taken together, our data suggest that -syn species with presumably lost physiological functions or altered aggregation properties may shift the cellular processing towards vesicular secretion. Our findings thus lend further support to the tenet that EVs can mediate spreading of harmful -syn species and thereby contribute to the pathology in -synucleinopathies.

Place, publisher, year, edition, pages
SPRINGER/PLENUM PUBLISHERS, 2018
Keywords
Alpha-synuclein; Parkinsons disease; Alpha-synuclein oligomers; Human neuroblastoma; Extracellular vesicles; Exosomes
National Category
Neurosciences
Identifiers
urn:nbn:se:liu:diva-152810 (URN)10.1007/s10571-018-0622-5 (DOI)000449258300008 ()30288631 (PubMedID)
Note

Funding Agencies|U4 Ageing Brain Network; Swedish Research Council [2011-4519, 2012-2172, 2010-6745, 2013-2735]; Marianne and Marcus Wallenberg Foundation; Swedish Brain Foundation; Parkinson Research Foundation; Swedish Alzheimer Foundation; Swedish Parkinson Foundation; Swedish Society of Medicine; Hans-Gabriel and Alice Trolle Wachtmeisters Foundation for Medical Research; Lundbeck Foundation; Stohnes Foundation; Soderstrom-Konigska Foundation; Swedish Dementia Foundation; Bjorklunds Foundation for ALS research; Magnus Bergwall Foundation; Thore Nilsson Foundation; Old Servants Foundation; Ahlen Foundation; Loo and Hans Ostermans Foundation; Jeanssons Foundation; Larsson-Rosts Foundation; King Gustaf Vs and Queen Victorias Freemason Foundation; Goransson Sandvikens Foundation; NIH [NCI U19 CA179563]; DFG Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB); Uppsala Berzelii Technology Center for Neurodiagnostics; Anna Maria Lundin Foundation; Goljes Foundation

Available from: 2018-11-22 Created: 2018-11-22 Last updated: 2019-10-14
Haj-Hosseini, N., Richter, J., Hallbeck, M., Milos, P. & Wårdell, K. (2018). Stereotactic Brain Tumor Optical Biopsy. In: : . Paper presented at World Conference on Medical Physics and Biomedical Engineering (IUPESM,Prague, Czeck Republic, June 3-8 2018. Prague
Open this publication in new window or tab >>Stereotactic Brain Tumor Optical Biopsy
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2018 (English)Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

To provide guidance for targeting diagnostic tumor tissue and to avoid vessel rupture during the biopsy procedure an application specific fiber optic probe was devel-oped. The setup incorporated an in-house developed fluorescence spectroscopy system for 5-aminolevulinic acid (5-ALA) induced protopophyrin IX (PpIX) for detection in the tumor, and laser Doppler flowmeter (LDF) system for measurement of blood perfusion. Fluorescence and blood flow were recorded millimeter-wise towards the pre-calculated target. In conclusion, the optical probe made real-time detection of tumor possible and has a potential for vessel detection during the biopsy procedures. Moreover, the PpIX fluorescence, autofluorescence and blood flow in the tumor could be studied at precise positions in the brain and the tumor. In the next step, further anal-ysis will be added.

Place, publisher, year, edition, pages
Prague: , 2018
National Category
Other Medical Engineering
Identifiers
urn:nbn:se:liu:diva-145220 (URN)
Conference
World Conference on Medical Physics and Biomedical Engineering (IUPESM,Prague, Czeck Republic, June 3-8 2018
Funder
Swedish Childhood Cancer Foundation, MT 2013-0043
Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2019-10-14Bibliographically approved
Richter, J., Haj Hosseini, N., Hallbeck, M. & Wårdell, K. (2017). Combination of Hand-Held Probe and Microscopy for Fluorescence Guided Surgery in the Brain Tumor Marginal Zone. Photodiagnosis and Photodynamic Therapy, 18, 185-192
Open this publication in new window or tab >>Combination of Hand-Held Probe and Microscopy for Fluorescence Guided Surgery in the Brain Tumor Marginal Zone
2017 (English)In: Photodiagnosis and Photodynamic Therapy, ISSN 1572-1000, Vol. 18, p. 185-192Article in journal (Refereed) Published
Abstract [en]

Background

Visualization of the tumor is crucial for differentiating malignant tissue from healthy brain during surgery, especially in the tumor marginal zone. The aim of the study was to introduce a fluorescence spectroscopy-based hand-held probe (HHF-probe) for tumor identification in combination with the fluorescence guided resection surgical microscope (FGR-microscope), and evaluate them in terms of diagnostic performance and practical aspects of fluorescence detection.

Material and Methods

Eighteen operations were performed on 16 patients with suspected high-grade glioma. The HHF-probe and the FGR-microscope were used for detection of protoporphyrin (PpIX) fluorescence induced by 5-aminolevulinic acid (5-ALA) and evaluated against histopathological analysis and visual grading done through the FGR-microscope by the surgeon. A ratio of PpIX fluorescence intensity to the autofluorescence intensity (fluorescence ratio) was used to quantify the spectra detected by the probe.

Results

Fluorescence ratio medians (range 0 – 40) measured by the probe were related to the intensity of the fluorescence in the FGR-microscope, categorized as “none” (0.3, n = 131), “weak” (1.6, n = 34) and “strong” (5.4, n = 28). Of 131 “none” points in the FGR-microscope, 88 (67%) exhibited fluorescence with the HHF-probe. For the tumor marginal zone, the area under the receiver operator characteristics (ROC) curve was 0.49 for the FGR-microscope and 0.65 for the HHF-probe.

Conclusions

The probe was integrated in the established routine of tumor resection using the FGR-microscope. The HHF-probe was superior to the FGR-microscope in sensitivity; it detected tumor remnants after debulking under the FGR-microscope. The combination of the HHF-probe and the FGR-microscope was beneficial especially in the tumor marginal zone.

Place, publisher, year, edition, pages
Amsterdam: Elsevier, 2017
Keywords
High-grade glioma, Fluorescence guided resection (FGR), 5-Aminolaevulinic acid (5-ALA), Fluorescence spectroscopy, Protoporphyrin (PpIX)
National Category
Medical Engineering
Identifiers
urn:nbn:se:liu:diva-134849 (URN)10.1016/j.pdpdt.2017.01.188 (DOI)000404315000028 ()28223144 (PubMedID)
Note

Funding agencies: Swedish Governmental Agency for Innovation Systems (Vinnova); Swedish Foundation for Strategic Research (SSF); Swedish Research Council (VR) [311-2006-7661, 523-2013-2735]; NovaMedTech; Swedish Childhood Cancer Foundation [MT 2013-0043]; ALF Grants Region

Available from: 2017-03-08 Created: 2017-03-08 Last updated: 2019-10-14Bibliographically approved
Nilsson, A., Elander, L., Hallbeck, M., Örtegren (Kugelberg), U., Engblom, D. & Blomqvist, A. (2017). The involvement of prostaglandin E2 in interleukin-1β evoked anorexia is strain dependent. Brain, behavior, and immunity, 60, 27-31
Open this publication in new window or tab >>The involvement of prostaglandin E2 in interleukin-1β evoked anorexia is strain dependent
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2017 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 60, p. 27-31Article in journal (Refereed) Published
Abstract [en]

From experiments in mice in which the prostaglandin E2 (PGE2) synthesizing enzyme mPGES-1 was genetically deleted, as well as from experiments in which PGE2 was injected directly into the brain, PGE2 has been implicated as a mediator of inflammatory induced anorexia. Here we aimed at examining which PGE2 receptor (EP1–4) that was critical for the anorexic response to peripherally injected interleukin-1β (IL-1β). However, deletion of neither EP receptor in mice, either globally (for EP1, EP2, and EP3) or selectively in the nervous system (EP4), had any effect on the IL-1β induced anorexia. Because these mice were all on a C57BL/6 background, whereas previous observations demonstrating a role for induced PGE2 in IL-1β evoked anorexia had been carried out on mice on a DBA/1 background, we examined the anorexic response to IL-1β in mice with deletion of mPGES-1 on a C57BL/6 background and a DBA/1 background, respectively. We confirmed previous findings that mPGES-1 knock-out mice on a DBA/1 background displayed attenuated anorexia to IL-1β; however, mice on a C57BL/6 background showed the same profound anorexia as wild type mice when carrying deletion of mPGES-1, while displaying almost normal food intake after pretreatment with a cyclooxygenase-2 inhibitor. We conclude that the involvement of induced PGE2 in IL-1β evoked anorexia is strain dependent and we suggest that different routes that probably involve distinct prostanoids exist by which inflammatory stimuli may evoke an anorexic response and that these routes may be of different importance in different strains of mice.

Place, publisher, year, edition, pages
Academic Press, 2017
Keywords
Anorexia, Prostaglandin E2, EP receptors, Interleukin-1, Cyclooxygenase-2, Mice
National Category
Immunology Cell Biology Pharmacology and Toxicology
Identifiers
urn:nbn:se:liu:diva-132639 (URN)10.1016/j.bbi.2016.06.014 (DOI)000391908200004 ()27375005 (PubMedID)
Note

Funding agencies: Swedish Research Council [07879, 20725]; Swedish Cancer Foundation [213/692]; County Council of Ostergotland; Knut and Alice Wallenberg Foundation

Available from: 2016-11-18 Created: 2016-11-18 Last updated: 2019-10-14Bibliographically approved
Haj-Hosseini, N., Milos, P., Hildesjö, C., Hallbeck, M., Richter, J. & Wårdell, K. (2016). Fluorescence spectroscopy and optical coherence tomography for brain tumor detection. In: : . Paper presented at SPIE Photonics Europe, Biophotonics: Photonic Solutions for Better Health Care, Brussels, Belgium, 3 - 7 April 2016 (pp. 9887-96). SPIE - International Society for Optical Engineering
Open this publication in new window or tab >>Fluorescence spectroscopy and optical coherence tomography for brain tumor detection
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2016 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Resection of brain tumor is a challenging task as the tumor does not have clear borders and the malignant types specifically have often a diffuse and infiltrative pattern of growth. Recently, neurosurgical microscopes have been modified to incorporate fluorescence modules for detection of tumor when 5-aminolevulinic acid (5-ALA) is used as a contrast. We have in combination with the fluorescence microscopes implemented and evaluated a fluorescence spectroscopy based handheld probe for detecting the 5-aminolevulinic acid (ALA) induced protoporphyrin IX (PpIX) in the gliomas in 50 patients intraoperatively. The results show a significantly high sensitivity for differentiating tumor from the healthy tissue and distinguished fluorescence intensity levels in the tumor cell infiltration zone around the tumor. However, knowledge on association of the quantified fluorescence signals specifically in the intermediate inflammatory zone with the infiltrative tumor cells can be complemented with volumetric tissue imaging and a higher precision histopathological analysis. In this work, a spectral domain optical coherence tomography (OCT) system with central wavelength of 1325nm has been used to image the tissue volume that the fluorescence is collected from and is evaluated against histopathological analysis for a higher precision slicing. The results show that although healthy brain has a homogenous microstructure in the OCT images, the brain tumor shows a distinguished texture in the images correlated with the PpIX fluorescence intensity and histopathology.

Place, publisher, year, edition, pages
SPIE - International Society for Optical Engineering, 2016
Keywords
Brain tumor, fluorescence, optical coherence tomography, hjärntumör, fluorescens, optisk koherenstomografi
National Category
Other Medical Engineering
Identifiers
urn:nbn:se:liu:diva-124008 (URN)
Conference
SPIE Photonics Europe, Biophotonics: Photonic Solutions for Better Health Care, Brussels, Belgium, 3 - 7 April 2016
Funder
Medical Research Council of Southeast Sweden (FORSS)
Available from: 2016-01-18 Created: 2016-01-18 Last updated: 2019-10-14Bibliographically approved
Lilledahl, M. B., Gustafsson, H., Gunnar Ellingsen, P., Zachrisson, H., Hallbeck, M., Stenhjem Hagen, V., . . . Lindgren, M. (2015). Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques. Journal of Biomedical Optics, 20(2), 020503
Open this publication in new window or tab >>Combined imaging of oxidative stress and microscopic structure reveals new features in human atherosclerotic plaques
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2015 (English)In: Journal of Biomedical Optics, ISSN 1083-3668, E-ISSN 1560-2281, Vol. 20, no 2, p. 020503-Article in journal (Refereed) Published
Abstract [en]

Human atherosclerotic samples collected by carotid endarterectomy were investigated using electronic paramagnetic resonance imaging (EPRI) for visualization of reactive oxygen species, and nonlinear optical microscopy (NLOM) to study structural features. Regions of strong EPRI signal, indicating a higher concentration of reactive oxygen species and increased inflammation, were found to colocalize with regions dense in cholesterol crystals as revealed by NLOM.

Place, publisher, year, edition, pages
Society of Photo-optical Instrumentation Engineers (SPIE), 2015
Keywords
atherosclerosis; electronic paramagnetic resonance imaging; polarimetry; nonlinear optical microscopy
National Category
Clinical Medicine Chemical Sciences Cell and Molecular Biology
Identifiers
urn:nbn:se:liu:diva-116839 (URN)10.1117/1.JBO.20.2.020503 (DOI)000350462900003 ()25714991 (PubMedID)
Note

Funding Agencies|Swedish Research Council [diarienr 2009-5430]

Available from: 2015-04-07 Created: 2015-04-07 Last updated: 2019-10-14
Haj-Hosseini, N., Milos, P., Richter, J., Hildesjö, C., Hallbeck, M. & Wårdell, K. (2015). Detection of brain tumor using fluorescence and optical coherence tomography. In: : . Paper presented at Medicinteknikdagarna 2015, 13–14 oktober 2015 Uppsala Konsert & Kongress. Uppsala
Open this publication in new window or tab >>Detection of brain tumor using fluorescence and optical coherence tomography
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2015 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Resection of brain tumor is a challenging task as the tumor does not have clear borders and the malignant types specifically have often a diffuse and infiltrative pattern of growth. We have previously implemented and evaluated a fluorescence spectroscopy based handheld probe for detecting the 5-aminolevulinic acid induced protoporphyrin IX (PpIX) in the gliomas. To add another dimension to the brain tumor detection and volumetric analysis of the tissue that exhibits fluorescence, optical coherence tomography was investigated on tumor specimens.

Material and Methods:

A fluorescence microscopy and a spectroscopy system as reported previously were used for detecting the fluorescence signals [1, 2]. A total of 50 patients have been included for intraoperative assessment of the tumor borders using the fluorescence techniques. A spectral domain OCT imaging system (TELESTO II, Thorlabs, Inc., NJ, USA) with central wavelength of 1325 nm was used to study the tissue microstructure post operatively. The system has a resolution of 13 and 5.5 μm in the lateral and axial directions, respectively. Tissue specimens from three patients undergoing brain tumor surgery were studied using the OCT system.

Results and Conclusion:

Using fluorescence spectroscopy the tumor could be detected with a sensitivity of 0.84 which was significantly higher than that of the surgical microscope (0.30). Brain tissue appeared rather homogeneous in the OCT images however the highly malignant tissue showed a clear structural difference from the non-malignant or low malignant brain tumor tissue which could be related to the fluorescence signal intensities.

Place, publisher, year, edition, pages
Uppsala: , 2015
Keywords
fluorescence, optical coherence tomography, brain tumor
National Category
Other Medical Engineering
Identifiers
urn:nbn:se:liu:diva-122286 (URN)
Conference
Medicinteknikdagarna 2015, 13–14 oktober 2015 Uppsala Konsert & Kongress
Funder
Swedish Research CouncilSwedish Childhood Cancer Foundation
Available from: 2015-10-27 Created: 2015-10-27 Last updated: 2019-10-14Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-6716-0314

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