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Säfström, Kåge
Publications (10 of 18) Show all publications
Jonsson, A., Liuba, I., Säfström, K. & Walfridsson, H. (2012). Arrhythmia symptoms with and without arrhythmias in patients monitored with transtelephonic ECG after AF-ablation in CIRCULATION, vol 125, issue 19, pp E687-E687. In: CIRCULATION (pp. E687-E687). American Heart Association, 125(19)
Open this publication in new window or tab >>Arrhythmia symptoms with and without arrhythmias in patients monitored with transtelephonic ECG after AF-ablation in CIRCULATION, vol 125, issue 19, pp E687-E687
2012 (English)In: CIRCULATION, American Heart Association , 2012, Vol. 125, no 19, p. E687-E687Conference paper, Published paper (Refereed)
Abstract [en]

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Place, publisher, year, edition, pages
American Heart Association, 2012
Series
CIRCULATION, ISSN 0009-7322
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-84362 (URN)000307009200106 ()
Available from: 2012-10-05 Created: 2012-10-05 Last updated: 2013-12-17
Mentesidou, E., Richter, J., Vigren, P., Säfström, K. & Landtblom, A.-M. (2010). Combination of vagal nerve stimulator and cardiac pace-maker in EUROPEAN JOURNAL OF NEUROLOGY, vol 17, issue SI, pp 456-456. In: EUROPEAN JOURNAL OF NEUROLOGY (pp. 456-456). Wiley-Blackwell, 17(SI)
Open this publication in new window or tab >>Combination of vagal nerve stimulator and cardiac pace-maker in EUROPEAN JOURNAL OF NEUROLOGY, vol 17, issue SI, pp 456-456
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2010 (English)In: EUROPEAN JOURNAL OF NEUROLOGY, Wiley-Blackwell , 2010, Vol. 17, no SI, p. 456-456Conference paper, Published paper (Refereed)
Abstract [en]

n/a

Place, publisher, year, edition, pages
Wiley-Blackwell, 2010
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-70230 (URN)000293331101205 ()
Available from: 2011-08-26 Created: 2011-08-26 Last updated: 2011-08-26
Caceres, R., Richter, J., Säfström, K. & Landtblom, A.-M. (2010). Letter: Increased need for combinated nervus vagus-stimulators and electronic cardiac devices: aspects on methods and safety [Letter to the editor]. Acta Neurologica Scandinavica, 121(4), 287-288
Open this publication in new window or tab >>Letter: Increased need for combinated nervus vagus-stimulators and electronic cardiac devices: aspects on methods and safety
2010 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 121, no 4, p. 287-288Article in journal, Letter (Other academic) Published
Abstract [en]

n/a

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-54513 (URN)10.1111/j.1600-0404.2010.01329.x (DOI)000275216400012 ()
Available from: 2010-03-19 Created: 2010-03-19 Last updated: 2017-12-12Bibliographically approved
Caceres, R., Richter, J., Säfström, K. & Landtblom, A.-M. (2009). Editorial: Application of a vagal nerve stimulator in an epilepsy patient with cardiac pacemaker after post-ictal cardiac arrest. Acta Neurologica Scandinavica, 120(2), 139-142
Open this publication in new window or tab >>Editorial: Application of a vagal nerve stimulator in an epilepsy patient with cardiac pacemaker after post-ictal cardiac arrest
2009 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 120, no 2, p. 139-142Article in journal, Editorial material (Other academic) Published
Abstract [en]

In this case report we present a patient with temporal lobe epilepsy (TLE) showing partial complex seizures and secondary generalization, and treated with several antiepileptic drugs. After two consecutive seizures she had an episode of cardiac arrest followed by AV-block III which led to the implantation of a cardiac pacemaker. She subsequently received a vagal nerve stimulator because of poor response to epilepsy treatment. Combined treatment with two different electromagnetic stimulators raises the question of safety during surgery which is discussed.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2009
Keywords
epilepsy; vagal nerve stimulation; cardiac pacemaker; arrhythmia
National Category
Neurology
Identifiers
urn:nbn:se:liu:diva-20210 (URN)10.1111/j.1600-0404.2008.01123.x (DOI)19053951 (PubMedID)2-s2.0-67651233834 (Scopus ID)
Available from: 2009-09-02 Created: 2009-08-31 Last updated: 2017-12-13Bibliographically approved
Liuba, I., Ahlmroth, H., Jonasson, L., Englund, A., Jönsson, A., Säfström, K. & Walfridsson, H. (2008). Source of inflammatory markers in patients with atrial fibrillation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 10(7), 848-853
Open this publication in new window or tab >>Source of inflammatory markers in patients with atrial fibrillation
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2008 (English)In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, ISSN 1532-2092, Vol. 10, no 7, p. 848-853Article in journal (Refereed) Published
Abstract [en]

AIMS: Elevated levels of C-reactive protein and other inflammatory markers have been reported in some patients with atrial fibrillation (AF). Whether this finding is related to AF per se or to other conditions remains unclear. In addition, the source of inflammatory markers is unknown. Therefore, in the present study, we sought to assess the extent and the source of inflammation in patients with AF and no other concomitant heart or inflammatory conditions.

METHODS AND RESULTS: The study group consisted of 29 patients referred for radiofrequency catheter ablation: 10 patients with paroxysmal AF, 8 patients with permanent AF, and 10 control patients with Wolf-Parkinson-White (WPW) syndrome and no evidence of AF (mean age 54 +/- 11 vs. 57 +/- 13 vs. 43 +/- 16). No patient had structural heart diseases or inflammatory conditions. High-sensitive C-reactive protein, interleukin-6 (IL-6), and interleukin-8 (IL-8) were assessed in blood samples from the femoral vein, right atrium, coronary sinus, and the left and right upper pulmonary veins. All samples were collected before ablation. Compared with controls and patients with paroxysmal AF, patients with permanent AF had higher plasma levels of IL-8 in the samples from the femoral vein, right atrium, and coronary sinus, but not in the samples from the pulmonary veins (median values in the femoral vein: 2.58 vs. 2.97 vs. 4.66 pg/mL, P = 0.003; right atrium: 2.30 vs. 3.06 vs. 3.93 pg/mL, P = 0.013; coronary sinus: 2.85 vs. 3.15 vs. 4.07, P = 0.016). A high-degree correlation existed between the IL-8 levels in these samples (correlation coefficient between 0.929 and 0.976, P < 0.05). No differences in the C-reactive protein and IL-6 levels were noted between the three groups of patients.

CONCLUSION: The normal levels of C-reactive protein and IL-6, along with the elevated levels of IL-8 in patients with permanent AF but not in those with paroxysmal AF, suggest a link between a low-grade inflammatory reaction and long-lasting AF. The elevated IL-8 levels in the peripheral blood, right atrium, and coronary sinus but not in the pulmonary veins suggest a possible source of inflammation in the systemic circulation.

Keywords
Atrial fibrillation, Inflammation, Catheter ablation
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-20458 (URN)10.1093/europace/eun111 (DOI)18523031 (PubMedID)
Available from: 2009-09-09 Created: 2009-09-09 Last updated: 2018-09-17Bibliographically approved
Kühme, T., Säfström, K., Nielsen, N. E., Nylander, E. & Olin, C. (2006). Rupture of a synthetic VSD patch 28 years after total correction of Fallot's anomaly. Annals of Thoracic Surgery, 81(4), 1510-1512
Open this publication in new window or tab >>Rupture of a synthetic VSD patch 28 years after total correction of Fallot's anomaly
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2006 (English)In: Annals of Thoracic Surgery, ISSN 0003-4975, E-ISSN 1552-6259, Vol. 81, no 4, p. 1510-1512Article in journal (Refereed) Published
Abstract [en]

Patients operated on for complex congenital heart malformations need continuous follow-up. We present a male patient born in 1948 with Fallot's anomaly. A total correction was performed when he was 21 years old. Twenty-eight years after the operation, at routine follow-up, he presented with a significant left-to-right shunt because of a new ventricular septal defect. During the operation we found the original patch to be fractured with a central perforation. The patient received a new patch and has been without any clinical symptoms since. © 2006 by The Society of Thoracic Surgeons.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-33765 (URN)10.1016/j.athoracsur.2005.03.068 (DOI)19816 (Local ID)19816 (Archive number)19816 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
Blomstrand, P., Maret, E., Ohlsson, J., Scheike, M., Karlsson, J.-E., Säfström, K., . . . Engvall, J. (2004). Pulsed tissue Doppler imaging for the detection of myocardial ischaemia, a comparison with myocardial perfusion SPECT. Clinical Physiology and Functional Imaging, 24(5), 289-295
Open this publication in new window or tab >>Pulsed tissue Doppler imaging for the detection of myocardial ischaemia, a comparison with myocardial perfusion SPECT
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2004 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 24, no 5, p. 289-295Article in journal (Refereed) Published
Abstract [en]

In order to compare the diagnostic ability of pulsed tissue Doppler and myocardial perfusion Single Photon Emission Computed Tomography (SPECT) in patients with a history of unstable coronary artery disease, CAD, 26 patients, 22 men and four women, age 47-76 years, were investigated in a prospective study, 5-10 day after an episode of unstable angina. Tissue Doppler and two-dimensional echocardiography were performed during dobutamine stress testing and myocardial scintigraphy after bicycle exercise and at rest. Patients with a normal SPECT had higher peak systolic velocity during dobutamine infusion, 18.9 +/- 4.1 cm s(-1), than patients with ischaemia, 12.2 +/- 3.8 cm s(-1) (P<0.001) or scar, 8.8 +/- 3.0 cm s(-1) (P<0.01). In a territorial analysis the difference in peak systolic velocity between areas with a normal and abnormal SPECT was less apparent. Failure to achieve >/=13 cm s(-1) in mean-peak systolic velocity was the most accurate criterion for detection of significant CAD on SPECT. We conclude that pulsed tissue Doppler can be used for objective quantification of left ventricular wall motion during dobutamine stress testing and for identification of patients with CAD on SPECT but not for identification of regional ischaemia.

Keywords
Dobutamine, echocardiography, myocardial perfusion SPECT, tissue Doppler
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-18310 (URN)10.1111/j.1475-097X.2004.00564.x (DOI)15383086 (PubMedID)
Available from: 2009-05-18 Created: 2009-05-18 Last updated: 2017-12-13Bibliographically approved
Landtblom, A.-M., Dige, N., Schwerdt, K., Säfström, K. & Granerus, G. (2003). Short-term memory dysfunction in Kleine-Levin syndrome. Acta Neurologica Scandinavica, 108(5), 363-367
Open this publication in new window or tab >>Short-term memory dysfunction in Kleine-Levin syndrome
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2003 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 108, no 5, p. 363-367Article in journal (Refereed) Published
Abstract [en]

Background - A previous investigation at our department of a young man with typical Kleine-Levin syndrome revealed short-term memory dysfunction as well as hypoperfusion of the temporal lobes on single photon emission tomography (SPECT) (CERETECR) examination, 6 and 7 years after recovery, suggesting long lasting or even permanent cerebral dysfunction. Patients and methods - We investigated four cases with classical adolescent Kleine-Levin syndrome characterized by hypersomnia and typical associated symptoms. We used neuropsychological testing and SPECT (CERETECR) of the brain. The results from the previous report related to above is included. Results - Examination with SPECT (CERETECR) during remission revealed hypoperfusion of the temporal lobes and fronto-temporal region in two of four cases. There were normal findings in two. Neuropsychological testing performed during remission showed reduction in the short-term memory capacity in all four cases. Conclusion - It is striking that all the cases investigated showed short-term memory dysfunction. One patient who had recovered from paroxysmal symptoms (hypersomnia attacks and bulimia) 6 years earlier showed progress in the short-term memory dysfunction. A pathologic condition in the temporal lobes may be suspected in Kleine-Levin syndrome.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26910 (URN)10.1034/j.1600-0404.2003.00171.x (DOI)11534 (Local ID)11534 (Archive number)11534 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Landtblom, A.-M., Dige, N., Schwerdt, K., Säfström, K. & Granerus, G. (2002). A case of Kleine-Levin syndrome examined with SPECT and neuropsychological testing. Acta Neurologica Scandinavica, 105(4), 318-321
Open this publication in new window or tab >>A case of Kleine-Levin syndrome examined with SPECT and neuropsychological testing
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2002 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 105, no 4, p. 318-321Article in journal (Refereed) Published
Abstract [en]

A case of Kleine-Levin syndrome with typical periodic hypersomnia and bulemia was diagnosed. On examination with single photo emission tomography (SPECT) (CERETEC«) during a relapse period and 2 weeks later there was marked cortical hypoperfusion of the frontal and temporal lobes, especially on the left side as well as in the right parietal lobe. Neuropsychological testing performed 1 week after a relapse showed a reduction in encoding to memory function of verbal learning indicating neocortical damage of the left fronto-temporal region. A follow-up 2 months later after the patient had spontaneously recovered showed only a slight left fronto-temporal disturbance. CT and MRI of the brain were normal although the MRI showed a large and asymmetric mamillary body. Neuropsychological testing 6 years after recovery showed pronounced reduction in short-time verbal and visual memory. Seven years after recovery SPECT demonstrated a normalized frontal perfusion but still a slight hypoperfusion in the left temporal lobe. Our results correlate to autopsy findings in two cases described previously.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26911 (URN)10.1034/j.1600-0404.2002.1c162.x (DOI)11535 (Local ID)11535 (Archive number)11535 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Lagerqvist, B., Säfström, K., Ståhle, E., Wallentin, L. & Swahn, E. (2001). Is early invasive treatment of unstable coronary artery disease equally effective for both women and men?. Journal of the American College of Cardiology, 38(1), 41-48
Open this publication in new window or tab >>Is early invasive treatment of unstable coronary artery disease equally effective for both women and men?
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2001 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 38, no 1, p. 41-48Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The Fragmin and fast Revascularization during InStability in Coronary artery disease (FRISC II) trial compared the effectiveness of an early invasive versus a noninvasive strategy in terms of the incidence of death and myocardial infarction (MI) in patients with unstable coronary artery disease (CAD). OBJECTIVES: In this subanalysis, we sought to evaluate gender differences in the effect of these different strategies. METHODS: The patients (749 women and 1,708 men) were randomized to early invasive or noninvasive strategies. Coronary angiography was performed within the first 7 days in 96% and 10% of the invasive and noninvasive groups, respectively, and revascularization was performed within the first 10 days in 71% and 9% of the invasive and noninvasive groups, respectively. RESULTS: Women presenting with unstable CAD were older, but fewer had previous infarctions, left ventricular dysfunction and elevated troponin T levels. Women had fewer angiographic changes. There was no difference in MI or death at 12 months among women in the invasive and noninvasive groups (12.4% vs. 10.5%, respectively), in contrast to the favorable effect in the invasively treated group of men (9.6% vs. 15.8%, p < 0.001). In an interaction analysis, there was a different effect of the early invasive strategy for the two genders (p = 0.008). CONCLUSIONS: Women with symptoms and/or signs of unstable CAD are older, but still have less severe CAD and a better prognosis compared with men. In contrast to its beneficial effect in men, an early invasive strategy did not reduce the risk of future events among women. Further research is warranted to identify the most appropriate treatment strategy in women with unstable CAD. ⌐ 2001 American College of Cardiology.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27164 (URN)10.1016/S0735-1097(01)01308-0 (DOI)11813 (Local ID)11813 (Archive number)11813 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
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