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Henriksson, Karl-Gösta
Publications (10 of 21) Show all publications
Stening, K., Eriksson, O., Henriksson, K.-G., Brynhildsen, J., Lindh-Åstrand, L., Berg, G., . . . Blomqvist, A. (2011). Hormonal replacement therapy does not affect self-estimated pain or experimental pain responses in post-menopausal women suffering from fibromyalgia: a double-blind, randomized, placebo-controlled trial. RHEUMATOLOGY, 50(3), 544-551
Open this publication in new window or tab >>Hormonal replacement therapy does not affect self-estimated pain or experimental pain responses in post-menopausal women suffering from fibromyalgia: a double-blind, randomized, placebo-controlled trial
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2011 (English)In: RHEUMATOLOGY, ISSN 1462-0324, Vol. 50, no 3, p. 544-551Article in journal (Refereed) Published
Abstract [en]

Methods. Twenty-nine post-menopausal women were randomized to either 8 weeks of treatment with transdermal 17 beta-oestradiol (50 mu g/day) or placebo according to a double-blind protocol. A self-estimation of pain, a set of quantitative sensory tests measuring thresholds to temperature, thermal pain, cold pain and pressure pain, and a cold pressor test were performed on three occasions: before treatment, after 8 weeks of treatment and 20 weeks after cessation of treatment. Results. Hormonal replacement treatment significantly increased serum oestradiol levels as expected (P andlt; 0.01). However, no differences in self-estimated pain were seen between treatment and placebo groups, nor were there any differences between the two groups regarding the results of the quantitative sensory tests or the cold pressor test at any of the examined time points. Conclusion. Eight weeks of transdermal oestradiol treatment does not influence perceived pain, pain thresholds or pain tolerance as compared with placebo treatment in post-menopausal women suffering from FM.

Place, publisher, year, edition, pages
Oxford University Press, 2011
Keywords
Oestrogen, Substitution, Pain, Hormonal levels, Quantitative sensory testing, Cold pressor test
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-66851 (URN)10.1093/rheumatology/keq348 (DOI)000287745600016 ()
Available from: 2011-03-22 Created: 2011-03-21 Last updated: 2011-11-08
Henriksson, K.-G. (2009). The Fibromyalgia Syndrome: Translating Science into Clinical Practice. JOURNAL OF MUSCULOSKELETAL PAIN, 17(2), 189-194
Open this publication in new window or tab >>The Fibromyalgia Syndrome: Translating Science into Clinical Practice
2009 (English)In: JOURNAL OF MUSCULOSKELETAL PAIN, ISSN 1058-2452, Vol. 17, no 2, p. 189-194Article in journal (Refereed) Published
Abstract [en]

Objectives: The first objective is to present the arguments in favor of considering the biological component of the fibromyalgia syndrome [FMS], a disease of the nociceptive nervous system. The second aim is to present reliable methods for diagnosing such a disease. Findings: Studies confirm that there is long-standing or permanent pain hypersensitivity in FMS. The main causes of the pain amplification are central and peripheral sensitization of pain transmission neurons and/or pain disinhibition due to a disturbed endogenous pain modulation. The manual palpation method for determining the number of tender points is a measure of pressure-pain thresholds and degree of pain perception. Pain perception is influenced by psychological factors. More objective measures of pain thresholds are available and are presented in the article. Conclusions: The biological part of FMS reflects a long-standing or permanent change in the function of the nociceptive nervous system, that can be equated with a disease. It is hoped that upgrading FMS from illness to disease will increase the awareness of FMS among health personnel. This will in turn help patients with FMS to get correct diagnosis and treatment.

Keywords
Fibromyalgia syndrome, muscle pain, central sensitization
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-18148 (URN)10.1080/10582450902816539 (DOI)
Available from: 2009-05-09 Created: 2009-05-08 Last updated: 2009-08-18
Cöster, L., Kendall, S., Gerdle, B., Henriksson, C., Henriksson, K.-G. & Bengtsson, A. (2008). Chronic widespread musculoskeletal pain - A comparison of those who meet criteria for fibromyalgia and those who do not. European Journal of Pain, 12(5), 600-610
Open this publication in new window or tab >>Chronic widespread musculoskeletal pain - A comparison of those who meet criteria for fibromyalgia and those who do not
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2008 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 12, no 5, p. 600-610Article in journal (Refereed) Published
Abstract [en]

Fibromyalgia is currently classified as chronic widespread pain with widespread allodynia to pressure pain. There are few data describing pain characteristics, quality of life, consequences for daily living, and psychosocial status in patients who meet the classification criteria for fibromyalgia proposed by the American College of Rheumatology compared with patients with chronic widespread pain but not widespread allodynia. This study used a randomly selected sample from the general population. A postal questionnaire and a pain mannequin were sent to 9952 people. The response rate was 76.7%. The pain drawings showed that 345 people had widespread pain, that is, they noted pain in all four extremities and axially. Clinical examination, which included a manual tender point examination, was performed in 125 subjects. These people answered commonly used questionnaires on pain, quality of life, coping strategies, depression, and anxiety. Compared with chronic widespread pain without widespread allodynia, fibromyalgia was associated with more severe symptoms/consequences for daily life and higher pain severity. Similar coping strategies were found. Chronic widespread pain without widespread allodynia to pressure pain was found in 4.5% in the population and fibromyalgia in 2.5%. © 2007 European Federation of Chapters of the International Association for the Study of Pain.

Keywords
Activities of Daily Living Adaptation, Psychological Adult Aged Anxiety/epidemiology Chronic Disease Creatine Kinase, MM Form/blood Depression/epidemiology Diagnosis, Differential Female Fibromyalgia/classification/*diagnosis/psychology Humans Male Middle
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-43334 (URN)10.1016/j.ejpain.2007.10.001 (DOI)73539 (Local ID)73539 (Archive number)73539 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Carville, S. F., Arendt-Nielsen, S., Bliddal, H., Blotman, F., Branco, J. C., Buskila, D., . . . Choy, E. H. (2008). EULAR evidence-based recommendations for the management of fibromyalgia syndrome. Annals of the Rheumatic Diseases, 67(4), 536-541
Open this publication in new window or tab >>EULAR evidence-based recommendations for the management of fibromyalgia syndrome
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2008 (English)In: Annals of the Rheumatic Diseases, ISSN 0003-4967, E-ISSN 1468-2060, Vol. 67, no 4, p. 536-541Article in journal (Refereed) Published
Abstract [en]

Objective: To develop evidence-based recommendations for the management of fibromyalgia syndrome. Methods: A multidisciplinary task force was formed representing 11 European countries. The design of the study, including search strategy, participants, interventions, outcome measures, data collection and analytical method, was defined at the outset. A systematic review was undertaken with the keywords "fibromyalgia", "treatment or management" and "trial". Studies were excluded if they did not utilise the American College of Rheumatology classification criteria, were not clinical trials, or included patients with chronic fatigue syndrome or myalgic encephalomyelitis. Primary outcome measures were change in pain assessed by visual analogue scale and fibromyalgia impact questionnaire. The quality of the studies was categorised based on randomisation, blinding and allocation concealment. Only the highest quality studies were used to base recommendations on. When there was insufficient evidence from the literature, a Delphi process was used to provide basis for recommendation. Results: 146 studies were eligible for the review. 39 pharmacological intervention studies and 59 non-pharmacological were included in the final recommendation summary tables once those of a lower quality or with insufficient data were separated. The categories of treatment identified were antidepressants, analgesics, and "other pharmacological" and exercise, cognitive behavioural therapy, education, dietary interventions and "other non-pharmacological". In many studies sample size was small and the quality of the study was insufficient for strong recommendations to be made. Conclusions: Nine recommendations for the management of fibromyalgia syndrome were developed using a systematic review and expert consensus.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-44195 (URN)10.1136/ard.2007.071522 (DOI)75993 (Local ID)75993 (Archive number)75993 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Gerdle, B., Björk, J., Cöster, L., Henriksson, K.-G., Henriksson, C. & Bengtsson, A. (2008). Prevalence of widespread pain and associations with work status: A population study. BMC Musculoskeletal Disorders, 9
Open this publication in new window or tab >>Prevalence of widespread pain and associations with work status: A population study
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2008 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 9Article in journal (Refereed) Published
Abstract [en]

Background. This population study based on a representative sample from a Swedish county investigates the prevalence, duration, and determinants of widespread pain (WSP) in the population using two constructs and estimates how WSP affects work status. In addition, this study investigates the prevalence of widespread pain and its relationship to pain intensity, gender, age, income, work status, citizenship, civil status, urban residence, and health care seeking. Methods. A cross-sectional survey using a postal questionnaire was sent to a representative sample (n = 9952) of the target population (284,073 people, 18-74 years) in a county (Östergötland) in the southern Sweden. The questionnaire was mailed and followed by two postal reminders when necessary. Results. The participation rate was 76.7% (n = 7637), the non-participants were on the average younger, earned less money, and male. Women had higher prevalences of pain in 10 different predetermined anatomical regions. WSP was generally chronic (90-94%) and depending on definition of WSP the prevalence varied between 4.8-7.4% in the population. Women had significantly higher prevalence of WSP than men and the age effect appeared to be stronger in women than in men. WSP was a significant negative factor - together with age 50-64 years, low annual income, and non-Nordic citizen - for work status in the community and in the group with chronic pain. Chronic pain but not the spreading of pain was related to health care seeking in the population. Conclusion. This study confirms earlier studies that report high prevalences of widespread pain in the population and especially among females and with increasing age. Widespread pain is associated with prominent effects on work status. © 2008 Gerdle et al, licensee BioMed Central Ltd.

Keywords
Adolescent Adult Aged Chronic Disease Cross-Sectional Studies Demography Employment/*statistics & numerical data Female Humans Male Middle Aged Occupational Diseases Pain/diagnosis/*epidemiology/physiopathology *Population Surveillance Prevalence Question
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-43153 (URN)10.1186/1471-2474-9-102 (DOI)72100 (Local ID)72100 (Archive number)72100 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Arendt Nielsen, L. & Henriksson, K.-G. (2007). Pathophysiological mechanisms in chronic musculoskeletal pain (fibromyalgia): the role of central and peripheral sensitization and pain disinhibition. Baillière's Best Practice & Research: Clinical Rheumatology, 21(3), 465-480
Open this publication in new window or tab >>Pathophysiological mechanisms in chronic musculoskeletal pain (fibromyalgia): the role of central and peripheral sensitization and pain disinhibition
2007 (English)In: Baillière's Best Practice & Research: Clinical Rheumatology, ISSN 1521-6942, E-ISSN 1532-1770, Vol. 21, no 3, p. 465-480Article in journal (Refereed) Published
Abstract [en]

Chronic musculoskeletal pain has biological, psychological and social components. This review deals with the biological factors, with emphasis on the fibromyalgia syndrome (FMS). Studies on central sensitization of pain-transmitting neurons, changes in endogenous pain modulation that give rise to pain disinhibition, referred pain, pain-related decrease in muscle strength and endurance, and pain generators in deep tissues are reviewed. In FMS there is strong scientific support for the statement that the biological part of the syndrome is a longstanding or permanent change in the function of the nociceptive nervous system that can be equated with a disease. Further research is necessary in order to determine which methods are best for diagnosis of the pain hypersensitivity in clinical practice. FMS may be the far end of a continuum that starts with chronic localized/regional musculoskeletal pain and ends with widespread chronic disabling pain. © 2007 Elsevier Ltd. All rights reserved.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-39519 (URN)10.1016/j.berh.2007.03.007 (DOI)49227 (Local ID)49227 (Archive number)49227 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Bengtsson, A., Henriksson, C. & Henriksson, K.-G. (2006). Fibromyalgi (1ed.). In: Jörgen Borg (Ed.), Rehabiliteringsmedicin: (pp. 156-161). Lund: Studentlitteratur
Open this publication in new window or tab >>Fibromyalgi
2006 (Swedish)In: Rehabiliteringsmedicin / [ed] Jörgen Borg, Lund: Studentlitteratur , 2006, 1, p. 156-161Chapter in book (Other academic)
Abstract [sv]

Kapitel om rehabiliteringsmedicinens utveckling och nuvarande plats i sjukvården samt begrepp och metodik inleder boken. I två delar ges därefter rehabiliteringsmedicinska aspekter på de dominerande sjukdomsgrupperna - komplexa smärttillstånd respektive skador och sjukdomar i nervsystemet. Som avslutning beskrivs bland annat  stressrelaterade tillstånd. Läroboken är avsedd för grundutbildning av läkare, arbetsterapeuter och sjukgymnaster, logopeder samt för läkare under AT-tjänstgöring. Den är också lämplig som introduktion i specialistutbildningen i rehabiliteringsmedicin, geriatrik, neurologi och smärtlindring. Vidareutbildningar av olika vårdyrkesgrupper kan ha nytta av boken och den kan också användas som referenslitteratur av yrkesverksamma med intresse för rehabiliteringsmedicin.

Place, publisher, year, edition, pages
Lund: Studentlitteratur, 2006 Edition: 1
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-36555 (URN)31619 (Local ID)91-44-04507-7 (ISBN)978-91-44-04507-8 (ISBN)31619 (Archive number)31619 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2013-09-02Bibliographically approved
Henriksson, C., Carlberg, U., Kjällman, M., Lundberg, G. & Henriksson, K.-G. (2004). Evaluation of four outpatient educational programmes for patients with longstanding fibromyalgia. Journal of Rehabilitation Medicine, 36(5), 211-219
Open this publication in new window or tab >>Evaluation of four outpatient educational programmes for patients with longstanding fibromyalgia
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2004 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 36, no 5, p. 211-219Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Four programmes based on educational and cognitive principles but with a variation in total length and number of staff/patient contact hours were compared in order to gain further insight into the importance of the format of the programme for the final outcome.

DESIGN: A prospective non-randomized intervention study with 191 persons with fibromyalgia. Data were collected before, after and at 1-year follow-up. Participants served as their own controls. Results within and between the programmes were calculated.

METHODS: Clinical investigations before and after intervention. Questionnaires were answered before, after and at 1-year follow-up.

RESULTS: Most instruments showed no significant improvements after the programme. However, some improvements were found in important variables such as attitudes, self-efficacy, vitality and "days feeling well". Results were unchanged at the 1-year follow-up and 16 persons had started working. Seven had ceased working. Participants reported frequent use of coping strategies in everyday life. No major differences could be found between the programmes. Conclusions: More comprehensive programmes did not produce better results at group level. Also short and less costly interventions based on educational and cognitive principles were valuable for persons with longstanding fibromyalgia. More attention must be given to evaluating the clinical effect of programmes.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-23590 (URN)10.1080/16501970410027494 (DOI)3077 (Local ID)3077 (Archive number)3077 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Aspegren Kendall, S., Henriksson, K.-G., Hurtig, I., Raak, R., Bengtsson, A., Sören, B., . . . Gerdle, B. (2003). Differences in sensory thresholds in the skin of women with fibromyalgia syndrome: A comparison between ketamine responders and ketamine non-responders. Journal of Musculoskeletal Pain, 11(2), 3-9
Open this publication in new window or tab >>Differences in sensory thresholds in the skin of women with fibromyalgia syndrome: A comparison between ketamine responders and ketamine non-responders
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2003 (English)In: Journal of Musculoskeletal Pain, ISSN 1058-2452, E-ISSN 1540-7012, Vol. 11, no 2, p. 3-9Article in journal (Refereed) Published
Abstract [en]

Objectives: To compare detection and pain thresholds in the skin of female fibromyalgia patients who were either ketamine responders or ketamine nonresponders.

Methods: Detection thresholds to innocuous warmth, of cold, heat or cold pain, and touch and dynamic touch sensation were determined in the skin. Pressure pain thresholds, local and widespread pain intensity, and pain duration were also registered.

Results: Ketamine nonresponse was associated with more pronounced hypersensitivity for thermal pain [especially cold pain] than ketamine response.

Conclusions: Blockade of N-metyl-D-aspartic acid receptors by ketamine and the recording of pain thresholds in the skin, especially for cold pain, might reveal different mechanisms of allodynia.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26380 (URN)10.1300/J094v11n02_02 (DOI)10914 (Local ID)10914 (Archive number)10914 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Henriksson, K.-G. (2003). Fibromyalgia - From syndrome to disease. Overview of pathogenetic mechanisms. Journal of Rehabilitation Medicine, 35, 89-94
Open this publication in new window or tab >>Fibromyalgia - From syndrome to disease. Overview of pathogenetic mechanisms
2003 (English)In: Journal of Rehabilitation Medicine, ISSN 1650-1977, E-ISSN 1651-2081, Vol. 35, p. 89-94Article in journal (Refereed) Published
Abstract [en]

According to the classification criteria proposed by the American College of Rheumatology, fibromyalgia is a long-standing multifocal pain condition combined with generalised allodynia/hyperalgesia. It is the generalised allodynia/hyperalgesia that distinguishes fibromyalgia from other conditions with chronic musculoskeletal pain. Central sensitisation of nociceptive neurons in the dorsal horn due to activation of N-methyl-D-aspartic acid receptors and disinhibition of pain due to deficient function of the descending inhibitory system are probable pathogenic factors for allodynia/hyperalgesia. Furthermore, chronic pain is a chronic emotional and physical stressor. Chronic stress and chronic sleep disturbance are not specific for fibromyalgia but could be the causes of symptoms like fatigue, cognitive difficulties and other stress-related symptoms. They may also cause neuroendocrinological and immunological aberrations.

Keywords
fibromyalgia, muscle pain, allodynia, hyperalgesia
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-47786 (URN)10.1080/16501960310010215 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13
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